LOCUS       NM_003076               3283 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens SWI/SNF related BAF chromatin remodeling complex
            subunit D1 (SMARCD1), transcript variant 1, mRNA.
ACCESSION   NM_003076
VERSION     NM_003076.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Ross,C., Gong,L.Y., Jenkins,L.M., Ha,N.H., Majocha,M. and
            Hunter,K.W.
  TITLE     SMARCD1 is an essential expression-restricted metastasis modifier
  JOURNAL   Commun Biol 7 (1), 1299 (2024)
   PUBMED   39390150
  REMARK    GeneRIF: SMARCD1 is an essential expression-restricted metastasis
            modifier.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Zhao,Y., Liu,Y., Zhao,G., Lu,H., Liu,Y., Xue,C., Chang,Z., Liu,H.,
            Deng,Y., Liang,W., Wang,H., Rom,O., Garcia-Barrio,M.T., Zhu,T.,
            Guo,Y., Chang,L., Lin,J., Chen,Y.E. and Zhang,J.
  TITLE     Myeloid BAF60a deficiency alters metabolic homeostasis and
            exacerbates atherosclerosis
  JOURNAL   Cell Rep 42 (10), 113171 (2023)
   PUBMED   37768825
  REMARK    GeneRIF: Myeloid BAF60a deficiency alters metabolic homeostasis and
            exacerbates atherosclerosis.
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Chen,J., Yu,N., Ou,S., Wang,X., Li,H. and Zhu,H.
  TITLE     Integrated analysis reveals SMARCD1 is a potential biomarker and
            therapeutic target in skin cutaneous melanoma
  JOURNAL   J Cancer Res Clin Oncol 149 (13), 11619-11634 (2023)
   PUBMED   37401939
  REMARK    GeneRIF: Integrated analysis reveals SMARCD1 is a potential
            biomarker and therapeutic target in skin cutaneous melanoma.
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Dong,C., Zhang,R., Xu,L., Liu,B. and Chu,X.
  TITLE     Assembly and interaction of core subunits of BAF complexes and
            crystal study of the SMARCC1/SMARCE1 binary complex
  JOURNAL   Biochem Biophys Res Commun 599, 9-16 (2022)
   PUBMED   35158202
  REMARK    GeneRIF: Assembly and interaction of core subunits of BAF complexes
            and crystal study of the SMARCC1/SMARCE1 binary complex.
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3283)
  AUTHORS   Cho,H., Orphanides,G., Sun,X., Yang,X.J., Ogryzko,V., Lees,E.,
            Nakatani,Y. and Reinberg,D.
  TITLE     A human RNA polymerase II complex containing factors that modify
            chromatin structure
  JOURNAL   Mol Cell Biol 18 (9), 5355-5363 (1998)
   PUBMED   9710619
REFERENCE   7  (bases 1 to 3283)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Wang,W., Crabtree,G.R. and Francke,U.
  TITLE     Five SWI/SNF-related, matrix-associated, actin-dependent regulator
            of chromatin (SMARC) genes are dispersed in the human genome
  JOURNAL   Genomics 51 (1), 140-143 (1998)
   PUBMED   9693044
REFERENCE   8  (bases 1 to 3283)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 3283)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   10 (bases 1 to 3283)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009368.2 and AA610093.1.
            
            On May 17, 2019 this sequence version replaced NM_003076.4.
            
            Summary: The protein encoded by this gene is a member of the
            SWI/SNF family of proteins, whose members display helicase and
            ATPase activities and which are thought to regulate transcription
            of certain genes by altering the chromatin structure around those
            genes. The encoded protein is part of the large ATP-dependent
            chromatin remodeling complex SNF/SWI and has sequence similarity to
            the yeast Swp73 protein. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            encodes the full-length isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.883052.1, BC009368.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394963.9/ ENSP00000378414.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3218              BC009368.2         93-3310
            3219-3283           AA610093.1         7-71                c
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..3283
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit D1"
                     /db_xref="GeneID:6602"
                     /db_xref="HGNC:HGNC:11106"
                     /db_xref="MIM:601735"
     exon            1..205
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1576
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /note="isoform a is encoded by transcript variant 1;
                     mammalian chromatin remodeling complex BRG1-associated
                     factor 60A; chromatin remodeling complex BAF60A subunit;
                     Swp73-like protein; SWI/SNF complex 60 kDa subunit A;
                     SWI/SNF related, matrix associated, actin dependent
                     regulator of chromatin, subfamily d, member 1;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily D member 1; 60 kDa
                     BRG-1/Brm-associated factor subunit A"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily D member
                     1 isoform a"
                     /protein_id="NP_003067.3"
                     /db_xref="CCDS:CCDS8797.2"
                     /db_xref="GeneID:6602"
                     /db_xref="HGNC:HGNC:11106"
                     /db_xref="MIM:601735"
                     /translation="MAARAGFQSVAPSGGAGASGGAGAAAALGPGGTPGPPVRMGPAP
                     GQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKR
                     PAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQT
                     IMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLED
                     SALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPG
                     DVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHER
                     EFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDI
                     DVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQG
                     FINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQ
                     ALGIRNT"
     exon            206..393
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            394..436
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            437..559
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            560..682
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            683..799
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            800..901
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1063
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1161
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1297
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1420
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1522
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..3283
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3200..3205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /note="hexamer: AATAAA"
     polyA_site      3218
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
                     /note="major polyA site"
     polyA_site      3283
                     /gene="SMARCD1"
                     /gene_synonym="BAF60A; CRACD1; CSS11; Rsc6p"
ORIGIN      
        1 gtgcggctgc atcggcggct ccgggaagat ggcggcccgg gcgggtttcc agtctgtggc
       61 tccaagcggc ggcgccggag cctcaggagg ggcgggcgcg gctgctgcct tgggcccggg
      121 cggaactccg gggcctcctg tgcgaatggg cccggctccg ggtcaagggc tgtaccgctc
      181 cccgatgccc ggagcggcct atccgagacc aggtatgttg ccaggcagcc gaatgacacc
      241 tcagggacct tccatgggac cccctggcta tggggggaac ccttcagtcc gacctggcct
      301 ggcccagtca gggatggatc agtcccgcaa gagacctgcc cctcagcaga tccagcaggt
      361 ccagcagcag gcggtccaaa atcgaaacca caatgcaaag aaaaagaaga tggctgacaa
      421 aattctacct caaaggattc gtgaactggt accagaatcc caggcctata tggatctctt
      481 ggcttttgaa aggaaactgg accagactat catgaggaaa cggctagata tccaagaggc
      541 cttgaaacgt cccatcaagc aaaaacggaa gctgcgaatt ttcatttcta acactttcaa
      601 tccggctaag tcagatgccg aggatgggga agggacggtg gcttcctggg agcttcgggt
      661 agaaggacgg ctcctggagg attcagcctt gtccaaatat gatgccacta aacaaaagag
      721 gaagttctct tcctttttta agtccttggt gattgaactg gacaaagacc tgtatgggcc
      781 agacaaccat ctggtagaat ggcacaggac cgccactacc caggagaccg atggctttca
      841 ggtgaagcgg ccgggagacg tgaatgtacg gtgtactgtc ctactgatgc tggattacca
      901 gcctccccag tttaaattag acccccgcct agctcgactc ctgggcatcc atacccagac
      961 tcgtccagtg atcatccaag cactgtggca atatattaag acacataagc tccaggaccc
     1021 tcacgagcgg gagtttgtca tctgtgacaa gtacctgcag cagatctttg agtctcaacg
     1081 tatgaagttt tcagagatcc ctcagcggct ccatgccttg cttatgccac cagaacctat
     1141 catcattaat catgtcatca gtgttgaccc gaatgatcag aaaaagacag cttgttatga
     1201 cattgatgtt gaagtggatg acaccttgaa gacccagatg aattcttttc tgctgtccac
     1261 tgccagccaa caggagattg ctactctaga caacaagatc catgagacaa tagaaaccat
     1321 caaccagctg aagactcagc gggagttcat gctgagcttt gccagagacc ctcagggttt
     1381 catcaatgac tggcttcagt cccagtgcag ggacctcaag acaatgactg atgtggtggg
     1441 taacccagag gaggagcgcc gagctgagtt ctacttccag ccctgggctc aggaggctgt
     1501 gtgccgatac ttctactcca aggtgcagca gagacgacaa gaattagagc aagccctggg
     1561 aatccggaat acatagggcc tctcccacag ccctgattcg actgcaccaa ttcttgattt
     1621 gggccctgtg ctgcctgcct catagtatct gccttggtct tgcttggggc gttccagggg
     1681 atgctgttgg ttcaaggaca acaccagaat gaagagggtc tcacaagaca cctgttatcc
     1741 tcttctttca ccctatctct tcccaccccc agcttccctt tgccccacaa agttcccatg
     1801 tgcctgtacc ctcccctggt ctacatagga cctctagata gtgttagaga gagaacatgt
     1861 agtggtaatg agtgcttgga atggattggg cctcaggcca ggtggtcttc aaggggacca
     1921 gctaactgat cctgcccttc agagacccag gagttgggag ctttcgctcc ttctccaaga
     1981 ctcaggcctg tgggcactct ataagctagt tgatcttggc tctcctgata acagaatcca
     2041 atttccttcc ttccctccac aggtttggaa caaactctcc cttcacttgt tgccctgtag
     2101 cactacagaa accctggttc ttgggctcca ctgagcccca ggtcagtccc cagccctctg
     2161 ggttggcctg ctgtcagtgc ttctctcact ccttagttgg ggtccacatc agtattggag
     2221 ttttgttctt tattgctccc tcccagacac tccctgtggc tgccctttgt gattccctca
     2281 gatctgccct aatcccgggc atttgggtgg gggaatcttg cctttccctt tcagagcccc
     2341 agggatctca tctggggaac tgtcattgcc agcagaggct gttccttcct gctgtttgga
     2401 gatgtgactc attcattcac tcactccacc ctgcctctgc atcccttaat ggagaaacgg
     2461 gcctaaaacc aaacgggtaa aaagccctgg gccatccctg tcttcctgtc ccttgtctgc
     2521 ccagttgaca cctactggtg acttctaggg cactgaggag tgaaagcgcc tagggctgga
     2581 gaatagcgct gagttgggtt tgtgactctt ccctctccct gcctcacagg attgtgactc
     2641 cccagcccct gccctcaaag cttcagaccc ctcaggtagc agcaggacct tgtgatcttg
     2701 gccccttgga tctgagatgg tttttgcatc tttccaggag agcctcacat tcttcttcca
     2761 ggttgtatca cccccgagtt agcatatccc aggctcgcag actcaacaca gcaagggtgg
     2821 gagacagctg ggcacaaagg gggaattccg ttcagcatgg gctctaaacc cacagaactg
     2881 acaaagcccc tgcttcccca ccccctcctc aggctcctgc gagcacaccc ccacccccaa
     2941 atccctccct gttctacact ggggacagca gaattttctc cccgtcttcc ccttcctgcc
     3001 attttccctc ccttgaaagg ttgacactgg acaaccttgg ggcagctgag ccctggccgc
     3061 ctcctggctg gaaccatgag aaggaagctc agtacttccc acagtgtccc tgttgataac
     3121 tgtttttatt aactgaattg tttttttcat ggaccaaact tttttttgta ctgtcccctt
     3181 attgatgtta cccagtttta ataaaagaat cttctgaagg atgggtcctc ctacctactg
     3241 tgagagagct cttccctgag ctcttcttcc ttcaatacca tta
//
