LOCUS       NM_022733               2905 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens small ArfGAP2 (SMAP2), transcript variant 1, mRNA.
ACCESSION   NM_022733
VERSION     NM_022733.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2905)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2905)
  AUTHORS   Matsudaira,T., Niki,T., Taguchi,T. and Arai,H.
  TITLE     Transport of the cholera toxin B-subunit from recycling endosomes
            to the Golgi requires clathrin and AP-1
  JOURNAL   J Cell Sci 128 (16), 3131-3142 (2015)
   PUBMED   26136365
  REMARK    GeneRIF: SMAP2 immunoprecipitated clathrin and AP-1 through a
            putative clathrin-binding domain and a CALM-binding domain, and
            SMAP2 mutants that did not interact with clathrin or AP-1 could not
            localize to recycling endosomes
REFERENCE   3  (bases 1 to 2905)
  AUTHORS   Kobayashi,N., Kon,S., Henmi,Y., Funaki,T., Satake,M. and Tanabe,K.
  TITLE     The Arf GTPase-activating protein SMAP1 promotes transferrin
            receptor endocytosis and interacts with SMAP2
  JOURNAL   Biochem Biophys Res Commun 453 (3), 473-479 (2014)
   PUBMED   25281535
  REMARK    GeneRIF: Results also demonstrated a physical association between
            SMAP1 and SMAP2, which might serve as a basis for a functional
            interaction, and identified the intramolecular domains responsible
            for this association
REFERENCE   4  (bases 1 to 2905)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2905)
  AUTHORS   Sakakura,I., Tanabe,K., Nouki,N., Suzuki,M., Satake,M. and
            Watanabe,T.
  TITLE     The carboxy-terminal region of SMAP2 directs subcellular
            localization as well as Arf protein specificity
  JOURNAL   Biochem Biophys Res Commun 404 (2), 661-666 (2011)
   PUBMED   21147065
  REMARK    GeneRIF: In the current study, there were identified sequences in
            the carboxy-terminal region of SMAP2 that are critical for its
            specific subcellular localization and its specificity for Arf
            proteins.
REFERENCE   6  (bases 1 to 2905)
  AUTHORS   Kim,J.Y., Kim,J.H., Park,B.L., Cheong,H.S., Park,J.S., Jang,A.S.,
            Uh,S.T., Choi,J.S., Kim,Y.H., Kim,M.K., Choi,I.S., Cho,S.H.,
            Choi,B.W., Park,C.S. and Shin,H.D.
  TITLE     Putative association of SMAPIL polymorphisms with risk of aspirin
            intolerance in asthmatics
  JOURNAL   J Asthma 47 (9), 959-965 (2010)
   PUBMED   20831471
  REMARK    GeneRIF: analyses revealed that three common polymorphisms,
            rs2982510, rs2294752, and rs446738, were putatively associated with
            the increased susceptibility to AIA
            GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 2905)
  AUTHORS   Natsume,W., Tanabe,K., Kon,S., Yoshida,N., Watanabe,T., Torii,T.
            and Satake,M.
  TITLE     SMAP2, a novel ARF GTPase-activating protein, interacts with
            clathrin and clathrin assembly protein and functions on the
            AP-1-positive early endosome/trans-Golgi network
  JOURNAL   Mol Biol Cell 17 (6), 2592-2603 (2006)
   PUBMED   16571680
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA082592.1, BC021133.1 and AL133206.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022733.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.145512.1,
                                           SRR1660809.52028.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372718.8/ ENSP00000361803.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               DA082592.1         22-350
            330-2321            BC021133.1         1-1992
            2322-2905           AL133206.1         1857-2440
FEATURES             Location/Qualifiers
     source          1..2905
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..2905
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /note="small ArfGAP2"
                     /db_xref="GeneID:64744"
                     /db_xref="HGNC:HGNC:25082"
                     /db_xref="MIM:616916"
     exon            1..497
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1684
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stromal membrane-associated GTPase-activating protein 2;
                     stromal membrane-associated protein 2"
                     /codon_start=1
                     /product="stromal membrane-associated protein 2 isoform 1"
                     /protein_id="NP_073570.1"
                     /db_xref="CCDS:CCDS451.1"
                     /db_xref="GeneID:64744"
                     /db_xref="HGNC:HGNC:25082"
                     /db_xref="MIM:616916"
                     /translation="MTGKSVKDVDRYQAVLANLLLEEDNKFCADCQSKGPRWASWNIG
                     VFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRLYEAYLPETFR
                     RPQIDPAVEGFIRDKYEKKKYMDRSLDINAFRKEKDDKWKRGSEPVPEKKLEPVVFEK
                     VKMPQKKEDPQLPRKSSPKSTAPVMDLLGLDAPVACSIANSKTSNTLEKDLDLLASVP
                     SPSSSGSRKVVGSMPTAGSAGSVPENLNLFPEPGSKSEEIGKKQLSKDSILSLYGSQT
                     PQMPTQAMFMAPAQMAYPTAYPSFPGVTPPNSIMGSMMPPPVGMVAQPGASGMVAPMA
                     MPAGYMGGMQASMMGVPNGMMTTQQAGYMAGMAAMPQTVYGVQPAQQLQWNLTQMTQQ
                     MAGMNFYGANGMMNYGQSMSGGNGQAANQTLSPQMWK"
     exon            498..631
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            632..717
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            718..796
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            797..883
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            884..965
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1075
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1241
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1558
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..2905
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2888..2893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /note="hexamer: AATAAA"
     polyA_site      2905
                     /gene="SMAP2"
                     /gene_synonym="SMAP1L"
                     /note="major polyA site"
ORIGIN      
        1 ggaggtggta gcggagctga cggcagctgc cagggaaacc gaggcgcggg acgcaaggcc
       61 agcagacagg ccggccagag ggtcatctgc gtccggcacc caggaggctc gtggtccgcc
      121 tttgcctggg ctgagggtct ctggccccgc agcctctctt ggaggcgggc ctgtccctaa
      181 gcccgccaag gggcgccgcg ccgaggggct gcggagtggg ggacggacgc ccccgacccg
      241 ggaaggggcg tccggcgggg ccggaggaga gggctctccc cgctcaggag gtgcccctgg
      301 gcgggggacc gggagtcctc aaccccggac tgaggcaggg gtctctgggg gcgaggaggg
      361 cgcgtcgccc tctgcccccg ccggcaccct ggccatgaca ggcaagtcgg tgaaggacgt
      421 ggatcggtac caggctgtcc tggccaacct gctgctggag gaggataaca agttttgtgc
      481 agattgccag tctaaagggc cgcgatgggc ctcttggaac attggtgtgt tcatctgcat
      541 tcgatgtgct ggaatccaca ggaatctggg ggtgcacata tccagggtaa agtcagttaa
      601 cctcgaccag tggactcaag aacagattca gtgcatgcaa gagatgggaa atggaaaggc
      661 aaaccgactt tatgaagcct atcttcctga gacctttcgg cgacctcaga tagacccagc
      721 tgttgaagga tttattcgag acaaatatga gaagaagaaa tacatggacc gaagtctgga
      781 catcaatgcc tttaggaaag aaaaagatga caagtggaaa agagggagcg aaccagttcc
      841 agaaaaaaaa ttggaacctg ttgtttttga gaaggtgaaa atgccacaga aaaaagaaga
      901 cccacagcta cctcggaaaa gctccccgaa atccacagcg cctgtcatgg atttgttggg
      961 ccttgatgct cctgtggcct gctccattgc aaatagtaag accagcaata ccctagagaa
     1021 ggatttagat ctgttggcct ctgttccatc cccttcttct tccggttcca gaaaggttgt
     1081 aggttccatg ccaactgcag ggagtgccgg ctctgttcct gaaaatctga acctgtttcc
     1141 ggagccaggg agcaaatcag aagaaatagg caagaaacag ctctctaaag actccattct
     1201 ttcactgtat ggatcccaga cgcctcaaat gcctactcaa gcaatgttca tggctcccgc
     1261 tcagatggca tatcccacag cctaccccag cttccccggg gttacacctc ctaacagcat
     1321 aatggggagc atgatgcctc caccagtagg catggttgct cagccaggag cttctgggat
     1381 ggttgccccc atggccatgc ctgcaggcta tatgggtggc atgcaggcat caatgatggg
     1441 tgtgccgaat ggaatgatga ccacccagca ggctggctac atggcaggca tggcagctat
     1501 gccccagact gtgtatgggg tccagccagc tcagcagctg caatggaacc ttactcagat
     1561 gacccagcag atggctggga tgaacttcta tggagccaat ggcatgatga actatggaca
     1621 gtcaatgagt ggcggaaatg gacaggcagc aaatcagact ctcagtcctc agatgtggaa
     1681 ataaaaacaa aacacctgta tggctgccat tctcttcagc cctcgctctc ccctttccac
     1741 agcctccacc cctgaccccc atcctctttt cctacctctc tgtttggttt agaaattgct
     1801 caataagtca tttggggttt ggcatcctgc ccagccactt cccaaacatg aagacctctc
     1861 tgttgcttta tgttgtacat gccccatagc catcccaacg tcctccccag tcctctcctg
     1921 gcaccagcac cttagaagtt gttggcagaa ggcacttaaa ctgtgggaga agtgtgcaca
     1981 cctttgagtc ccttccctca aggttaaagc tcctgtcaga ctctcagaag ggtctgtggg
     2041 tgttgtatat taggcaaaca ggggaaagct tagaggtcct tctatatgtg ttaataagct
     2101 gtttctaagt gtttaaattt gaaaagcatc atgttctcat gatttatggg aatgaagcaa
     2161 gtactgaaat caaattaaat actccctggg tcctgggtca gtttgaccct agccctgggg
     2221 tgaggcaagc cccctcctat gaggatgagc aaaaatacta ctctcttcgc cctgagttgc
     2281 tttctggatc tggggcttca ggacttgctg cttcagtcag cctttattag caccaaagac
     2341 tttatgaaga tcccacacac agacacacat cccttcccgc ctcccccctg ccttcagtag
     2401 gatctggctc cgtggctgga ggaccaaccc ctatagtggg aatgcagagc ttaacgtgta
     2461 ctgcttgtgt gtgtgcgtga gtgtgtgtgt gtgtatgagt gtgtgttccg cctcccaccc
     2521 tctccccatc tgctctgggt atttttgttt ttgtttagtt ttaggtttac aacagagagg
     2581 aattaattta tcagcagcct aaaactgttg tgtttttctt atggtttaaa aaacgccatg
     2641 tcattgataa ctccctttct cccttccctt ctcccggtct gctgatcact ctttcatgcc
     2701 tgtgtatcca gggtgctctg tttccccacc gttcccaggt gtacgaggca gagggccggg
     2761 acagctttcc tctcagtcat tgttcacccc acttgaaaat tcagacaaga aaactttgct
     2821 taaaagattt catgtgtggg aaccacagtt cctggctgcc tttctcctgt gtatgtgtaa
     2881 attccttaat aaatattgca gggaa
//
