LOCUS       NM_001142286            5240 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens structural maintenance of chromosomes 6 (SMC6),
            transcript variant 1, mRNA.
ACCESSION   NM_001142286
VERSION     NM_001142286.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5240)
  AUTHORS   Diman,A., Panis,G., Castrogiovanni,C., Prados,J., Baechler,B. and
            Strubin,M.
  TITLE     Human Smc5/6 recognises transcription-generated positive DNA
            supercoils
  JOURNAL   Nat Commun 15 (1), 7805 (2024)
   PUBMED   39242537
  REMARK    GeneRIF: Human Smc5/6 recognises transcription-generated positive
            DNA supercoils.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5240)
  AUTHORS   Fingerman,D.F., O'Leary,D.R., Hansen,A.R., Tran,T., Harris,B.R.,
            DeWeerd,R.A., Hayer,K.E., Fan,J., Chen,E., Tennakoon,M., Meroni,A.,
            Szeto,J.H., Devenport,J., LaVigne,D., Weitzman,M.D., Shalem,O.,
            Bednarski,J., Vindigni,A., Zhao,X. and Green,A.M.
  TITLE     The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated
            replication stress
  JOURNAL   EMBO J 43 (15), 3240-3255 (2024)
   PUBMED   38886582
  REMARK    GeneRIF: The SMC5/6 complex prevents genotoxicity upon
            APOBEC3A-mediated replication stress.
REFERENCE   3  (bases 1 to 5240)
  AUTHORS   Roy,S., Adhikary,H. and D'Amours,D.
  TITLE     The SMC5/6 complex: folding chromosomes back into shape when
            genomes take a break
  JOURNAL   Nucleic Acids Res 52 (5), 2112-2129 (2024)
   PUBMED   38375830
  REMARK    GeneRIF: The SMC5/6 complex: folding chromosomes back into shape
            when genomes take a break.
            Review article
REFERENCE   4  (bases 1 to 5240)
  AUTHORS   Irwan,I.D., Bogerd,H.P. and Cullen,B.R.
  TITLE     Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
  JOURNAL   Nat Microbiol 7 (12), 2101-2113 (2022)
   PUBMED   36376394
  REMARK    GeneRIF: Epigenetic silencing by the SMC5/6 complex mediates HIV-1
            latency.
REFERENCE   5  (bases 1 to 5240)
  AUTHORS   Oravcova,M., Nie,M., Zilio,N., Maeda,S., Jami-Alahmadi,Y.,
            Lazzerini-Denchi,E., Wohlschlegel,J.A., Ulrich,H.D., Otomo,T. and
            Boddy,M.N.
  TITLE     The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral
            replication centers
  JOURNAL   Elife 11, e79676 (2022)
   PUBMED   36373674
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5240)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     Human MMS21/NSE2 is a SUMO ligase required for DNA repair
  JOURNAL   Mol Cell Biol 25 (16), 7021-7032 (2005)
   PUBMED   16055714
  REMARK    GeneRIF: the human SMC5/6 complex and the SUMO ligase activity of
            hMMS21 are required for the prevention of DNA damage-induced
            apoptosis by facilitating DNA repair in human cells
REFERENCE   7  (bases 1 to 5240)
  AUTHORS   Sergeant,J., Taylor,E., Palecek,J., Fousteri,M., Andrews,E.A.,
            Sweeney,S., Shinagawa,H., Watts,F.Z. and Lehmann,A.R.
  TITLE     Composition and architecture of the Schizosaccharomyces pombe Rad18
            (Smc5-6) complex
  JOURNAL   Mol Cell Biol 25 (1), 172-184 (2005)
   PUBMED   15601840
REFERENCE   8  (bases 1 to 5240)
  AUTHORS   Harvey,S.H., Sheedy,D.M., Cuddihy,A.R. and O'Connell,M.J.
  TITLE     Coordination of DNA damage responses via the Smc5/Smc6 complex
  JOURNAL   Mol Cell Biol 24 (2), 662-674 (2004)
   PUBMED   14701739
REFERENCE   9  (bases 1 to 5240)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
REFERENCE   10 (bases 1 to 5240)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB451629.1, AL136544.1, BC039828.1, AL832979.1 and CD369665.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001142286.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136544.1, SRR1660803.160497.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448223.7/ ENSP00000404092.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DB451629.1         20-26
            8-3656              AL136544.1         1-3649
            3657-3927           BC039828.1         3573-3843
            3928-5022           AL832979.1         3823-4917
            5023-5240           CD369665.1         18-235              c
FEATURES             Location/Qualifiers
     source          1..5240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.2"
     gene            1..5240
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="structural maintenance of chromosomes 6"
                     /db_xref="GeneID:79677"
                     /db_xref="HGNC:HGNC:20466"
                     /db_xref="MIM:609387"
     exon            1..185
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..272
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..397
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..3553
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="SMC protein 6; SMC6 structural maintenance of
                     chromosomes 6-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 6"
                     /protein_id="NP_001135758.1"
                     /db_xref="CCDS:CCDS1690.1"
                     /db_xref="GeneID:79677"
                     /db_xref="HGNC:HGNC:20466"
                     /db_xref="MIM:609387"
                     /translation="MAKRKEENFSSPKNAKRPRQEELEDFDKDGDEDECKGTTLTAAE
                     VGIIESIHLKNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGRAVATNR
                     GSSLKGFVKDGQNSADISITLRNRGDDAFKASVYGNSILIQQHISIDGSRSYKLKSAT
                     GSVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQ
                     MKEDYSYIMETKERTKEQIHQGEERLTELKRQCVEKEERFQSIAGLSTMKTNLESLKH
                     EMAWAVVNEIEKQLNAIRDNIKIGEDRAARLDRKMEEQQVRLNEAEQKYKDIQDKLEK
                     ISEETNARAPECMALKADVVAKKRAYNEAEVLYNRSLNEYKALKKDDEQLCKRIEELK
                     KSTDQSLEPERLERQKKISWLKERVKAFQNQENSVNQEIEQFQQAIEKDKEEHGKIKR
                     EELDVKHALSYNQRQLKELKDSKTDRLKRFGPNVPALLEAIDDAYRQGHFTYKPVGPL
                     GACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQALMKRFYLPGTSRPPIIVSE
                     FRNEIYDVRHRAAYHPDFPTVLTALEIDNAVVANSLIDMRGIETVLLIKNNSVARAVM
                     QSQKPPKNCREAFTADGDQVFAGRYYSSENTRPKFLSRDVDSEISDLENEVENKTAQI
                     LNLQQHLSALEKDIKHNEELLKRCQLHYKELKMKIRKNISEIRELENIEEHQSVDIAT
                     LEDEAQENKSKMKMVEEHMEQQKENMEHLKSLKIEAENKYDAIKFKINQLSELADPLK
                     DELNLADSEVDNQKRGKRHYEEKQKEHLDTLNKKKRELDMKEKELEEKMSQARQICPE
                     RIEVEKSASILDKEINRLRQKIQAEHASHGDREEIMRQYQEARETYLDLDSKVRTLKK
                     FIKLLGEIMEHRFKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSISVQ
                     PGEGNKAAFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAM
                     DLILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDD
                     DQR"
     exon            398..515
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            516..621
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..758
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..820
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..901
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1003
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1123
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1222
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1369
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1458
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1623
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1802
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..2007
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2122
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2283
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2419
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2500
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2671
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2809
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2955
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3081
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3187
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3340
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3438
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..5240
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3628..3633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="hexamer: AATAAA"
     polyA_site      3656
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="major polyA site"
     regulatory      3907..3912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="hexamer: AATAAA"
     polyA_site      3927
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="major polyA site"
     regulatory      4947..4952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="hexamer: CATAAA"
     polyA_site      4970
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
     regulatory      5217..5222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
                     /note="hexamer: AATAAA"
     polyA_site      5240
                     /gene="SMC6"
                     /gene_synonym="hSMC6; SMC-6; SMC6L1"
ORIGIN      
        1 ggttagtacc gcggtgggcg ccggggctcc cgggaatcta ccttctcctg cggccggcac
       61 gcggttccca gggggccagc ggcggtcagc cgaggtcgag acgcccgcag ggtggcctta
      121 gcggccggtc gtaccacggc agccccgccg atcaggttcc tttgggagac ttcgacttgt
      181 tggcgaaatg aaccggagaa gaatcccaat tgggaattgc ggaaaacagg actctagggt
      241 agagaaaggt tgtagaacca atagggtttg agacctgatg gccaaaagaa aggaagaaaa
      301 tttttcctct cctaaaaatg ccaaaaggcc aagacaagaa gaattggagg attttgataa
      361 agatggtgac gaagacgaat gtaaaggtac tactttgact gcagcagaag ttggaataat
      421 tgagagtatt cacctaaaaa acttcatgtg tcattcaatg cttggacctt ttaagtttgg
      481 ttctaatgtc aactttgttg ttggcaacaa tggaagtggg aagagtgcag tactcacagc
      541 tctcatagtc ggtcttggtg gaagagcagt tgctactaat agaggatcct ctttaaaagg
      601 ttttgtgaaa gatggacaga actctgcaga tatctcaata acattgagga acagaggaga
      661 tgatgccttt aaagccagtg tgtatggtaa ctctatactt atacagcaac acatcagcat
      721 agatggaagt cgatcttata aacttaaaag tgcaacaggc tccgtggttt ccacgaggaa
      781 agaagagctg attgcaattc ttgatcattt taacatccag gtggataatc cagtttctgt
      841 tttaacacaa gaaatgagca agcagttctt acagtctaaa aatgaaggag acaaatacaa
      901 attcttcatg aaagcaacgc aacttgaaca gatgaaggaa gattattcat acattatgga
      961 aacgaaagaa agaacaaagg agcagataca tcaaggagaa gagcggctta ctgaactaaa
     1021 gcgccagtgt gtagagaaag aggaacgttt tcaaagtatt gctggtttaa gtacaatgaa
     1081 gactaattta gagtccttga aacatgaaat ggcttgggca gtggtcaatg aaattgaaaa
     1141 acaattgaat gccatcagag ataatatcaa aattggagaa gatcgtgctg ctagacttga
     1201 caggaaaatg gaagaacagc aggtcagact taatgaggca gaacaaaagt acaaggatat
     1261 tcaagacaaa ctagaaaaga ttagtgaaga gacaaatgca cgagcaccag aatgtatggc
     1321 attgaaagca gatgttgttg ctaagaaaag ggcctataat gaagctgagg ttttatataa
     1381 ccgatcctta aacgaatata aagcattaaa gaaagatgat gagcagcttt gtaaacgaat
     1441 tgaagagctg aaaaaaagta ctgaccaatc tttggaacct gaacggttgg aaagacaaaa
     1501 aaaaatatct tggttaaaag agagagtaaa ggcctttcaa aatcaagaaa attcagtcaa
     1561 tcaagagatc gaacagtttc agcaagccat agaaaaggac aaagaagaac atggcaaaat
     1621 taagagagaa gaattagatg tgaagcatgc actgagctac aatcagaggc aactgaaaga
     1681 attgaaagat agtaaaactg atcgactcaa aagatttggc cctaatgttc cagctcttct
     1741 tgaagccata gatgatgctt atagacaagg acattttacc tataaacctg taggcccttt
     1801 aggagcttgc attcatcttc gggacccaga acttgctttg gctattgaat cttgcttaaa
     1861 agggcttctg caggcctatt gttgccataa tcatgctgat gaaagggtcc ttcaggcact
     1921 catgaaaagg ttttatttac cagggacctc acggccaccg ataatagttt ctgagtttcg
     1981 gaatgagata tatgatgtaa gacacagagc tgcttatcat ccagactttc caacagttct
     2041 gacagcttta gaaatagata atgcggttgt ggcaaatagc ctaattgaca tgagaggcat
     2101 agagacagtg ctactaatca aaaataattc tgtagctcgt gcagtaatgc agtcccaaaa
     2161 gccacccaaa aattgtagag aagcttttac tgctgatggt gatcaagttt ttgcaggacg
     2221 ttattattca tctgaaaata caagacctaa gttcctaagc agagatgtgg attctgaaat
     2281 aagtgacttg gagaatgagg ttgaaaataa gacggcccag atattaaatc ttcagcaaca
     2341 tttatctgcc cttgaaaaag atattaaaca caatgaggaa cttcttaaaa ggtgccaact
     2401 acattataaa gaactaaaga tgaaaataag aaaaaatatt tctgaaattc gggaacttga
     2461 gaacatagaa gaacaccagt ctgtagatat tgcaactttg gaagatgaag ctcaggaaaa
     2521 taaaagcaaa atgaaaatgg ttgaggaaca tatggagcaa caaaaagaaa atatggagca
     2581 tcttaaaagt ctgaaaatag aagcagaaaa taagtatgat gcaattaaat tcaaaattaa
     2641 tcaactatcg gagctagcag acccacttaa ggatgaatta aaccttgctg attctgaagt
     2701 ggataaccaa aaacgaggga aacgacatta tgaagaaaaa caaaaagaac acttggatac
     2761 cttaaataaa aagaaacgag aactggatat gaaagagaaa gaactagagg agaaaatgtc
     2821 acaagcaaga caaatctgcc cagagcgtat agaagtagaa aaatctgcat caattctgga
     2881 caaagaaatt aatcgattaa ggcagaagat acaggcagaa catgctagtc atggagatcg
     2941 agaggaaata atgaggcagt accaagaagc aagagagacc tatcttgatc tggatagtaa
     3001 agtgaggact ttaaaaaagt ttattaaatt actgggagaa atcatggagc acagattcaa
     3061 gacatatcaa caatttagaa ggtgtttgac tttacgatgc aaattatact ttgacaactt
     3121 actatctcag cgggcctatt gtggaaaaat gaattttgac cacaagaatg aaactctaag
     3181 tatatcagtt cagcctggag aaggaaataa agctgctttc aatgacatga gagccttgtc
     3241 tggaggtgaa cgttctttct ccacagtgtg ttttattctt tccctgtggt ccatcgcaga
     3301 atctcctttc agatgcctgg atgaatttga tgtctacatg gatatggtta ataggagaat
     3361 tgccatggac ttgatactga agatggcaga ttcccagcgt tttagacagt ttatcttgct
     3421 cacacctcaa agcatgagtt cacttccatc cagtaaactg ataagaattc tccgaatgtc
     3481 tgatcctgaa agaggacaaa ctacattgcc tttcagacct gtgactcaag aagaagatga
     3541 tgaccaaagg tgatttgtaa cttaacatgc cttgtcctga tgttgaagga tttgtgaagg
     3601 gaaaaaaaat tctggactct ttgatataat aaaatgagac tggaggcatt ctgaaatgaa
     3661 agaaactcct ttatatatcc aaccacaatc aaacatataa ataagcctgg aaaaccaact
     3721 acaacctgca atttaagatt actattactt taagaaaatc aatttcatag tattggtttt
     3781 aaatcttttt aagttttttt aatacgatct atttttatag gttctttttc agaagtaaaa
     3841 ttttgtacat atatacatgt acatatctgt ttagtttggg ttcatttcta taacattttg
     3901 taagaaaata aaagtttgag cacctgatta tatttagttt tgcttttcca gatattacat
     3961 tctatagtta ccaaaaatgg ttgaagggag ggatttctca ttgcagaggg tggggtgcaa
     4021 gggaataaga cacttgtacg gaacactgaa gctttgccaa cttctacaca tgcctttttt
     4081 gcagtccttt aactgtccac cctaccaaga gcttataacc agtatcagaa ctggataatg
     4141 acgcagtttt tcactctgac ctccatcatg cttgcctgat ttaaaagccc tcagtttgca
     4201 gtccagggac tgttcaggct tgtcctcagc tgagaggaca caggctagag ggactgtgca
     4261 gaaccaggct gggagaaggg ctgggaaaac tgggagtgga gggtggatcc tcatggagca
     4321 ggagagtagc tcatggctcc aggagcctga ggccatgcag ttgatggtga gctgacatca
     4381 attctaagac tcatcctaat tgaggggtgt taaaaagtgt gctgcttaga atgaccaaat
     4441 atagttattg taaaaaatga tatttatgaa ctttttattt tagaaaacat gaattttatt
     4501 gctccctgta ttatttgttt gatactagga ttcatgctaa actttttaag aatgtattgg
     4561 atatcaagaa gcattcctta cattagtagc aataaatatt agaataaata tgaaattgaa
     4621 ctattttcag aaaaagggca gtatattaag agcagggact gttctctagt tattgaggaa
     4681 aactggactt tgtttgtgtt tttggtggag gaagaagttt aagatacttt agtcttaaat
     4741 tgaggtttgc caaatgagaa gttcaaaaac ttgggctttc taatcagaat ttccaggagg
     4801 aggaaagtgt gtgctgaata ttttaaacat ttcccactga tcatacaaag tctgattttt
     4861 aaatttacac ttataatgcc tttgtattaa aattattttt aacatgtgct tttccaaatt
     4921 aaaaatgaag tagagtatac caaatgcata aactttcatt agctaaggaa ctcatgtctg
     4981 aattttgttg tagttttgaa tgttgtgctc tttcatacag aatgggaaac ataatcctca
     5041 ggtatcccag catctcttgt tgaattgaag attattcatt gctttggcct cacaaagttt
     5101 tgatttcaac tatcataagt gaaaatatct tcctttaatg ttctaagtag tgataatatt
     5161 actagaatga aagaataaaa agaaattgtt cttttaaaat atgtgtaact tctaaaaata
     5221 aaacttaaaa tttatatgta
//
