LOCUS       NM_015110               5949 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens structural maintenance of chromosomes 5 (SMC5), mRNA.
ACCESSION   NM_015110
VERSION     NM_015110.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5949)
  AUTHORS   Diman,A., Panis,G., Castrogiovanni,C., Prados,J., Baechler,B. and
            Strubin,M.
  TITLE     Human Smc5/6 recognises transcription-generated positive DNA
            supercoils
  JOURNAL   Nat Commun 15 (1), 7805 (2024)
   PUBMED   39242537
  REMARK    GeneRIF: Human Smc5/6 recognises transcription-generated positive
            DNA supercoils.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5949)
  AUTHORS   Fingerman,D.F., O'Leary,D.R., Hansen,A.R., Tran,T., Harris,B.R.,
            DeWeerd,R.A., Hayer,K.E., Fan,J., Chen,E., Tennakoon,M., Meroni,A.,
            Szeto,J.H., Devenport,J., LaVigne,D., Weitzman,M.D., Shalem,O.,
            Bednarski,J., Vindigni,A., Zhao,X. and Green,A.M.
  TITLE     The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated
            replication stress
  JOURNAL   EMBO J 43 (15), 3240-3255 (2024)
   PUBMED   38886582
  REMARK    GeneRIF: The SMC5/6 complex prevents genotoxicity upon
            APOBEC3A-mediated replication stress.
REFERENCE   3  (bases 1 to 5949)
  AUTHORS   Roy,S., Adhikary,H. and D'Amours,D.
  TITLE     The SMC5/6 complex: folding chromosomes back into shape when
            genomes take a break
  JOURNAL   Nucleic Acids Res 52 (5), 2112-2129 (2024)
   PUBMED   38375830
  REMARK    GeneRIF: The SMC5/6 complex: folding chromosomes back into shape
            when genomes take a break.
            Review article
REFERENCE   4  (bases 1 to 5949)
  AUTHORS   Zhu,W., Shi,Y., Zhang,C., Peng,Y., Wan,Y., Xu,Y., Liu,X., Han,B.,
            Zhao,S., Kuang,Y., Song,H. and Qiao,J.
  TITLE     In-frame deletion of SMC5 related with the phenotype of primordial
            dwarfism, chromosomal instability and insulin resistance
  JOURNAL   Clin Transl Med 13 (1), e1007 (2023)
   PUBMED   36627765
  REMARK    GeneRIF: In-frame deletion of SMC5 related with the phenotype of
            primordial dwarfism, chromosomal instability and insulin
            resistance.
REFERENCE   5  (bases 1 to 5949)
  AUTHORS   Irwan,I.D., Bogerd,H.P. and Cullen,B.R.
  TITLE     Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency
  JOURNAL   Nat Microbiol 7 (12), 2101-2113 (2022)
   PUBMED   36376394
  REMARK    GeneRIF: Epigenetic silencing by the SMC5/6 complex mediates HIV-1
            latency.
REFERENCE   6  (bases 1 to 5949)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
  REMARK    GeneRIF: SMC5/6 complex is recruited to nuclease-induced
            double-strand breaks (DSBs) and is required for the recruitment of
            cohesin to DSBs.
REFERENCE   7  (bases 1 to 5949)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     Human MMS21/NSE2 is a SUMO ligase required for DNA repair
  JOURNAL   Mol Cell Biol 25 (16), 7021-7032 (2005)
   PUBMED   16055714
  REMARK    GeneRIF: the human SMC5/6 complex and the SUMO ligase activity of
            hMMS21 are required for the prevention of DNA damage-induced
            apoptosis by facilitating DNA repair in human cells
REFERENCE   8  (bases 1 to 5949)
  AUTHORS   Sergeant,J., Taylor,E., Palecek,J., Fousteri,M., Andrews,E.A.,
            Sweeney,S., Shinagawa,H., Watts,F.Z. and Lehmann,A.R.
  TITLE     Composition and architecture of the Schizosaccharomyces pombe Rad18
            (Smc5-6) complex
  JOURNAL   Mol Cell Biol 25 (1), 172-184 (2005)
   PUBMED   15601840
REFERENCE   9  (bases 1 to 5949)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   10 (bases 1 to 5949)
  AUTHORS   Taylor,E.M., Moghraby,J.S., Lees,J.H., Smit,B., Moens,P.B. and
            Lehmann,A.R.
  TITLE     Characterization of a novel human SMC heterodimer homologous to the
            Schizosaccharomyces pombe Rad18/Spr18 complex
  JOURNAL   Mol Biol Cell 12 (6), 1583-1594 (2001)
   PUBMED   11408570
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB220819.1, BC038225.1, DB318469.1, AB011166.2 and AA709087.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015110.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011166.2, SRR1803614.52446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361138.7/ ENSP00000354957.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB220819.1         17-27
            12-1016             BC038225.1         11-1015
            1017-1272           DB318469.1         1-256               c
            1273-3496           BC038225.1         1272-3495
            3497-5676           AB011166.2         3454-5633
            5677-5791           AA709087.1         160-274             c
            5792-5949           AB011166.2         5749-5906
FEATURES             Location/Qualifiers
     source          1..5949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.12"
     gene            1..5949
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /note="structural maintenance of chromosomes 5"
                     /db_xref="GeneID:23137"
                     /db_xref="HGNC:HGNC:20465"
                     /db_xref="MIM:609386"
     exon            1..286
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..3407
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /note="SMC-5; hSMC5; SMC protein 5; SMC5 structural
                     maintenance of chromosomes 5-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 5"
                     /protein_id="NP_055925.2"
                     /db_xref="CCDS:CCDS6632.1"
                     /db_xref="GeneID:23137"
                     /db_xref="HGNC:HGNC:20465"
                     /db_xref="MIM:609386"
                     /translation="MATPSKKTSTPSPQPSKRALPRDPSSEVPSKRKNSAPQLPLLQS
                     SGPFVEGSIVRISMENFLTYDICEVSPGPHLNMIVGANGTGKSSIVCAICLGLAGKPA
                     FMGRADKVGFFVKRGCSRGMVEIELFRASGNLVITREIDVAKNQSFWFINKKSTTQKI
                     VEEKVAALNIQVGNLCQFLPQDKVGEFAKLSKIELLEATEKSIGPPEMHKYHCELKNL
                     REKEKQLETSCKEKTEYLQKMVQRNERYKQDVERFYERKRHLDLIEMLEAKRPWVEYE
                     NVRQEYEEVKLVRDRVKEEVRKLKEGQIPVTCRIEEMENERHNLEARIKEKATDIKEA
                     SQKCKQKQDVIERKDKHIEELQQALIVKQNEELDRQRRIGNTRKMIEDLQNELKTTEN
                     CENLQPQIDAITNDLRRIQDEKALCEGEIIDKRRERETLEKEKKSVDDHIVRFDNLMN
                     QKEDKLRQRFRDTYDAVLWLRNNRDKFKQRVCEPIMLTINMKDNKNAKYIENHIPSND
                     LRAFVFESQEDMEVFLKEVRDNKKLRVNAVIAPKSSYADKAPSRSLNELKQYGFFSYL
                     RELFDAPDPVMSYLCCQYHIHEVPVGTEKTRERIERVIQETRLKQIYTAEEKYVVKTS
                     FYSNKVISSNTSLKVAQFLTVTVDLEQRRHLEEQLKEIHRKLQAVDSGLIALRETSKH
                     LEHKDNELRQKKKELLERKTKKRQLEQKISSKLGSLKLMEQDTCNLEEEERKASTKIK
                     EINVQKAKLVTELTNLIKICTSLHIQKVDLILQNTTVISEKNKLESDYMAASSQLRLT
                     EQHFIELDENRQRLLQKCKELMKRARQVCNLGAEQTLPQEYQTQVPTIPNGHNSSLPM
                     VFQDLPNTLDEIDALLTEERSRASCFTGLNPTIVQEYTKREEEIEQLTEELKGKKVEL
                     DQYRENISQVKERWLNPLKELVEKINEKFSNFFSSMQCAGEVDLHTENEEDYDKYGIR
                     IRVKFRSSTQLHELTPHHQSGGERSVSTMLYLMALQELNRCPFRVVDEINQGMDPINE
                     RRVFEMVVNTACKENTSQYFFITPKLLQNLPYSEKMTVLFVYNGPHMLEPNTWNLKAF
                     QRRRRRITFTQPS"
     exon            287..428
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..481
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..644
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..779
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..920
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1082
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1154
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1410
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1565
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1679
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1774
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1907
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2081
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2251
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2375
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2498
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2624
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2669
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2765
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2870
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2990
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3170
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..3266
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..5949
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /note="hexamer: AATAAA"
     polyA_site      3496
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
     regulatory      5927..5932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /note="hexamer: AATAAA"
     polyA_site      5949
                     /gene="SMC5"
                     /gene_synonym="ATELS2; SMC5L1"
                     /note="major polyA site"
ORIGIN      
        1 agttcgcgcg ggagcggggc gcctgggtgg atgggcgctt gggcgcctgg gctgccggac
       61 ggtgggaacg gaagtcgctg tgggacgctg aggaagccag gatggcgact ccgagcaaga
      121 agacgtcaac tccaagcccc cagccttcca agagagctct cccgagagac ccttcgtcgg
      181 aggtcccgag caagaggaag aattcggccc cgcagctgcc gctgttgcag tcgtccgggc
      241 ctttcgtgga aggctctatc gtccgcatct cgatggagaa cttcctaaca tatgatattt
      301 gtgaagtatc tcctggaccc cacttgaata tgatcgttgg agccaatgga acagggaagt
      361 cgagcattgt gtgtgccatt tgccttggtt tagctggaaa acctgctttc atgggacgag
      421 cagataaggt tgggtttttt gtgaagagag gatgttctag aggcatggtt gaaattgaat
      481 tgttcagggc ttctggaaat cttgtaatca cccgtgagat tgatgtggca aaaaatcagt
      541 ccttttggtt catcaacaaa aaatctacaa cccagaaaat agtggaagag aaagttgcag
      601 ccttaaatat tcaagtgggg aatctttgcc agtttctccc tcaggacaaa gttggagaat
      661 ttgctaaact cagcaaaatt gaactcctcg aagccactga aaagtcaatt ggtcccccag
      721 aaatgcacaa atatcactgt gaactcaaaa acttaaggga gaaagaaaaa cagctcgaga
      781 cctcatgcaa agagaaaact gagtatctac agaaaatggt tcagaggaat gaaagatata
      841 aacaagatgt ggagaggttc tatgaacgga agcgacattt agatttaatt gagatgcttg
      901 aagcaaaaag gccatgggtg gaatatgaaa atgttcgtca ggaatatgaa gaagtaaaac
      961 tagttcgtga ccgagtgaag gaagaggtca gaaaacttaa agaagggcag attcctgtaa
     1021 catgtcgaat tgaagaaatg gaaaacgagc gtcacaattt ggaggctcga atcaaagaaa
     1081 aggcaacaga tattaaggag gcatctcaaa aatgcaaaca gaagcaagat gttatagaaa
     1141 ggaaagataa acatattgag gaacttcagc aggctttaat agtaaagcaa aatgaagagc
     1201 ttgaccgaca gaggagaata ggtaataccc gcaaaatgat agaggatttg caaaatgaac
     1261 taaagaccac ggaaaactgc gagaatcttc agccccagat tgatgccatt acaaatgatc
     1321 tgagacggat tcaggatgaa aaggcattat gtgaaggcga aataattgat aagcgaagag
     1381 agagggaaac tctagagaag gagaaaaaga gtgtggacga tcatattgta cgttttgaca
     1441 atcttatgaa tcagaaggaa gataagctaa gacagagatt ccgtgacacg tatgatgctg
     1501 ttttatggct aagaaataac agagacaaat ttaaacaaag agtctgtgag cccataatgc
     1561 tcacgatcaa tatgaaagat aataaaaatg ccaaatatat tgaaaatcat attccatcaa
     1621 atgacttaag agcctttgta tttgaaagtc aagaagatat ggaggttttc ctcaaagagg
     1681 ttcgtgacaa taaaaaatta agagtaaatg ctgttattgc tcccaagagt tcatatgcag
     1741 acaaagcacc ttcaagatct ttgaatgaac ttaaacaata cggatttttc tcttatttga
     1801 gagaattatt tgatgcacct gatcctgtaa tgagttacct ttgctgtcag tatcatattc
     1861 atgaagttcc tgtaggaact gaaaagacca gagaaagaat tgaacgggta atacaagaaa
     1921 cccgattaaa acagatttat acagcagaag aaaagtatgt ggtgaaaact tctttttatt
     1981 caaacaaagt tatttctagt aacacatctc taaaagtagc gcagtttctc actgtcactg
     2041 tggacctaga gcagagaaga cacttagaag aacagctaaa ggaaattcat agaaaattgc
     2101 aagcagtgga ttcagggttg attgccttac gtgaaacaag caaacatctg gagcacaaag
     2161 acaatgaact tagacaaaag aagaaggagc ttcttgagag aaaaaccaag aaaagacaac
     2221 tggaacaaaa aatcagttcc aaactaggaa gtttaaagct gatggaacag gatacttgca
     2281 atcttgaaga ggaagagcga aaagcaagta ccaaaatcaa agaaataaat gttcaaaaag
     2341 cgaaacttgt taccgaatta acaaacctaa taaagatttg tacttctttg catatacaaa
     2401 aagtagattt aattctccaa aatactacag tgatctctga gaagaacaaa ttagaatcag
     2461 attatatggc cgcatcttca caactccgtc ttacagagca acatttcatt gaattggatg
     2521 aaaatagaca gagattattg cagaaatgca aggaacttat gaaaagagct aggcaagtat
     2581 gtaacctggg tgcagagcag actcttcctc aagaatacca gacacaagta cccaccattc
     2641 caaatggaca caactcctca ctccccatgg ttttccaaga ccttccaaac acattggatg
     2701 aaattgatgc tttattaact gaagaaagat caagagcttc ctgcttcacg ggactgaatc
     2761 ctacaattgt tcaggaatat acaaaaagag aagaagaaat agaacagtta actgaggaac
     2821 taaagggaaa gaaagttgaa ctagatcaat acagggaaaa catttcacag gtaaaagaaa
     2881 ggtggcttaa tcctttaaaa gagctggtag aaaaaattaa tgaaaaattc agcaattttt
     2941 ttagttccat gcagtgtgct ggtgaagttg atctccatac agaaaatgag gaagattatg
     3001 ataaatatgg aattcgaatt agagtcaaat ttcgaagtag tactcaactg catgaattaa
     3061 ctcctcatca tcaaagtgga ggtgaaagaa gtgtttctac catgttatac ttgatggcac
     3121 ttcaggagct aaatagatgt ccattcagag tagttgatga aatcaatcag ggaatggacc
     3181 caatcaatga acggagagtg tttgaaatgg ttgtaaatac tgcctgtaaa gaaaatacat
     3241 ctcaatactt tttcataaca ccaaagctcc tgcaaaatct tccttattct gaaaagatga
     3301 cagttttgtt tgtctacaat ggccctcata tgctggaacc aaacacatgg aatttaaagg
     3361 ctttccaaag gcggcggcgc cgtattacat tcactcaacc ttcttaataa aagtaaagag
     3421 agggaacttg ggaatttttt ttgttaaatt ctgtttataa gtatggctca actgaataaa
     3481 aggagattca ctaaaacgaa aagcagttat ttttggaaac ctgcttttaa atacaaatag
     3541 gttgataatg gaaactataa tgacctttcc aaaatagcag ctggtagtaa aagttaagtc
     3601 ttcttcagtc ttggttgaac ttgagttctt ggcactctga ccatgagtca ttcagttctc
     3661 atgttaaaat gtacttaata ttacaaatca aaggtacagt ggaagaaggg ttaatcacaa
     3721 gaagttactt atatggtagc cctgagcttt aattgcagag taactttaat tacttttaga
     3781 gcctaaagat gactctagag cctaagtcct agtttctccc aatgttatat ttaattttaa
     3841 aaaattgata tgaaaatgtc taatgtatag taataattta tgacagatct agtcatttct
     3901 tcctattaaa aaagattacc ttatctccag taggaaatgg aattttatgg gcctttaaaa
     3961 gaaagtttta tgaaacttga tgctataatt ttattggtat ttcaagggga aaaaagcact
     4021 ggggttcaaa aatggtagca gaactgcttt gaaatgctgc aaggtggcca ctagatgatg
     4081 caaaatacaa ccaaaagatt gactgagaat aaaattaggt gacaagggtt tttaaagaat
     4141 aaccttttaa agtgtggggg caggggttgc ttttttttat tttatttaaa gtcaattata
     4201 ttttacatct tacatttcta aaagcatttt ataattattt ttagtaagat ttttcttaaa
     4261 atttcatata ctggtttcta caatttatat ttgaaatttc tcagtgttat gtaaagagtg
     4321 atggaaaagc attgatttct ttaaaaccgt aatgttttta gaacttaagc ctatagggcc
     4381 tttcttacaa tgttgatgta cccattatct tagaaaatct agtttaaact gttttctttc
     4441 accgcaaaag aattaaatgg gaaaatcatt tgtttatctc taagttatac taattagtag
     4501 aaccaaacaa attatcttct tttaaaaaat aaatcttata ggaaaataga cagtccaaag
     4561 tcatgtcttt gaacagtgga ttggatctgt gccagtaatg acaaaattat ttttttgact
     4621 tgcttgcctg aataaattga agaattgctt tcagtttggg ttttgtatat tcttaagtag
     4681 ccattgaaat ttatattctt aactaggtca aaaaataatg agccataagt ttatgtcctc
     4741 tcacttagac attttctctt taaaaaggta ttttcttctt tataaacatt ttaaaagagc
     4801 cttcccttct taaactaact ccagtgcatg aagtgtgaaa atattttaaa atgacatttt
     4861 tactaatatg agcaagtcat gtaaacattg aagaacttgg taacatatta gtaaatggat
     4921 attaccaaat gttttcatcg ttaattactt tgcgttccac caaaatatct ttactaaaat
     4981 gtgcttggtg tagtttgttt attgtctaaa ttagtaccag tcatcttatt tctgcaaaat
     5041 gagtatcaat gtgaaaaaga cacgtgaaga ttaagcatgt ttgaaaataa aatggtcaat
     5101 tacatttcaa tttacatagg ccaacaactg ttccatactt tgtttgtaaa catttaattt
     5161 ctctactgga caaaattaat atttggcttt acattgaatt ttgagctgtg aagaataaat
     5221 tatgtatcat tttagcatat taaacagtag taagtctagc acatagtctc agccacttaa
     5281 aacaaaagtt tttttgtttg tttgtttgtt tgtttttttg agatggagtc tcactctgtt
     5341 gcccaggctg gagtgcagtg gcgtgatctc ggcttactgc aacctccgcc tcccgggttc
     5401 aagcgattct cctgcctcag cctcccaagt aactgggaca acaggcgcgt cccaccacac
     5461 ccagctaatt ttttatactt ttagtagaga tggggtttca gcatattggc caggctggtc
     5521 tcgaactcct gaccttgtga tccacccgcc tcggcctccc aaagtgctgg gattataggc
     5581 gtgagcccct gcacccggcc aaaagttgat ttttaattac ataaaaatcg taaaaacttc
     5641 tagtaaaaac ttgatttggt gaatacagtt atatttaaaa accttaaggt gacaagcatt
     5701 ttctatgcct aaatcttcat tggtttgcct ggaaagagtc tctgttaaaa gattttccat
     5761 attcaaagta aaaggaaaga tttcttgctt tctaattgtc ttttggacac atgcctattt
     5821 tctttgaggt ataaaccttt agatgtgaaa aatgtaattt cattctgcta ttgtgtgtgc
     5881 ttgtgtgtgt gtaattgaaa aaactgggaa atcctgcttt gttggtaata aatcaatatt
     5941 tttatattc
//
