LOCUS       NM_020159               5094 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SNF2 related chromatin remodeling ATPase with DExD box
            1 (SMARCAD1), transcript variant 3, mRNA.
ACCESSION   NM_020159
VERSION     NM_020159.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5094)
  AUTHORS   Mathews,I., Wagh,S., Baby,A., Chandrashekar,L. and Dalal,A.
  TITLE     Basan syndrome in a family from South India: a novel SMARCAD1
            variant
  JOURNAL   Clin Exp Dermatol 49 (4), 437-440 (2024)
   PUBMED   37966719
  REMARK    GeneRIF: Basan syndrome in a family from South India: a novel
            SMARCAD1 variant.
REFERENCE   2  (bases 1 to 5094)
  AUTHORS   Sachs,P., Bergmaier,P., Treutwein,K. and Mermoud,J.E.
  TITLE     The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC
            and Architectural Proteins in Human and Mouse
  JOURNAL   Genes (Basel) 14 (9), 1793 (2023)
   PUBMED   37761933
  REMARK    GeneRIF: The Conserved Chromatin Remodeler SMARCAD1 Interacts with
            TFIIIC and Architectural Proteins in Human and Mouse.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5094)
  AUTHORS   Oh,J.M., Kang,Y., Park,J., Sung,Y., Kim,D., Seo,Y., Lee,E.A.,
            Ra,J.S., Amarsanaa,E., Park,Y.U., Lee,S.Y., Hwang,J.M., Kim,H.,
            Scharer,O., Cho,S.W., Lee,C., Takata,K.I., Lee,J.Y. and Myung,K.
  TITLE     MSH2-MSH3 promotes DNA end resection during homologous
            recombination and blocks polymerase theta-mediated end-joining
            through interaction with SMARCAD1 and EXO1
  JOURNAL   Nucleic Acids Res 51 (11), 5584-5602 (2023)
   PUBMED   37140056
  REMARK    GeneRIF: MSH2-MSH3 promotes DNA end resection during homologous
            recombination and blocks polymerase theta-mediated end-joining
            through interaction with SMARCAD1 and EXO1.
REFERENCE   4  (bases 1 to 5094)
  AUTHORS   Loh,A.Y.T., Ho,C.M., Muthiah,S., Venkatesh,B., Zwolinski,S.,
            Bray,A.P.J.J., Reversade,B., Rajan,N. and Carney,T.J.
  TITLE     Huriez syndrome caused by a large deletion that abrogates the
            skin-specific isoform of SMARCAD1
  JOURNAL   Br J Dermatol 184 (6), 1205-1207 (2021)
   PUBMED   33400266
  REMARK    GeneRIF: Huriez syndrome caused by a large deletion that abrogates
            the skin-specific isoform of SMARCAD1.
REFERENCE   5  (bases 1 to 5094)
  AUTHORS   Mermoud,J.E., Rowbotham,S.P. and Varga-Weisz,P.D.
  TITLE     Keeping chromatin quiet: how nucleosome remodeling restores
            heterochromatin after replication
  JOURNAL   Cell Cycle 10 (23), 4017-4025 (2011)
   PUBMED   22101266
  REMARK    Review article
REFERENCE   6  (bases 1 to 5094)
  AUTHORS   Nousbeck,J., Burger,B., Fuchs-Telem,D., Pavlovsky,M., Fenig,S.,
            Sarig,O., Itin,P. and Sprecher,E.
  TITLE     A mutation in a skin-specific isoform of SMARCAD1 causes
            autosomal-dominant adermatoglyphia
  JOURNAL   Am J Hum Genet 89 (2), 302-307 (2011)
   PUBMED   21820097
  REMARK    GeneRIF: The existence of a short isoform of SMARCAD1 exclusively
            expressed in the skin, is demonstrated.
REFERENCE   7  (bases 1 to 5094)
  AUTHORS   Rowbotham,S.P., Barki,L., Neves-Costa,A., Santos,F., Dean,W.,
            Hawkes,N., Choudhary,P., Will,W.R., Webster,J., Oxley,D.,
            Green,C.M., Varga-Weisz,P. and Mermoud,J.E.
  TITLE     Maintenance of silent chromatin through replication requires
            SWI/SNF-like chromatin remodeler SMARCAD1
  JOURNAL   Mol Cell 42 (3), 285-296 (2011)
   PUBMED   21549307
  REMARK    GeneRIF: Findings suggest that chromatin remodeling by SMARCAD1
            ensures that silenced loci, such as pericentric heterochromatin,
            are correctly perpetuated.
REFERENCE   8  (bases 1 to 5094)
  AUTHORS   Okazaki,N., Ikeda,S., Ohara,R., Shimada,K., Yanagawa,T., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     The novel protein complex with SMARCAD1/KIAA1122 binds to the
            vicinity of TSS
  JOURNAL   J Mol Biol 382 (2), 257-265 (2008)
   PUBMED   18675275
  REMARK    GeneRIF: Results suggest a novel model for gene regulation via the
            SMARCAD1/KIAA1122 protein complex.
REFERENCE   9  (bases 1 to 5094)
  AUTHORS   Adra,C.N., Donato,J.L., Badovinac,R., Syed,F., Kheraj,R., Cai,H.,
            Moran,C., Kolker,M.T., Turner,H., Weremowicz,S., Shirakawa,T.,
            Morton,C.C., Schnipper,L.E. and Drews,R.
  TITLE     SMARCAD1, a novel human helicase family-defining member associated
            with genetic instability: cloning, expression, and mapping to
            4q22-q23, a band rich in breakpoints and deletion mutants involved
            in several human diseases
  JOURNAL   Genomics 69 (2), 162-173 (2000)
   PUBMED   11031099
REFERENCE   10 (bases 1 to 5094)
  AUTHORS   Lee,Y.A., Stevens,H.P., Delaporte,E., Wahn,U. and Reis,A.
  TITLE     A gene for an autosomal dominant scleroatrophic syndrome
            predisposing to skin cancer (Huriez syndrome) maps to chromosome
            4q23
  JOURNAL   Am J Hum Genet 66 (1), 326-330 (2000)
   PUBMED   10631162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL704040.1, AY008271.1 and
            AB032948.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_020159.4.
            
            Summary: This gene encodes a member of the SNF subfamily of
            helicase proteins. The encoded protein plays a critical role in the
            restoration of heterochromatin organization and propagation of
            epigenetic patterns following DNA replication by mediating histone
            H3/H4 deacetylation. Mutations in this gene are associated with
            adermatoglyphia. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.43093.1,
                                           SRR1803616.212925.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354268.9/ ENSP00000346217.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AL704040.1         21-168
            149-182             AL704040.1         170-203
            183-1156            AY008271.1         6-979
            1157-2094           AB032948.2         965-1902
            2095-3379           AY008271.1         1918-3202
            3380-5092           AB032948.2         3194-4906
            5093-5094           AY008271.1         4920-4921
FEATURES             Location/Qualifiers
     source          1..5094
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.3"
     gene            1..5094
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /note="SNF2 related chromatin remodeling ATPase with DExD
                     box 1"
                     /db_xref="GeneID:56916"
                     /db_xref="HGNC:HGNC:18398"
                     /db_xref="MIM:612761"
     exon            1..206
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            207..445
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..3336
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /EC_number="3.6.4.12"
                     /note="isoform b is encoded by transcript variant 3;
                     SWI/SNF-related, matrix-associated actin-dependent
                     regulator of chromatin, subfamily a, containing DEAD/H box
                     1; ATP-dependent helicase 1; sclerotylosis"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A
                     containing DEAD/H box 1 isoform b"
                     /protein_id="NP_064544.2"
                     /db_xref="CCDS:CCDS3639.1"
                     /db_xref="GeneID:56916"
                     /db_xref="HGNC:HGNC:18398"
                     /db_xref="MIM:612761"
                     /translation="MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEEN
                     AEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQYIDLSSDSEDVV
                     SPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDA
                     KLQTLKELFPQRSDNDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYE
                     EDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLK
                     EHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSM
                     KAQNGFNKKRKKNVFNPKRVVEDSEYDSGSDVGSSLDEDYSSGEEVMEDGYKGKILHF
                     LQDASIGELTLIPQCSQKKAQKITELRPFNSWEALFTKMSKTNGLSEDLIWHCKTLIQ
                     ERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLNWL
                     ALVHKHGLNGILADEMGLGKTIQAIAFLAYLYQEGNNGPHLIVVPASTIDNWLREVNL
                     WCPTLKVLCYYGSQEERKQIRFNIHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNY
                     AIFDEGHMLKNMGSIRYQHLMTINANNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSS
                     TSEIRRMFSSKTKSADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKQLPPKKDRIEL
                     CAMSEKQEQLYLGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLK
                     EMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYRHINNFQLDMDLILDSGKF
                     RVLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLID
                     EFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEV
                     LVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEGDEGSMPADIATLLKTSMGL"
     exon            446..623
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            624..792
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            793..859
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            860..960
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1062
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1144
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1536
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1736
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1827
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1927
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1987
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2063
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2199
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2337
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2433
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2551
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2673
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2862
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2981
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3164
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3274
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..5094
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4601..4606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /note="hexamer: AATAAA"
     polyA_site      4623
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /note="major polyA site"
     regulatory      5072..5077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /note="hexamer: AATAAA"
     polyA_site      5094
                     /gene="SMARCAD1"
                     /gene_synonym="ADERM; BASNS; ETL1; HEL1; HRZ; TYS"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcaactt ccgggcggat gcccgccagc acggcctccg ccgctcccct tctttggccc
       61 ctttgtgtcc ccgcagtgtc gaggcgcggg ccctggcagg tcctttctcg aggcaggggg
      121 cacggtagca cagggagctt ctctttgtgg gcgggcgcga ggcccgctag ggggttatac
      181 tggggaacgt gcctgcgcgt gcttggatag ttcatttaaa gcccccatcc ctgcaaggtg
      241 gtgctttcta ccaatatgaa tcttttcaac ctggaccgtt ttcgctttga gaaaaggaat
      301 aagattgagg aagcgcccga agcaacccct caaccttccc agcctggccc ttcttcacca
      361 atttctctta gtgctgaaga ggagaatgct gaaggggaag ttagcagggc aaacactcct
      421 gattcagata taactgaaaa aacagaagat tctagtgttc cagaaactcc agataatgaa
      481 agaaaagcaa gtatatcata tttcaaaaat caaagaggaa tacagtatat tgatttgtct
      541 tctgatagtg aagatgtcgt ttccccaaat tgctccaata cagttcaaga gaaaacattc
      601 aacaaagata cagtgattat agtttctgag ccatctgaag atgaagagtc ccaaggcctt
      661 cctaccatgg cacgtagaaa tgatgatatt tcagaactgg aagacctttc ggaattggaa
      721 gaccttaaag atgctaaact tcagactttg aaggaacttt ttccacaaag aagtgacaat
      781 gatttactta agttgattga atcaacaagc actatggatg gagcaattgc tgctgccttg
      841 ctgatgtttg gtgatgcagg tggtgggccc aggaaaagaa aattatcttc ttcttcagag
      901 ccatatgagg aagatgaatt taatgatgat caatctataa aaaagacaag actggatcat
      961 ggagaggaat caaatgagtc tgcagaatct agcagtaatt gggaaaagca ggaaagtatt
     1021 gtactgaaat tgcaaaagga atttcccaat tttgataaac aggaacttag agaagtactc
     1081 aaggaacatg aatggatgta cacagaagct ttagaatctc taaaagtgtt tgcagaagac
     1141 caagatatgc aatatgtatc acaaagtgag gttccaaatg gaaaagaagt ttcttcaaga
     1201 agtcaaaatt accctaaaaa tgcaactaaa acaaaactaa aacagaaatt ttcaatgaaa
     1261 gcacaaaatg gctttaacaa gaaacgtaaa aaaaatgttt ttaatccaaa gagagttgtt
     1321 gaagactctg aatatgattc aggttctgat gtcggtagtt cactagatga ggactatagt
     1381 agtggtgaag aagtgatgga ggatggctat aaaggtaaaa ttcttcactt ccttcaagat
     1441 gcttcaattg gtgaacttac tttgattcct cagtgttctc agaaaaaggc tcagaagata
     1501 acagaactcc ggccctttaa tagttgggag gctctgttca caaagatgtc caaaactaat
     1561 ggcttatcag aagatttgat atggcactgt aaaacactga tccaagaaag agatgtagtt
     1621 ataaggctta tgaacaaatg tgaagacatt tcaaataaat tgaccaaaca agttaccatg
     1681 cttactggaa atggaggtgg atggaacata gaacaacctt ccattctaaa ccaaagtttg
     1741 tcactcaagc cctatcagaa ggttggtttg aattggctgg cattggtaca taaacatgga
     1801 cttaatggca ttttggcaga tgaaatgggc ctaggaaaaa ctattcaagc cattgcattt
     1861 ctggcatacc tctatcagga gggtaataat ggtcctcatt tgatcgttgt tccagcttca
     1921 actatagata actggttaag ggaagttaat ttatggtgcc ctactttgaa ggtcctctgt
     1981 tactatggtt ctcaagaaga acgtaaacaa attagattta acattcatag tagatatgaa
     2041 gattacaatg taattgtgac cacatataac tgtgcgatca gcagttctga tgaccgtagt
     2101 ctgtttcgac ggctgaaact taattacgca atttttgatg agggccatat gctgaagaat
     2161 atgggctcca ttcgctacca gcaccttatg acaattaatg caaataaccg tttgctgctc
     2221 acaggcacac ctgtacagaa caatctgtta gaactcatgt cgctgttgaa ttttgttatg
     2281 ccacacatgt ttagtagtag caccagtgaa atacgaagaa tgttttcctc taagacaaaa
     2341 tcagcagatg agcaaagcat atatgaaaag gagagaatag cacatgcaaa acaaattata
     2401 aagccattta ttctcagaag agtaaaagaa gaggttctca agcagttacc ccccaagaaa
     2461 gatcgaattg agttgtgtgc aatgtcggag aagcaggagc aactctattt gggtcttttc
     2521 aacagattga aaaaatctat caataacttg gaaaaaaaca cagaaatgtg caatgtcatg
     2581 atgcagttga ggaaaatggc caatcatcct ttattacatc gccaatatta cacagctgaa
     2641 aaactcaagg aaatgtctca gcttatgcta aaggaaccta cacattgtga ggctaaccct
     2701 gacctgatct ttgaagatat ggaagttatg acagacttcg aactacatgt actttgtaaa
     2761 cagtaccgac acattaataa ctttcagtta gacatggact tgattttaga ttctggaaaa
     2821 tttcgagttt taggatgcat cttgtctgaa ttgaaacaga agggtgatag agttgtgtta
     2881 tttagccaat ttaccatgat gctggatatc ttagaggttc tattaaaaca tcatcagcat
     2941 aggtacctca gattagatgg aaagactcag atttctgaaa ggattcatct aattgatgag
     3001 tttaataccg atatggatat ctttgtgttt ctgctatcaa caaaagctgg tggattagga
     3061 ataaatctga cttcagcaaa tgttgttata cttcacgata ttgactgtaa tccttataat
     3121 gacaaacaag cagaagatag atgccataga gtaggccaga ctaaagaagt actagttata
     3181 aaactaataa gccaagggac gattgaagaa tccatgctaa aaattaacca acagaaattg
     3241 aaactagaac aggatatgac tacagtagat gaaggtgatg aagggagtat gccagcagat
     3301 atagccacat tactaaaaac atcaatgggc ctgtgaaata agaactgtga actctcaatt
     3361 gatgaggaaa tatcaacttg gtgcactcaa ggacatttac attatgatga ccatggggtt
     3421 tatgaacatt tataactttt tataatttcc atattacatt tctcatagta tggacaactt
     3481 tttgccacta actgaattct ccaaatactc acacgtgaaa tttcaaaaaa gaagccacaa
     3541 atatgtagtt ctgaagatgt tgaataatca ttttacaaag cagttttctg aatggggatt
     3601 agttggtgat tgtttgtaac aaatatgcta atgctttaga aatgtcagta tttttgtaat
     3661 tatttctacc tccaaatata tatatattgt ctttcactgg ataatgtgtg tagattttta
     3721 catgtgcctt atttgacaat gcttatgtct tgtttttgct tgtctcattt gaagttcttt
     3781 tttattatgt taaagaatgc agctgtatag attatatagc tttcatttta ttgctatttg
     3841 aagcagatgt tcaccaatgt cagcaagaac tcaacctgaa tttaaaggtg gcattccata
     3901 tactaacatc ccccaggtcc tctcaagtac ttctgctgaa acaaatttat ttggctaggc
     3961 actaagttgt tttccagtga atagtaacta aagaagcccc taccttgctc catggattaa
     4021 ttccttctgt tcattttcca actgcactaa ttgtgcatat tactctgcct aatcttgtgc
     4081 atgttttcat tgatttccct ctcccggctt ttgcttctct tgaaactgtt gcccagtcac
     4141 ttctgctcca attctcttcc tctctaaata gtagtttatt actgccacat ctccatgcat
     4201 cagcaaaatg ttggtgacat ttttctagcc tggcagaaca gattacttaa agctatttca
     4261 tttcaaagca gactgaatgt gacttcatct aaaggcagca ttaggtactg catggaaata
     4321 ggtcattaac ttgaaactct tatcaaaata tattttacca gtttccagaa tttccagtac
     4381 aggaccgcct gaagagagag ccattgttca attccaattc agtgtgagtg acaaagtgaa
     4441 atttagaagt gaagttgtct atttgatatt taactcttta ttaaatcttt ctttaaattt
     4501 ctgcctgtca gtctatattg ctgtttttat tatacatcag tttctttgta taacttgtga
     4561 gttccatgtg ttttgttttt attatgtaaa tatcattata aataaactta tttataaatc
     4621 aaagatttgt taatttttgg aaatcatgct tttcaaagca tcctaacttg ctaagatgct
     4681 aggtagtacg accctctgga tttggaaggc aaataaaact cttacagtga ttatttagat
     4741 attaaagact gagaactcac ggcttaaccc cagtcttgat ggtatattga acagactgaa
     4801 tatattttac cattacaggg ctaaaaggag tcttcatgtg ttaatactac ctccttgtac
     4861 atcactatac ccaaatcagt tattcaaatt gttaggaatt ttacctttta aaatctcata
     4921 atggatatct catgttttct gtattaatgt attttcaatg ataggctgtt tctttttttg
     4981 ttgttattgt tgttgttgtt atatccatac ttttatctct aatgaaatgt agttgggttc
     5041 ttcctgtaat gcgctattat gtcttgggct taataaaaat atttgtgatc ataa
//
