LOCUS       NM_006444               5928 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens structural maintenance of chromosomes 2 (SMC2),
            transcript variant 3, mRNA.
ACCESSION   NM_006444
VERSION     NM_006444.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5928)
  AUTHORS   He,Y., Wang,Y., Luo,Z., Zhang,X., Bai,H. and Wang,J.
  TITLE     SMC2 knockdown inhibits malignant progression of lung
            adenocarcinoma by upregulating BTG2 expression
  JOURNAL   Cell Signal 120, 111216 (2024)
   PUBMED   38729325
  REMARK    GeneRIF: SMC2 knockdown inhibits malignant progression of lung
            adenocarcinoma by upregulating BTG2 expression.
REFERENCE   2  (bases 1 to 5928)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 5928)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5928)
  AUTHORS   Han,Y.H., Wan,Y., Xiong,H. and Sun,G.L.
  TITLE     Structural maintenance of chromosomes 2 is identified as an
            oncogene in bladder cancer in vitro and in vivo
  JOURNAL   Neoplasma 67 (2), 364-370 (2020)
   PUBMED   31986889
  REMARK    GeneRIF: Structural maintenance of chromosomes 2 is identified as
            an oncogene in bladder cancer in vitro and in vivo.
REFERENCE   5  (bases 1 to 5928)
  AUTHORS   Feng,Y., Liu,H., Duan,B., Liu,Z., Abbruzzese,J., Walsh,K.M.,
            Zhang,X. and Wei,Q.
  TITLE     Potential functional variants in SMC2 and TP53 in the AURORA
            pathway genes and risk of pancreatic cancer
  JOURNAL   Carcinogenesis 40 (4), 521-528 (2019)
   PUBMED   30794721
  REMARK    GeneRIF: Rs3818626 and rs9895829 were significantly associated with
            SMC2 and TP53 messenger RNA expression.
REFERENCE   6  (bases 1 to 5928)
  AUTHORS   Kueng,S., Hegemann,B., Peters,B.H., Lipp,J.J., Schleiffer,A.,
            Mechtler,K. and Peters,J.M.
  TITLE     Wapl controls the dynamic association of cohesin with chromatin
  JOURNAL   Cell 127 (5), 955-967 (2006)
   PUBMED   17113138
REFERENCE   7  (bases 1 to 5928)
  AUTHORS   Cobbe,N. and Heck,M.M.
  TITLE     The evolution of SMC proteins: phylogenetic analysis and structural
            implications
  JOURNAL   Mol Biol Evol 21 (2), 332-347 (2004)
   PUBMED   14660695
REFERENCE   8  (bases 1 to 5928)
  AUTHORS   Przewloka,M.R., Pardington,P.E., Yannone,S.M., Chen,D.J. and
            Cary,R.B.
  TITLE     In vitro and in vivo interactions of DNA ligase IV with a subunit
            of the condensin complex
  JOURNAL   Mol Biol Cell 14 (2), 685-697 (2003)
   PUBMED   12589063
REFERENCE   9  (bases 1 to 5928)
  AUTHORS   Schmiesing,J.A., Gregson,H.C., Zhou,S. and Yokomori,K.
  TITLE     A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a
            homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone
            H3 during the early stage of mitotic chromosome condensation
  JOURNAL   Mol Cell Biol 20 (18), 6996-7006 (2000)
   PUBMED   10958694
REFERENCE   10 (bases 1 to 5928)
  AUTHORS   Schmiesing,J.A., Ball,A.R. Jr., Gregson,H.C., Alderton,J.M.,
            Zhou,S. and Yokomori,K.
  TITLE     Identification of two distinct human SMC protein complexes involved
            in mitotic chromosome dynamics
  JOURNAL   Proc Natl Acad Sci U S A 95 (22), 12906-12911 (1998)
   PUBMED   9789013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL833191.1, BC055081.1, AF092563.1, BC017845.1, BC032705.1,
            AL354938.12, AK124957.1 and BF969462.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006444.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. All variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.176322.1,
                                           SRR1803616.146152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374793.8/ ENSP00000363925.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL833191.1         50-92
            44-140              BC055081.1         60-156
            141-141             AF092563.1         124-124
            142-491             BC017845.1         130-479
            492-703             AF092563.1         476-687
            704-1071            BC017845.1         692-1059
            1072-1110           AF092563.1         1056-1094
            1111-2563           BC032705.1         1218-2670
            2564-2899           AF092563.1         2548-2883
            2900-4134           AL833191.1         2959-4193
            4135-4166           AF092563.1         4122-4153
            4167-5243           AL354938.12        6490-7566
            5244-5926           AK124957.1         948-1630
            5927-5928           BF969462.1         561-562
FEATURES             Location/Qualifiers
     source          1..5928
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.1"
     gene            1..5928
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="structural maintenance of chromosomes 2"
                     /db_xref="GeneID:10592"
                     /db_xref="HGNC:HGNC:14011"
                     /db_xref="MIM:605576"
     exon            1..169
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..398
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3824
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="structural maintenance of chromosomes (SMC) family
                     member, chromosome-associated protein E; SMC2 (structural
                     maintenance of chromosomes 2, yeast)-like 1; SMC protein
                     2; XCAP-E homolog"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 2"
                     /protein_id="NP_006435.2"
                     /db_xref="CCDS:CCDS35086.1"
                     /db_xref="GeneID:10592"
                     /db_xref="HGNC:HGNC:14011"
                     /db_xref="MIM:605576"
                     /translation="MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDS
                     ICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEIT
                     VTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE
                     ILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYL
                     EYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKA
                     LNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKEL
                     EKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNED
                     GAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA
                     LEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRF
                     AYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLER
                     GELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVF
                     GTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELK
                     DVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHK
                     QQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKL
                     DCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEV
                     MAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELD
                     HNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKL
                     QEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQAL
                     NIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGG
                     QRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLK
                     EGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV"
     exon            399..548
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            549..671
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..710
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..821
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..866
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1100
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1250
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1484
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1644
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1762
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1901
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2021
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2226
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2362
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2487
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2681
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2825
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3020
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3221
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3338
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3499
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3500..3647
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3648..5928
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4140..4145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      4161
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="major polyA site"
     regulatory      5300..5305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="hexamer: ATTAAA"
     polyA_site      5327
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="major polyA site"
     regulatory      5644..5649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="hexamer: AACAAG"
     polyA_site      5665
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="major polyA site"
     regulatory      5910..5915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
                     /note="hexamer: AATAAA"
     polyA_site      5928
                     /gene="SMC2"
                     /gene_synonym="CAP-E; CAPE; SMC-2; SMC2L1"
ORIGIN      
        1 aaaggaataa atagttccgg cgcgggtgtt gagagcggtg tggcaggtgt tgtagccgct
       61 atggtgaagt tcgctttgta gcggccccgg ctagagagtt gttctgttcc ctgcctttgt
      121 gacccggagg agcttttggg gtgcgtcaag cccctggcct gaggcagcga actggtttgt
      181 ggcctgtttg attcctgtca gaggtttgct gacccaagac agtatcgaaa atgcatatta
      241 agtcaattat tctagaggga ttcaagtcct atgctcagag gaccgaagtc aatggttttg
      301 accccctctt caatgctatc actggcttaa atggtagtgg gaaatccaac atattggact
      361 ccatctgctt tttgctgggc atctccaacc tgtctcaggt tcgggcttct aatttacaag
      421 atttagttta caaaaatggg caggctggta ttaccaaagc ctctgtgtca atcacttttg
      481 ataattctga caaaaagcaa agtcctttag gatttgaggt tcatgatgaa atcacagtaa
      541 caaggcaggt ggttattggt ggtagaaata aatatttaat caatggagtc aatgccaaca
      601 acaccagagt acaggatctc ttctgttctg ttggccttaa tgttaacaac cctcactttc
      661 tcatcatgca gggccgaatt acaaaagtat tgaatatgaa acctccagag attttatcca
      721 tgatagaaga agcagctgga accaggatgt atgaatacaa aaaaatagct gcacagaaaa
      781 ctatagaaaa aaaggaggct aagctgaaag aaattaagac gatacttgaa gaagagatta
      841 ctccaaccat tcaaaaatta aaagaggaaa gatcgtccta cttggagtac caaaaagtaa
      901 tgagagaaat agaacatttg agtcgtttat atattgctta tcagtttttg ctggctgaag
      961 ataccaaagt acgctcagct gaggaattaa aagaaatgca agataaagtt ataaagcttc
     1021 aggaagaatt gtctgagaat gataaaaaaa taaaagcact taatcatgaa atagaagaat
     1081 tggaaaaaag aaaagataag gaaactggag gtatacttcg atctttagaa gatgctcttg
     1141 cagaggctca gcgagttaat actaaatctc aaagcgcatt tgatctcaag aagaaaaatc
     1201 tggcatgtga ggaaagcaaa cgcaaagagc tggaaaaaaa tatggttgag gactcaaaaa
     1261 ctttagcagc aaaggaaaaa gaggttaaaa agataacaga tggactgcat gcccttcaag
     1321 aagcaagtaa taaagatgct gaagctctgg cagctgcaca gcagcacttc aatgctgttt
     1381 ccgctggcct gtccagtaat gaagatggag cagaagcaac tcttgctggt caaatgatgg
     1441 cctgtaaaaa tgatataagt aaagctcaga cagaagccaa acaggctcag atgaagttga
     1501 agcatgctca acaggaatta aagaataaac aagctgaagt taagaagatg gatagtggct
     1561 acaggaagga tcaagaagct ctagaagctg taaaaagact taaagaaaaa cttgaagctg
     1621 aaatgaaaaa gctaaattat gaagaaaata aagaggaaag ccttttggaa aagcgcaggc
     1681 agctgtctcg tgatattggt agattgaaag aaacatatga agctctatta gccagatttc
     1741 ccaatcttcg atttgcatac aaggatccag agaagaactg gaatagaaat tgtgtgaaag
     1801 gacttgtggc ttctctgatt agtgtgaaag acacttctgc aaccacagct ttagaattag
     1861 tggctggaga acgactctac aatgttgtag tagacacaga agttactggt aaaaagctac
     1921 tagaaagggg ggaactgaaa cgtcgataca ctataattcc actcaataaa atttcagcca
     1981 gatgtattgc accagaaact ctgagagttg ctcagaatct tgttggccct gacaacgttc
     2041 atgtggctct ttccttggtt gaatataaac cagaacttca gaaagcaatg gagtttgtct
     2101 ttggaacaac atttgtttgt gacaatatgg ataatgccaa aaaagtggcc tttgataaga
     2161 ggataatgac tagaactgta actctcggag gtgatgtgtt tgatcctcat gggacattga
     2221 gtggaggtgc tcgatcccag gcagcttcca ttttaaccaa gtttcaagaa ctcaaagatg
     2281 ttcaggatga actgagaatc aaagagaatg agctgcgggc tctagaagag gaattagcag
     2341 gtcttaaaaa cactgctgaa aagtatcgcc aactaaaaca gcagtgggag atgaaaactg
     2401 aagaggcaga tttattacaa accaagctcc agcaaagctc atatcacaag caacaagaag
     2461 aattagatgc ccttaaaaaa accattgagg aaagtgagga gactttgaaa aacactaaag
     2521 aaatccaaag aaaagcagaa gaaaaatatg aagtattgga aaataaaatg aaaaatgcag
     2581 aagctgaaag agagcgagaa ctgaaagatg ctcagaaaaa actggattgt gccaaaacaa
     2641 aggcagatgc atctagcaag aagatgaaag aaaaacaaca ggaagttgaa gctatcactc
     2701 tggaactgga agagctcaag agagagcata catcttacaa acaacagctt gaagctgtaa
     2761 atgaagctat caaatcctat gaaagtcaga ttgaagtaat ggcagctgag gtggctaaaa
     2821 ataaggagtc agtaaataaa gctcaagaag aggtgaccaa gcaaaaagag gtgataacag
     2881 cccaagacac tgtaattaaa gctaaatatg cagaagtggc aaaacacaag gagcaaaaca
     2941 atgattctca gcttaaaatt aaggaattag accacaacat cagcaaacat aaacgggagg
     3001 ctgaagatgg tgctgcaaag gtatccaaaa tgttgaaaga ttatgactgg attaatgcag
     3061 agagacacct ctttggccaa cccaatagtg cctatgattt caaaactaac aaccctaaag
     3121 aagctggtca gagacttcag aagttgcaag aaatgaagga gaaactagga agaaatgtca
     3181 atatgagagc tatgaatgta ttgacagaag ctgaagagcg atacaatgac ttgatgaaga
     3241 agaagagaat tgtagaaaat gacaaatcca aaattcttac aactatagaa gaccttgacc
     3301 agaagaaaaa ccaagcccta aatattgcat ggcaaaaggt gaacaaggac tttgggtcta
     3361 ttttttctac tcttttgcct ggtgctaatg ctatgcttgc accaccagag ggtcaaactg
     3421 ttttggatgg tctggagttc aaggttgcct tgggaaatac ctggaaagaa aacctaactg
     3481 aacttagtgg tggtcagagg tctttagtgg ccttgtcatt aatactgtcc atgcttctct
     3541 tcaaacctgc tccaatttat atccttgatg aggtagatgc agccttggat ctttctcata
     3601 cccaaaacat tggacagatg ctgcgtactc atttcacaca ttctcagttc attgtggtgt
     3661 cactaaaaga aggtatgttc aacaatgcaa acgttctttt caaaaccaag tttgtggatg
     3721 gtgtttctac agtagccaga tttactcaat gtcaaaatgg aaagatttca aaggaagcaa
     3781 aatccaaggc aaaaccaccc aaaggagcac atgtggaagt ttaaactaca aagttatttc
     3841 ttcatcttga cctgtttttt taaatgtaaa cttttaagga cttgagataa ctaatttgtt
     3901 tatatacaaa aattaatgtt actgtgttac ttaacccatg ttttctcttt atataatcac
     3961 ttatcgctta caaatgagca tatattcctc atctcttaac tagtctaatt atggtccaat
     4021 tattgtggtt gtgattttat gcatatcatc aaatgttttt ttcttatgcg ggtcttttat
     4081 atattaggga tcctgagata cccgattcta tatgtaaaag ctaatataca aaaaagcaga
     4141 ttaaattaca tgataaatgt agctgatcat cagtgtttaa ttgatttaat tcctaaggca
     4201 atattaatgt gttttctaaa gtcattcagg taaggaagaa ttataaatca ggtaactgga
     4261 ccaacaaagg gaacacatat aaagctatta tgcatgcatg gagccgtttg aggctagttt
     4321 tttaaggcca caactccaga cccctgattt agactgagat aggaaacaga tcttgaaaga
     4381 atccttattt taatgataca tgaatatcat gttcctatac gcttaataat tggtctctac
     4441 gttttaatga tacatgaata tcatgttcct atacgcttaa taattggtct ctacgacttt
     4501 aatgtttttg tttttttaag ctgtgtaagt atttttaaat caaagcttag gaggtgtgtt
     4561 gcgtggtact atctgctgca aatttatctg aagtttgtta atattttcca agatttttgt
     4621 cagccttttc ataatccagt cattaacaac ctattggtaa acaagaatgt aggtgccagt
     4681 agactaaacc aaatttattt ttccctgagt ctgatatata tatgtataaa tataaataac
     4741 tcaatccatc tgttccacca aaataactca aaagttggat gattatttgt cttccgcttt
     4801 ccagttcaaa gggatgaaat tcctttagaa cttgaaagat gacactagcg aacaccatga
     4861 gaatactgtc tacagttttt ggtacgtcat cactagaaca gtgaccccaa actgaatcat
     4921 gaaaggtctg acatgatgta atctgatctt ccatgtgtta ttttggcccc acatctcttc
     4981 ttgatttttt agtcttattt ccttagtgtt attatcatac ttcccctgat atatggccgt
     5041 acttcctggc cctgggcttg acatttccca cccttcattc tccatacata tgagatgtca
     5101 gaaaacatgc agtaattgat attatgggac acattggaaa ggattgaatc tggaattagt
     5161 tctgtccact gtggagggga gaggaaataa tgctgtaaat gttgagttac agaaagtcca
     5221 atgtcaaata tagttttttt gtttcctttc aaatgtatta cagactgtgc caaaacagtt
     5281 accaattcac actgtcaata ttaaagtata ccatagtata caaattagtc agtacttgct
     5341 gttaatttta atatttctga tttaacagtt agttattaag tggtacttca ttgctgtttt
     5401 agccaacgtt ttaaaaataa tttgggagtt tgactatttt ggcttacgta ctcatttcct
     5461 tttctctgct aaaaatgttt tgcttgtgtg cgttcctgat ttttgtcttg tataatcttg
     5521 atctttgaaa accctcaaac atgtattaaa ttgttgtaac tttttttcat tagagggaag
     5581 acattaaggg gattggggac atttgtttca cacatctgca gtaatatgag ttaactaata
     5641 tttaacaagc tctttcttta cattagctgc tgttctcatt tgtatgtatt gtcatattta
     5701 atcctcagag taacctagtg aggtaaatac tgttgttgtc agcatggtgt aatcgaggaa
     5761 ttgagtgagt tgagcagaaa agttaggaaa cttgctcagg gtgataatac agttaggagt
     5821 gtcagggccc atggacaaat cttgtcagtc tccagaacct aagatatact acgtcactga
     5881 cagcttgaac atttgtattt attgtacaga ataaatttaa gaaaaata
//
