LOCUS       NM_003601               7684 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SNF2 related chromatin remodeling ATPase 5 (SMARCA5),
            mRNA.
ACCESSION   NM_003601
VERSION     NM_003601.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7684)
  AUTHORS   Yu,P.C., Hou,D., Chang,B., Liu,N., Xu,C.H., Chen,X., Hu,C.L.,
            Liu,T., Wang,X., Zhang,Q., Liu,P., Jiang,Y., Fei,M.Y., Zong,L.J.,
            Zhang,J.Y., Liu,H., Chen,B.Y., Chen,S.B., Wang,Y., Li,Z.J., Li,X.,
            Deng,C.H., Ren,Y.Y., Zhao,M., Jiang,S., Wang,R., Jin,J., Yang,S.,
            Xue,K., Shi,J., Chang,C.K., Shen,S., Wang,Z., He,P.C., Chen,Z.,
            Chen,S.J., Sun,X.J. and Wang,L.
  TITLE     SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control
            leukemogenesis
  JOURNAL   Dev Cell 59 (15), 1954-1971 (2024)
   PUBMED   38776924
  REMARK    GeneRIF: SMARCA5 reprograms AKR1B1-mediated fructose metabolism to
            control leukemogenesis.
REFERENCE   2  (bases 1 to 7684)
  AUTHORS   Jiang,Y., Sun,S., Quan,Y., Wang,X., You,Y., Zhang,X., Zhang,Y.,
            Liu,Y., Wang,B., Xu,H. and Cao,X.
  TITLE     Nuclear RPSA senses viral nucleic acids to promote the innate
            inflammatory response
  JOURNAL   Nat Commun 14 (1), 8455 (2023)
   PUBMED   38114488
  REMARK    Erratum:[Nat Commun. 2024 Jan 29;15(1):855. doi:
            10.1038/s41467-024-45275-2.. PMID: 38287017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7684)
  AUTHORS   Chang,Z., Song,Y., Luo,F., Yang,X., Cai,Y. and Guo,H.
  TITLE     Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy
            Resistance for Patients with Hepatocellular Carcinoma
  JOURNAL   Ann Clin Lab Sci 53 (4), 573-577 (2023)
   PUBMED   37625840
  REMARK    GeneRIF: Circular RNA SMARCA5 Promotes a Poor Prognosis and
            Radiotherapy Resistance for Patients with Hepatocellular Carcinoma.
REFERENCE   4  (bases 1 to 7684)
  AUTHORS   Li,J., Zhao,J., Gan,X., Wang,Y., Jiang,D., Chen,L., Wang,F., Xu,J.,
            Pei,H., Huang,J. and Chen,X.
  TITLE     The RPA-RNF20-SNF2H cascade promotes proper chromosome segregation
            and homologous recombination repair
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2303479120 (2023)
   PUBMED   37155876
  REMARK    GeneRIF: The RPA-RNF20-SNF2H cascade promotes proper chromosome
            segregation and homologous recombination repair.
REFERENCE   5  (bases 1 to 7684)
  AUTHORS   Wang,J., Zhou,H., Shao,J., Zhang,S. and Jin,J.
  TITLE     Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional
            Homeostasis to Facilitate Endothelial Dysfunction in Diabetes
  JOURNAL   Diabetes Metab J 47 (3), 366-381 (2023)
   PUBMED   36872061
  REMARK    GeneRIF: Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional
            Homeostasis to Facilitate Endothelial Dysfunction in Diabetes.
REFERENCE   6  (bases 1 to 7684)
  AUTHORS   Poot,R.A., Dellaire,G., Hulsmann,B.B., Grimaldi,M.A., Corona,D.F.,
            Becker,P.B., Bickmore,W.A. and Varga-Weisz,P.D.
  TITLE     HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1
            and two novel histone-fold proteins
  JOURNAL   EMBO J 19 (13), 3377-3387 (2000)
   PUBMED   10880450
REFERENCE   7  (bases 1 to 7684)
  AUTHORS   Bochar,D.A., Savard,J., Wang,W., Lafleur,D.W., Moore,P., Cote,J.
            and Shiekhattar,R.
  TITLE     A family of chromatin remodeling factors related to Williams
            syndrome transcription factor
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1038-1043 (2000)
   PUBMED   10655480
REFERENCE   8  (bases 1 to 7684)
  AUTHORS   Jones,M.H., Hamana,N., Nezu,Ji. and Shimane,M.
  TITLE     A novel family of bromodomain genes
  JOURNAL   Genomics 63 (1), 40-45 (2000)
   PUBMED   10662543
REFERENCE   9  (bases 1 to 7684)
  AUTHORS   LeRoy,G., Orphanides,G., Lane,W.S. and Reinberg,D.
  TITLE     Requirement of RSF and FACT for transcription of chromatin
            templates in vitro
  JOURNAL   Science 282 (5395), 1900-1904 (1998)
   PUBMED   9836642
REFERENCE   10 (bases 1 to 7684)
  AUTHORS   Aihara,T., Miyoshi,Y., Koyama,K., Suzuki,M., Takahashi,E.,
            Monden,M. and Nakamura,Y.
  TITLE     Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human
            homologue of Drosophila ISWI
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 191-193 (1998)
   PUBMED   9730600
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104685.2, AC099396.5 and
            AC139713.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003601.3.
            
            Summary: The protein encoded by this gene is a member of the
            SWI/SNF family of proteins. Members of this family have helicase
            and ATPase activities and are thought to regulate transcription of
            certain genes by altering the chromatin structure around those
            genes. The protein encoded by this gene is a component of the
            chromatin remodeling and spacing factor RSF, a facilitator of the
            transcription of class II genes by RNA polymerase II. The encoded
            protein is similar in sequence to the Drosophila ISWI chromatin
            remodeling protein. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.141949.1,
                                           SRR1660803.215414.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283131.4/ ENSP00000283131.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-400               AC104685.2         123065-123464
            401-475             AC104685.2         126718-126792
            476-642             AC104685.2         130792-130958
            643-743             AC104685.2         133730-133830
            744-844             AC104685.2         134814-134914
            845-967             AC104685.2         135644-135766
            968-1024            AC099396.5         2001-2057
            1025-1180           AC099396.5         3465-3620
            1181-1312           AC099396.5         4180-4311
            1313-1381           AC099396.5         6055-6123
            1382-1491           AC099396.5         10452-10561
            1492-1718           AC099396.5         12049-12275
            1719-1840           AC099396.5         14187-14308
            1841-1993           AC099396.5         14383-14535
            1994-2126           AC099396.5         15960-16092
            2127-2275           AC139713.1         2521-2669
            2276-2395           AC139713.1         2865-2984
            2396-2506           AC139713.1         3749-3859
            2507-2620           AC139713.1         4482-4595
            2621-2743           AC139713.1         4937-5059
            2744-2876           AC139713.1         5788-5920
            2877-2995           AC139713.1         6397-6515
            2996-3208           AC139713.1         6940-7152
            3209-3316           AC139713.1         9009-9116
            3317-7684           AC139713.1         12131-16498
FEATURES             Location/Qualifiers
     source          1..7684
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..7684
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="SNF2 related chromatin remodeling ATPase 5"
                     /db_xref="GeneID:8467"
                     /db_xref="HGNC:HGNC:11101"
                     /db_xref="MIM:603375"
     exon            1..400
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..3382
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="sucrose nonfermenting-like 5; SWI/SNF-related
                     matrix-associated actin-dependent regulator of chromatin
                     A5; sucrose nonfermenting protein 2 homolog; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily a, member 5"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A member
                     5"
                     /protein_id="NP_003592.3"
                     /db_xref="CCDS:CCDS3761.1"
                     /db_xref="GeneID:8467"
                     /db_xref="HGNC:HGNC:11101"
                     /db_xref="MIM:603375"
                     /translation="MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQA
                     VASAASAGPADAEMEEIFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELF
                     AHFIQPAAQKTPTSPLKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSK
                     ATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISL
                     LGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLL
                     PGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLL
                     LTGTPLQNNLHELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQKLVERLHMVLRPFL
                     LRRIKADVEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSAGKMDKMRLLNIL
                     MQLRKCCNHPYLFDGAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQM
                     TRVLDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGI
                     NLATADVVILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMK
                     LRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGA
                     KKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYREKQKIAFTEWIEPPKRERKA
                     NYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGY
                     KVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKRDFNQFIKA
                     NEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARIQRR
                     ISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLHKLGFDKENVYDE
                     LRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEKAEKKKRGPKP
                     STQKRKMDGAPDGRGRKKKLKL"
     exon            401..475
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            476..642
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            643..743
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            744..844
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1024
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1180
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1312
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1381
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1491
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1718
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1840
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1993
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2126
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2275
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2395
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2506
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2620
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2743
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2876
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..2995
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            2996..3208
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3316
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..7684
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="hexamer: AATATA"
     polyA_site      4570
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="major polyA site"
     regulatory      7617..7622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="hexamer: AATAAA"
     polyA_site      7639
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
     regulatory      7664..7669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
                     /note="hexamer: ATTAAA"
     polyA_site      7684
                     /gene="SMARCA5"
                     /gene_synonym="hISWI; hSNF2H; ISWI; SNF2H; WCRF135"
ORIGIN      
        1 gccggtggaa cctagagccc cgcggaagag cagaacgttt gggagtgtgc agctcctggg
       61 cccggctcag gcccgtcgcg gaggcgcggc gcaggggagc gctcgggtgg gagtctcgct
      121 cctccaccag tttattgcga cgtagcatcc aggcctaggc ctccccgtcc atccccgccg
      181 gactcgggcc tctggcagca gcgggtgacg cagacggaac atcatgtcgt ccgcggccga
      241 gcctccgcca cccccgcctc ccgagagcgc gccttccaag cccgcagcct cgatcgccag
      301 cggcgggagc aacagcagca acaaaggcgg ccccgaaggc gtcgcggcgc aggcggttgc
      361 gtctgcggcc agcgctggtc ccgcagacgc cgagatggag gaaatatttg atgatgcgtc
      421 acctggaaag caaaaggaaa tccaagaacc agatcctacc tatgaagaaa aaatgcaaac
      481 tgaccgggca aatagattcg agtatttatt aaagcagaca gaactttttg cacatttcat
      541 tcaacctgct gctcagaaga ctccaacttc acctttgaag atgaaaccag ggcgcccacg
      601 aataaaaaaa gatgagaagc agaacttact atccgttggc gattaccgac accgtagaac
      661 agagcaagag gaggatgaag agctattaac agaaagctcc aaagcaacca atgtttgcac
      721 tcgatttgaa gactctccat cgtatgtaaa atggggtaaa ctgagagatt atcaggtccg
      781 aggattaaac tggctcattt ctttgtatga gaatggcatc aatggtatcc ttgcagatga
      841 aatgggccta ggaaagactc ttcaaacaat ttctcttctt gggtacatga aacattatag
      901 aaacattcct gggcctcata tggttttggt tcctaagtct acattacaca actggatgag
      961 tgaattcaag agatgggtac caacacttag atctgtttgt ttgataggag ataaagaaca
     1021 aagagctgct tttgtcagag acgttttatt accgggagaa tgggatgtat gtgtaacatc
     1081 ttatgaaatg cttattaaag agaagtctgt gttcaaaaaa tttaattgga gatacttagt
     1141 aatagatgaa gctcacagga tcaaaaatga aaaatctaag ttgtcagaaa tagtgaggga
     1201 attcaagact acaaatagac tattattaac tggaacacct cttcagaaca acttgcatga
     1261 gctgtggtca cttcttaact ttctgttgcc agatgtgttt aattcagcag atgactttga
     1321 ttcctggttt gatacaaaca actgccttgg ggatcaaaaa ctagttgaga ggcttcatat
     1381 ggttttgcgt ccattcctcc ttcgtcgaat taaggctgat gttgaaaaga gtttgcctcc
     1441 aaagaaggaa gtaaaaatct atgtgggcct cagcaaaatg caaagggaat ggtatactcg
     1501 gatattaatg aaggatatag atatactcaa ctcagcaggc aagatggaca aaatgaggtt
     1561 attgaacatc ctaatgcagt tgagaaaatg ttgtaatcat ccatatctct ttgatggagc
     1621 agaacctggt ccaccttata caacagatat gcatctagta accaacagtg gcaaaatggt
     1681 ggttttagac aagctgctcc ctaagttaaa agaacaaggt tcacgagtac taatcttcag
     1741 tcaaatgaca agggtattgg acattttgga agattattgc atgtggagaa attatgagta
     1801 ctgcaggttg gatggtcaga caccccatga tgagagacaa gactccatca atgcatacaa
     1861 tgaaccaaac agcacaaagt ttgttttcat gttaagcacg cgtgctggtg gtcttggcat
     1921 caatcttgcg actgctgatg tagtaatttt gtatgattct gattggaatc cccaagtaga
     1981 tcttcaggct atggaccgag cacatagaat tgggcagact aagacagtca gagtgttccg
     2041 ctttataact gataacactg tagaagaaag aatagtagaa cgtgctgaga tgaaactcag
     2101 actggattca atagtcattc aacaagggag gcttgtggat cagaatctga acaaaattgg
     2161 gaaagatgaa atgcttcaaa tgattagaca tggagcaaca catgtgtttg cttcaaagga
     2221 aagtgagatc actgatgaag atatcgatgg tattttggaa agaggtgcaa agaagactgc
     2281 agagatgaat gaaaagctct ccaagatggg cgaaagttca cttagaaact ttacaatgga
     2341 tacagagtca agtgtttata acttcgaagg agaagactat agagaaaaac aaaagattgc
     2401 attcacagag tggattgaac cacctaaacg agaaagaaaa gccaactatg ccgttgatgc
     2461 atatttcagg gaagctcttc gtgttagtga acctaaagca cccaaggctc ctcgacctcc
     2521 aaaacaaccc aatgttcagg atttccagtt ctttcctcca cgtttatttg aattactgga
     2581 aaaagaaatt ctgttttaca gaaaaactat tgggtacaag gtacctcgaa atcctgagct
     2641 gcctaatgca gcacaggcac aaaaagaaga acagcttaaa attgatgaag ctgaatccct
     2701 taatgatgaa gagttagagg aaaaagagaa gcttctaaca cagggattta ccaattggaa
     2761 taagagagat tttaaccagt ttatcaaagc taatgagaag tggggtcgtg atgatattga
     2821 aaatatagca agagaagtag aaggcaaaac tccagaagaa gtcattgaat attcagctgt
     2881 gttttgggaa aggtgcaacg agctccagga catagagaag attatggctc agattgaaag
     2941 gggagaggcg agaattcaaa gaagaataag catcaagaaa gcacttgaca caaagattgg
     3001 acggtacaaa gcaccttttc atcagctgag aatatcatat ggtactaaca aaggaaaaaa
     3061 ctatactgaa gaagaagatc gttttctgat ttgtatgctt cacaaacttg gatttgacaa
     3121 agaaaatgtt tatgatgaat tgcgacagtg tattcgcaac tctcctcagt tcagatttga
     3181 ctggtttctt aagtccagaa ctgcaatgga gctccagagg agatgtaata ccttaattac
     3241 tttgattgaa agagaaaaca tggaactaga agaaaaggag aaggcagaga aaaagaaacg
     3301 aggaccaaag ccttcaacac agaaacgtaa aatggatggc gcacctgatg gtcgaggaag
     3361 aaaaaagaag ctgaaactat gaatatgttt ttgtttcata atcactaact ttaaaccagt
     3421 agttctttaa tttacgggtc ttcataagat gtactgtaca atgctcaatt gttatgtcat
     3481 ttaaagacat caggttcatc tgtttactga gctagaaaca tagtatgtag tttcactttt
     3541 ttaaatgcaa cagctgtgct gaaatttttt tatcattaac acttgaagta ataaaatagg
     3601 cttcatttat tactaagtgt ttcatttgat ttatttttct attgtagttc catttgtgaa
     3661 gattgtgact ttttgtttat tagctataat ttctacactt gtaaggctta aaaacaagtt
     3721 aaaaagaaaa ttgcaaataa catttgtccc tttcagtctt cacctagttg tgtaattatt
     3781 ttaattcact ttgcctttgc agaaatttgg gtattttctt tgtagtgcta ttgagtctca
     3841 tctggaaaga ttatataaat tgcattctcc ttgcttatgt gggtagaatg ggaaaagaag
     3901 gcaagacaaa gtatacttaa attctatgca tatttctgtt atgctttctg ttttttttag
     3961 ttgattctga aatgaatatg ccctattctt ttgaaagaat ggccttttag ttgtatagcc
     4021 aaagacattt agtattttcc ggttccttaa ggtattactg taccattttg taaaaggaat
     4081 attattatta ttatttttaa ttatttggta aatattttgt catatgacct tctgaagcag
     4141 ccacaactta gataatgtca gaactaaggt gatttttttt ttttaatttt gaaagcccag
     4201 ccaaaatgag gtgtgaattt gtcatactgt tacattgaaa ttggtaacaa aatatatccc
     4261 ctcccatttg gacttttagg gtaaatgaaa attttattgt attttaaagt agtttctaag
     4321 tgttagcaag actgactata attccagttt ctgttttcta tggacagacc tgataaactg
     4381 gagaccctaa agcaggaata cccaaattat agtgtcagga ttttagctgt accagaggcc
     4441 tttatgtgct acacataatt tgtataaaat tttatatgtg cagattgggt acataaacag
     4501 ttctccattt ttctaaggga atgcaataaa tgtagcatcg tgaataaata taacttttat
     4561 aatccgtaaa gtggtctttt ctttccattt ctttaattgt tttctcaatt tttattcact
     4621 ttttccttta ggacacattt cccttaattg gatatctttc ccttaaattt ctattagtag
     4681 ttgttttcat ctgcccacat gtaattgaag atttaaaaaa aaaattttga tacctgcagt
     4741 attactaata ctgcttaatt tcttgaaatg tggaattgct gctgttaatg tcaagcaaaa
     4801 cgcagtattt atggcaaatt gtaaagtaat ttgaatttag tgctacctca aaattaactt
     4861 tttaaatact atgttagatt cttaacagtt aaaggtctaa tacatgcatg aggaatggtt
     4921 acttatgaaa ggaaaaagaa tttgtaagag ttatcacctc agtttggaag aaattgaaaa
     4981 aatgtaaggc tgaagaaaac ttacggaggt cacaaaagtg atgttttcaa gaggaggaga
     5041 aactgggagg gagatacaca gtggaaatgc aaaatgaatc aagtatagtg gtagccctga
     5101 gagcttaggg actcaaatgg aaactgtgtg aagggaaact cacttgaaaa aaaagcatga
     5161 accagctagg ccctgccacc actgtgtttg gccaagttca caaatctgtt ttaacctgtc
     5221 acttccctgt cacttctctg gctttcctct cccgctaagc ttttgtttcc tggcagtaat
     5281 taaaatcttc tgtcagtgcc acagctacta ctgctactgg aactgcctta accactactg
     5341 ctactggaac tgccttagcc accttggtat cgtggtttgg caaagtattg gcctctacca
     5401 ccatagggcc cagagcttct gcctccaaag tttcctccct tcatgggtcc aaaatttgaa
     5461 gactgattgt tgtcattgcc aaaatcattg tagcttttac cacctccaaa attgcttcaa
     5521 tcattaccaa atctattata gcaatcccca ctgccaccat atccatcacc accaccatgg
     5581 ctgccaccaa agccaccacg atcacagaac ttgatgactg tatttgtgac taattgtata
     5641 atagtttctg ttctgtggaa agtaaagcat tccaacacag ggtttcagtg tagattgttt
     5701 tgttttgtac ccatgctgtt gattgctaaa tgttttaata atctgatcat gatactgaat
     5761 aaatgtcttt tttttttttt aacaacaaag catgaaagat tgcttaattg tacatctgac
     5821 aaagtgctgg aggctattat aaagtgtaat tattactact tttaagagac agggtcttgc
     5881 tctgtcaccc aggctggagt gcagtggtgc aatcacagct cactgcaacc tcaaacttca
     5941 gggctcaagt gatcctccca cctcagcttc ccaagtagct aggactacag ataccacgcc
     6001 cagctaagtt tttttagttt ttgtagagat agggccttgc tatgttgccc agtccggtct
     6061 caaacgccga cttcaggcaa tcctcttgcg tcaacctctc aaagtgctgg gattacatgt
     6121 gtaagcctac attccaaagt gctgggatca tagttgtgag cctacaccac acctggccta
     6181 cattttgttt ttcataaagt tgagagaagc aaatcctaag catagagtac aagttgagca
     6241 tccctaatca aaaaatctaa aatcagaaat gctccataat ttgaatgctc attagggcat
     6301 ttctgatttt tggattaggg atgctgaact gataagtata atgcaagtat tctaaagtct
     6361 ggaaaatgct aaaaacactt ctggttccag gcatttcaga taaggattgc tccatctgcc
     6421 ctttgagtat ttaatatatg ccgattgttt gaactaatct ggatttaatt atataaatga
     6481 ttatataaat gatctttggc ttagtacctt tcttaatctc gatcttaaaa agcattgtaa
     6541 aacacccctg tggtttttca gaaaaattct gagtaaaaaa taaatttcat cttgttctat
     6601 ccctttgaat ctaaaaaaca aatctttttg aaaggatgtg ctactatatt tcaaaccagt
     6661 agttttggag tagaacattg ctaaaaaaat gggtactaag gagggtaatt taaacaaagt
     6721 agattaatga cacaaggtgg attgatgaac tcataaatcc aaatgaatgg aatgctagaa
     6781 gacatgtatt aacggagtag ctgttaccaa aatatataca tattttgtat atgtacatag
     6841 ctgttaccaa aatgtatctt tgcctgttgg aatctgatgt caagatcaaa ggtgagggca
     6901 tccctcagat gacagataat gggcaaaata cattcttggt gtggagcagt gctgcagaat
     6961 taacttcgct gtgtacatcc cagaatcgtt ttggatctgt taaggttttt attagaatga
     7021 ttaaataggc ttttgcagca ttaactttac agtagttacc agaaaagact atgctacaag
     7081 aaccaaaatt gaagtaagaa gaaaaagact gaaatgatat gattctaaat gaaaaaaatg
     7141 aagaagtgga atagtttctc cacaggcata agaggcaaag cattgtttca gaagtggact
     7201 ggcacctcac ctgagatact caagactggc aacatgggtc tacattcttt gttaccacag
     7261 attcccttgt gtccggagag attccctagc tctaatgaca gcttttttgg ggggtaatga
     7321 ggctatgaga agattgagga tctaggtact tgcctttaac tctacagcat acaaggtgtg
     7381 tggctcttat ctctaggaca ccaatattta atgttgcata tcatgtatct ccagtacaag
     7441 aagaaagttt atcagaattt agttaatgtt ggaaactttg taatataaac aatgtaaaca
     7501 ctacattgac aaaaatattt tattaataca aagaatatgc atatagtttg cttactacag
     7561 aaattcttgt ttttgatgta gacaacccaa aggagttttt atgtatatag attgtgaata
     7621 aattgggaaa agaaatagag ataagtagag attatttcac ttcattaaac ttttgaagtc
     7681 ctaa
//
