LOCUS       NM_006306               9710 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens structural maintenance of chromosomes 1A (SMC1A),
            transcript variant 1, mRNA.
ACCESSION   NM_006306
VERSION     NM_006306.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9710)
  AUTHORS   Ibstedt,S., Piccinelli,P., Sydow,S., Koster,J. and Mertens,F.
  TITLE     Structural Variants in the SMC1A Gene Associated With Near-Haploidy
            in Undifferentiated Pleomorphic Sarcomas
  JOURNAL   Genes Chromosomes Cancer 63 (8), e23255 (2024)
   PUBMED   39149945
  REMARK    GeneRIF: Structural Variants in the SMC1A Gene Associated With
            Near-Haploidy in Undifferentiated Pleomorphic Sarcomas.
REFERENCE   2  (bases 1 to 9710)
  AUTHORS   Li,K., Dai,P., Li,J., Liu,L., Cheng,S., Fang,Q. and Wu,B.
  TITLE     AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes
            tumor growth in breast cancer
  JOURNAL   J Gene Med 26 (1), e3661 (2024)
   PUBMED   38282144
  REMARK    GeneRIF: AKT/FOXM1/STMN1 signaling pathway activation by SMC1A
            promotes tumor growth in breast cancer.
REFERENCE   3  (bases 1 to 9710)
  AUTHORS   Liu,Y., Fang,X., Wang,Q., Xiao,D., Zhou,T., Kang,K., Peng,Z.,
            Ren,F. and Zhou,J.
  TITLE     SMC1A facilitates gastric cancer cell proliferation, migration, and
            invasion via promoting SNAIL activated EMT
  JOURNAL   BMC Gastroenterol 23 (1), 268 (2023)
   PUBMED   37537540
  REMARK    GeneRIF: SMC1A facilitates gastric cancer cell proliferation,
            migration, and invasion via promoting SNAIL activated EMT.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9710)
  AUTHORS   Lin,W., Wang,K., Mo,J., Wang,L., Song,Z., Jiang,H., Wang,C. and
            Jin,C.
  TITLE     PIK3R3 is upregulated in liver cancer and activates Akt signaling
            to control cancer growth by regulation of CDKN1C and SMC1A
  JOURNAL   Cancer Med 12 (13), 14413-14425 (2023)
   PUBMED   37212524
  REMARK    GeneRIF: PIK3R3 is upregulated in liver cancer and activates Akt
            signaling to control cancer growth by regulation of CDKN1C and
            SMC1A.
REFERENCE   5  (bases 1 to 9710)
  AUTHORS   Chen,Y., Sharp,Z.D. and Lee,W.H.
  TITLE     HEC binds to the seventh regulatory subunit of the 26 S proteasome
            and modulates the proteolysis of mitotic cyclins
  JOURNAL   J Biol Chem 272 (38), 24081-24087 (1997)
   PUBMED   9295362
REFERENCE   6  (bases 1 to 9710)
  AUTHORS   Brown,C.J., Miller,A.P., Carrel,L., Rupert,J.L., Davies,K.E. and
            Willard,H.F.
  TITLE     The DXS423E gene in Xp11.21 escapes X chromosome inactivation
  JOURNAL   Hum Mol Genet 4 (2), 251-255 (1995)
   PUBMED   7757075
REFERENCE   7  (bases 1 to 9710)
  AUTHORS   Rocques,P.J., Clark,J., Ball,S., Crew,J., Gill,S.,
            Christodoulou,Z., Borts,R.H., Louis,E.J., Davies,K.E. and
            Cooper,C.S.
  TITLE     The human SB1.8 gene (DXS423E) encodes a putative chromosome
            segregation protein conserved in lower eukaryotes and prokaryotes
  JOURNAL   Hum Mol Genet 4 (2), 243-249 (1995)
   PUBMED   7757074
REFERENCE   8  (bases 1 to 9710)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   9  (bases 1 to 9710)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
REFERENCE   10 (bases 1 to 9710)
  AUTHORS   Deardorff,M.A., Noon,S.E. and Krantz,I.D.
  TITLE     Cornelia de Lange Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC080185.1, D80000.2 and
            AC233728.4.
            
            On Aug 31, 2019 this sequence version replaced NM_006306.3.
            
            Summary: Proper cohesion of sister chromatids is a prerequisite for
            the correct segregation of chromosomes during cell division. The
            cohesin multiprotein complex is required for sister chromatid
            cohesion. This complex is composed partly of two structural
            maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or
            the protein encoded by this gene. Most of the cohesin complexes
            dissociate from the chromosomes before mitosis, although those
            complexes at the kinetochore remain. Therefore, the encoded protein
            is thought to be an important part of functional kinetochores. In
            addition, this protein interacts with BRCA1 and is phosphorylated
            by ATM, indicating a potential role for this protein in DNA repair.
            This gene, which belongs to the SMC gene family, is located in an
            area of the X-chromosome that escapes X inactivation. Mutations in
            this gene result in Cornelia de Lange syndrome. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D80000.2, S78271.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322213.9/ ENSP00000323421.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BC080185.1         10-63
            55-5879             D80000.2           1-5825
            5880-9710           AC233728.4         146641-150471
FEATURES             Location/Qualifiers
     source          1..9710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.22"
     gene            1..9710
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /note="structural maintenance of chromosomes 1A"
                     /db_xref="GeneID:8243"
                     /db_xref="HGNC:HGNC:11111"
                     /db_xref="MIM:300040"
     exon            1..163
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3756
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /note="isoform 1 is encoded by transcript variant 1; SMC1
                     (structural maintenance of chromosomes 1, yeast)-like 1;
                     segregation of mitotic chromosomes 1; SMC-1-alpha; SMC
                     protein 1A; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="structural maintenance of chromosomes protein 1A
                     isoform 1"
                     /protein_id="NP_006297.2"
                     /db_xref="CCDS:CCDS14352.1"
                     /db_xref="GeneID:8243"
                     /db_xref="HGNC:HGNC:11111"
                     /db_xref="MIM:300040"
                     /translation="MGFLKLIEIENFKSYKGRQIIGPFQRFTAIIGPNGSGKSNLMDA
                     ISFVLGEKTSNLRVKTLRDLIHGAPVGKPAANRAFVSMVYSEEGAEDRTFARVIVGGS
                     SEYKINNKVVQLHEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTALFEEISR
                     SGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVR
                     AQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMDKVEDELKEKKKELGKMMRE
                     QQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHYKKRKGDMD
                     ELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQE
                     LEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQKRIEKLEEYITTSKQSLE
                     EQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQESSRQQRKAEIMESIK
                     RLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTGRDCIQYIKEQRGE
                     PETFLPLDYLEVKPTDEKLRELKGAKLVIDVIRYEPPHIKKALQYACGNALVCDNVED
                     ARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLT
                     EELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESE
                     LANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCREIGVRNIREFEEEKVK
                     RQNEIAKKRLEFENQKTRLGIQLDFEKNQLKEDQDKVHMWEQTVKKDENEIEKLKKEE
                     QRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEMEEIRKKLGGANKEMTHLQKEVTA
                     IETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDISQEEGSSQGEDSVSGSQRISSI
                     YAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQKLNEQQSVLQRIAAPNMKAMEK
                     LESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFDRFNACFESVATNIDEIYKAL
                     SRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNLSGGEKTVAALALLFAIHS
                     YKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVISLKEEFYTKAESLIGVY
                     PEQGDCVISKVLTFDLTKYPDANPNPNEQ"
     exon            164..352
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            353..465
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            466..669
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            670..908
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1167
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1308
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1391
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1599
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1785
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1965
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2112
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2250
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2367
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2474
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2616
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2762
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2916
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3027
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3184
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3339
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3491
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3561
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3672
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..9710
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /note="hexamer: ATTAAA"
     polyA_site      5883
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /note="major polyA site"
     polyA_site      8311
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
     regulatory      9692..9697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
                     /note="hexamer: AATAAA"
     polyA_site      9710
                     /gene="SMC1A"
                     /gene_synonym="CDLS2; DEE85; DXS423E; EIEE85; SB1.8; SMC1;
                     SMC1alpha; SMC1L1; SMCB"
ORIGIN      
        1 agttctcggg cgtacggcgc ggcctgtcct actgccgccg gcgccgcggc cgtcatgggg
       61 ttcctgaaac tgattgagat tgagaacttt aagtcgtaca agggtcgaca gattatcgga
      121 ccatttcaga ggttcaccgc catcattgga cccaatggct ctggtaagtc aaatctcatg
      181 gatgccatca gctttgtgct aggtgaaaaa accagcaacc tgcgggtaaa gaccctgcgg
      241 gacctgatcc atggagctcc tgtgggcaag ccagctgcca accgggcctt tgtcagcatg
      301 gtctactctg aggagggtgc tgaggaccgt acctttgccc gtgtcattgt aggaggttct
      361 tctgagtaca agatcaacaa caaagtggtc caactacatg agtacagtga ggaattagag
      421 aagttgggca ttctcatcaa agctcgtaac ttcctcgttt tccagggtgc tgtggaatct
      481 attgccatga agaaccccaa agagaggaca gctctatttg aagagattag tcgttctggg
      541 gagctggcgc aggagtatga caagcgaaag aaggaaatgg tgaaggctga agaggacaca
      601 cagtttaatt accatcgcaa gaaaaatatt gcggctgaac gcaaggaagc aaagcaggag
      661 aaagaagagg ctgaccggta ccagcgcctg aaggatgagg tagtacgggc tcaggtacag
      721 ctgcagctct ttaagcttta ccataatgaa gtggaaattg agaagctcaa caaggaactg
      781 gcctcaaaga acaaggagat cgagaaggac aagaagcgta tggacaaggt ggaggatgaa
      841 ctgaaggaga agaagaagga gctgggcaaa atgatgcggg agcagcagca gattgagaag
      901 gagatcaagg agaaggactc agaattgaac cagaagcggc ctcagtacat caaagccaag
      961 gagaacacct cccacaaaat caagaagctg gaagcagcca agaagtctct gcagaatgct
     1021 cagaagcact acaagaagcg taaaggtgac atggatgagc tggagaagga gatgctgtca
     1081 gtggagaagg ctcggcagga gtttgaagaa cggatggaag aagagagtca gagtcagggc
     1141 agagatttga cgttggagga gaatcaggtg aagaaatacc accggttgaa agaagaagcc
     1201 agcaagagag cagctaccct ggcccaggag ctggagaaat tcaatcgaga ccagaaagct
     1261 gaccaggacc gtctggatct ggaagaacgg aagaaagtag agacagaggc caagatcaag
     1321 caaaagctgc gggaaattga agagaatcag aagcggattg agaaactgga ggaatacatc
     1381 accactagca agcagtccct agaagagcag aagaagctag agggggagct gacagaggag
     1441 gtggagatgg ccaagcggcg tattgatgaa atcaataagg agctgaacca ggtgatggag
     1501 cagctagggg atgcccgcat cgaccgccag gagagcagcc gccagcagcg aaaggcagag
     1561 ataatggaaa gcatcaagcg cctttaccct ggctctgtgt acggccgcct cattgaccta
     1621 tgccagccca cacaaaagaa gtatcagatt gctgtaacca aggttttggg caagaacatg
     1681 gatgccatta ttgtggactc ggagaagaca ggccgggact gtattcagta tatcaaggag
     1741 cagcgtgggg agcctgagac cttcttgcct cttgactacc tggaggtgaa gcctacagat
     1801 gagaaactcc gggagctgaa gggggccaag ctagtgattg atgtgattcg ctatgagcca
     1861 cctcatatca aaaaggccct gcagtatgct tgtggcaatg cccttgtctg tgacaacgtg
     1921 gaagatgccc gccgcattgc ctttggaggc caccagcgcc acaagacagt ggcactggat
     1981 ggaaccctat tccagaagtc aggagtgatc tctggtgggg ccagtgacct gaaggccaag
     2041 gcacggcgct gggatgagaa agcagtagac aagttgaaag agaagaagga gcgcttgaca
     2101 gaggagctga aagagcagat gaaggcaaaa cggaaagagg cagagctgcg tcaggtgcag
     2161 tctcaggccc atggactgca gatgcggctc aagtactccc agagtgacct agaacagacc
     2221 aagacacgac atctagccct gaatctgcag gaaaaatcca agctggagag tgagctagcc
     2281 aactttgggc ctcgcattaa tgatatcaag aggatcattc agagccgaga gagggaaatg
     2341 aaagacttga aggagaagat gaaccaggta gaggatgagg tgtttgaaga gttttgtcgg
     2401 gagattggtg tgcgcaacat ccgggagttt gaggaagaaa aggtgaaacg gcagaatgaa
     2461 atcgccaaga agcgtttgga gtttgagaat cagaagactc gcttgggcat tcagttggat
     2521 tttgaaaaga accaactgaa ggaggaccaa gataaagtac acatgtggga gcagacagtg
     2581 aaaaaagatg aaaatgagat agaaaagctc aaaaaggagg aacaaagaca catgaagatc
     2641 atagatgaga ccatggctca gctacaagac ctgaagaatc agcatctggc caagaagtcg
     2701 gaagtgaatg acaagaatca tgagatggag gagattcgta agaaactcgg gggcgccaac
     2761 aaggaaatga cccatttaca gaaggaggtg acagccattg agaccaagct tgaacagaag
     2821 cgcagtgacc gtcacaactt gctacaggcc tgtaagatgc aggacattaa gttgccactg
     2881 tcaaaaggca ccatggatga tattagtcag gaagagggta gctcccaggg ggaggactca
     2941 gtgagtggtt cacagagaat ttccagtatc tatgcacgag aggccctcat tgagattgac
     3001 tacggtgatc tgtgtgagga tctgaaggat gcccaggctg aggaagagat caagcaagag
     3061 atgaacacac tgcagcagaa gctgaatgag cagcagagtg tgcttcagcg tattgccgcc
     3121 cccaacatga aggccatgga aaagctggaa agtgtccgag acaagttcca ggagacctca
     3181 gatgagtttg aagcagcccg aaagcgagca aagaaggcca agcaggcatt cgaacagatc
     3241 aagaaggagc gctttgaccg cttcaatgct tgttttgaat ctgtggctac caacattgat
     3301 gagatctata aggccctgtc ccgcaatagc agtgcccagg cattcctggg ccctgagaac
     3361 cctgaagagc cctacttgga tggcatcaac tacaactgtg tggctcctgg gaaacgcttc
     3421 cggcctatgg acaacttgtc aggcggggag aagacagtgg cagctctggc cctgctcttt
     3481 gccatccaca gctacaagcc agcccccttc ttcgtcctgg atgagattga tgctgccttg
     3541 gataacacca acattggcaa ggtggcaaat tacatcaagg agcagtcgac ttgcaacttc
     3601 caggccatcg tcatctctct caaggaggag ttctacacca aggccgagag cctcattgga
     3661 gtctatcctg agcaagggga ctgtgtgatc agcaaagtcc tgaccttcga cctcaccaag
     3721 tacccagatg ccaaccccaa ccccaatgag cagtagcagt atttttgccc tcccgccctg
     3781 tctggatccc taagctgtcc ctctcccaat ctctggatat ttgactccca accttccccc
     3841 tacctcctgg ccctttttgg tgtagtcatg ggatttaggc actgctaatc aagcatgaag
     3901 aggaacagag gtgatgttag gtctggagca aaaattcctg aacgacaggg agtattctgg
     3961 cctctgaaag gaggtgctga gctgaacagg gccatctgtt catcacacac acccccttcc
     4021 tccccctcat cacccataat cgtgggcccc ttgggcctct tgcccactgt gtgtgtgggt
     4081 atgtatgtgt gtatgtatgt atccgcatgt gtgcatgtga gtatgtttgc aaaataataa
     4141 aggatattgg agacctgttt tagaaggagc ctaggctgaa tttgattcca agagagctta
     4201 ggatgacagc acccctgagc tgggcaaagg tactcaggac ctcataggag tcttaggcag
     4261 ttacctgaaa ctgccttcat tcactcattt gtgtattcat tcatttatgt attcatcaga
     4321 cacataccga acaccctcta tttgtcaggc tctgtgcttg gaatacagag ttgaatcaga
     4381 catgatctct accctcctag taaggagata cagtgggttc atgaatgact atagttagct
     4441 gaatgtcata tgtactttga atttgagaag tgggtgatcc cctctaggct tcctggaggt
     4501 cacatttaag ctagaccttg acaaattggt aggatttggt caggcactag gagtggagca
     4561 tgagctctgg ggacagacag ttatgggttc tggtcccact ttttatcact tactagttgt
     4621 ttgaccttgg gcaagtcatt tgaccttctg tgcctcagtt tcctcatctg taaaatgggg
     4681 ctaacaatat tacctacctc ataggattta atgatgtcaa gctcctcact ggaggcctta
     4741 tcccttcgtg gagcccacta ggtgccgacc cctcagaata taaccctcat gcctggaccc
     4801 ctgagagctt ctgatcccag ctattaggga cagaagaagc ctccaaatct ggaaggtgct
     4861 gaatgccctg ctgactggga aagtttcagg gcactgatgg ggtctacctg gtaagcggag
     4921 ggcctgagga aacctgtagc ttcaatcatg tctggtaacc gggtgcctga gccccaatct
     4981 gggttgtgag gaaatagggg agaggtatcc tgggccacat cccagcctaa cacctgtgag
     5041 gttcatttta ggaactaacc tcattagcta taaggatcat gcagaggcag caaagccggg
     5101 tgcgatgagc tcagccttta ctcattcaca tacaccatca cactttaatt ccaatctgta
     5161 tattgctttt taaaagttaa gtccattcta attacccaaa tatgcatgaa ttcattctcc
     5221 ttttgagaag ttagattgtt aaagatagtc tcattcagct accaaccact ccttgatcct
     5281 tcccttctta gtggctgttg tttgttgtac ttccgtttag actttgtttt aatgcttgta
     5341 cgtacatatg tgaactcatt ggaaatattg tgtgtttaat gcaaatgata tattgaattg
     5401 tttagcaatt tgttttcttt gcttaacgat gtttttgaga tctgtgcatg ttacttaatg
     5461 tagctcaatc catcttctgt aattgctgta tagattgtca tcatatgatt accacatttt
     5521 acttacgcat ttcttttgtg atggacatta agactgtttt taggttttgc tattacaaaa
     5581 tactacacag gagcatcact atgcctgtgt gaaagtatat gtatgaaagt ttacctaggg
     5641 ttgattccta gaagtggaat tgcaaagtca taggatattt atatattggt ttttaataat
     5701 acttccaaat tgccctcctg tactatttac tcagtatttt tcttgaggtt gatctgaggt
     5761 ctaacattgt tatcctatat cattttcatc ccaagtagtg atatctgtga aatcacaggt
     5821 ttgatgtgtg ctaattatgt attcttctaa tacatattaa aagacataac tatcaaaaca
     5881 aaataaattt gtctgttttc aaccaaagaa gtcacgtacc actggtggta ctgtgtgcca
     5941 taatttggca aatgctggcc tttatggacg agcacaattc gggggtcaga cctggttcaa
     6001 attctagctg tagaaacttg tgcaagttac ttcacctctg agcctaagtt tccacatctg
     6061 taaaaggaga taataaacac ctaccttgca gtagtgaagc aaagagaaaa ttaaatatat
     6121 atgaagcaat ttggctggca tctagatcat tcacagccct ttaaaggtca cctttgctgt
     6181 tctccccact ttacagataa ggaaactgag gcccaaaaag gtttgaaccc aggtcttcca
     6241 agtcattcaa gtgctttctc cactgtacag gtggttatca accttggctg cgcatcagaa
     6301 tcgtttgtaa agctttttct ttttcctttt taaaaagtaa agcaatatat acacaggtaa
     6361 aaaaataaaa tagtacagaa gggcttataa tgagaagcag cagttccctg cttgcacccc
     6421 cacatccaaa ggatgtggag ctctttaaaa ataaattgct ctggtcccac ctctggaaat
     6481 ctgattcagc cagcatggat aataacccag ataactaacc cctacctcac aggataaaaa
     6541 ggattacatg agatgcctta ggctaaggcc ctggcacaca ggaacacatg tgctacaaag
     6601 gagctttggg gacttaagtc ctgaggatcc aggaggtgag gtgacttgtc caagattcca
     6661 ctggtttagt ggcagagcct agacttccac tcggatctat ttagtgcttg ccccctgctc
     6721 tctcctgtcg tgccccacca cctcctggca tcacagggca accgttgtca aggctatgct
     6781 cacgggaggc tgggcaccac agtgtttcca agagcaagct ggatccgagt agattcccta
     6841 gggcttgttg gaggaactag tttgactccc ttatactgtg gacgcagtag ccttgctgta
     6901 gggagttgaa gagtactcca caacagtatc ttaagtttaa ctgggcactt ccctctggaa
     6961 atcacagtgt tgtgcaccag gaacacaaag atgagtcaaa tctttatcct gcctttgagg
     7021 agctcactgt ttagttgggg aaaccatttg taaaacagcc attaaccata cagtgtgatc
     7081 aacactgaca ggagcacagg aaaaacatct agcttatgtg aagattcaga gaaggcatcc
     7141 tgtagtctag gtggtgatac ctgaactgag tcttgaggga cgggtaggaa ttagccagtt
     7201 gaggaagtag aaggaatttc cagatattgg aaacagtatg catgaagaca tgaaggcaag
     7261 aaacagcaaa acaaatactg aagcatgaag attcctgggg tggggggaaa gcagcaagaa
     7321 aaggtagaga ggaaccagat tggaagaggg tcgtaaatgc atggctacag aattcagatt
     7381 tgttttgtag gacagtgtgg ttcccaaact ggctgtatac cacaaacagg tacggcattc
     7441 tgggccccgg cccctaaaac attcattaag tctggggtga agatttggaa tcttgaatgc
     7501 ttataaaggt taccacatga ctagggtaca gccagatttg gaaaccatag cttgaaggca
     7561 gtgagggagc catgaaatgg tttttaatag ggggactcca gatcagatgt gaacttaacc
     7621 tgtttctggc tggctagcca accagcatgg aaaacagatt aggttagatg ttcatgctgt
     7681 atgtgcccgt gcctgtagct tccctgttaa tcagcttctt acactactat atttgcttat
     7741 tttgtctctg aataagcttt aggcaccaca agggtgggcc tggggatatt ttgcttacca
     7801 gtatagcccc tgcaaaaaag cacagtgcct gacacaaaac aggcacccag taaagttttt
     7861 gaatgaatga atgcatgagt gaatccattt gtgagagagc gaatggagat gacaagatta
     7921 gctaggagac tggaaaaaga ccaggaggcc tgcactaggg caaaggccag taggaataga
     7981 ttggaggtgt taaggtgtga actgttaagg taagatgata acttaatgac tgattattgg
     8041 atgtggaggg tgactgagag gatagaatga gtacccatga atagccatga ttcctaccct
     8101 gtcccagtca tctctttcct tatccatctc tgaaacaatc tgcttacatc ctcctcagca
     8161 actggaattc ctcaagttag ttagacattc tgtgtgctgt gtggtctctc actgcccccc
     8221 cactccccac ccctccacaa gccattgatt cattcatcca gttcaataaa tcttggctaa
     8281 gcacctccag tgtgcagtaa ggctcttcca agccaggact ctgactccct ctttcctacc
     8341 tcaagagatg tttttgaggg ctttcccagg taagagtcac atctcttata caataactta
     8401 tagtgagata cccagaatgt cagacttgta agggaagact gcccaaaccc cttctgaggt
     8461 cctcagaggg gaattaactt cctaaggtcc gactgctagg aagtgttgga gccagaaatg
     8521 gaagctaggt ttcctttcta tgtcatctct ggagtcttga tcttgatcta tcccattgta
     8581 gatcaggaca ggcagaggtg gtcagggaga aggtgggact taggttgaac cttgaaggtc
     8641 aatgtattgg acaggtcaaa caagatggtt gccaattaca ctgccccctt ctggaaaccc
     8701 ttagcaaacc tgccatgctt gcagtccctt ctaaggggtt tccttagcat aagttgccat
     8761 gctctgtacc atgtgacctc acaatcctgg ccacagatag ctagatgtgg atagtgtctg
     8821 gttcaagggc aaccaatctc taggctggcc agtggcctgt tagctggact ggcataagga
     8881 cttcacctta caggggtggc atgtatcaaa tggcaaatgt atgaaacaac cagatctttc
     8941 agggaggcag aatgtgagct attcagaaga agtgaacgtt aattagaatt taatgaggca
     9001 ttagtggtgg tggatgaggg gtggccagaa actaaacagc aaaagcaaag agaaagctgc
     9061 agaaaccata agtaagcaga ggtcatgaga catttgtata atgagatcac ggagccacag
     9121 ggtggcagaa gccatgaagc agcaaggcaa caatgggcta gaagccatga agcaatagga
     9181 gccacgagga acagaaaccg tgagacaaaa ctgactatga gatccacaaa gcagcagaag
     9241 gcttgaatag ataagatcat gagacagtag aagcgatgag actgcaagaa ccacaaggta
     9301 gccagaacca tgtggcaaca tggcaacagg aatggaagag gcagcaggag ctacaatgca
     9361 gaaaagccat ggattaatag gaactgaagc gccgggagcc atgaagctgc aggacccatg
     9421 aggcagaaaa agccatgggc tagcatcgag gggggcagaa agaagttagt cagtagcagt
     9481 aggaggagta taaatacagc cagaaaggag ttgagtcacc aatttgggaa gcactagaga
     9541 agggagcaac agatgcctgc agctgagggg gtgacaagat aagccaggct ctagagctgc
     9601 tttggatcat gaaccatttt caagtttctg ttcttccatg aggctgcctg tgtagctgtt
     9661 cttgtcttcc ttatttccct gtgaatgctt taataaatcc ccatcactaa
//
