LOCUS       NM_003074               6354 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SWI/SNF related BAF chromatin remodeling complex
            subunit C1 (SMARCC1), mRNA.
ACCESSION   NM_003074
VERSION     NM_003074.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6354)
  AUTHORS   Singh,A.K., Allington,G., Viviano,S., McGee,S., Kiziltug,E., Ma,S.,
            Zhao,S., Mekbib,K.Y., Shohfi,J.P., Duy,P.Q., DeSpenza,T. Jr.,
            Furey,C.G., Reeves,B.C., Smith,H., Sousa,A.M.M., Cherskov,A.,
            Allocco,A., Nelson-Williams,C., Haider,S., Rizvi,S.R.A.,
            Alper,S.L., Sestan,N., Shimelis,H., Walsh,L.K., Lifton,R.P.,
            Moreno-De-Luca,A., Jin,S.C., Kruszka,P., Deniz,E. and Kahle,K.T.
  TITLE     A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic
            dysregulation in human hydrocephalus
  JOURNAL   Brain 147 (4), 1553-1570 (2024)
   PUBMED   38128548
  REMARK    GeneRIF: A novel SMARCC1 BAFopathy implicates neural progenitor
            epigenetic dysregulation in human hydrocephalus.
REFERENCE   2  (bases 1 to 6354)
  AUTHORS   Hourvitz,N., Kurolap,A., Mory,A., Haratz,K.K., Kidron,D.,
            Malinger,G., Baris Feldman,H. and Yaron,Y.
  TITLE     SMARCC1 is a susceptibility gene for congenital hydrocephalus with
            an autosomal dominant inheritance mode and incomplete penetrance
  JOURNAL   Prenat Diagn 43 (10), 1374-1377 (2023)
   PUBMED   37639281
  REMARK    GeneRIF: SMARCC1 is a susceptibility gene for congenital
            hydrocephalus with an autosomal dominant inheritance mode and
            incomplete penetrance.
REFERENCE   3  (bases 1 to 6354)
  AUTHORS   Rive Le Gouard,N., Nicolle,R., Lefebvre,M., Gelot,A., Heide,S.,
            Gerasimenko,A., Grigorescu,R., Derive,N., Jouannic,J.M., Garel,C.,
            Valence,S., Quenum-Miraillet,G., Chantot-Bastaraud,S., Keren,B.,
            Heron,D. and Attie-Bitach,T.
  TITLE     First reports of fetal SMARCC1 related hydrocephalus
  JOURNAL   Eur J Med Genet 66 (8), 104797 (2023)
   PUBMED   37285932
  REMARK    GeneRIF: First reports of fetal SMARCC1 related hydrocephalus.
            Review article
REFERENCE   4  (bases 1 to 6354)
  AUTHORS   Paun,O., Tan,Y.X., Patel,H., Strohbuecker,S., Ghanate,A.,
            Cobolli-Gigli,C., Llorian Sopena,M., Gerontogianni,L.,
            Goldstone,R., Ang,S.L., Guillemot,F. and Dias,C.
  TITLE     Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal
            regulatory elements to regulate human neural differentiation
  JOURNAL   Genes Dev 37 (5-6), 218-242 (2023)
   PUBMED   36931659
REFERENCE   5  (bases 1 to 6354)
  AUTHORS   Liu,W., Wang,Z., Liu,S., Zhang,X., Cao,X. and Jiang,M.
  TITLE     RNF138 inhibits late inflammatory gene transcription through
            degradation of SMARCC1 of the SWI/SNF complex
  JOURNAL   Cell Rep 42 (2), 112097 (2023)
   PUBMED   36800290
  REMARK    GeneRIF: RNF138 inhibits late inflammatory gene transcription
            through degradation of SMARCC1 of the SWI/SNF complex.
REFERENCE   6  (bases 1 to 6354)
  AUTHORS   Ring,H.Z., Vameghi-Meyers,V., Wang,W., Crabtree,G.R. and Francke,U.
  TITLE     Five SWI/SNF-related, matrix-associated, actin-dependent regulator
            of chromatin (SMARC) genes are dispersed in the human genome
  JOURNAL   Genomics 51 (1), 140-143 (1998)
   PUBMED   9693044
REFERENCE   7  (bases 1 to 6354)
  AUTHORS   Fryer,C.J. and Archer,T.K.
  TITLE     Chromatin remodelling by the glucocorticoid receptor requires the
            BRG1 complex
  JOURNAL   Nature 393 (6680), 88-91 (1998)
   PUBMED   9590696
REFERENCE   8  (bases 1 to 6354)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   9  (bases 1 to 6354)
  AUTHORS   Wang,W., Cote,J., Xue,Y., Zhou,S., Khavari,P.A., Biggar,S.R.,
            Muchardt,C., Kalpana,G.V., Goff,S.P., Yaniv,M., Workman,J.L. and
            Crabtree,G.R.
  TITLE     Purification and biochemical heterogeneity of the mammalian SWI-SNF
            complex
  JOURNAL   EMBO J 15 (19), 5370-5382 (1996)
   PUBMED   8895581
REFERENCE   10 (bases 1 to 6354)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012101.1, BC050564.1, BC040242.1 and AC112512.6.
            
            On Nov 23, 2018 this sequence version replaced NM_003074.3.
            
            Summary: The protein encoded by this gene is a member of the
            SWI/SNF family of proteins, whose members display helicase and
            ATPase activities and which are thought to regulate transcription
            of certain genes by altering the chromatin structure around those
            genes. The encoded protein is part of the large ATP-dependent
            chromatin remodeling complex SNF/SWI and contains a predicted
            leucine zipper motif typical of many transcription factors.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U66615.1, BC050564.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254480.10/ ENSP00000254480.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2540              BC012101.1         23-2562
            2541-3893           BC050564.1         2492-3844
            3894-4311           BC040242.1         2348-2765
            4312-5735           BC040242.1         2767-4190
            5736-6354           AC112512.6         121467-122085       c
FEATURES             Location/Qualifiers
     source          1..6354
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..6354
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit C1"
                     /db_xref="GeneID:6599"
                     /db_xref="HGNC:HGNC:11104"
                     /db_xref="MIM:601732"
     exon            1..291
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3414
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="chromatin remodeling complex BAF155 subunit;
                     SWI/SNF complex 155 kDa subunit; mammalian chromatin
                     remodeling complex BRG1-associated factor 155;
                     SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily C member 1; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin subfamily c member 1"
                     /codon_start=1
                     /product="SWI/SNF complex subunit SMARCC1"
                     /protein_id="NP_003065.3"
                     /db_xref="CCDS:CCDS2758.1"
                     /db_xref="GeneID:6599"
                     /db_xref="HGNC:HGNC:11104"
                     /db_xref="MIM:601732"
                     /translation="MAAAAGGGGPGTAVGATGSGIAAAAAGLAVYRRKDGGPATKFWE
                     SPETVSQLDSVRVWLGKHYKKYVHADAPTNKTLAGLVVQLLQFQEDAFGKHVTNPAFT
                     KLPAKCFMDFKAGGALCHILGAAYKYKNEQGWRRFDLQNPSRMDRNVEMFMNIEKTLV
                     QNNCLTRPNIYLIPDIDLKLANKLKDIIKRHQGTFTDEKSKASHHIYPYSSSQDDEEW
                     LRPVMRKEKQVLVHWGFYPDSYDTWVHSNDVDAEIEDPPIPEKPWKVHVKWILDTDIF
                     NEWMNEEDYEVDENRKPVSFRQRISTKNEEPVRSPERRDRKASANARKRKHSPSPPPP
                     TPTESRKKSGKKGQASLYGKRRSQKEEDEQEDLTKDMEDPTPVPNIEEVVLPKNVNLK
                     KDSENTPVKGGTVADLDEQDEETVTAGGKEDEDPAKGDQSRSVDLGEDNVTEQTNHII
                     IPSYASWFDYNCIHVIERRALPEFFNGKNKSKTPEIYLAYRNFMIDTYRLNPQEYLTS
                     TACRRNLTGDVCAVMRVHAFLEQWGLVNYQVDPESRPMAMGPPPTPHFNVLADTPSGL
                     VPLHLRSPQVPAAQQMLNFPEKNKEKPVDLQNFGLRTDIYSKKTLAKSKGASAGREWT
                     EQETLLLLEALEMYKDDWNKVSEHVGSRTQDECILHFLRLPIEDPYLENSDASLGPLA
                     YQPVPFSQSGNPVMSTVAFLASVVDPRVASAAAKAALEEFSRVREEVPLELVEAHVKK
                     VQEAARASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEKMEADPDGQQPEKAENKVE
                     NETDEGDKAQDGENEKNSEKEQDSEVSEDTKSEEKETEENKELTDTCKERESDTGKKK
                     VEHEISEGNVATAAAAALASAATKAKHLAAVEERKIKSLVALLVETQMKKLEIKLRHF
                     EELETIMDREKEALEQQRQQLLTERQNFHMEQLKYAELRARQQMEQQQHGQNPQQAHQ
                     HSGGPGLAPLGAAGHPGMMPHQQPPPYPLMHHQMPPPHPPQPGQIPGPGSMMPGQHMP
                     GRMIPTVAANIHPSGSGPTPPGMPPMPGNILGPRVPLTAPNGMYPPPPQQQPPPPPPA
                     DGVPPPPAPGPPASAAP"
     exon            292..411
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            412..497
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            498..579
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..672
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..742
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            743..812
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            813..888
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1014
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1136
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1261
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1321
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1359
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1481
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1553
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1667
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1821
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1935
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..1995
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2254
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2416
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2472
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2587
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2742
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2877
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3139
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3316
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..6354
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5580..5585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="hexamer: AATAAT"
     polyA_site      5603
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
     regulatory      5707..5712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="hexamer: AATAAA"
     polyA_site      5730
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="major polyA site"
     regulatory      6251..6256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="hexamer: AATAAA"
     polyA_site      6270
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
     regulatory      6335..6340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
                     /note="hexamer: ACTAAA"
     polyA_site      6354
                     /gene="SMARCC1"
                     /gene_synonym="BAF155; CRACC1; HYC5; Rsc8; SRG3; SWI3"
ORIGIN      
        1 agtggcggct acgcgcgcgg gggtgcgcgc gggaacgacc gggaaacacc gcgagggccg
       61 gggtgggcca ggctgtgggg acgacgggct gcgacgatgg ccgcagcggc gggcggcggc
      121 gggccgggga cagcggtagg cgccacgggc tcggggattg cggcggcagc cgcaggccta
      181 gctgtttatc gacggaagga tgggggcccg gccaccaagt tttgggagag cccggagacg
      241 gtgtcccagc tggattcggt gcgggtctgg ctgggcaagc actacaagaa gtatgttcat
      301 gcggatgctc ctaccaataa aacactggct gggctggtgg tgcagcttct tcagttccag
      361 gaagatgcct ttgggaagca tgtcaccaac ccggccttca ccaaactccc tgcaaagtgt
      421 ttcatggatt tcaaagctgg aggcgcctta tgtcacattc ttggggctgc ttacaagtat
      481 aaaaatgaac agggatggcg gaggtttgac ctacagaacc catctcgaat ggatcgtaat
      541 gtggaaatgt ttatgaacat tgaaaaaaca ttggtgcaga acaattgttt gaccagaccc
      601 aacatctacc tcattccaga cattgatctg aagttggcta acaaattgaa agatatcatc
      661 aaacgacatc agggaacatt tacggatgag aagtcaaaag cttcccacca catttaccca
      721 tattcttcct cacaagacga tgaagaatgg ttgagaccgg tgatgagaaa agagaagcaa
      781 gtgttagtgc attggggctt ttacccagac agctatgata cttgggtcca tagtaatgat
      841 gttgatgctg aaattgaaga tccaccaatt ccagaaaaac catggaaggt tcatgtgaaa
      901 tggattttgg acactgatat tttcaatgaa tggatgaatg aggaggatta tgaggtggat
      961 gaaaatagga agcctgtgag ttttcgtcag cggatttcaa ccaagaatga agagccagtc
     1021 agaagtccag aaagaagaga tagaaaagca tcagctaatg ctcgaaagag gaaacattcg
     1081 ccttcgcctc cccctccgac accaacagaa tcacggaaga agagtgggaa gaaaggccaa
     1141 gctagccttt atgggaagcg cagaagtcag aaagaggaag atgagcaaga agatctaacc
     1201 aaggatatgg aagacccaac acctgtaccc aatatagaag aagtagtact tcccaaaaat
     1261 gtgaacctaa agaaagatag tgaaaataca cctgttaaag gaggaactgt agcggatcta
     1321 gatgagcagg atgaagaaac agtcacagca ggaggaaagg aagatgaaga tcctgccaaa
     1381 ggtgatcaga gtcgatcagt tgaccttggg gaagataatg tgacagagca gaccaatcac
     1441 attattattc ctagttatgc atcatggttt gattataact gtattcatgt gattgaacgg
     1501 cgtgctcttc ctgagttctt caatggaaaa aacaaatcca agactccaga aatatacttg
     1561 gcatatcgaa attttatgat tgacacgtat cgtctaaacc cccaagagta tttaactagc
     1621 actgcttgtc ggaggaactt gactggagat gtgtgtgctg tgatgagggt ccatgccttt
     1681 ttagagcagt ggggactcgt taattaccaa gttgacccgg aaagtagacc catggcaatg
     1741 ggacctcctc ctactcctca ttttaatgta ttagctgata ccccctctgg gcttgtgcct
     1801 ctgcatcttc gatcacctca ggttcctgct gctcaacaga tgctaaattt tcctgagaaa
     1861 aacaaggaaa aaccagttga tttgcagaac tttggtctcc gtactgacat ttactccaag
     1921 aaaacattag caaagagtaa aggtgctagt gctggaagag aatggactga acaggagacc
     1981 cttctactcc tggaggccct ggagatgtac aaggatgatt ggaacaaagt gtcggaacat
     2041 gttggaagtc gtactcagga tgaatgcatc ctccactttt tgagacttcc cattgaggac
     2101 ccataccttg agaattcaga tgcttccctt gggcctttgg cctaccagcc tgtccccttc
     2161 agtcagtcag gaaatccagt tatgagtact gttgcttttt tggcatctgt ggtggaccct
     2221 cgcgtggcat ctgctgcagc aaaagcggct ttggaggagt tttctcgggt ccgggaggag
     2281 gtaccactgg aattggttga agctcatgtc aagaaagtac aagaagcagc acgagcctct
     2341 gggaaagtgg atcccaccta cggtctggag agcagctgca ttgcaggcac agggcccgat
     2401 gagccagaga agcttgaagg agctgaagag gaaaaaatgg aagccgaccc tgatggtcag
     2461 cagcctgaaa aggcagaaaa taaagtggaa aatgaaacgg atgaaggtga taaagcacaa
     2521 gatggagaaa atgaaaaaaa tagtgaaaag gaacaggata gtgaagtgag tgaggatacc
     2581 aaatcagaag aaaaggagac tgaagagaac aaagaactca ctgatacatg taaagaaaga
     2641 gaaagtgata ctgggaagaa gaaagtagaa catgaaattt ccgaaggaaa tgttgccaca
     2701 gccgcagcag ctgctcttgc ctcagcggct accaaagcca agcacctggc tgcagtggaa
     2761 gaaagaaaga tcaagtccct ggtagctctc ttggttgaga cacaaatgaa gaaactagag
     2821 atcaaacttc gacattttga agagctggaa actatcatgg acagagagaa agaagctcta
     2881 gaacaacaga ggcagcagtt gcttactgaa cgccaaaact tccacatgga acagctgaag
     2941 tatgctgaat tacgagcacg acagcaaatg gaacagcagc agcatggcca gaaccctcaa
     3001 caggcacacc agcactcagg aggacctggc ctggccccac ttggagcagc agggcaccct
     3061 ggcatgatgc ctcatcaaca gccccctccc taccctctga tgcaccacca gatgccacca
     3121 cctcatccac cccagccagg tcagatacca ggcccaggtt ccatgatgcc cgggcagcac
     3181 atgccaggcc gcatgattcc cactgttgca gccaacatcc acccctctgg gagtggccct
     3241 acccctcctg gcatgccacc aatgccagga aacatcttag gaccccgggt acccctgaca
     3301 gcacctaacg gcatgtatcc ccctccacca cagcagcagc caccgccacc accacctgca
     3361 gatggggtcc ctccgcctcc tgctcctggc ccgccagcct cagctgctcc ttagcctgga
     3421 agatgcaggg aacctccacg cccaccacca tgagctggag tggggatgac aagacttgtg
     3481 ttcctcaact ttcttgggtt tctttcagga tttttcttct cacagctcca agcacgtgtc
     3541 ccgtgcctcc ccactcctct taccacccct ctctctgaca ctttttgtgt tgggtcctca
     3601 gccaacactc aaggggaaac ctgtagtgac agtgtgccct ggtcatcctt aaaataacct
     3661 gcatctcccc tgtcctggtg tgggagtaag ctgacagttt ctctgcaggt cctgtcaact
     3721 ttagcatgct atgtctttac catttttgct ctcttgcagt tttttgcttt gtcttatgct
     3781 tctatggata atgctatata atcattatct ttttatcttt ctgttattat tgttttaaag
     3841 gagagcatcc taagttaata ggaaccaaaa aataatgatg ggcagaaggg ggggaatagc
     3901 cacaggggac aaaccttaag gcattataag tgaccttatt tctgcttttc tgagctaaga
     3961 atggtgctga tggtaaagtt tgagactttt gccacacaca aatttgtgaa aattaaacga
     4021 gatgtggaag gagaacctca gtgattttat tccctagtga ggcctctgag ggcctccaca
     4081 ctgcctggca gaacatacca ctgaactagt atgtgctaga ggagggcaca aacatccgct
     4141 ccttccctag gcctgctggc tctggttttc tatgcagatg attcattgga ttgggggtga
     4201 gtgttttgtt tttctggggg cagtgtgagc tttgagggtt ggaatattgg gaggcattcc
     4261 ttagtttcct caactagcct ggaaagttag gagtctaggg taattacccc caatgagtct
     4321 agcctactat tcactgcttt gtgtgcattt ttttctccct ctttaaaaaa ccctttaaaa
     4381 gaaaaaaaaa agtagatagt gctaaatatt ttagctcatg aaacttggtt aggatggctg
     4441 ggggtacaag tccccaaact acctcttgtt acagtagcca gggagtggaa tttcgtcaac
     4501 cggtactttt aaggttagga tgggacggga aaagtgaagc aggatattag ctccttatac
     4561 cttctccctt ccatttctga gatctcacat tccatctatc acagggtttt caaagagatg
     4621 ctgagggtaa caaggaactc acttggcagt cagagcatca tgctttgagg tttggggtgc
     4681 tcaggctggg agggtagaat gccattccag aggacaagcc acaaaaatgc cttaatttga
     4741 gctcgtattt acccctgctg ataagtgact tgagagttcc cggttttttc ctcttgtcct
     4801 tccctccctt ctgtccttcc atgtgtgggg aaagggtgtt tttggtagag cttggtttcc
     4861 aaagcgcctg gctttctcac ttcacattct caagtggcag tttcattatt tagaatgcaa
     4921 ggtggacatc ttttggatat ctttttctat atattttcta aagctttaca tatgagaggg
     4981 tatagggagg tgtttataaa acacttgaga acttttttcc ttaatatcag aaagcaaaaa
     5041 aataaaacca caattgagat ttgcctttca aaccctcagg tttgcctcta accaggtgtc
     5101 cctggtcacc atcagagtac tggaatacgg gaaccgagga gaccttggtc cttttgtttt
     5161 tgttctggac tcttgggagt ggaaatgaga atgagtttat tcctactgga gcttagttcc
     5221 aatgcatttg gctccagaaa gaccccagtg ccttttgaca atggccaggg ttttacctac
     5281 ttcctgccag tctttcccaa aggaaactca ttccaaatac ttcttttttc ccctggagtc
     5341 cgagaaggaa aatggaattc tggttcatac tgtggtccct tgtaacctca ggtctttaat
     5401 gtgatcactt tcaaatttaa aagatccagg tggaaatatt tttactatag taataattct
     5461 acaaaatacc tgaattctta acactgttat atttcagtat aagtggtggc tttttctttt
     5521 catgtctttg atctggtttt attcctgtaa ttcagccacc tgattttgtg agggggggga
     5581 ataatatgtg gtttttgtac aaacatgttt ctcagtgtgt tgttattttg gaaaaaatga
     5641 ggggagggag tttggcaaga atggagaaaa tgaatgaaga aggcctaatc tctctctttt
     5701 tcagtgaata aatggaacac catttctgga ttctagtccc attctctgca ttcatacacc
     5761 agtttcttca tatatcctat gaagaaccta aacatttggc cccacctggt cttggtttga
     5821 tcagcagtta aaattctgtg actcgggctt ccttcccgac tgcccacctt catgatgtgt
     5881 aaggaacata cattttgagg gtacctcacc cactgttcat ttgcatggtc aaagtgaaaa
     5941 tgagtggaag ttctccaaaa atgatggcca acatcctggc acctccaggt gtgagaaata
     6001 gctttgcttg gtgaatggga taatgtttgt caggatgcag tttagacagt cccaagttgg
     6061 aggcaggcct tgagggcaga agattctgtg aaccttgggg gacagctttt gggtactcac
     6121 agatataaac cctgtgcaga aaaaaagaag tgattgtttt caggatgctt ataaatcgag
     6181 tgaagcaaaa gaagaggatt ctgtgtctgc catgagatga acgccctgct cttcacgaag
     6241 gtgtgcctct aataaagaga gccaaagcca gctgggtctc accagattcc tatactttct
     6301 caaggatgtt gggggaggtt aatcctttat cgaaactaaa gactggttta taaa
//
