LOCUS       NM_001330288            5090 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SWI/SNF related BAF chromatin remodeling complex
            subunit C2 (SMARCC2), transcript variant 4, mRNA.
ACCESSION   NM_001330288 XM_005269101
VERSION     NM_001330288.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5090)
  AUTHORS   Bosch,E., Popp,B., Guse,E., Skinner,C., van der Sluijs,P.J.,
            Maystadt,I., Pinto,A.M., Renieri,A., Bruno,L.P., Granata,S.,
            Marcelis,C., Baysal,O., Hartwich,D., Holthofer,L., Isidor,B.,
            Cogne,B., Wieczorek,D., Capra,V., Scala,M., De Marco,P.,
            Ognibene,M., Jamra,R.A., Platzer,K., Carter,L.B., Kuismin,O., van
            Haeringen,A., Maroofian,R., Valenzuela,I., Cusco,I.,
            Martinez-Agosto,J.A., Rabani,A.M., Mefford,H.C., Pereira,E.M.,
            Close,C., Anyane-Yeboa,K., Wagner,M., Hannibal,M.C., Zacher,P.,
            Thiffault,I., Beunders,G., Umair,M., Bhola,P.T., McGinnis,E.,
            Millichap,J., van de Kamp,J.M., Prijoles,E.J., Dobson,A.,
            Shillington,A., Graham,B.H., Garcia,E.J., Galindo,M.K.,
            Ropers,F.G., Nibbeling,E.A.R., Hubbard,G., Karimov,C., Goj,G.,
            Bend,R., Rath,J., Morrow,M.M., Millan,F., Salpietro,V., Torella,A.,
            Nigro,V., Kurki,M., Stevenson,R.E., Santen,G.W.E., Zweier,M.,
            Campeau,P.M., Severino,M., Reis,A., Accogli,A. and Vasileiou,G.
  TITLE     Elucidating the clinical and molecular spectrum of
            SMARCC2-associated NDD in a cohort of 65 affected individuals
  JOURNAL   Genet Med 25 (11), 100950 (2023)
   PUBMED   37551667
  REMARK    GeneRIF: Elucidating the clinical and molecular spectrum of
            SMARCC2-associated NDD in a cohort of 65 affected individuals.
REFERENCE   2  (bases 1 to 5090)
  AUTHORS   Liu,S., Liu,P., Zhu,C., Yang,R., He,Z., Li,Y., Li,Y., Fei,X.,
            Hou,J., Wang,X. and Pan,Y.
  TITLE     FBXO28 promotes proliferation, invasion, and metastasis of
            pancreatic cancer cells through regulation of SMARCC2
            ubiquitination
  JOURNAL   Aging (Albany NY) 15 (12), 5381-5398 (2023)
   PUBMED   37348029
  REMARK    GeneRIF: FBXO28 promotes proliferation, invasion, and metastasis of
            pancreatic cancer cells through regulation of SMARCC2
            ubiquitination.
            Erratum:[Aging (Albany NY). 2023 Sep 14;15(17):9230-9232. doi:
            10.18632/aging.205071.. PMID: 37708091]
REFERENCE   3  (bases 1 to 5090)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5090)
  AUTHORS   Li,C., Wang,T., Gu,J., Qi,S., Li,J., Chen,L., Wu,H., Shi,L.,
            Song,C., Li,H., Zhu,L., Lu,Y. and Zhou,Q.
  TITLE     SMARCC2 mediates the regulation of DKK1 by the transcription factor
            EGR1 through chromatin remodeling to reduce the proliferative
            capacity of glioblastoma
  JOURNAL   Cell Death Dis 13 (11), 990 (2022)
   PUBMED   36418306
  REMARK    GeneRIF: SMARCC2 mediates the regulation of DKK1 by the
            transcription factor EGR1 through chromatin remodeling to reduce
            the proliferative capacity of glioblastoma.
            Erratum:[Cell Death Dis. 2022 Dec 12;13(12):1033. doi:
            10.1038/s41419-022-05498-x.. PMID: 36509739]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5090)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5090)
  AUTHORS   Wang,W., Chi,T., Xue,Y., Zhou,S., Kuo,A. and Crabtree,G.R.
  TITLE     Architectural DNA binding by a high-mobility-group/kinesin-like
            subunit in mammalian SWI/SNF-related complexes
  JOURNAL   Proc Natl Acad Sci U S A 95 (2), 492-498 (1998)
   PUBMED   9435219
REFERENCE   7  (bases 1 to 5090)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   8  (bases 1 to 5090)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   9  (bases 1 to 5090)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
REFERENCE   10 (bases 1 to 5090)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY118539.1, AK315153.1,
            DA768316.1, BC009067.1, CX165574.1 and BM875330.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001330288.1.
            
            Summary: The protein encoded by this gene is a member of the
            SWI/SNF family of proteins, whose members display helicase and
            ATPase activities and which are thought to regulate transcription
            of certain genes by altering the chromatin structure around those
            genes. The encoded protein is part of the large ATP-dependent
            chromatin remodeling complex SNF/SWI and contains a predicted
            leucine zipper motif typical of many transcription factors.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (4) contains an alternate in-frame
            exon in the central coding region compared to variant 1. The
            encoded isoform (d), contains the same N- and C-termini, but is
            longer than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.7638.1,
                                           SRR14038192.2638112.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000550164.6/ ENSP00000449396.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                HY118539.1         92-108
            18-1548             AK315153.1         2-1532
            1549-2070           DA768316.1         1-522
            2071-2993           AK315153.1         1962-2884
            2994-4121           BC009067.1         633-1760
            4122-4594           CX165574.1         221-693
            4595-5090           BM875330.1         19-514              c
FEATURES             Location/Qualifiers
     source          1..5090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..5090
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit C2"
                     /db_xref="GeneID:6601"
                     /db_xref="HGNC:HGNC:11105"
                     /db_xref="MIM:601734"
     exon            1..133
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..3760
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /note="isoform d is encoded by transcript variant 4;
                     chromatin remodeling complex BAF170 subunit; SWI3-like
                     protein; SWI/SNF complex 170 kDa subunit; mammalian
                     chromatin remodeling complex BRG1-associated factor 170;
                     SWI/SNF complex subunit SMARCC2; SWI/SNF related, matrix
                     associated, actin dependent regulator of chromatin
                     subfamily c member 2"
                     /codon_start=1
                     /product="SWI/SNF complex subunit SMARCC2 isoform d"
                     /protein_id="NP_001317217.1"
                     /db_xref="CCDS:CCDS81698.1"
                     /db_xref="GeneID:6601"
                     /db_xref="HGNC:HGNC:11105"
                     /db_xref="MIM:601734"
                     /translation="MAVRKKDGGPNVKYYEAADTVTQFDNVRLWLGKNYKKYIQAEPP
                     TNKSLSSLVVQLLQFQEEVFGKHVSNAPLTKLPIKCFLDFKAGGSLCHILAAAYKFKS
                     DQGWRRYDFQNPSRMDRNVEMFMTIEKSLVQNNCLSRPNIFLCPEIEPKLLGKLKDII
                     KRHQGTVTEDKNNASHVVYPVPGNLEEEEWVRPVMKRDKQVLLHWGYYPDSYDTWIPA
                     SEIEASVEDAPTPEKPRKVHAKWILDTDTFNEWMNEEDYEVNDDKNPVSRRKKISAKT
                     LTDEVNSPDSDRRDKKGGNYKKRKRSPSPSPTPEAKKKNAKKGPSTPYTKSKRGHREE
                     EQEDLTKDMDEPSPVPNVEEVTLPKTVNTKKDSESAPVKGGTMTDLDEQEDESMETTG
                     KDEDENSTGNKGEQTKNPDLHEDNVTEQTHHIIIPSYAAWFDYNSVHAIERRALPEFF
                     NGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTSTACRRNLAGDVCAIMRVHAFLEQWG
                     LINYQVDAESRPTPMGPPPTSHFHVLADTPSGLVPLQPKTPQGRQVDADTKAGRKGKE
                     LDDLVPETAKGKPELQTSASQQMLNFPDKGKEKPTDMQNFGLRTDMYTKKNVPSKSKA
                     AASATREWTEQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLED
                     SEASLGPLAYQPIPFSQSGNPVMSTVAFLASVVDPRVASAAAKSALEEFSKMKEEVPT
                     ALVEAHVRKVEEAAKVTGKADPAFGLESSGIAGTTSDEPERIEESGNDEARVEGQATD
                     EKKEPKEPREGGGAIEEEAKEKTSEAPKKDEEKGKEGDSEKESEKSDGDPIVDPEKEK
                     EPKEGQEEVLKEVVESEGERKTKVERDIGEGNLSTAAAAALAAAAVKAKHLAAVEERK
                     IKSLVALLVETQMKKLEIKLRHFEELETIMDREREALEYQRQQLLADRQAFHMEQLKY
                     AEMRARQQHFQQMHQQQQQPPPALPPGSQPIPPTGAAGPPAVHGLAVAPASVVPAPAG
                     SGAPPGSLGPSEQIGQAGSTAGPQQQQPAGAPQPGAVPPGVPPPGPHGPSPFPNQQTP
                     PSMMPGAVPGSGHPGVAGNAPLGLPFGMPPPPPPPAPSIIPFGSLADSISINLPAPPN
                     LHGHHHHLPFAPGTLPPPNLPVSMANPLHPNLPATTTMPSSLPLGPGLGSAAAQSPAI
                     VAAVQGNLLPSASPLPDPGTPLPPDPTAPSPGTVTPVPPPQ"
     exon            134..253
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            254..339
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            340..421
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            422..514
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            515..584
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            585..654
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            655..730
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            731..862
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            863..978
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1103
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1163
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1201
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1332
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1404
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1518
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1672
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1765
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1885
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1948
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2207
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2369
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2434
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2435..2570
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2737
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..2872
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3254
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3683
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..5090
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4472
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
     regulatory      5065..5070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /note="hexamer: TATAAA"
     polyA_site      5090
                     /gene="SMARCC2"
                     /gene_synonym="BAF170; CRACC2; CSS8; Rsc8"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggccc gagccggaga agatggcggt gcggaagaag gacggcggcc ccaacgtgaa
       61 gtactacgag gccgcggaca ccgtgaccca gttcgacaac gtgcggctgt ggctcggcaa
      121 gaactacaag aagtatatac aagctgaacc acccaccaac aagtccctgt ctagcctggt
      181 tgtacagttg ctacaatttc aggaagaagt ttttggcaaa catgtcagca atgcaccgct
      241 cactaaactg ccgatcaaat gtttcctaga tttcaaagcg ggaggctcct tgtgccacat
      301 tcttgcagct gcctacaaat tcaagagtga ccagggatgg cggcgttacg atttccagaa
      361 tccatcacgc atggaccgca atgtggaaat gtttatgacc attgagaagt ccttggtgca
      421 gaataattgc ctgtctcgac ctaacatttt tctgtgccca gaaattgagc ccaaactact
      481 agggaaatta aaggacatta tcaagagaca ccagggaaca gtcactgagg ataagaacaa
      541 tgcctcccat gttgtgtatc ctgtcccggg gaatctagaa gaagaggaat gggtacgacc
      601 agtcatgaag agggataagc aggttcttct gcactggggc tactatcctg acagttacga
      661 cacgtggatc ccagcgagtg aaattgaggc atctgtggaa gatgctccaa ctcctgagaa
      721 acctaggaag gttcatgcaa agtggatcct ggacaccgac accttcaatg aatggatgaa
      781 tgaggaagac tatgaagtaa atgatgacaa aaaccctgtc tcccgccgaa agaagatttc
      841 agccaagaca ctgacagatg aggtgaacag cccagattca gatcgacggg acaagaaggg
      901 gggaaactat aagaagagga agcgctcccc ctctccttca ccaaccccag aagcaaagaa
      961 gaaaaatgct aagaaaggtc cctcaacacc ttacactaag tcaaagcgtg gccacagaga
     1021 agaggagcaa gaagacctga caaaggacat ggacgagccc tcaccagtcc ccaatgtaga
     1081 agaggtgaca cttcccaaaa cagtcaacac aaagaaagac tcagagtcgg ccccagtcaa
     1141 aggcggcacc atgaccgacc tggatgaaca ggaagatgaa agcatggaga cgacgggcaa
     1201 ggatgaggat gagaacagta cggggaacaa gggagagcag accaagaatc cagacctgca
     1261 tgaggacaat gtgactgaac agacccacca catcatcatt cccagctacg ctgcctggtt
     1321 tgactacaat agtgttcatg ccattgagcg gagggctctc cccgagttct tcaacggcaa
     1381 gaacaagtcc aagactccag agatctacct ggcctatcga aactttatga ttgacactta
     1441 ccgactgaac ccccaagagt atcttacctc taccgcctgc cgccgaaacc tagcgggtga
     1501 tgtctgtgcc atcatgaggg tccatgcctt cctagaacag tggggtctta ttaactacca
     1561 ggtggatgct gagagtcgac caaccccaat ggggcctccg cctacctctc acttccatgt
     1621 cttggctgac acaccatcag ggctggtgcc tctgcagccc aagacacctc agggccgcca
     1681 ggttgatgct gataccaagg ctgggcgaaa gggcaaagag ctggatgacc tggtgccaga
     1741 gacggctaag ggcaagccag agctgcagac ctctgcttcc caacaaatgc tcaactttcc
     1801 tgacaaaggc aaagagaaac caacagacat gcaaaacttt gggctgcgca cagacatgta
     1861 cacaaaaaag aatgttccct ccaagagcaa ggctgcagcc agtgccactc gtgagtggac
     1921 agaacaggaa accctgcttc tcctggaggc actggaaatg tacaaagatg actggaacaa
     1981 agtgtccgag catgtgggaa gccgcacaca ggacgagtgc atcttgcatt ttcttcgtct
     2041 tcccattgaa gacccatacc tggaggactc agaggcctcc ctaggccccc tggcctacca
     2101 acccatcccc ttcagtcagt cgggcaaccc tgttatgagc actgttgcct tcctggcctc
     2161 tgtcgtcgat ccccgagtcg cctctgctgc tgcaaagtca gccctagagg agttctccaa
     2221 aatgaaggaa gaggtaccca cggccttggt ggaggcccat gttcgaaaag tggaagaagc
     2281 agccaaagta acaggcaagg cggaccctgc cttcggtctg gaaagcagtg gcattgcagg
     2341 aaccacctct gatgagcctg agcggattga ggagagcggg aatgacgagg ctcgggtgga
     2401 aggccaggcc acagatgaga agaaggagcc caaggaaccc cgagaaggag ggggtgctat
     2461 agaggaggaa gcaaaagaga aaaccagcga ggctcccaag aaggatgagg agaaagggaa
     2521 agaaggcgac agtgagaagg agtccgagaa gagtgatgga gacccaatag tcgatcctga
     2581 gaaggagaag gagccaaagg aagggcagga ggaagtgctg aaggaagtgg tggagtctga
     2641 gggggaaagg aagacaaagg tggagcggga cattggcgag ggcaacctct ccaccgctgc
     2701 tgccgccgcc ctggccgccg ccgcagtgaa agctaagcac ttggctgctg ttgaggaaag
     2761 gaagatcaaa tctttggtgg ccctgctggt ggagacccag atgaaaaagt tggagatcaa
     2821 acttcggcac tttgaggagc tggagactat catggaccgg gagcgagaag cactggagta
     2881 tcagaggcag cagctcctgg ccgacagaca agccttccac atggagcagc tgaagtatgc
     2941 ggagatgagg gctcggcagc agcacttcca acagatgcac caacagcagc agcagccacc
     3001 accagccctg cccccaggct cccagcctat ccccccaaca ggggctgctg ggccacccgc
     3061 agtccatggc ttggctgtgg ctccagcctc tgtagtccct gctcctgctg gcagtggggc
     3121 ccctccagga agtttgggcc cttctgaaca gattgggcag gcagggtcaa ctgcagggcc
     3181 acagcagcag caaccagctg gagcccccca gcctggggca gtcccaccag gggttccccc
     3241 ccctggaccc catggcccct caccgttccc caaccaacaa actcctccct caatgatgcc
     3301 aggggcagtg ccaggcagcg ggcacccagg cgtggcgggt aatgctcctt tgggtttgcc
     3361 ttttggcatg ccgcctcctc ctcctcctcc tgctccatcc atcatcccat ttggtagtct
     3421 agctgactcc atcagtatta acctccccgc tcctcctaac ctgcatgggc atcaccacca
     3481 tctcccgttc gccccgggca ctctcccccc acctaacctg cctgtgtcca tggcgaaccc
     3541 tctacatcct aacctgccgg cgaccaccac catgccatct tccttgcctc tcgggccggg
     3601 gctcggatcc gccgcagccc aaagccctgc cattgtggca gctgttcagg gcaacctcct
     3661 gcccagtgcc agcccactgc cagacccagg cacccccctg cctccagacc ccacagcccc
     3721 gagcccaggc acggtcaccc ctgtgccacc tccacagtga ggagccagcc agacatctct
     3781 ccccctcacc ccctgtggac atcacggttc caggaacagc ccttccccca ccactgggac
     3841 cctccccagc ctggagagtt catcactacg taaggaaagc tccttccgcc cctccaaagc
     3901 cctcaccatg cctaacagag gcatgcattt ttatatcaga ttattcaagg acttctgttt
     3961 aaaagatgtt tataatgtct gggagagagg ataggatggg aatgctgccc taaaggaagg
     4021 gctggtgaaa ggtgtttata caaggttcta ttaaccactt ctaagggtac acctccctcc
     4081 aaactactgc attttctatg gattaaaaaa aaaaaaaaaa agtagatttt aaaaagccac
     4141 attggagctc ccttctaccc actaaaaaat aaccaatttt tacatttttt gagggggagt
     4201 gagttttagg aaaggggaat taagattcca gggagagctc tggggataga acagggcgca
     4261 gattccatct ctccccaagc ccctttttag tgactaagtc aaggccccaa ctcccctccc
     4321 ccaccctacg ctgagcttat tcgagttcat tcgtactaat aatccctcct gcggcttcct
     4381 cattgttgct gttttaggcc accccagctc agccaatgat tcctttccct ctgaatgtca
     4441 gttttgtttt taaaagtcac ttgcttagtt gatgtcagcg tatgtgtatt tggtggggaa
     4501 aacctaattt cggggatttc tgtggtaggt aataggagaa gaaagggcac tgggggctgt
     4561 tctccttcct tccctgggct gtatccatgg actcctggaa ggcacagaga agggagctat
     4621 aagaggatgt gaagttttaa aacctgaaat tgttttttaa agcacttaag cacctccata
     4681 ttatgacttg gtgggtcacc ccttagcttc ctccctctcc caccaagact atgagaactt
     4741 cagctgatag ctgggggctc cccagatgag gatgcaggga tttgggagca gtggaagagg
     4801 gtgcccaacc ttgggttgga ccaacccttg gctcgcagct caactctgct tcccgcattc
     4861 ctgctccacg tgtcccagct tctcccctgt gacgggaagg caggtgtgac tccaggctct
     4921 gcactggttc ttcttggttc ctcccaccag gccctttgtt cctcatgtcc ccatgtttct
     4981 ctccctctgc gtcttagcac ctttcttctg ttcaaagttt tctgtaaatt ttctcttttt
     5041 ttctttcttt cttttttttt tttttataaa ttaatttgct ttcagttcca
//
