LOCUS       NM_001031628            1875 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens small cell adhesion glycoprotein (SMAGP), transcript
            variant 1, mRNA.
ACCESSION   NM_001031628
VERSION     NM_001031628.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Xiao,H., Yang,X. and Huang,S.
  TITLE     SMAGP regulates doxorubicin sensitivity in triple-negative breast
            cancer cells via modulating mitochondrial respiration
  JOURNAL   Cancer Chemother Pharmacol 91 (1), 43-52 (2023)
   PUBMED   36436062
  REMARK    GeneRIF: SMAGP regulates doxorubicin sensitivity in triple-negative
            breast cancer cells via modulating mitochondrial respiration.
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Ni,H., Ji,D., Huang,Z. and Li,J.
  TITLE     SMAGP knockdown inhibits the malignant phenotypes of glioblastoma
            cells by inactivating the PI3K/Akt pathway
  JOURNAL   Arch Biochem Biophys 695, 108628 (2020)
   PUBMED   33049294
  REMARK    GeneRIF: SMAGP knockdown inhibits the malignant phenotypes of
            glioblastoma cells by inactivating the PI3K/Akt pathway.
REFERENCE   3  (bases 1 to 1875)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1875)
  AUTHORS   Tarbe,N.G., Rio,M.C., Hummel,S., Weidle,U.H. and Zoller,M.
  TITLE     Overexpression of the small transmembrane and glycosylated protein
            SMAGP supports metastasis formation of a rat pancreatic
            adenocarcinoma line
  JOURNAL   Int J Cancer 117 (6), 913-922 (2005)
   PUBMED   15986429
REFERENCE   5  (bases 1 to 1875)
  AUTHORS   Tarbe,N.G., Rio,M.C. and Weidle,U.H.
  TITLE     SMAGP, a new small trans-membrane glycoprotein altered in cancer
  JOURNAL   Oncogene 23 (19), 3395-3403 (2004)
   PUBMED   15021913
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA776511.1, BC008712.1 and AC139768.14.
            
            On Nov 22, 2018 this sequence version replaced NM_001031628.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.514370.1, BC045658.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603798.6/ ENSP00000475068.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-541               CA776511.1         25-565
            542-1077            BC008712.1         522-1057
            1078-1084           AC139768.14        600-606
            1085-1875           AC139768.14        607-1397
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.13"
     gene            1..1875
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /note="small cell adhesion glycoprotein"
                     /db_xref="GeneID:57228"
                     /db_xref="HGNC:HGNC:26918"
     exon            1..160
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /inference="alignment:Splign:2.1.0"
     exon            161..232
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..492
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /note="small trans-membrane and glycosylated protein;
                     small cell transmembrane and glycosylated protein; small
                     transmembrane and glycosylated protein"
                     /codon_start=1
                     /product="small cell adhesion glycoprotein"
                     /protein_id="NP_001026798.1"
                     /db_xref="CCDS:CCDS44889.1"
                     /db_xref="GeneID:57228"
                     /db_xref="HGNC:HGNC:26918"
                     /translation="MTSLLTTPSPREELMTTPILQPTEALSPEDGASTALIAVVITVV
                     FLTLLSVVILIFFYLYKNKGSYVTYEPTEGEPSAIVQMESDLAKGSEKEEYFI"
     exon            233..313
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /inference="alignment:Splign:2.1.0"
     exon            314..1875
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1057..1062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /note="hexamer: ATTAAA"
     polyA_site      1082
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /note="major polyA site"
     polyA_site      1107
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
     polyA_site      1134
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
     regulatory      1846..1851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
                     /note="hexamer: ATTAAA"
     polyA_site      1875
                     /gene="SMAGP"
                     /gene_synonym="hSMAGP"
ORIGIN      
        1 ctctgcgcca accccgcgcg ccacccgcgg cttcctccgc tcggggtcct cgttcggcct
       61 ctgctggcct ccgcgactcc gcggtgcccg cccccgttga gttcaaaagg acgcgcggag
      121 cggcgccggc ccttcaccag cagcccgtcc gactggaaag atctgcctct tctccaagaa
      181 actcaaccac tagtgacaat gaccagcctc ctgactactc cttctccaag agaagaactg
      241 atgaccaccc caattttaca gcccactgag gccctgtccc cagaagatgg agccagcaca
      301 gcactcattg cagttgttat caccgttgtc ttcctcaccc tgctctcggt cgtgatcttg
      361 atcttctttt acctgtacaa gaacaaaggc agctacgtca cctatgaacc tacagaaggt
      421 gagcccagtg ccatcgtcca gatggagagt gacttggcca agggcagcga gaaagaggaa
      481 tatttcatct aatgactccc aggccccaag gagcttattc ctggctccat cgctaacacg
      541 ttgactgctt attatgggaa agttttctct gaagccaggg agaagcattg attgatgtgg
      601 gcaaatccaa gctccagcca ggtcgcagtc ccaaatgccg acatcactga ctccagggac
      661 cagggacatg gagaaagctg tttatgatat ctttaaccag gccctcttac tagagctggt
      721 gtttgtgact ggccaacaag atgtggctat gccaggggac atctgagtat gtgcccagtc
      781 atcttttttc acaggttgaa gggagagaaa agattttgag ttaaggtcat tggctgctct
      841 actctgtccc ctacctggtc acctagtgat agccccagtg gagatactgt ccatacaagg
      901 tcttcccaga ggctggatac cacagtaaaa ggccaggcca ggaggggtag gagactatgg
      961 agatcttacc tcctgataaa tgtgctacac cccctaatct gagcccttcc tttccgtgtt
     1021 ccccaacaac ctcatgctta cgtgattttt attcaaatta aaaattttca ttgctacaga
     1081 aatcagattc tcatgtgcaa gaagtaacta cattttgact tatttttgct taaacatttt
     1141 tgacattttc ttttccctat ttaacgcctt tacatatgtt ctcttccaag caataagaac
     1201 cctaggaaag ttctagaagt ttgcagaact atctcaggga tttgagacaa agatggtgca
     1261 ggaaagcttg ttccagggga acatcattag aaacataccc tgggagggcc gggttcggtg
     1321 gctcacgcct gtgatcccag cactttggga ggccgaggca ggcggatcac aaggttagga
     1381 gatcgagacc atcctggcta acacggtgaa accccgtctc tactaaaaat atataaaaaa
     1441 aatagctggg cgtggtggcg ggcgcccata gtcccagctg cttgggaggc tgaggcagga
     1501 gaatggcttg aacccaggag gcggagcttg cagtgagctg agattgcacc actatactcc
     1561 agcctgggca acagagtgag actccgtctc aaaaaaaaaa aaaaaaaaaa aagtaccctg
     1621 ggagatgagt tggttcaagc ctccatcctg gcaagggcca gaatttccca gaatcccttc
     1681 tacatatata cagaaggaac cagaaaaaat caacctacca cctttcccag tgtatcctca
     1741 gaatcaagcc aagaagcttc ttggatttta gtctcaagat aagttgtgtt taaaaggcac
     1801 attttggtat aaattattag ctcatcagat attgttcact ttggaattaa agctagatct
     1861 cctttgaagt cttaa
//
