LOCUS       NM_001282874            3989 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens SNF2 related chromatin remodeling ATPase 1 (SMARCA1),
            transcript variant 4, mRNA.
ACCESSION   NM_001282874 XM_005262459
VERSION     NM_001282874.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3989)
  AUTHORS   Li,D., Wang,X., Miao,H., Liu,H., Pang,M., Guo,H., Ge,M.,
            Glass,S.E., Emmrich,S., Ji,S., Zhou,Y., Ye,X., Mao,H., Wang,J.,
            Liu,Q., Kim,T., Klusmann,J.H., Li,C., Liu,Z., Jin,H., Nie,Y.,
            Wu,K., Fan,D., Song,X., Wang,X., Li,L., Lu,Y. and Zhao,X.
  TITLE     The lncRNA MIR99AHG directs alternative splicing of SMARCA1 by
            PTBP1 to enable invadopodia formation in colorectal cancer cells
  JOURNAL   Sci Signal 16 (803), eadh4210 (2023)
   PUBMED   37725664
  REMARK    GeneRIF: The lncRNA MIR99AHG directs alternative splicing of
            SMARCA1 by PTBP1 to enable invadopodia formation in colorectal
            cancer cells.
REFERENCE   2  (bases 1 to 3989)
  AUTHORS   Dai,L., Mugaanyi,J., Zhang,T., Tong,J., Cai,X., Lu,C. and Lu,C.
  TITLE     A pan-cancer bioinformatic analysis of the carcinogenic role of
            SMARCA1 in human carcinomas
  JOURNAL   PLoS One 17 (9), e0274823 (2022)
   PUBMED   36126083
  REMARK    GeneRIF: A pan-cancer bioinformatic analysis of the carcinogenic
            role of SMARCA1 in human carcinomas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3989)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3989)
  AUTHORS   Zheng,B., Chen,Q., Wang,C., Zhou,W., Chen,Y., Ding,G., Jia,Z.,
            Zhang,A. and Huang,S.
  TITLE     Whole-genome sequencing revealed an interstitial deletion
            encompassing OCRL and SMARCA1 gene in a patient with Lowe syndrome
  JOURNAL   Mol Genet Genomic Med 7 (9), e876 (2019)
   PUBMED   31376231
  REMARK    GeneRIF: This is the first report of an interstitial deletion
            encompassing OCRL and SMARCA1 gene in Lowe syndrome.
REFERENCE   5  (bases 1 to 3989)
  AUTHORS   Ding,L., Zhao,Y., Dang,S., Wang,Y., Li,X., Yu,X., Li,Z., Wei,J.,
            Liu,M. and Li,G.
  TITLE     Circular RNA circ-DONSON facilitates gastric cancer growth and
            invasion via NURF complex dependent activation of transcription
            factor SOX4
  JOURNAL   Mol Cancer 18 (1), 45 (2019)
   PUBMED   30922402
  REMARK    GeneRIF: High SNF2L expression is associated with gastric cancer
            growth and invasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3989)
  AUTHORS   Barak,O., Lazzaro,M.A., Cooch,N.S., Picketts,D.J. and
            Shiekhattar,R.
  TITLE     A tissue-specific, naturally occurring human SNF2L variant
            inactivates chromatin remodeling
  JOURNAL   J Biol Chem 279 (43), 45130-45138 (2004)
   PUBMED   15310751
  REMARK    GeneRIF: a neuronal SNF2L variant inactivates chromatin remodeling
REFERENCE   7  (bases 1 to 3989)
  AUTHORS   Barak,O., Lazzaro,M.A., Lane,W.S., Speicher,D.W., Picketts,D.J. and
            Shiekhattar,R.
  TITLE     Isolation of human NURF: a regulator of Engrailed gene expression
  JOURNAL   EMBO J 22 (22), 6089-6100 (2003)
   PUBMED   14609955
REFERENCE   8  (bases 1 to 3989)
  AUTHORS   Maguire,P.B., Wynne,K.J., Harney,D.F., O'Donoghue,N.M., Stephens,G.
            and Fitzgerald,D.J.
  TITLE     Identification of the phosphotyrosine proteome from thrombin
            activated platelets
  JOURNAL   Proteomics 2 (6), 642-648 (2002)
   PUBMED   12112843
REFERENCE   9  (bases 1 to 3989)
  AUTHORS   Bozhenok,L., Wade,P.A. and Varga-Weisz,P.
  TITLE     WSTF-ISWI chromatin remodeling complex targets heterochromatic
            replication foci
  JOURNAL   EMBO J 21 (9), 2231-2241 (2002)
   PUBMED   11980720
  REMARK    Erratum:[EMBO J 2002 Jun 17;21(12):3212]
REFERENCE   10 (bases 1 to 3989)
  AUTHORS   Okabe,I., Bailey,L.C., Attree,O., Srinivasan,S., Perkel,J.M.,
            Laurent,B.C., Carlson,M., Nelson,D.L. and Nussbaum,R.L.
  TITLE     Cloning of human and bovine homologs of SNF2/SWI2: a global
            activator of transcription in yeast S. cerevisiae
  JOURNAL   Nucleic Acids Res 20 (17), 4649-4655 (1992)
   PUBMED   1408766
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY043725.1, BC143954.1 and
            BQ006393.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2019 this sequence version replaced NM_001282874.1.
            
            Summary: This gene encodes a member of the SWI/SNF family of
            proteins. The encoded protein is an ATPase which is expressed in
            diverse tissues and contributes to the chromatin remodeling complex
            that is involved in transcription. The protein may also play a role
            in DNA damage, growth inhibition and apoptosis of cancer cells.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143954.1, SRR18074967.2265655.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371121.5/ ENSP00000360162.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                HY043725.1         2-86
            86-3649             BC143954.1         1-3564
            3650-3989           BQ006393.1         22-361              c
FEATURES             Location/Qualifiers
     source          1..3989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq25-q26.1"
     gene            1..3989
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /note="SNF2 related chromatin remodeling ATPase 1"
                     /db_xref="GeneID:6594"
                     /db_xref="HGNC:HGNC:11097"
                     /db_xref="MIM:300012"
     exon            1..294
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3333
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /note="isoform d is encoded by transcript variant 4;
                     global transcription activator homologous sequence;
                     SNF2-like 1; sucrose nonfermenting 2-like protein 1;
                     SWI/SNF related, matrix associated, actin dependent
                     regulator of chromatin, subfamily a, member 1; probable
                     global transcription activator SNF2L1; ATP-dependent
                     helicase SMARCA1; nucleosome-remodeling factor subunit
                     SNF2L"
                     /codon_start=1
                     /product="probable global transcription activator SNF2L1
                     isoform d"
                     /protein_id="NP_001269803.1"
                     /db_xref="CCDS:CCDS76019.1"
                     /db_xref="GeneID:6594"
                     /db_xref="HGNC:HGNC:11097"
                     /db_xref="MIM:300012"
                     /translation="MEQDTAAVAATVAAADATATIVVIEDEQPGPSTSQEEGAAAAAT
                     EATAATEKGEKKKEKNVSSFQLKLAAKAPKSEKEMDPEYEEKMKADRAKRFEFLLKQT
                     ELFAHFIQPSAQKSPTSPLNMKLGRPRIKKDEKQSLISAGDYRHRRTEQEEDEELLSE
                     SRKTSNVCIRFEVSPSYVKGGPLRDYQIRGLNWLISLYENGVNGILADEMGLGKTLQT
                     IALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRVICFVGDKDARAAFIRD
                     EMMPGEWDVCVTSYEMVIKEKSVFKKFHWRYLVIDEAHRIKNEKSKLSEIVREFKSTN
                     RLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLK
                     PFLLRRIKTDVEKSLPPKKEIKIYLGLSKMQREWYTKILMKDIDVLNSSGKMDKMRLL
                     NILMQLRKCCNHPYLFDGAEPGPPYTTDEHIVSNSGKMVVLDKLLAKLKEQGSRVLIF
                     SQMTRLLDILEDYCMWRGYEYCRLDGQTPHEEREDKFLEVEFLGQREAIEAFNAPNSS
                     KFIFMLSTRAGGLGINLASADVVILYDSDWNPQVDLQAMDRAHRIGQKKPVRVFRLIT
                     DNTVEERIVERAEIKLRLDSIVIQQGRLIDQQSNKLAKEEMLQMIRHGATHVFASKES
                     ELTDEDITTILERGEKKTAEMNERLQKMGESSLRNFRMDIEQSLYKFEGEDYREKQKL
                     GMVEWIEPPKRERKANYAVDAYFREALRVSEPKIPKAPRPPKQPNVQDFQFFPPRLFE
                     LLEKEILYYRKTIGYKVPRNPDIPNPALAQREEQKKIDGAEPLTPEETEEKEKLLTQG
                     FTNWTKRDFNQFIKANEKYGRDDIDNIAREVEGKSPEEVMEYSAVFWERCNELQDIEK
                     IMAQIERGEARIQRRISIKKALDAKIARYKAPFHQLRIQYGTSKGKNYTEEEDRFLIC
                     MLHKMGFDRENVYEELRQCVRNAPQFRFDWFIKSRTAMEFQRRCNTLISLIEKENMEI
                     EERERAEKKKRATKTPMSQKRKAESATESSGKKDVKKVKS"
     exon            295..381
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..548
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..649
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            650..750
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..930
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1086
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1218
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1287
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1397
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1624
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1746
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1782
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1935
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2068
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2217
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2337
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2448
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2562
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2685
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2818
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2937
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3150
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3261
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3989
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /note="hexamer: ATTAAA"
     polyA_site      3739
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /note="major polyA site"
     regulatory      3971..3976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
                     /note="hexamer: AAGAAA"
     polyA_site      3989
                     /gene="SMARCA1"
                     /gene_synonym="hSNF2L; ISWI; NURF140; SNF2L; SNF2L1;
                     SNF2LB; SNF2LT; SWI; SWI2"
ORIGIN      
        1 gttggaagcg gagtgattcc ccacccctgc tccatctagc tctttccagt gcagccactg
       61 ccgccgccca ggagccctcg tcccctgcct tgtcccccta ctcgttcccg ctcccacggc
      121 atggagcagg acactgccgc agtggcagcc accgtggcag ccgcggatgc gaccgccact
      181 atcgtggtca tagaggacga gcagcccggg ccgtccacct ctcaggagga gggagcggcc
      241 gccgcggcca ccgaagccac cgcggccacg gagaagggcg agaagaagaa ggagaaaaac
      301 gtttcttcat ttcaactcaa acttgctgct aaagcgccta aatctgaaaa ggaaatggac
      361 ccagaatatg aagagaaaat gaaagccgac cgagcaaaga gatttgaatt tttactgaag
      421 cagacagaac tttttgcaca tttcattcag ccttcagcac agaaatctcc aacatctcca
      481 ctgaacatga aattgggacg tccccgaata aagaaagatg aaaagcagag cttaatttct
      541 gctggagact accgccatag gcgcacagag caagaagaag atgaagagct actgtctgag
      601 agtcggaaaa catctaatgt gtgtattaga tttgaggtgt caccttcata tgtgaaaggg
      661 gggccactga gagattatca gattcgagga ctgaattggt tgatctcttt atatgaaaat
      721 ggagtcaatg gcattttggc tgatgaaatg ggccttggga aaactttaca aacaattgct
      781 ttgcttggtt acctgaaaca ctaccgaaat attcctggac ctcacatggt tttagttcca
      841 aagtctactt tacacaactg gatgaatgaa tttaaacgat gggtcccatc tctccgtgtc
      901 atttgttttg tcggagacaa ggatgccaga gctgctttta ttcgtgatga aatgatgcca
      961 ggagagtggg atgtttgcgt tacttcttat gagatggtaa ttaaagaaaa atctgtattc
     1021 aaaaagtttc actggcgata cctggtcatt gatgaagctc acagaataaa gaatgaaaaa
     1081 tctaagcttt cagagattgt tcgtgagttc aagtcgacta accgcttgct cctaactgga
     1141 acacctttgc agaataacct gcatgaactg tgggccttac tcaacttttt attgcctgat
     1201 gtctttaatt ctgcagatga ctttgattct tggtttgaca ctaaaaattg tcttggtgat
     1261 caaaaactcg tggaaagact tcatgcagtt ttaaaaccat ttttgttacg ccgtataaaa
     1321 actgatgtag agaagagtct gccacctaaa aaggaaataa agatttactt ggggctgagt
     1381 aagatgcaac gagaatggta tacaaaaatc ctgatgaaag atattgatgt tttaaactct
     1441 tctggcaaga tggacaagat gcgactctta aacattctga tgcagcttcg aaagtgttgt
     1501 aatcatccat atctgtttga tggtgctgaa cctggtccac cttataccac tgatgagcat
     1561 attgtcagca acagtggtaa aatggtagtt ctggataaac tattggccaa actcaaagaa
     1621 cagggttcaa gggttctcat tttcagccag atgactcgct tgctggatat tttggaagat
     1681 tattgcatgt ggcgtggtta tgagtattgt cgactggatg gacaaacccc gcatgaagaa
     1741 agagaggata aattcctaga agtggaattt ctgggtcaaa gggaagcaat agaggctttt
     1801 aatgctccta atagtagcaa attcatcttt atgctaagta ccagggctgg aggtctcgga
     1861 attaacctgg caagtgctga tgtggttata ctatatgatt cagactggaa cccacaggtt
     1921 gatctacaag ctatggatcg agcacatcgt attggtcaga agaaaccagt acgtgtattc
     1981 cgtctcatca ctgacaacac tgttgaagag aggattgtag aaagagctga gataaaactg
     2041 agactcgatt caattgttat acaacaagga agactcattg accaacagtc taacaagctg
     2101 gcaaaagagg aaatgttaca aatgatacgg catggagcca cccatgtttt tgcttctaaa
     2161 gagagtgagt tgacagatga agacattaca actattctgg aaagagggga aaagaagact
     2221 gcagagatga atgaacgcct gcaaaaaatg ggagagtctt ctctaagaaa ttttagaatg
     2281 gacattgaac aaagtttata caaatttgag ggagaagatt atagagaaaa acagaagctt
     2341 ggcatggtgg aatggattga acctcctaaa cgagaacgca aagcaaacta cgcagtggat
     2401 gcctacttta gagaggcttt gcgtgtcagc gagccaaaga ttccaaaggc tccacggcct
     2461 ccaaaacagc caaatgttca ggattttcaa tttttcccac cacgcttatt tgagctcctg
     2521 gaaaaggaaa ttctttatta tcggaagaca ataggctata aggttccaag gaatcctgat
     2581 atcccaaatc cagctctggc tcaaagagaa gagcaaaaaa agattgatgg agctgaacct
     2641 cttacaccag aagagactga agaaaaggaa aaacttctca cacaaggttt cacaaactgg
     2701 actaaacgag attttaacca gtttattaaa gctaatgaga aatatggaag agatgacatt
     2761 gataacatag ctcgagaggt agagggcaaa tcccctgagg aggtcatgga gtattcagct
     2821 gtattttggg aacgttgcaa tgaattacag gacattgaga aaattatggc tcaaattgaa
     2881 cgtggagaag caagaattca acgaaggatc agtatcaaga aagccctgga tgccaaaatt
     2941 gcaagataca aggctccatt tcatcagttg cgcattcagt atggaaccag caaaggaaag
     3001 aactatactg aggaagaaga tagattcttg atttgtatgt tacacaaaat gggctttgat
     3061 agagaaaatg tatatgaaga attaagacag tgtgtacgaa atgctcccca gtttagattt
     3121 gactggttta tcaagtctag gactgccatg gaattccaga gacgctgtaa cactctgatt
     3181 tcattgattg agaaagaaaa tatggaaatt gaggaaagag agagagcaga aaagaagaaa
     3241 cgggcaacta aaactccaat gtcacagaaa agaaaagcag agtcagctac tgagagctct
     3301 ggaaagaagg atgtcaagaa ggtgaaatcc taaagcctag aaataaagtt ttaaatggga
     3361 aactgctatt ttcttgttcc catcttcaaa tgctaattgc cagttccagt gtattcatgg
     3421 tactctaaga aaaatctctt tggttttgat ttcttgcata ttttatatat tttacaatgc
     3481 tttctacctg aaatgtgtag ctttatattt tatggcattc tagtattttt gtgtactgta
     3541 ttttgtgcat ttcatgtctt catcaaaatc ctctcagtcc ttgttctttt gaagcttgtg
     3601 ctgaggtttt agcttttcta tgttttatat gccgctgctt tgaaagagaa cctagattct
     3661 atagttgtat tattgttgtt tcatacttta aatttatatg gctgtggaaa aacgaattaa
     3721 aatgttttga ggagaaagac tttttcactt ctttgttgct ttcttttcta ttgagtctgg
     3781 gcttgtttgt gttactgcat actgtgatta gcataataat tgtttctttg aggtcatcta
     3841 aatatttttt tcctaaagga ataaagggtg aggaaagaaa aatattaaaa aagctaatat
     3901 ttgatactgt gcttgctgtc agtatgcatt acatttaaat tattctctat tcaagtggga
     3961 aaatataata aagaaatgtc tataagaaa
//
