LOCUS       NM_005904               3341 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens SMAD family member 7 (SMAD7), transcript variant 1,
            mRNA.
ACCESSION   NM_005904
VERSION     NM_005904.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3341)
  AUTHORS   Qiu,D., Gao,L. and Yu,X.
  TITLE     Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and thus
            Inhibit Bladder Cancer Stem Cell Stemness
  JOURNAL   Discov Med 36 (186), 1486-1498 (2024)
   PUBMED   39054719
  REMARK    GeneRIF: Knockdown of YAP1 Reduces YTHDF3 to Stabilize SMAD7 and
            thus Inhibit Bladder Cancer Stem Cell Stemness.
REFERENCE   2  (bases 1 to 3341)
  AUTHORS   Li,W., Bai,P. and Li,W.
  TITLE     UHRF1 inhibition mitigates vascular endothelial cell injury and
            ameliorates atherosclerosis in mice via regulating the SMAD7/YAP1
            axis
  JOURNAL   Mol Immunol 170, 119-130 (2024)
   PUBMED   38657333
  REMARK    GeneRIF: UHRF1 inhibition mitigates vascular endothelial cell
            injury and ameliorates atherosclerosis in mice via regulating the
            SMAD7/YAP1 axis.
REFERENCE   3  (bases 1 to 3341)
  AUTHORS   Dai,T., Qiu,S., Gao,X., Zhao,C., Ge,Z., Yang,Y., Tang,C. and
            Feng,S.
  TITLE     Circular RNA circWNK1 inhibits the progression of gastric cancer
            via regulating the miR-21-3p/SMAD7 axis
  JOURNAL   Cancer Sci 115 (3), 974-988 (2024)
   PUBMED   38287200
  REMARK    GeneRIF: Circular RNA circWNK1 inhibits the progression of gastric
            cancer via regulating the miR-21-3p/SMAD7 axis.
REFERENCE   4  (bases 1 to 3341)
  AUTHORS   Liang,S., Zheng,R., Zuo,B., Li,J., Wang,Y., Han,Y., Dong,H.,
            Zhao,X., Zhang,Y., Wang,P., Meng,R., Jia,L., Yang,A. and Yan,B.
  TITLE     SMAD7 expression in CAR-T cells improves persistence and safety for
            solid tumors
  JOURNAL   Cell Mol Immunol 21 (3), 213-226 (2024)
   PUBMED   38177245
  REMARK    GeneRIF: SMAD7 expression in CAR-T cells improves persistence and
            safety for solid tumors.
REFERENCE   5  (bases 1 to 3341)
  AUTHORS   Wu,Y., Xu,J., Tan,B., Yi,T., Liu,S., Yang,G., Li,K. and Zhao,X.
  TITLE     SMAD7 gene polymorphisms and their influence on patients with
            colorectal cancer
  JOURNAL   Cell Cycle 22 (21-22), 2424-2435 (2023)
   PUBMED   38146644
  REMARK    GeneRIF: SMAD7 gene polymorphisms and their influence on patients
            with colorectal cancer.
REFERENCE   6  (bases 1 to 3341)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   7  (bases 1 to 3341)
  AUTHORS   Roijer,E., Moren,A., ten Dijke,P. and Stenman,G.
  TITLE     Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1
            by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 189-190 (1998)
   PUBMED   9730599
REFERENCE   8  (bases 1 to 3341)
  AUTHORS   Nakao,A., Afrakhte,M., Moren,A., Nakayama,T., Christian,J.L.,
            Heuchel,R., Itoh,S., Kawabata,M., Heldin,N.E., Heldin,C.H. and ten
            Dijke,P.
  TITLE     Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta
            signalling
  JOURNAL   Nature 389 (6651), 631-635 (1997)
   PUBMED   9335507
REFERENCE   9  (bases 1 to 3341)
  AUTHORS   Topper,J.N., Cai,J., Qiu,Y., Anderson,K.R., Xu,Y.Y., Deeds,J.D.,
            Feeley,R., Gimeno,C.J., Woolf,E.A., Tayber,O., Mays,G.G.,
            Sampson,B.A., Schoen,F.J., Gimbrone,M.A. Jr. and Falb,D.
  TITLE     Vascular MADs: two novel MAD-related genes selectively inducible by
            flow in human vascular endothelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (17), 9314-9319 (1997)
   PUBMED   9256479
REFERENCE   10 (bases 1 to 3341)
  AUTHORS   Hayashi,H., Abdollah,S., Qiu,Y., Cai,J., Xu,Y.Y., Grinnell,B.W.,
            Richardson,M.A., Topper,J.N., Gimbrone,M.A. Jr., Wrana,J.L. and
            Falb,D.
  TITLE     The MAD-related protein Smad7 associates with the TGFbeta receptor
            and functions as an antagonist of TGFbeta signaling
  JOURNAL   Cell 89 (7), 1165-1173 (1997)
   PUBMED   9215638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114684.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 16, 2020 this sequence version replaced NM_005904.3.
            
            Summary: The protein encoded by this gene is a nuclear protein that
            binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex
            translocates to the cytoplasm, where it interacts with TGF-beta
            receptor type-1 (TGFBR1), leading to the degradation of both the
            encoded protein and TGFBR1. Expression of this gene is induced by
            TGFBR1. Variations in this gene are a cause of susceptibility to
            colorectal cancer type 3 (CRCS3). Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF010193.1, SRR14038193.3544238.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262158.8/ ENSP00000262158.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1154              AC114684.10        47050-48203
            1155-1208           AC114684.10        49578-49631
            1209-1283           AC114684.10        55460-55534
            1284-3341           AC114684.10        76105-78162
FEATURES             Location/Qualifiers
     source          1..3341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..3341
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /note="SMAD family member 7"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
     exon            1..1154
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..1822
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Mothers against decapentaplegic, drosophila, homolog of,
                     7; MAD (mothers against decapentaplegic, Drosophila)
                     homolog 7; hSMAD7; MAD homolog 8; mothers against DPP
                     homolog 8; SMAD, mothers against DPP homolog 7"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 7
                     isoform 1"
                     /protein_id="NP_005895.1"
                     /db_xref="CCDS:CCDS11936.1"
                     /db_xref="GeneID:4092"
                     /db_xref="HGNC:HGNC:6773"
                     /db_xref="MIM:602932"
                     /translation="MFRTKRSALVRRLWRSRAPGGEDEEEGAGGGGGGGELRGEGATD
                     SRAHGAGGGGPGRAGCCLGKAVRGAKGHHHPHPPAAGAGAAGGAEADLKALTHSVLKK
                     LKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPAGAQPAQPPSSYSLPLLLC
                     KVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDF
                     LKPTADCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRL
                     YCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYN
                     RSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTG
                     FTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR"
     exon            1155..1208
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1283
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..3341
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3227..3232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /note="hexamer: ATTAAA"
     polyA_site      3246
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
     regulatory      3313..3318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /note="hexamer: ATTAAA"
     polyA_site      3341
                     /gene="SMAD7"
                     /gene_synonym="CRCS3; MADH7; MADH8"
                     /note="major polyA site"
ORIGIN      
        1 attgcctgct tctccccacc cccaaattaa gttgcttagc aagggggaaa gaggcttttt
       61 ccttcttcca acagcccagc cgaacgcctt tcgttttttg cccccgcgga ccttccatgt
      121 aggaagccga ggctggcgag cccgacattc gggagccact gcgggggggc ctctttttgg
      181 ggaggcgccg acgggggcag gctcggccgt ccccagggaa gcggcggccg ggttcctccg
      241 gggcgcgccg gggccggaga gccgcgcagg gcgcgggccg cgcggggtgg ggcagccgga
      301 gcgcaggccc ccgatccccg gcgggcgccc ccgggccccc gcgcgcgccc cggcctccgg
      361 gagactggcg catgccacgg agcgcccctc gggccgccgc cgctcctgcc cgggcccctg
      421 ctgctgctgc tgtcgcctgc gcctgctgcc ccaactcggc gcccgacttc ttcatggtgt
      481 gcggaggtca tgttcgctcc ttagcaggca aacgactttt ctcctcgcct cctcgccccg
      541 catgttcagg accaaacgat ctgcgctcgt ccggcgtctc tggaggagcc gtgcgcccgg
      601 cggcgaggac gaggaggagg gcgcaggggg aggtggagga ggaggcgagc tgcggggaga
      661 aggggcgacg gacagccgag cgcatggggc cggtggcggc ggcccgggca gggctggatg
      721 ctgcctgggc aaggcggtgc gaggtgccaa aggtcaccac catccccacc cgccagccgc
      781 gggcgccggc gcggccgggg gcgccgaggc ggatctgaag gcgctcacgc actcggtgct
      841 caagaaactg aaggagcggc agctggagct gctgctccag gccgtggagt cccgcggcgg
      901 gacgcgcacc gcgtgcctcc tgctgcccgg ccgcctggac tgcaggctgg gcccgggggc
      961 gcccgccggc gcgcagcctg cgcagccgcc ctcgtcctac tcgctccccc tcctgctgtg
     1021 caaagtgttc aggtggccgg atctcaggca ttcctcggaa gtcaagaggc tgtgttgctg
     1081 tgaatcttac gggaagatca accccgagct ggtgtgctgc aacccccatc accttagccg
     1141 actctgcgaa ctagagtctc ccccccctcc ttactccaga tacccgatgg attttctcaa
     1201 accaactgca gactgtccag atgctgtgcc ttcctccgct gaaacagggg gaacgaatta
     1261 tctggcccct ggggggcttt cagattccca acttcttctg gagcctgggg atcggtcaca
     1321 ctggtgcgtg gtggcatact gggaggagaa gacgagagtg gggaggctct actgtgtcca
     1381 ggagccctct ctggatatct tctatgatct acctcagggg aatggctttt gcctcggaca
     1441 gctcaattcg gacaacaaga gtcagctggt gcagaaggtg cggagcaaaa tcggctgcgg
     1501 catccagctg acgcgggagg tggatggtgt gtgggtgtac aaccgcagca gttaccccat
     1561 cttcatcaag tccgccacac tggacaaccc ggactccagg acgctgttgg tacacaaggt
     1621 gttccccggt ttctccatca aggctttcga ctacgagaag gcgtacagcc tgcagcggcc
     1681 caatgaccac gagtttatgc agcagccgtg gacgggcttt accgtgcaga tcagctttgt
     1741 gaagggctgg ggccagtgct acacccgcca gttcatcagc agctgcccgt gctggctaga
     1801 ggtcatcttc aacagccggt agccgcgtgc ggaggggaca gagcgtgagc tgagcaggcc
     1861 acacttcaaa ctactttgct gctaatattt tcctcctgag tgcttgcttt tcatgcaaac
     1921 tctttggtcg tttttttttt gtttgttggt tggttttctt cttctcgtcc tcgtttgtgt
     1981 tctgttttgt ttcgctcttt gagaaatagc ttatgaaaag aattgttggg ggtttttttg
     2041 gaagaagggg caggtatgat cggcaggaca ccctgatagg aagaggggaa gcagaaatcc
     2101 aagcaccacc aaacacagtg tatgaagggg ggcggtcatc atttcacttg tcaggagtgt
     2161 gtgtgagtgt gagtgtgcgg ctgtgtgtgc acgcgtgtgc aggagcggca gatggggaga
     2221 caacgtgctc tttgttttgt gtctcttatg gatgtcccca gcagagaggt ttgcagtccc
     2281 aagcggtgtc tctcctgccc cttggacacg ctcagtgggg cagaggcagt acctgggcaa
     2341 gctggcggct ggggtcccag cagctgccag gagcacggct ctgtccccag cctgggaaag
     2401 cccctgcccc tcctctccct catcaaggac acgggcctgt ccacaggctt ctgagcagcg
     2461 agcctgctag tggccgaacc agaaccaatt attttcatcc ttgtcttatt cccttcctgc
     2521 cagcccctgc cattgtagcg tctttctttt ttggccatct gctcctggat ctccctgaga
     2581 tgggcttccc aagggctgcc ggggcagccc cctcacagta ttgctcaccc agtgccctct
     2641 cccctcagcc tctcccctgc ctgccctggt gacatcaggt ttttcccgga cttagaaaac
     2701 cagctcagca ctgcctgctc ccatcctgtg tgttaagctc tgctattagg ccagcaagcg
     2761 gggatgtccc tgggagggac atgcttagca gtccccttcc ctccaagaag gatttggtcc
     2821 gtcataaccc aaggtaccat cctaggctga cacctaactc ttctttcatt tcttctacaa
     2881 ctcatacact cgtatgatac ttcgacactg ttcttagctc aatgagcatg tttagacttt
     2941 aacataagct atttttctaa ctacaaaggt ttaaatgaac aagagaagca ttctcattgg
     3001 aaatttagca ttgtagtgct ttgagagaga aaggactcct gaaaaaaaac ctgagattta
     3061 ttaaagaaaa aaatgtattt tatgttatat ataaatatat tattacttgt aaatataaag
     3121 acgttttata agcatcatta tttatgtatt gtgcaatgtg tataaacaag aaaaataaag
     3181 aaaagatgca ctttgcttta atataaatgc aaataacaaa tgccaaatta aaaaagataa
     3241 acacaagatt ggtgtttttt tctatgggtg ttatcaccta gctgaatgtt tttctaaagg
     3301 agtttatgtt ccattaaacg atttttaaaa tgtacacttg a
//
