LOCUS       NM_003072               5577 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens SWI/SNF related BAF chromatin remodeling complex
            subunit ATPase 4 (SMARCA4), transcript variant 3, mRNA.
ACCESSION   NM_003072
VERSION     NM_003072.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5577)
  AUTHORS   Kang,Q., Ma,D., Zhao,P., Chai,X., Huang,Y., Gao,R., Zhang,T.,
            Liu,P., Deng,B., Feng,C., Zhang,Y., Lu,Y., Li,Y., Fang,Q. and
            Wang,J.
  TITLE     BRG1 promotes progression of B-cell acute lymphoblastic leukemia by
            disrupting PPP2R1A transcription
  JOURNAL   Cell Death Dis 15 (8), 621 (2024)
   PUBMED   39187513
  REMARK    GeneRIF: BRG1 promotes progression of B-cell acute lymphoblastic
            leukemia by disrupting PPP2R1A transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5577)
  AUTHORS   Schneppenheim,R., Fruhwald,M.C., Gesk,S., Hasselblatt,M.,
            Jeibmann,A., Kordes,U., Kreuz,M., Leuschner,I., Martin Subero,J.I.,
            Obser,T., Oyen,F., Vater,I. and Siebert,R.
  TITLE     Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1
            in a family with rhabdoid tumor predisposition syndrome
  JOURNAL   Am J Hum Genet 86 (2), 279-284 (2010)
   PUBMED   20137775
  REMARK    GeneRIF: SMARCA4 is involved in cancer predisposition
REFERENCE   3  (bases 1 to 5577)
  AUTHORS   Wong,A.K., Shanahan,F., Chen,Y., Lian,L., Ha,P., Hendricks,K.,
            Ghaffari,S., Iliev,D., Penn,B., Woodland,A.M., Smith,R., Salada,G.,
            Carillo,A., Laity,K., Gupte,J., Swedlund,B., Tavtigian,S.V.,
            Teng,D.H. and Lees,E.
  TITLE     BRG1, a component of the SWI-SNF complex, is mutated in multiple
            human tumor cell lines
  JOURNAL   Cancer Res 60 (21), 6171-6177 (2000)
   PUBMED   11085541
REFERENCE   4  (bases 1 to 5577)
  AUTHORS   Muchardt,C., Reyes,J.C., Bourachot,B., Leguoy,E. and Yaniv,M.
  TITLE     The hbrm and BRG-1 proteins, components of the human SNF/SWI
            complex, are phosphorylated and excluded from the condensed
            chromosomes during mitosis
  JOURNAL   EMBO J 15 (13), 3394-3402 (1996)
   PUBMED   8670841
REFERENCE   5  (bases 1 to 5577)
  AUTHORS   Muchardt,C., Sardet,C., Bourachot,B., Onufryk,C. and Yaniv,M.
  TITLE     A human protein with homology to Saccharomyces cerevisiae SNF5
            interacts with the potential helicase hbrm
  JOURNAL   Nucleic Acids Res 23 (7), 1127-1132 (1995)
   PUBMED   7739891
REFERENCE   6  (bases 1 to 5577)
  AUTHORS   Chiba,H., Muramatsu,M., Nomoto,A. and Kato,H.
  TITLE     Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and
            Drosophila brahma are transcriptional coactivators cooperating with
            the estrogen receptor and the retinoic acid receptor
  JOURNAL   Nucleic Acids Res 22 (10), 1815-1820 (1994)
   PUBMED   8208605
REFERENCE   7  (bases 1 to 5577)
  AUTHORS   Khavari,P.A., Peterson,C.L., Tamkun,J.W., Mendel,D.B. and
            Crabtree,G.R.
  TITLE     BRG1 contains a conserved domain of the SWI2/SNF2 family necessary
            for normal mitotic growth and transcription
  JOURNAL   Nature 366 (6451), 170-174 (1993)
   PUBMED   8232556
REFERENCE   8  (bases 1 to 5577)
  AUTHORS   Nemes,K., Bens,S., Bourdeaut,F., Johann,P., Kordes,U., Siebert,R.
            and Fruhwald,M.C.
  TITLE     Rhabdoid Tumor Predisposition Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29215836
REFERENCE   9  (bases 1 to 5577)
  AUTHORS   Schrier Vergano,S., Santen,G., Wieczorek,D., Wollnik,B.,
            Matsumoto,N. and Deardorff,M.A.
  TITLE     Coffin-Siris Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23556151
REFERENCE   10 (bases 1 to 5577)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011442.5, AC006127.1 and
            AC011485.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced NM_003072.4.
            
            Summary: The protein encoded by this gene is a member of the
            SWI/SNF family of proteins and is similar to the brahma protein of
            Drosophila. Members of this family have helicase and ATPase
            activities and are thought to regulate transcription of certain
            genes by altering the chromatin structure around those genes. The
            encoded protein is part of the large ATP-dependent chromatin
            remodeling complex SNF/SWI, which is required for transcriptional
            activation of genes normally repressed by chromatin. In addition,
            this protein can bind BRCA1, as well as regulate the expression of
            the tumorigenic protein CD44. Mutations in this gene cause rhabdoid
            tumor predisposition syndrome type 2. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150298.1, D26156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344626.10/ ENSP00000343896.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC011442.5         82725-82869
            146-398             AC011442.5         105816-106068
            399-531             AC011442.5         106968-107100
            532-936             AC011442.5         107884-108288
            937-1035            AC011442.5         108600-108698
            1036-1294           AC011442.5         109361-109619
            1295-1421           AC011442.5         111012-111138
            1422-1595           AC011442.5         112845-113018
            1596-1769           AC011442.5         116523-116696
            1770-1937           AC011442.5         117908-118075
            1938-1988           AC011442.5         118189-118239
            1989-2119           AC011442.5         124724-124854
            2120-2177           AC011442.5         125035-125092
            2178-2299           AC011442.5         129597-129718
            2300-2450           AC011442.5         132076-132226
            2451-2614           AC011442.5         134644-134807
            2615-2681           AC011442.5         140652-140718
            2682-2792           AC011442.5         141286-141396
            2793-2930           AC011442.5         143420-143557
            2931-3035           AC006127.1         6081-6185
            3036-3149           AC006127.1         7736-7849
            3150-3257           AC006127.1         8549-8656
            3258-3344           AC006127.1         9640-9726
            3345-3391           AC006127.1         10518-10564
            3392-3558           AC006127.1         12002-12168
            3559-3722           AC006127.1         14948-15111
            3723-3950           AC006127.1         17508-17735
            3951-4049           AC006127.1         17985-18083
            4050-4127           AC006127.1         18341-18418
            4128-4346           AC006127.1         19132-19350
            4347-4600           AC006127.1         25525-25778
            4601-4709           AC011485.6         121547-121655       c
            4710-4811           AC011485.6         121021-121122       c
            4812-4944           AC011485.6         120025-120157       c
            4945-5087           AC011485.6         119723-119865       c
            5088-5577           AC011485.6         117637-118126       c
FEATURES             Location/Qualifiers
     source          1..5577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..5577
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /note="SWI/SNF related BAF chromatin remodeling complex
                     subunit ATPase 4"
                     /db_xref="GeneID:6597"
                     /db_xref="HGNC:HGNC:11100"
                     /db_xref="MIM:603254"
     exon            1..145
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..398
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..5120
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /note="isoform B is encoded by transcript variant 3;
                     sucrose nonfermenting-like 4; mitotic growth and
                     transcription activator; BRM/SWI2-related gene 1; homeotic
                     gene regulator; nuclear protein GRB1; brahma protein-like
                     1; SNF2-like 4; global transcription activator homologous
                     sequence; transcription activator BRG1; ATP-dependent
                     helicase SMARCA4; protein BRG-1; protein brahma homolog 1;
                     BRG1-associated factor 190A; SWI/SNF related, matrix
                     associated, actin dependent regulator of chromatin,
                     subfamily a, member 4"
                     /codon_start=1
                     /product="transcription activator BRG1 isoform B"
                     /protein_id="NP_003063.2"
                     /db_xref="CCDS:CCDS12253.1"
                     /db_xref="GeneID:6597"
                     /db_xref="HGNC:HGNC:11100"
                     /db_xref="MIM:603254"
                     /translation="MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMG
                     PSPGPPSAGHPIPTQGPGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGG
                     HAGMGPPPSPMDQHSQGYPSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQ
                     ALGQQNRGPTPFNQNQLHQLRAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMP
                     TLPPPSVSATGPGPGPGPGPGPGPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQP
                     PGGPPKPWPEGPMANAAAPTSTPQKLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPG
                     QPAQPAPMVPLHQKQSRITPIQKPRGLDPVEILQEREYRLQARIAHRIQELENLPGSL
                     AGDLRTKATIELKALRLLNFQRQLRQEVVVCMRRDTALETALNAKAYKRSKRQSLREA
                     RITEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVTGKIQKLTKAVATYH
                     ANTEREQKKENERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAYLLQQTDEYVANLTE
                     LVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIGPDGEPLDETSQMSDLPVKVIHVES
                     GKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEESGSEEEEEEEEEEQPQAAQPPTL
                     PVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGVSQALARGLQSYYAVAHAVTE
                     RVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLME
                     HKRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVL
                     LTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRLLLTGTPL
                     QNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILIIRRLHKVL
                     RPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTDGSEKDKKGKG
                     GTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASGKFELLDRI
                     LPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLKTFNEPG
                     SEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRL
                     CTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESRHC
                     STGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMD
                     LDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVD
                     YSDSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDE
                     SKKQKKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKEL
                     PEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIV
                     LQSVFTSVRQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLK
                     GGRRRPSRGSRAKPVVSDDDSEEEQEEDRSGSGSEED"
     exon            399..531
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..936
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1035
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1294
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1421
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1595
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1769
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1937
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..1988
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2119
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2177
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2299
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2450
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2614
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2681
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2792
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..3035
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3149
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3257
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3344
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3391
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3558
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3722
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3950
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4049
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4050..4127
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4346
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4347..4600
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4601..4709
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4710..4811
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4944
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4945..5087
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5577
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5371
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
     regulatory      5560..5565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /note="hexamer: ATTAAA"
     polyA_site      5577
                     /gene="SMARCA4"
                     /gene_synonym="BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16;
                     OTSC12; RTPS2; SNF2; SNF2-beta; SNF2L4; SNF2LB; SWI2"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgcgc gcgaggcttc ccctcgtttg gcggcggcgg cggcttcttt gtttcgtgaa
       61 gagaagcgag acgcccattc tgcccccggc cccgcgcgga ggggcggggg aggcgccggg
      121 aagtcgacgg cgccggcggc tcctgcagga ggccactgtc tgcagctccc gtgaagatgt
      181 ccactccaga cccacccctg ggcggaactc ctcggccagg tccttccccg ggccctggcc
      241 cttcccctgg agccatgctg ggccctagcc cgggtccctc gccgggctcc gcccacagca
      301 tgatggggcc cagcccaggg ccgccctcag caggacaccc catccccacc caggggcctg
      361 gagggtaccc tcaggacaac atgcaccaga tgcacaagcc catggagtcc atgcatgaga
      421 agggcatgtc ggacgacccg cgctacaacc agatgaaagg aatggggatg cggtcagggg
      481 gccatgctgg gatggggccc ccgcccagcc ccatggacca gcactcccaa ggttacccct
      541 cgcccctggg tggctctgag catgcctcta gtccagttcc agccagtggc ccgtcttcgg
      601 ggccccagat gtcttccggg ccaggaggtg ccccgctgga tggtgctgac ccccaggcct
      661 tggggcagca gaaccggggc ccaaccccat ttaaccagaa ccagctgcac cagctcagag
      721 ctcagatcat ggcctacaag atgctggcca gggggcagcc cctccccgac cacctgcaga
      781 tggcggtgca gggcaagcgg ccgatgcccg ggatgcagca gcagatgcca acgctacctc
      841 caccctcggt gtccgcaaca ggacccggcc ctggccctgg ccctggcccc ggcccgggtc
      901 ccggcccggc acctccaaat tacagcaggc ctcatggtat gggagggccc aacatgcctc
      961 ccccaggacc ctcgggcgtg ccccccggga tgccaggcca gcctcctgga gggcctccca
     1021 agccctggcc tgaaggaccc atggcgaatg ctgctgcccc cacgagcacc cctcagaagc
     1081 tgattccccc gcagccaacg ggccgccctt cccccgcgcc ccctgccgtc ccacccgccg
     1141 cctcgcccgt gatgccaccg cagacccagt cccccgggca gccggcccag cccgcgccca
     1201 tggtgccact gcaccagaag cagagccgca tcacccccat ccagaagccg cggggcctcg
     1261 accctgtgga gatcctgcag gagcgcgagt acaggctgca ggctcgcatc gcacaccgaa
     1321 ttcaggaact tgaaaacctt cccgggtccc tggccgggga tttgcgaacc aaagcgacca
     1381 ttgagctcaa ggccctcagg ctgctgaact tccagaggca gctgcgccag gaggtggtgg
     1441 tgtgcatgcg gagggacaca gcgctggaga cagccctcaa tgctaaggcc tacaagcgca
     1501 gcaagcgcca gtccctgcgc gaggcccgca tcactgagaa gctggagaag cagcagaaga
     1561 tcgagcagga gcgcaagcgc cggcagaagc accaggaata cctcaatagc attctccagc
     1621 atgccaagga tttcaaggaa tatcacagat ccgtcacagg caaaatccag aagctgacca
     1681 aggcagtggc cacgtaccat gccaacacgg agcgggagca gaagaaagag aacgagcgga
     1741 tcgagaagga gcgcatgcgg aggctcatgg ctgaagatga ggaggggtac cgcaagctca
     1801 tcgaccagaa gaaggacaag cgcctggcct acctcttgca gcagacagac gagtacgtgg
     1861 ctaacctcac ggagctggtg cggcagcaca aggctgccca ggtcgccaag gagaaaaaga
     1921 agaaaaagaa aaagaagaag gcagaaaatg cagaaggaca gacgcctgcc attgggccgg
     1981 atggcgagcc tctggacgag accagccaga tgagcgacct cccggtgaag gtgatccacg
     2041 tggagagtgg gaagatcctc acaggcacag atgcccccaa agccgggcag ctggaggcct
     2101 ggctcgagat gaacccgggg tatgaagtag ctccgaggtc tgatagtgaa gaaagtggct
     2161 cagaagaaga ggaagaggag gaggaggaag agcagccgca ggcagcacag cctcccaccc
     2221 tgcccgtgga ggagaagaag aagattccag atccagacag cgatgacgtc tctgaggtgg
     2281 acgcgcggca catcattgag aatgccaagc aagatgtcga tgatgaatat ggcgtgtccc
     2341 aggcccttgc acgtggcctg cagtcctact atgccgtggc ccatgctgtc actgagagag
     2401 tggacaagca gtcagcgctt atggtcaatg gtgtcctcaa acagtaccag atcaaaggtt
     2461 tggagtggct ggtgtccctg tacaacaaca acctgaacgg catcctggcc gacgagatgg
     2521 gcctggggaa gaccatccag accatcgcgc tcatcacgta cctcatggag cacaaacgca
     2581 tcaatgggcc cttcctcatc atcgtgcctc tctcaacgct gtccaactgg gcgtacgagt
     2641 ttgacaagtg ggccccctcc gtggtgaagg tgtcttacaa gggatcccca gcagcaagac
     2701 gggcctttgt cccccagctc cggagtggga agttcaacgt cttgctgacg acgtacgagt
     2761 acatcatcaa agacaagcac atcctcgcca agatccgttg gaagtacatg attgtggacg
     2821 aaggtcaccg catgaagaac caccactgca agctgacgca ggtgctcaac acgcactatg
     2881 tggcaccccg ccgcctgctg ctgacgggca caccgctgca gaacaagctt cccgagctct
     2941 gggcgctgct caacttcctg ctgcccacca tcttcaagag ctgcagcacc ttcgagcagt
     3001 ggtttaacgc accctttgcc atgaccgggg aaaaggtgga cctgaatgag gaggaaacca
     3061 ttctcatcat ccggcgtctc cacaaagtgc tgcggccctt cttgctccga cgactcaaga
     3121 aggaagtcga ggcccagttg cccgaaaagg tggagtacgt catcaagtgc gacatgtctg
     3181 cgctgcagcg agtgctctac cgccacatgc aggccaaggg cgtgctgctg actgatggct
     3241 ccgagaagga caagaagggc aaaggcggca ccaagaccct gatgaacacc atcatgcagc
     3301 tgcggaagat ctgcaaccac ccctacatgt tccagcacat cgaggagtcc ttttccgagc
     3361 acttggggtt cactggcggc attgtccaag ggctggacct gtaccgagcc tcgggtaaat
     3421 ttgagcttct tgatagaatt cttcccaaac tccgagcaac caaccacaaa gtgctgctgt
     3481 tctgccaaat gacctccctc atgaccatca tggaagatta ctttgcgtat cgcggcttta
     3541 aatacctcag gcttgatgga accacgaagg cggaggaccg gggcatgctg ctgaaaacct
     3601 tcaacgagcc cggctctgag tacttcatct tcctgctcag cacccgggct ggggggctcg
     3661 gcctgaacct ccagtcggca gacactgtga tcatttttga cagcgactgg aatcctcacc
     3721 aggacctgca agcgcaggac cgagcccacc gcatcgggca gcagaacgag gtgcgtgtgc
     3781 tccgcctctg caccgtcaac agcgtggagg agaagatcct agctgcagcc aagtacaagc
     3841 tcaacgtgga ccagaaggtg atccaggccg gcatgttcga ccagaagtcc tccagccatg
     3901 agcggcgcgc cttcctgcag gccatcctgg agcacgagga gcaggatgag agcagacact
     3961 gcagcacggg cagcggcagt gccagcttcg cccacactgc ccctccgcca gcgggcgtca
     4021 accccgactt ggaggagcca cctctaaagg aggaagacga ggtgcccgac gacgagaccg
     4081 tcaaccagat gatcgcccgg cacgaggagg agtttgatct gttcatgcgc atggacctgg
     4141 accgcaggcg cgaggaggcc cgcaacccca agcggaagcc gcgcctcatg gaggaggacg
     4201 agctcccctc gtggatcatc aaggacgacg cggaggtgga gcggctgacc tgtgaggagg
     4261 aggaggagaa gatgttcggc cgtggctccc gccaccgcaa ggaggtggac tacagcgact
     4321 cactgacgga gaagcagtgg ctcaaggcca tcgaggaggg cacgctggag gagatcgaag
     4381 aggaggtccg gcagaagaaa tcatcacgga agcgcaagcg agacagcgac gccggctcct
     4441 ccaccccgac caccagcacc cgcagccgcg acaaggacga cgagagcaag aagcagaaga
     4501 agcgcgggcg gccgcctgcc gagaaactct cccctaaccc acccaacctc accaagaaga
     4561 tgaagaagat tgtggatgcc gtgatcaagt acaaggacag cagcagtgga cgtcagctca
     4621 gcgaggtctt catccagctg ccctcgcgaa aggagctgcc cgagtactac gagctcatcc
     4681 gcaagcccgt ggacttcaag aagataaagg agcgcattcg caaccacaag taccgcagcc
     4741 tcaacgacct agagaaggac gtcatgctcc tgtgccagaa cgcacagacc ttcaacctgg
     4801 agggctccct gatctatgaa gactccatcg tcttgcagtc ggtcttcacc agcgtgcggc
     4861 agaaaatcga gaaggaggat gacagtgaag gcgaggagag tgaggaggag gaagagggcg
     4921 aggaggaagg ctccgaatcc gaatctcggt ccgtcaaagt gaagatcaag cttggccgga
     4981 aggagaaggc acaggaccgg ctgaagggcg gccggcggcg gccgagccga gggtcccgag
     5041 ccaagccggt cgtgagtgac gatgacagtg aggaggaaca agaggaggac cgctcaggaa
     5101 gtggcagcga agaagactga gccccgacat tccagtctcg accccgagcc cctcgttcca
     5161 gagctgagat ggcataggcc ttagcagtaa cgggtagcag cagatgtagt ttcagacttg
     5221 gagtaaaact gtataaacaa aagaatcttc catatttata cagcagagaa gctgtaggac
     5281 tgtttgtgac tggccctgtc ctggcatcag tagcatctgt aacagcatta actgtcttaa
     5341 agagagagag agagaattcc gaattgggga acacacgata cctgtttttc ttttccgttg
     5401 ctggcagtac tgttgcgccg cagtttggag tcactgtagt taagtgtgga tgcatgtgcg
     5461 tcaccgtcca ctcctcctac tgtattttat tggacaggtc agactcgccg ggggcccggc
     5521 gagggtatgt cagtgtcact ggatgtcaaa cagtaataaa ttaaaccaac aacaaaa
//
