LOCUS       NM_001002800            5116 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens structural maintenance of chromosomes 4 (SMC4),
            transcript variant 2, mRNA.
ACCESSION   NM_001002800
VERSION     NM_001002800.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5116)
  AUTHORS   Tan,L., Wang,S., Huang,S., Tie,Y., Sai,N., Mao,Y., Zhao,S., Hou,Y.
            and Dou,H.
  TITLE     FoxO1 promotes ovarian cancer by increasing transcription and
            METTL14-mediated m6A modification of SMC4
  JOURNAL   Cancer Sci 115 (4), 1224-1240 (2024)
   PUBMED   38403332
  REMARK    GeneRIF: FoxO1 promotes ovarian cancer by increasing transcription
            and METTL14-mediated m[6]A modification of SMC4.
REFERENCE   2  (bases 1 to 5116)
  AUTHORS   Zhu,M., Zhang,X., Gao,K., Zhang,L., Feng,X., Wang,H., Li,J. and
            Jia,J.
  TITLE     Structural Maintenance of Chromosome Protein 4 Promotes the
            Progression of Cardia Adenocarcinoma via Regulation of the
            Wnt/beta-catenin Signaling Pathway
  JOURNAL   Comb Chem High Throughput Screen 27 (4), 611-620 (2024)
   PUBMED   37170988
  REMARK    GeneRIF: Structural Maintenance of Chromosome Protein 4 Promotes
            the Progression of Cardia Adenocarcinoma via Regulation of the
            Wnt/beta-catenin Signaling Pathway.
REFERENCE   3  (bases 1 to 5116)
  AUTHORS   Yang,Z., Pan,X., Wu,X., Lin,Q., Chen,Y., Cai,S., Zhang,Y., Mai,Z.,
            Ahmad,N., Ma,D. and Deng,L.
  TITLE     TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3
            inflammasome through the SMC4/NEMO pathway
  JOURNAL   FEBS J 290 (6), 1549-1562 (2023)
   PUBMED   36181338
  REMARK    GeneRIF: TREM-1 induces pyroptosis in cardiomyocytes by activating
            NLRP3 inflammasome through the SMC4/NEMO pathway.
REFERENCE   4  (bases 1 to 5116)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5116)
  AUTHORS   Wang,J., Shao,J., Lu,Y., Su,W., Dong,H., Wang,P., Lin,Z., Feng,J.,
            Wang,D., Zhao,H. and Tan,J.
  TITLE     Screening Differential CircRNAs Expression Profiles Reveals the
            Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4
            Signaling Axis in Bladder Carcinoma Progression
  JOURNAL   DNA Cell Biol 41 (2), 128-141 (2022)
   PUBMED   35005988
  REMARK    GeneRIF: Screening Differential CircRNAs Expression Profiles
            Reveals the Regulatory Role of the
            has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in
            Bladder Carcinoma Progression.
REFERENCE   6  (bases 1 to 5116)
  AUTHORS   Kimura,K., Cuvier,O. and Hirano,T.
  TITLE     Chromosome condensation by a human condensin complex in Xenopus egg
            extracts
  JOURNAL   J Biol Chem 276 (8), 5417-5420 (2001)
   PUBMED   11136719
REFERENCE   7  (bases 1 to 5116)
  AUTHORS   Ball,A.R. Jr. and Yokomori,K.
  TITLE     The structural maintenance of chromosomes (SMC) family of proteins
            in mammals
  JOURNAL   Chromosome Res 9 (2), 85-96 (2001)
   PUBMED   11321372
  REMARK    Review article
REFERENCE   8  (bases 1 to 5116)
  AUTHORS   Schmiesing,J.A., Gregson,H.C., Zhou,S. and Yokomori,K.
  TITLE     A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a
            homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone
            H3 during the early stage of mitotic chromosome condensation
  JOURNAL   Mol Cell Biol 20 (18), 6996-7006 (2000)
   PUBMED   10958694
REFERENCE   9  (bases 1 to 5116)
  AUTHORS   Nishiwaki,T., Daigo,Y., Kawasoe,T., Nagasawa,Y., Ishiguro,H.,
            Fujita,M., Furukawa,Y. and Nakamura,Y.
  TITLE     Isolation and characterization of a human cDNA homologous to the
            Xenopus laevis XCAP-C gene belonging to the structural maintenance
            of chromosomes (SMC) family
  JOURNAL   J Hum Genet 44 (3), 197-202 (1999)
   PUBMED   10319587
REFERENCE   10 (bases 1 to 5116)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC106033.1, AB019987.1 and
            AL136877.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001002800.2.
            
            Summary: This gene belongs to the 'structural maintenance of
            chromosomes' (SMC) gene family. Members of this gene family play a
            role in two changes in chromosome structure during mitotic
            segregation of chromosomes- chromosome condensation and sister
            chromatid cohesion. The protein encoded by this gene is likely a
            subunit of the 13S condensin complex, which is involved in
            chromosome condensation. A pseudogene related to this gene is
            located on chromosome 2. [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (2) is the longest transcript and
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315070.1, SRR1803615.24208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357388.8/ ENSP00000349961.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC106033.1         19-57
            40-1282             AB019987.1         47-1289
            1283-5116           AL136877.1         1410-5243
FEATURES             Location/Qualifiers
     source          1..5116
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.33"
     gene            1..5116
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /note="structural maintenance of chromosomes 4"
                     /db_xref="GeneID:10051"
                     /db_xref="HGNC:HGNC:14013"
                     /db_xref="MIM:605575"
     exon            1..100
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..244
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..3972
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     chromosome-associated polypeptide C; SMC protein 4; SMC4
                     structural maintenance of chromosomes 4-like 1"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 4
                     isoform 1"
                     /protein_id="NP_001002800.1"
                     /db_xref="CCDS:CCDS3189.1"
                     /db_xref="GeneID:10051"
                     /db_xref="HGNC:HGNC:14013"
                     /db_xref="MIM:605575"
                     /translation="MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPAT
                     AAETASEELDNRSLEEILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILG
                     PFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTV
                     EVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGI
                     DLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEI
                     LNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI
                     AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQ
                     LDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE
                     KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDI
                     YLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLT
                     QEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGA
                     IDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMT
                     EIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTL
                     QGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKV
                     QLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQ
                     KLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLD
                     ECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV
                     VKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNS
                     KIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKP
                     NLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKL
                     KENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALV
                     FALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRL
                     IGIYKTYNITKSVAVNPKEIASKGLC"
     exon            245..423
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..615
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..792
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..957
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1085
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1226
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1377
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1542
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1776
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1962
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2124
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2350
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2430
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2583
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2710
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2900
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3045
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3219
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3220..3402
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3635
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3636..3819
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..5116
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5095..5100
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /note="hexamer: AATAAA"
     polyA_site      5116
                     /gene="SMC4"
                     /gene_synonym="CAP-C; CAPC; SMC-4; SMC4L1"
                     /note="major polyA site"
ORIGIN      
        1 attttcgagt gaaggacccg gagccgaaac accggtagga gcggggaggt gggtactaca
       61 caaccgtctc cagccttggt ctgagtggac tgtcctgcag cgaccatgcc ccgtaaaggc
      121 acccagccct ccactgcccg gcgcagagag gaagggccgc cgccgccgtc ccctgacggc
      181 gccagcagcg acgcggagcc tgagccgccg tccggccgca cggagagccc agccaccgcc
      241 gcagagactg caagtgagga acttgataat agaagtttag aagagatttt gaacagcatt
      301 cctcctcccc cgcctccagc aatgaccaat gaagctggag ctcctcggct tatgataact
      361 catattgtaa accagaactt caaatcctat gctggggaga aaattctggg acctttccat
      421 aagcgctttt cctgtattat cgggccaaat ggcagtggca aatccaatgt tattgattct
      481 atgctttttg tgtttggcta tcgagcacaa aaaataagat ctaaaaaact ctcagtatta
      541 atacataatt ctgatgaaca caaggacatt cagagttgta cagtagaagt tcattttcaa
      601 aagataattg ataaggaagg ggatgattat gaagtcattc ctaacagtaa tttctatgta
      661 tccagaacgg cctgcagaga taatacttct gtctatcaca taagtggaaa gaaaaagaca
      721 tttaaggatg ttggaaatct tcttcgaagc catggaattg acttggacca taatagattt
      781 ttaattttac agggtgaagt tgaacaaatt gctatgatga aaccaaaagg ccagactgaa
      841 cacgatgagg gtatgcttga atatttagaa gatataattg gttgtggacg gctaaatgaa
      901 cctattaaag tcttgtgtcg gagagttgaa atattaaatg aacacagagg agagaagtta
      961 aacagggtaa agatggtgga aaaggaaaag gatgccttag aaggagagaa aaacatagct
     1021 atcgaatttc ttaccttgga aaatgaaata tttagaaaaa agaatcatgt ttgtcaatat
     1081 tatatttatg agttgcagaa acgaattgct gaaatggaaa ctcaaaagga aaaaattcat
     1141 gaagatacca aagaaattaa tgagaagagc aatatactat caaatgaaat gaaagctaag
     1201 aataaagatg taaaagatac agaaaagaaa ctgaataaaa ttacaaaatt tattgaggag
     1261 aataaagaaa aatttacaca gctagatttg gaagatgttc aagttagaga aaagttaaaa
     1321 catgccacga gtaaagccaa aaaactggag aaacaacttc aaaaagataa agaaaaggtt
     1381 gaagaattta aaagtatacc tgccaagagt aacaatatca ttaatgaaac aacaaccaga
     1441 aacaatgccc tcgagaagga aaaagagaaa gaagaaaaaa aattaaagga agttatggat
     1501 agccttaaac aggaaacaca agggcttcag aaagaaaaag aaagtcgaga gaaagaactt
     1561 atgggtttca gcaaatcggt aaatgaagca cgttcaaaga tggatgtagc ccagtcagaa
     1621 cttgatatct atctcagtcg tcataatact gcagtgtctc aattaactaa ggctaaggaa
     1681 gctctaattg cagcttctga gactctcaaa gaaaggaaag ctgcaatcag agatatagaa
     1741 ggaaaactcc ctcaaactga acaagaatta aaggagaaag aaaaagaact tcaaaaactt
     1801 acacaagaag aaacaaactt taaaagtttg gttcatgatc tctttcaaaa agttgaagaa
     1861 gcaaagagct cattagcaat gaatcgaagt agggggaaag tccttgatgc aataattcaa
     1921 gaaaaaaaat ctggcaggat tccaggaata tatggaagat tgggggactt aggagccatt
     1981 gatgaaaaat acgacgtggc tatatcatcc tgttgtcatg cactggacta cattgttgtt
     2041 gattctattg atatagccca agaatgtgta aacttcctta aaagacaaaa tattggagtt
     2101 gcaaccttta taggtttaga taagatggct gtatgggcga aaaagatgac cgaaattcaa
     2161 actcctgaaa atactcctcg tttatttgat ttagtaaaag taaaagatga gaaaattcgc
     2221 caagcttttt attttgcttt acgagatacc ttagtagctg acaacttgga tcaagccaca
     2281 agagtagcat atcaaaaaga tagaagatgg agagtggtaa ctttacaggg acaaatcata
     2341 gaacagtcag gtacaatgac tggtggtgga agcaaagtaa tgaaaggaag aatgggttcc
     2401 tcacttgtta ttgaaatctc tgaagaagag gtaaacaaaa tggaatcaca gttgcaaaac
     2461 gactctaaaa aagcaatgca aatccaagaa cagaaagtac aacttgaaga aagagtagtt
     2521 aagttacggc atagtgaacg agaaatgagg aacacactag aaaaatttac tgcaagcatc
     2581 cagcgtttaa tagagcaaga agaatatttg aatgtccaag ttaaggaact tgaagctaat
     2641 gtacttgcta cagcccctga caaaaaaaag cagaaattgc tagaagaaaa cgttagtgct
     2701 ttcaaaacag aatatgatgc tgtggctgag aaagctggta aagtagaagc tgaggttaaa
     2761 cgcttacaca ataccatcgt agaaatcaat aatcataaac tcaaggccca acaagacaaa
     2821 cttgataaaa taaataagca attagatgaa tgtgcttctg ctattactaa agcccaagta
     2881 gcaatcaaga ctgctgacag aaaccttcaa aaggcacaag actctgtctt gcgtacagag
     2941 aaagaaataa aagatactga gaaagaggtg gatgacctaa cagcagagct gaaaagtctt
     3001 gaggacaaag cagcagaggt cgtaaagaat acaaatgctg cagaggaatc cttaccagag
     3061 atccagaaag aacatcgcaa tctgcttcaa gaattaaaag ttattcaaga aaatgaacat
     3121 gctcttcaaa aagatgcact tagtattaag ttgaaacttg aacaaataga tggtcacatt
     3181 gctgaacata attctaaaat aaaatattgg cacaaagaga tttcaaaaat atcactgcat
     3241 cctatagaag ataatcctat tgaagagatt tcggttctaa gcccagagga tcttgaagcg
     3301 atcaagaatc cagattctat aacaaatcaa attgcacttt tggaagcccg gtgtcatgaa
     3361 atgaaaccaa acctcggtgc catcgcagag tataaaaaga aggaagaatt gtatttgcaa
     3421 cgggtagcag aattggacaa aattacttat gaaagagaca gttttagaca ggcatatgaa
     3481 gatcttcgga aacaaaggct taatgaattt atggcaggtt tttatataat aacaaataaa
     3541 ttaaaggaaa attaccaaat gcttactttg ggaggggacg ccgaactcga gcttgtagac
     3601 agcttggatc ctttctctga aggaatcatg ttcagtgttc gaccacctaa gaaaagttgg
     3661 aaaaagatct tcaacctttc gggaggagag aaaacactta gttcattggc tttagtattt
     3721 gctcttcacc actacaagcc cactcccctt tacttcatgg atgagattga tgcagccctt
     3781 gattttaaaa atgtgtccat tgttgcattt tatatatatg aacaaacaaa aaatgcacag
     3841 ttcataataa tttctcttcg aaataatatg tttgagattt cggatagact tattggaatt
     3901 tacaagacat acaacataac aaaaagtgtt gctgtaaatc caaaagaaat tgcatctaag
     3961 ggactttgtt gaactttatg ctgaagattc ttcaagttga ttcagtgtat tactgatttt
     4021 tttctatttg taaaggatta tgagttgtat aaaatacata ctccctaaac tagatcatga
     4081 aactggtttc tgttttatgc agttgtcatt tgtaaagtct aataaaatat tctctataat
     4141 tgcttctaga ttacaaaaat atgacaatct tgtaagtagc agactatgga gaaaaatgag
     4201 ttacctggag ggtcaggtaa cttgccaaac taaaaagtat gttagttgag gcaaagtcct
     4261 aagcaaggtt gtgctatcaa ggctcagcat accttcgtgg gcctttgatt taccaacact
     4321 ggaaatgcct gccaactaat cttggataga ttctttaagg cattccactt agcttgccag
     4381 ttgagacaat caccacagtt attacccaaa tactatgaac atatttttgt aaaccagtca
     4441 ttctgaatta tagtgatgag aatttaaata tatgcttttc tagaatttga tgtttgacca
     4501 tttatgactt aattaccaga gagccagtaa attaggacag tgtttcaaca agcctaggct
     4561 atctcgtaag ttgaaaaata tcccactata gttgcttcat gagtatgaag taagatggcc
     4621 tctgatttac actggttcaa tttacaaatt ttcaacttta tgataggttt atccgggtac
     4681 taaatgcatt tcaacttgat agtttcaact tatgataggt ttaccaggat gtagtcccac
     4741 tgttgaggag catctattta ggggttaatt actttagtaa taagtggaaa gtaagatacc
     4801 ttgagtaatg tttgcctata aaattgtcag cgtattttta cactattggc tcaagaatgt
     4861 tataatgcta agggacataa gttggcaacc acttggtttt tggaaggact ttcggtattg
     4921 tattagaagt ctgccctagc tgttaaattt ctgggtattt atcctaagga attaattaaa
     4981 gagttaattg ttcctttctt cagtgggcca ttgttttaga tatttaaaaa atccaacagt
     5041 ttctatcata atgtaactgt aaaaatgtaa acacattatt agcatggact tttaaataaa
     5101 gatttaaaga aagcaa
//
