LOCUS       NM_005445               5522 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens structural maintenance of chromosomes 3 (SMC3), mRNA.
ACCESSION   NM_005445
VERSION     NM_005445.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5522)
  AUTHORS   Ansari,M., Faour,K.N.W., Shimamura,A., Grimes,G., Kao,E.M.,
            Denhoff,E.R., Blatnik,A., Ben-Isvy,D., Wang,L., Helm,B.M.,
            Firth,H., Breman,A.M., Bijlsma,E.K., Iwata-Otsubo,A., de
            Ravel,T.J.L., Fusaro,V., Fryer,A., Nykamp,K., Stuhn,L.G.,
            Haack,T.B., Korenke,G.C., Constantinou,P., Bujakowska,K.M.,
            Low,K.J., Place,E., Humberson,J., Napier,M.P., Hoffman,J.,
            Juusola,J., Deardorff,M.A., Shao,W., Rockowitz,S., Krantz,I.,
            Kaur,M., Raible,S., Dortenzio,V., Kliesch,S., Singer-Berk,M.,
            Groopman,E., DiTroia,S., Ballal,S., Srivastava,S., Rothfelder,K.,
            Biskup,S., Rzasa,J., Kerkhof,J., McConkey,H., Sadikovic,B.,
            Hilton,S., Banka,S., Tuttelmann,F., Conrad,D.F.,
            O'Donnell-Luria,A., Talkowski,M.E., FitzPatrick,D.R. and Boone,P.M.
  TITLE     Heterozygous loss-of-function SMC3 variants are associated with
            variable growth and developmental features
  JOURNAL   HGG Adv 5 (2), 100273 (2024)
   PUBMED   38297832
  REMARK    GeneRIF: Heterozygous loss-of-function SMC3 variants are associated
            with variable growth and developmental features.
REFERENCE   2  (bases 1 to 5522)
  AUTHORS   Su,Y., Lin,H., Yu,J., Mao,L., Jin,W., Liu,T., Jiang,S., Wu,Y.,
            Zhang,S., Geng,Q., Ge,C., Zhao,F., Chen,T., Cui,Y., Li,J., Hou,H.,
            Zhou,X. and Li,H.
  TITLE     RIT1 regulates mitosis and promotes proliferation by interacting
            with SMC3 and PDS5 in hepatocellular carcinoma
  JOURNAL   J Exp Clin Cancer Res 42 (1), 326 (2023)
   PUBMED   38017479
  REMARK    GeneRIF: RIT1 regulates mitosis and promotes proliferation by
            interacting with SMC3 and PDS5 in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5522)
  AUTHORS   Bastos,N., Castaldo,S.A., Adem,B., Machado,J.C., Melo,C.A. and
            Melo,S.A.
  TITLE     SMC3 epigenetic silencing regulates Rab27a expression and drives
            pancreatic cancer progression
  JOURNAL   J Transl Med 21 (1), 578 (2023)
   PUBMED   37641131
  REMARK    GeneRIF: SMC3 epigenetic silencing regulates Rab27a expression and
            drives pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5522)
  AUTHORS   Arkoun,B., Robert,E., Boudia,F., Mazzi,S., Dufour,V., Siret,A.,
            Mammasse,Y., Aid,Z., Vieira,M., Imanci,A., Aglave,M., Cambot,M.,
            Petermann,R., Souquere,S., Rameau,P., Catelain,C., Diot,R.,
            Tachdjian,G., Hermine,O., Droin,N., Debili,N., Plo,I., Malinge,S.,
            Soler,E., Raslova,H., Mercher,T. and Vainchenker,W.
  TITLE     Stepwise GATA1 and SMC3 mutations alter megakaryocyte
            differentiation in a Down syndrome leukemia model
  JOURNAL   J Clin Invest 132 (14) (2022)
   PUBMED   35587378
  REMARK    GeneRIF: Stepwise GATA1 and SMC3 mutations alter megakaryocyte
            differentiation in a Down syndrome leukemia model.
REFERENCE   5  (bases 1 to 5522)
  AUTHORS   Shimizu,K., Shirataki,H., Honda,T., Minami,S. and Takai,Y.
  TITLE     Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated
            protein, with a human chromosome-associated polypeptide
  JOURNAL   J Biol Chem 273 (12), 6591-6594 (1998)
   PUBMED   9506951
REFERENCE   6  (bases 1 to 5522)
  AUTHORS   Gupta,K., Anand,G., Yin,X., Grove,L. and Prochownik,E.V.
  TITLE     Mmip1: a novel leucine zipper protein that reverses the suppressive
            effects of Mad family members on c-myc
  JOURNAL   Oncogene 16 (9), 1149-1159 (1998)
   PUBMED   9528857
REFERENCE   7  (bases 1 to 5522)
  AUTHORS   Couchman,J.R., Kapoor,R., Sthanam,M. and Wu,R.R.
  TITLE     Perlecan and basement membrane-chondroitin sulfate proteoglycan
            (bamacan) are two basement membrane chondroitin/dermatan sulfate
            proteoglycans in the Engelbreth-Holm-Swarm tumor matrix
  JOURNAL   J Biol Chem 271 (16), 9595-9602 (1996)
   PUBMED   8621634
REFERENCE   8  (bases 1 to 5522)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   9  (bases 1 to 5522)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 5522)
  AUTHORS   Deardorff,M.A., Noon,S.E. and Krantz,I.D.
  TITLE     Cornelia de Lange Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA439554.1, AF020043.1 and
            AL359260.20.
            
            On Dec 4, 2019 this sequence version replaced NM_005445.3.
            
            Summary: This gene belongs to the SMC3 subfamily of SMC proteins.
            The encoded protein occurs in certain cell types as either an
            intracellular, nuclear protein or a secreted protein. The nuclear
            form, known as structural maintenance of chromosomes 3, is a
            component of the multimeric cohesin complex that holds together
            sister chromatids during mitosis, enabling proper chromosome
            segregation. Post-translational modification of the encoded protein
            by the addition of chondroitin sulfate chains gives rise to the
            secreted proteoglycan bamacan, an abundant basement membrane
            protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289771.1, AF020043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361804.5/ ENSP00000354720.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CA439554.1         19-88
            71-3160             AF020043.1         40-3129
            3161-3161           AL359260.20        78758-78758
            3162-4108           AF020043.1         3131-4077
            4109-5522           AL359260.20        81281-82694
FEATURES             Location/Qualifiers
     source          1..5522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..5522
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /note="structural maintenance of chromosomes 3"
                     /db_xref="GeneID:9126"
                     /db_xref="HGNC:HGNC:2468"
                     /db_xref="MIM:606062"
     exon            1..137
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..3776
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /note="chondroitin sulfate proteoglycan 6 (bamacan);
                     basement membrane-associated chondroitin proteoglycan;
                     chromosome-associated polypeptide; SMC protein 3"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 3"
                     /protein_id="NP_005436.1"
                     /db_xref="CCDS:CCDS31285.1"
                     /db_xref="GeneID:9126"
                     /db_xref="HGNC:HGNC:2468"
                     /db_xref="MIM:606062"
                     /translation="MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYA
                     IQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVI
                     GAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLR
                     EVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDK
                     MRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRE
                     LKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLL
                     EKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERD
                     KWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEE
                     LDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNG
                     IDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSD
                     EVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFK
                     HVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDV
                     RKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMK
                     MLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVD
                     ALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGG
                     TVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDA
                     INHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQC
                     NTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQ
                     LTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVP
                     SVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEID
                     QALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAE
                     MAKDFVEDDTTHG"
     exon            138..213
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..252
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..320
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..392
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..472
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..551
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..669
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..845
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..926
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1091
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1213
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1427
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1531
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1631
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1792
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1934
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2085
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2238
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2390
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2549
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2657
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2766
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..3014
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3227
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3419
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3420..3597
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3598..3704
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..5522
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /note="hexamer: AATAAT"
     polyA_site      4108
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /note="major polyA site"
     regulatory      5495..5500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
                     /note="hexamer: AATAAA"
     polyA_site      5522
                     /gene="SMC3"
                     /gene_synonym="BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1"
ORIGIN      
        1 gtttggctga ggggagcgag cggcgctttg ggggaggggt cgcgtaggcg cctcacctga
       61 ccctgcggcc gtgcggttgc tgctccgggg caggtctcct tccaggccag gggcccggaa
      121 tcatgtacat aaagcaggtg attatccagg gttttcgaag ttacagagat caaacaattg
      181 tagatccctt cagttcaaaa cataatgtga ttgtgggcag aaatggatct ggaaaaagta
      241 acttttttta tgcaattcag tttgttctca gtgatgagtt tagtcatctt cgtccagaac
      301 agcggttggc tttattgcat gaaggtactg gtcctcgtgt tatttctgct tttgtggaga
      361 ttatttttga taattcagac aaccggttac caatcgataa agaggaagtt tcacttcgaa
      421 gagttattgg tgccaaaaag gatcagtatt tcttagacaa gaagatggtc acgaaaaatg
      481 atgtgatgaa cctccttgaa agcgctggtt tttctcgaag caatccttat tatattgtta
      541 aacaaggaaa gatcaaccag atggcaacag caccagattc tcagagatta aagctattaa
      601 gagaagtagc tggtactaga gtgtatgacg aacgaaagga agaaagcatc tccttaatga
      661 aagaaacaga gggcaaacgg gaaaaaatca atgagttgtt aaaatacatt gaagagagat
      721 tacatactct agaggaagaa aaggaagaac tagctcagta tcagaagtgg gataaaatga
      781 gacgagccct ggaatatacc atttacaatc aggaacttaa cgagactcgt gccaaacttg
      841 atgagctttc tgctaagcga gagactagtg gagaaaaatc cagacaatta agagatgctc
      901 agcaggatgc aagagataaa atggaggata tcgaacgcca agttagagaa ttgaaaacaa
      961 aaatttcagc tatgaaagaa gaaaaagaac agcttagtgc tgaaagacaa gagcagatta
     1021 agcagaggac taagttggag cttaaagcca aggatttaca agatgaacta gcaggcaata
     1081 gtgaacaaag gaaacgttta ttaaaagaga ggcagaagct gcttgaaaaa atagaagaaa
     1141 agcagaaaga actggcagaa acagaaccca aattcaacag tgtgaaagag aaagaagaac
     1201 gaggaattgc tagattggct caagctaccc aggaaagaac ggatctttat gcaaagcagg
     1261 gtcgaggaag ccagtttaca tcaaaagaag aaagggataa gtggattaaa aaggaactca
     1321 agtctttaga tcaggctatt aatgacaaga aaagacagat tgctgctata cataaggatt
     1381 tggaagacac tgaagcaaat aaagagaaaa atctggagca gtataataaa ctggaccagg
     1441 atcttaatga agtcaaagct cgagtagaag aactggacag aaaatattac gaagtaaaaa
     1501 ataagaaaga tgaactacaa agtgaaagaa actacttgtg gagagaagag aatgcagaac
     1561 agcaagcact tgctgctaaa agagaagatc ttgaaaagaa gcaacaactt cttagagcag
     1621 caacaggaaa ggccatttta aatggaatag acagcataaa caaagtgcta gaccacttcc
     1681 gtcgaaaagg aataaaccag catgttcaaa atggctatca tggtattgta atgaataact
     1741 ttgaatgtga accagctttc tacacatgcg tggaagtcac tgctggaaac aggttatttt
     1801 atcacattgt tgattcagat gaagtcagca cgaagatttt aatggagttt aataaaatga
     1861 atcttcctgg agaggttact tttctgcctc ttaacaagtt agatgtcagg gatacagcct
     1921 atcctgaaac caatgatgct attcctatga tcagcaaact gaggtacaat cccagatttg
     1981 acaaagcttt caaacatgtg tttggaaaga ctcttatttg tcgtagcatg gaagtttcaa
     2041 cccagctggc ccgtgctttc actatggact gtattacttt ggaaggtgac caagtcagcc
     2101 atcggggtgc tctaactggg ggttattatg acacaaggaa gtctcgactt gaattgcaaa
     2161 aagatgttag aaaagcagaa gaagaactag gtgaacttga agcaaagctc aatgaaaacc
     2221 tgcgcagaaa tattgaaagg attaataatg aaattgatca gttgatgaac caaatgcaac
     2281 agatcgagac ccagcaaagg aaatttaaag catctagaga tagcatatta tcagaaatga
     2341 agatgctaaa agagaagagg cagcagtcag agaaaacctt catgcctaag caacgtagct
     2401 tacagagttt ggaggcaagc ttgcatgcta tggagtctac cagagagtca ttgaaagcag
     2461 aactgggaac tgatttgctt tctcaactga gtttggaaga tcagaagaga gtagatgcac
     2521 tgaatgatga gattcgtcaa cttcagcagg aaaacagaca gttgctaaat gaaagaatta
     2581 aattagaagg tattattact cgagtagaga cttatctcaa tgagaatctg agaaaacgct
     2641 tggaccaagt agaacaggaa cttaatgagc tgagagagac agaagggggt actgttctca
     2701 cagccacaac atcagaactt gaagccatca ataaaagagt aaaagacact atggcacgat
     2761 cagaagattt ggacaattcc attgataaaa cagaagctgg aattaaggag cttcagaaga
     2821 gtatggagcg ctggaaaaat atggaaaaag aacatatgga tgctataaat catgatacta
     2881 aagaactgga aaagatgaca aatcggcaag gcatgctatt gaagaagaaa gaagagtgta
     2941 tgaagaaaat tcgagaactt ggatcacttc cccaggaagc atttgaaaag taccagacac
     3001 tgagcctcaa acagttgttt cgaaaacttg agcagtgcaa cacagaatta aagaagtaca
     3061 gccatgttaa caaaaaggct ttggatcagt ttgtaaattt ctccgagcag aaagaaaagt
     3121 taataaagcg tcaagaagag ttagataggg gttacaaatc aatcatggaa ctgatgaatg
     3181 tacttgaact tcggaaatat gaagctattc agttaacttt caaacaggta tctaagaact
     3241 tcagtgaagt attccagaag ttagtacctg gtggcaaagc tactttggtg atgaagaaag
     3301 gagatgtgga gggcagtcag tctcaagatg aaggagaagg gagtggtgag agtgagaggg
     3361 gttctggctc acaaagcagt gtcccatcag ttgaccagtt tactggagtt ggaattaggg
     3421 tgtcatttac aggaaaacaa ggtgaaatga gagaaatgca acagctttca ggtggacaga
     3481 aatccttggt agcccttgct ctgatttttg ccattcagaa atgtgacccg gctccatttt
     3541 acttgtttga tgaaattgac caggctctgg atgctcagca cagaaaggct gtgtcagata
     3601 tgattatgga acttgctgta catgctcagt ttattacaac tacttttagg cctgaactgc
     3661 ttgagtcagc tgacaaattc tatggtgtaa agttcagaaa taaggttagt catattgatg
     3721 tgatcacagc agagatggcc aaagactttg tagaagatga taccacacat ggttaattgg
     3781 aaaatactac ctactggttt gggagatgta tatagtaata tgattctcat acccaggaac
     3841 tgtaaattta aacctaaata tttggccaat agttttcaga cttaaagcat catagtcctt
     3901 ttatatttgt ctttgtattt tataagatac tctgtaatgt catgtttgta ctgatagttt
     3961 aagaatttaa tttcctgtac aactttttgt aaaatgttct gctcctattt taaatgtttt
     4021 gaaacatgct aaatattctt tcctaattat tttatcactt atactacctt ttttatagct
     4081 tcaattaaat aatcggtttt atgactaata tagtgtttta tgtggctttt catttgtcat
     4141 agtctcttcc agtgagaaca ctaatcagat tggatgtaag gcctcatttt aacttaatca
     4201 cctctttaaa agacctgtct ccaaatacag ttaaatttga ggtattgagg gttaggactt
     4261 caacatgtga gtttgggaag ggaagcacaa aatcagcccc taccatggta tatttatcat
     4321 tgatacatta ctatcaacta agctcaagat tttattcaga tttgactagt ttttccacta
     4381 aggccctttt tcttttctag gatcccacag aggatacatt acatttactt acatctcctc
     4441 tagtctgtga caatttctct gtcattgttt atcatatctt gacaattttg aataatattc
     4501 acatattttg tagaatgtcc ctcaaattag gtttgtctaa tatttttctc atggttagat
     4561 tggagctaat accacagaag cgaagtattc tcattacctc atataatagt acatattatt
     4621 aacatgtttt atcactgatg tttaccttga tcacctaccc aacattgtac ttgccaggtt
     4681 tctttgttgt gaagttacat ttttttccct ttccatacta ctcttttctt tgaaagtagg
     4741 tctttaagca ctgggggtct cctgtgaccc tggaaaacta cctcaatagt cctcgtagct
     4801 ttttgtagat tctttgagat tttctacata gacagtcatg tcatttgcaa gaaagaggca
     4861 gttttatttc ttccttttca aatatttacc tttaatttct ttttcttgat ttcccctggc
     4921 ctgagtttat actggttatc tgcaggagaa tttgttagga gctactcttc catcattgga
     4981 aaccagaaat acctaaagag atacttttaa aataaagaaa tagtaatggg actttaaatt
     5041 gaatttaaaa atgtgagttt actttgggtt ttcattttga ctggctgaat ctttaaatgt
     5101 tcggtgtatt atttatactt tgtagctttg ctataacata actgatctat aatagagaat
     5161 ttggtatatg ttctatctat gactacattc aaagggttac gtaactataa tatctttcta
     5221 atatttctac catttttctt acacatttac ccaagaattt ttctcaaaca actacctaag
     5281 aatattcatc atgaatgctt ggtgtatagt ttacgatttg tagagttgct ctgatatgac
     5341 caacccctta taatacagaa tttggtgtaa ggtaagttcc aggattcaat tcaagggatg
     5401 ttacaaacat aacatcattc tagaacttct taatattgtt cttaagcatt tccccaagga
     5461 tattagtata atgaaatgcc agtaaattta taacaataaa gcatctaaat aatgaaacaa
     5521 aa
//
