LOCUS       NM_003073               5191 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens SWI/SNF related BAF chromatin remodeling complex
            subunit B1 (SMARCB1), transcript variant 1, mRNA.
ACCESSION   NM_003073
VERSION     NM_003073.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5191)
  AUTHORS   Fischer,A., Albert,T.K., Moreno,N., Interlandi,M., Mormann,J.,
            Glaser,S., Patil,P., de Faria,F.W., Richter,M., Verma,A.,
            Balbach,S.T., Wagener,R., Bens,S., Dahlum,S., Gobel,C., Munter,D.,
            Inserte,C., Graf,M., Kremer,E., Melcher,V., Di Stefano,G.,
            Santi,R., Chan,A., Dogan,A., Bush,J., Hasselblatt,M., Cheng,S.,
            Spetalen,S., Fossa,A., Hartmann,W., Herbruggen,H., Robert,S.,
            Oyen,F., Dugas,M., Walter,C., Sandmann,S., Varghese,J., Rossig,C.,
            Schuller,U., Tzankov,A., Pedersen,M.B., d'Amore,F.A., Mellgren,K.,
            Kontny,U., Kancherla,V., Veloza,L., Missiaglia,E., Fataccioli,V.,
            Gaulard,P., Burkhardt,B., Soehnlein,O., Klapper,W., de Leval,L.,
            Siebert,R. and Kerl,K.
  TITLE     Lack of SMARCB1 expression characterizes a subset of human and
            murine peripheral T-cell lymphomas
  JOURNAL   Nat Commun 15 (1), 8571 (2024)
   PUBMED   39362842
  REMARK    GeneRIF: Lack of SMARCB1 expression characterizes a subset of human
            and murine peripheral T-cell lymphomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5191)
  AUTHORS   Patel,A.J., Hemead,H., Jesani,H., Bille,A., Taniere,P. and
            Middleton,G.
  TITLE     Squamous Cell Carcinoma in Never Smokers: An Insight into SMARCB1
            Loss
  JOURNAL   Int J Mol Sci 25 (15), 8165 (2024)
   PUBMED   39125735
  REMARK    GeneRIF: Squamous Cell Carcinoma in Never Smokers: An Insight into
            SMARCB1 Loss.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5191)
  AUTHORS   Bielamowicz,K.J., Littrell,M.B., Albert,G.W., Parker,L.S.,
            Jayappa,S., Aldape,K. and Gokden,M.
  TITLE     Central nervous system embryonal tumors with EWSR1-PLAGL1
            rearrangements reclassified as INI-1 deficient tumors at relapse
  JOURNAL   J Neurooncol 168 (2), 367-373 (2024)
   PUBMED   38639853
  REMARK    GeneRIF: Central nervous system embryonal tumors with EWSR1-PLAGL1
            rearrangements reclassified as INI-1 deficient tumors at relapse.
REFERENCE   4  (bases 1 to 5191)
  AUTHORS   Muchardt,C., Sardet,C., Bourachot,B., Onufryk,C. and Yaniv,M.
  TITLE     A human protein with homology to Saccharomyces cerevisiae SNF5
            interacts with the potential helicase hbrm
  JOURNAL   Nucleic Acids Res 23 (7), 1127-1132 (1995)
   PUBMED   7739891
REFERENCE   5  (bases 1 to 5191)
  AUTHORS   Miller,M.D. and Bushman,F.D.
  TITLE     HIV integration. Ini1 for integration?
  JOURNAL   Curr Biol 5 (4), 368-370 (1995)
   PUBMED   7627549
  REMARK    Review article
REFERENCE   6  (bases 1 to 5191)
  AUTHORS   Kalpana,G.V., Marmon,S., Wang,W., Crabtree,G.R. and Goff,S.P.
  TITLE     Binding and stimulation of HIV-1 integrase by a human homolog of
            yeast transcription factor SNF5
  JOURNAL   Science 266 (5193), 2002-2006 (1994)
   PUBMED   7801128
REFERENCE   7  (bases 1 to 5191)
  AUTHORS   Dhamija,R., Plotkin,S., Gomes,A. and Babovic-Vuksanovic,D.
  TITLE     LZTR1- and SMARCB1-Related Schwannomatosis
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29517885
REFERENCE   8  (bases 1 to 5191)
  AUTHORS   Nemes,K., Bens,S., Bourdeaut,F., Johann,P., Kordes,U., Siebert,R.
            and Fruhwald,M.C.
  TITLE     Rhabdoid Tumor Predisposition Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29215836
REFERENCE   9  (bases 1 to 5191)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   10 (bases 1 to 5191)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY013730.1, AJ011737.1,
            R37717.1 and AP000350.1.
            
            On Jun 2, 2019 this sequence version replaced NM_003073.4.
            
            Summary: The protein encoded by this gene is part of a complex that
            relieves repressive chromatin structures, allowing the
            transcriptional machinery to access its targets more effectively.
            The encoded nuclear protein may also bind to and enhance the DNA
            joining activity of HIV-1 integrase. This gene has been found to be
            a tumor suppressor, and mutations in it have been associated with
            malignant rhabdoid tumors. Alternatively spliced transcript
            variants have been found for this gene. [provided by RefSeq, Dec
            2015].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.684713.1,
                                           SRR7410570.684710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644036.2/ ENSP00000494049.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                HY013730.1         38-94
            58-1478             AJ011737.1         1-1421
            1479-1696           AJ011737.1         1423-1640
            1697-1700           R37717.1           15-18               c
            1701-5191           AP000350.1         28563-32053
FEATURES             Location/Qualifiers
     source          1..5191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..5191
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit B1"
                     /db_xref="GeneID:6598"
                     /db_xref="HGNC:HGNC:11103"
                     /db_xref="MIM:601607"
     exon            1..297
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1362
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /note="isoform a is encoded by transcript variant 1;
                     malignant rhabdoid tumor suppressor; SWI/SNF related,
                     matrix associated, actin dependent regulator of chromatin,
                     subfamily b, member 1; sucrose nonfermenting, yeast,
                     homolog-like 1; SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily B member
                     1; integrase interactor 1 protein; hSNF5; SNF5 homolog;
                     SWI/SNF-related matrix-associated protein; protein
                     phosphatase 1, regulatory subunit 144; BRG1-associated
                     factor 47"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily B member
                     1 isoform a"
                     /protein_id="NP_003064.2"
                     /db_xref="CCDS:CCDS13817.1"
                     /db_xref="GeneID:6598"
                     /db_xref="HGNC:HGNC:11103"
                     /db_xref="MIM:601607"
                     /translation="MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLY
                     KRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDG
                     NDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDK
                     KRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMF
                     SEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLV
                     DQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLP
                     TVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW"
     exon            298..436
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..566
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..704
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..832
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..999
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1190
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1322
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..5191
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /note="hexamer: AATAAA"
     polyA_site      1698
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /note="major polyA site"
     polyA_site      1723
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
     regulatory      5167..5172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
                     /note="hexamer: AATAAA"
     polyA_site      5191
                     /gene="SMARCB1"
                     /gene_synonym="BAF47; CSS3; hSNFS; INI-1; INI1; MRD15;
                     PPP1R144; RDT; RTPS1; Sfh1p; SNF5; SNF5L1; Snr1; SWNTS1"
ORIGIN      
        1 gccagcgcct gcgcactgag ggcggcctgg tcgtcgtctg cggcggcggc ggcggctgag
       61 gagcccggct gaggcgccag tacccggccc ggtccgcatt tcgccttccg gcttcggttt
      121 ccctcggccc agcacgcccc ggccccgccc cagccctcct gatccctcgc agcccggctc
      181 cggccgcccg cctctgccgc cgcaatgatg atgatggcgc tgagcaagac cttcgggcag
      241 aagcccgtga agttccagct ggaggacgac ggcgagttct acatgatcgg ctccgaggtg
      301 ggaaactacc tccgtatgtt ccgaggttct ctgtacaaga gatacccctc actctggagg
      361 cgactagcca ctgtggaaga gaggaagaaa atagttgcat cgtcacatgg taaaaaaaca
      421 aaacctaaca ctaaggatca cggatacacg actctagcca ccagtgtgac cctgttaaaa
      481 gcctcggaag tggaagagat tctggatggc aacgatgaga agtacaaggc tgtgtccatc
      541 agcacagagc cccccaccta cctcagggaa cagaaggcca agaggaacag ccagtgggta
      601 cccaccctgc ccaacagctc ccaccactta gatgccgtgc catgctccac aaccatcaac
      661 aggaaccgca tgggccgaga caagaagaga accttccccc tttgctttga tgaccatgac
      721 ccagctgtga tccatgagaa cgcatctcag cccgaggtgc tggtccccat ccggctggac
      781 atggagatcg atgggcagaa gctgcgagac gccttcacct ggaacatgaa tgagaagttg
      841 atgacgcctg agatgttttc agaaatcctc tgtgacgatc tggatttgaa cccgctgacg
      901 tttgtgccag ccatcgcctc tgccatcaga cagcagatcg agtcctaccc cacggacagc
      961 atcctggagg accagtcaga ccagcgcgtc atcatcaagc tgaacatcca tgtgggaaac
     1021 atttccctgg tggaccagtt tgagtgggac atgtcagaga aggagaactc accagagaag
     1081 tttgccctga agctgtgctc ggagctgggg ttgggcgggg agtttgtcac caccatcgca
     1141 tacagcatcc ggggacagct gagctggcat cagaagacct acgccttcag cgagaaccct
     1201 ctgcccacag tggagattgc catccggaac acgggcgatg cggaccagtg gtgcccactg
     1261 ctggagactc tgacagacgc tgagatggag aagaagatcc gcgaccagga caggaacacg
     1321 aggcggatga ggcgtcttgc caacacggcc ccggcctggt aaccagccca tcagcacacg
     1381 gctcccacgg agcatctcag aagattgggc cgcctctcct ccatcttctg gcaaggacag
     1441 aggcgagggg acagcccagc gccatcctga ggatcgggtg ggggtggagt gggggcttcc
     1501 aggtggccct tcccggcaca cattccattt gttgagcccc agtcctgccc cccaccccac
     1561 cctccctacc cctccccagt ctctggggtc aggaagaaac cttattttag gttgtgtttt
     1621 gtttttgtat aggagcccca ggcagggcta gtaacagttt ttaaataaaa ggcaacaggt
     1681 catgttcaat ttcttcaaca ggtcatgttc aatttcttca aagttttaac ataaaaataa
     1741 tgagagccag gagtggggcc ggggcctggg gggacgaagg tggtatgtga acaaggttgg
     1801 cacacaggcc tcaccctcct ctgcctcaga ttcccaagtg ggcaggtggg ggtgaatggg
     1861 gctccgggta gcacctcagc tcctctcagc tcccctcagc ctgttctcct tccagaccca
     1921 gagagctgag aagagtagct gtgaggctca gggcaagagg ctctctgcct ttcaggaaca
     1981 gccctaaccc tgctcccctt gcttggcctc aggaaggtgc cgcgagctct cctgccgtcc
     2041 ctgggccgcc ctggctctgc tgtgtccaga tggtcaggct actgccagct ggggccttgc
     2101 tgctctgaag tcccctgcgg agggcccagt cctgtgtggg cactgctggg ctgtcgccag
     2161 cctgggtgca ggagggctgt tctagctcca gtggcaccca tagccaggtc agctggggcc
     2221 ctttcccacc ccagcaggtg ctgtggcctg ggccagctcc tgccttacaa gccagctgtg
     2281 aggaatatgg gaatagccct cccggcctgg tgccagctct tggagttgac acggtacagg
     2341 gaggagacac agcccagggt cccttcccag ccctgcctcc aaggagttca tgtcccctct
     2401 gttctcatct gtaataggga ggtgtcccca ttcttcagaa tggacacagg atctgggagg
     2461 gcagcaaact ggctcgcagc tccagcctta ctgaagagaa tgggcacaga tccgggcaca
     2521 gatcccagca cagactgctg ccaccctcag ctgttggcag gtcccatgct gccagggcag
     2581 ggctagggtc agaggctgct gtgctccctg gaagtggggt agggccccat gtggggcaga
     2641 ggcagagctc tgattaggga ttggggttct tggtcgctga gatgtgagag gagggctcct
     2701 ttgagcacat gttagcatgg gactcttccc agggagtttg cactcagggc ctctgccctc
     2761 catcaaagag tggaactccc cagagcccca tgcacagcaa ggggacagct gggccttact
     2821 ggaaggcctt gaacaaaggg gaagattccc agcccagctg ctcttagaca tgaacaggtt
     2881 tcattgctga ggtgtttgtt ctgtccatga ggtaggaacc tcggcaatga aagggtgagg
     2941 cagccctgtg tctccacaac tggggggatg gaaggaacct tggctgcctc accccacagg
     3001 tcgggcaggg ccacctggct gggaggtgcc gggaaggctg ggccctcact cctgaccgcc
     3061 agctcacacc gccgcaaagc catctccaca aggtctggct acaacacgga gggcagactc
     3121 aacagagaac agtgttgtta ccatgaaaat gacaacctgt ctttggagga ggccccgtgc
     3181 cactgagcat ccagaaataa accacaacat ggacaggctt agaacaacaa ggaaagctgc
     3241 caggtcagaa gagaaaaatg agccacaggg gtcggataag gctcacacac gtcctcagct
     3301 aaaaagggca ggaacagaac cttccagaag tccctgcctc acccagtctc agaactctgc
     3361 taaggtgaaa acttaggctc tgaggtcata gaaagggcag aagacctagt cctggccctc
     3421 ttctgcacct gaatccatgg ggctttggca tcaccagatg aaaaatgagg catacgccca
     3481 cctgtcaggg tggctgatga gagacaggag aggctagatt ggcatcagcc tgaaggcacc
     3541 actggcagga acatctgtag gctggtttgg cacaacctag gagacgcctg tcctggcccc
     3601 agcagccgaa atctggtgaa cttccccgct gactggcagg tagcagaggc ctatggtggg
     3661 caggacttgc ccaaggccct ggtggggcca ggatgagaac cctgagcctg tcacctgtga
     3721 gctcaaaagc tctgcctggc aacctgtgag ctcaaagctc tgccaggcaa ccatgggcag
     3781 tttctttgcc ctctgtgggc acccctatcc taccacctgc agttgggctg agaggccaca
     3841 ctgagtgagg acggggcagg catagaagga tgtggccagg tgagatgggg aagccagtgc
     3901 tgtgggccaa gagactgcag ctcattctgt ttattcaggt gggcccttgc atgggcccag
     3961 cctttaggat gggttttttc tgccccaagt aggggtcatg ggtaggatgg aagctgccag
     4021 aagcctctta ggcctggccc tgggtggggg tcactgctgc gggggtggca gatggggtcc
     4081 tggctgttcc tcagggaggg gcaggtaatt ggggtcttct gcaggggcat ccaggagcag
     4141 ctttctgtgg ggaggggccc gtgttgagca caggccagca caggtcccca tcggtgggga
     4201 tccttctgag ggtggggaga gggagggagg gctctcaaca ctcacaggaa gccaggggtc
     4261 tgcaggagcc tcttgcctcc aggctggttg gggaagacgt cctccaggaa gtagtagata
     4321 tggcccaccg caatccctgt gagacagcca cggactgtgg ggtcaccctc cacagcccag
     4381 agtcctagac cagcagagcc tgccccaggc ccccatccac agcctggtgg ccctgcaggc
     4441 cccacagcat gagtgcccca aagccttgca cagagtgcca gccccgggtt ggccgtgaag
     4501 gacaagctta aaaggcccag aagcaggcag gacccaggga ggggagggcc tgagaatagt
     4561 ggaggagtgg gagccatggg gcaggaaccc tgaccctccc atcctcactc ccatcaggac
     4621 cgtgcaagca tcagtagatc cgtcctgacg atgcaaatta tgtgggccgg ctggcttgag
     4681 gggctgtaag agcacagcag ctgggagggc aggaagatgg ggatggagcc aggtgtgagg
     4741 agaactccag caaggatggg agaggggccc cagggcataa gcagcgtgtc ctgaggggag
     4801 tggccagcct ggggcggact agatgtaccg ggaggctcac ccagcaggtc cacgaggatg
     4861 gagttgccca gcagcagcga gaagcccatg agcgcccaag gcaggaacgg tgcctggaaa
     4921 gtgagcaggc cgaagaagtt gaccctcacc cgagggctgc ggcggctcca cacgtacacc
     4981 agcatggcca tgagggcctg gcccaggaag aacaggctgc ccaggagtcc cagcagctgg
     5041 gccagagtca aggtgctccg gtgcaggcct cagcccaagc ccagggcccc tctgacttcc
     5101 caagaccctg gaattcttcc cctcatctcc cctatgtgct attccctcat caagatgagc
     5161 cagtccaata aaggcgacac actccacggg c
//
