LOCUS       NM_005903               7013 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens SMAD family member 5 (SMAD5), transcript variant 1,
            mRNA.
ACCESSION   NM_005903
VERSION     NM_005903.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7013)
  AUTHORS   Que,X., Ren,L., Yang,L., Wang,L., Li,J., Wu,R. and Chen,Q.
  TITLE     Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2
            affects the decidualization in endometriosis patients through the
            SMAD1/5/9 pathway
  JOURNAL   FASEB J 38 (9), e23622 (2024)
   PUBMED   38703029
  REMARK    GeneRIF: Long noncoding RNA BMPR1B-AS1 stability regulated by
            IGF2BP2 affects the decidualization in endometriosis patients
            through the SMAD1/5/9 pathway.
REFERENCE   2  (bases 1 to 7013)
  AUTHORS   Gu,Y. and Bai,Y.
  TITLE     LncRNA MALAT1 promotes osteogenic differentiation through the
            miR-93-5p/SMAD5 axis
  JOURNAL   Oral Dis 30 (4), 2398-2409 (2024)
   PUBMED   37533355
  REMARK    GeneRIF: LncRNA MALAT1 promotes osteogenic differentiation through
            the miR-93-5p/SMAD5 axis.
REFERENCE   3  (bases 1 to 7013)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   4  (bases 1 to 7013)
  AUTHORS   Zheng,C., Ding,L., Xiang,Z., Feng,M., Zhao,F., Zhou,Z. and She,C.
  TITLE     Circ_0001825 promotes osteogenic differentiation in human-derived
            mesenchymal stem cells via miR-1270/SMAD5 axis
  JOURNAL   J Orthop Surg Res 18 (1), 663 (2023)
   PUBMED   37674252
  REMARK    GeneRIF: Circ_0001825 promotes osteogenic differentiation in
            human-derived mesenchymal stem cells via miR-1270/SMAD5 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7013)
  AUTHORS   Qin,X., Jiang,Z., Zhu,Y., Xue,H. and Wei,C.
  TITLE     Long noncoding RNA TMEM147-AS1 serves as a microRNA-326 sponge to
            aggravate the malignancy of gastric cancer by upregulating SMAD5
  JOURNAL   Oncol Res 29 (4), 263-273 (2022)
   PUBMED   37303938
  REMARK    GeneRIF: Long noncoding RNA TMEM147-AS1 serves as a microRNA-326
            sponge to aggravate the malignancy of gastric cancer by
            upregulating SMAD5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7013)
  AUTHORS   Nishimura,R., Kato,Y., Chen,D., Harris,S.E., Mundy,G.R. and
            Yoneda,T.
  TITLE     Smad5 and DPC4 are key molecules in mediating BMP-2-induced
            osteoblastic differentiation of the pluripotent mesenchymal
            precursor cell line C2C12
  JOURNAL   J Biol Chem 273 (4), 1872-1879 (1998)
   PUBMED   9442019
REFERENCE   7  (bases 1 to 7013)
  AUTHORS   Hata,A., Lagna,G., Massague,J. and Hemmati-Brivanlou,A.
  TITLE     Smad6 inhibits BMP/Smad1 signaling by specifically competing with
            the Smad4 tumor suppressor
  JOURNAL   Genes Dev 12 (2), 186-197 (1998)
   PUBMED   9436979
REFERENCE   8  (bases 1 to 7013)
  AUTHORS   Hejlik,D.P., Kottickal,L.V., Liang,H., Fairman,J., Davis,T.,
            Janecki,T., Sexton,D., Perry,W. 3rd, Tavtigian,S.V., Teng,D.H. and
            Nagarajan,L.
  TITLE     Localization of SMAD5 and its evaluation as a candidate myeloid
            tumor suppressor
  JOURNAL   Cancer Res 57 (17), 3779-3783 (1997)
   PUBMED   9288787
REFERENCE   9  (bases 1 to 7013)
  AUTHORS   Zavadil,J., Brezinova,J., Svoboda,P., Zemanova,Z. and Michalova,K.
  TITLE     Smad5, a tumor suppressor candidate at 5q31.1, is hemizygously lost
            and not mutated in the retained allele in human leukemia cell line
            HL60
  JOURNAL   Leukemia 11 (8), 1187-1192 (1997)
   PUBMED   9264367
REFERENCE   10 (bases 1 to 7013)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat Genet 13 (3), 347-349 (1996)
   PUBMED   8673135
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313397.1, CR749366.1 and
            BK001394.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005903.6.
            
            Summary: The protein encoded by this gene is involved in the
            transforming growth factor beta signaling pathway that results in
            an inhibition of the proliferation of hematopoietic progenitor
            cells. The encoded protein is activated by bone morphogenetic
            proteins type 1 receptor kinase, and may be involved in cancer.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 2. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313397.1, SRR1660809.246802.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000545279.6/ ENSP00000441954.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK313397.1         1-62
            63-2214             CR749366.1         2-2153
            2215-7013           BK001394.1         455-5253
FEATURES             Location/Qualifiers
     source          1..7013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..7013
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /note="SMAD family member 5"
                     /db_xref="GeneID:4090"
                     /db_xref="HGNC:HGNC:6771"
                     /db_xref="MIM:603110"
     exon            1..118
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            119..193
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            194..765
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1760
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /note="mothers against decapentaplegic, drosophila,
                     homolog of, 5; MAD, mothers against decapentaplegic
                     homolog 5; SMA- and MAD-related protein 5; SMAD, mothers
                     against DPP homolog 5"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 5"
                     /protein_id="NP_005894.3"
                     /db_xref="CCDS:CCDS75308.1"
                     /db_xref="GeneID:4090"
                     /db_xref="HGNC:HGNC:6771"
                     /db_xref="MIM:603110"
                     /translation="MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKK
                     KKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHH
                     ELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNL
                     SHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLP
                     ADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLL
                     AQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPLNPISSVS"
     exon            766..1017
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1137
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1359
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1616
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..7013
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6996..7001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /note="hexamer: AATAAA"
     polyA_site      7013
                     /gene="SMAD5"
                     /gene_synonym="DWFC; JV5-1; MADH5"
                     /note="major polyA site"
ORIGIN      
        1 atccgggtcc tgggcgagcg ggcgccgtgc gcgtgtcccg cggccgagct gctaataaag
       61 ttgcagcgag gagaagcgca gcgacggcgt cgggagagcg cgcctagccg gctcgcgaaa
      121 aggaagctgt tgaagttatt gaagtacctg ttgctatatt ctaagaaatt aaaatgtcca
      181 gaaatctgcc tctgacttga cccaatgaaa gaagcatatg gcacttgtga agataaatgt
      241 tactcctccc tttttaattg gaacttctgc ttaggacctg tgtatgacgt ttcacctgtg
      301 atctgttctt tcggtagcca ctgactttga gttacaggaa ggtctccgaa gatttgtgtc
      361 aaatgacgtc aatggccagc ttgttttctt ttactagtcc agcagtaaag cgattgttgg
      421 gctggaaaca aggtgatgag gaggagaaat gggcagaaaa ggcagttgat gctttggtga
      481 agaaactaaa aaagaaaaag ggtgccatgg aggaactgga gaaagccttg agcagtccag
      541 gacagccgag taaatgtgtc actattccca gatctttaga tggacgcctg caggtttctc
      601 acagaaaagg cttaccccat gttatatatt gtcgtgtttg gcgctggccg gatttgcaga
      661 gtcatcatga gctaaagccg ttggatattt gtgaatttcc ttttggatct aagcaaaaag
      721 aagtttgtat caacccatac cactataaga gagtggagag tccagtctta cctccagtat
      781 tagtgcctcg tcataatgaa ttcaatccac aacacagcct tctggttcag tttaggaacc
      841 tgagccacaa tgaaccacac atgccacaaa atgccacgtt tccagattct ttccaccagc
      901 ccaacaacac tccttttccc ttatctccaa acagccctta tcccccttct cctgctagca
      961 gcacatatcc caactcccca gcaagttctg gaccaggaag tccatttcag ctcccagctg
     1021 atacgcctcc tcctgcctat atgccacctg atgatcagat gggtcaagat aattcccagc
     1081 ctatggatac aagcaataat atgattcctc agattatgcc cagtatatcc agcagggatg
     1141 ttcagcctgt tgcctatgaa gagcctaaac attggtgttc aatagtctac tatgaattaa
     1201 acaatcgtgt tggagaagct tttcatgcat cttctactag tgtgttagta gatggattca
     1261 cagatccttc aaataacaaa agtagattct gcttgggttt gttgtcaaat gttaatcgta
     1321 attcgacaat tgaaaacact aggcgacata ttggaaaagg tgttcatctg tactatgttg
     1381 gtggagaggt gtatgcggaa tgcctcagtg acagcagcat atttgtacag agtaggaact
     1441 gcaactttca tcatggcttt catcccacca ctgtctgtaa gattcccagc agctgcagcc
     1501 tcaaaatttt taacaatcag gagtttgctc agcttctggc tcaatctgtc aaccatgggt
     1561 ttgaggcagt atatgagctc accaaaatgt gtaccattcg gatgagtttt gtcaagggtt
     1621 ggggagcaga atatcaccgg caggatgtaa ccagcacccc atgttggatt gagattcatc
     1681 ttcatgggcc tcttcagtgg ctggataaag tccttactca gatgggctcc cctctgaacc
     1741 ccatatcttc tgtttcataa tgcagaagta ttcttttcaa ttatattgtt agtggacttg
     1801 ttttaatttt agagaaactt tgagtacaga tactgtgagc ttacattgaa aacagatatt
     1861 acagcttatt tttttctaca taattgtgac caatacattt gtattttgtg atgaatctac
     1921 atttgtttgt attcatgttc atgtgattaa ctcttagaag tgttgtaaaa gatgcagagt
     1981 aagtattatg ccccagttca gaaatttggc attgatctta aactggaaca tgcttttact
     2041 ttattgccct aacaattttt tattaaattt atttgaaaat gcatcacatg atgaaaaatt
     2101 atagtagctt ataagagggc atatacagtg aagagtaagt tttccctcct actctcgatc
     2161 ttccagaagc tgtactttta ccagtttctt tgtcccacca acttaaaaaa aaaaagtaca
     2221 attcattgtt ttgcaaaagt gtatggtagg ggcttaaaag aaactataaa gttttatttg
     2281 aatgaacact atgcactgct gtaactggta gtgttcagta aaagcaaaat gatagttttc
     2341 tagatgacat aaaatttaca tttaatacag ataagtgttc ttcagtgtaa tgtgacttca
     2401 tgctatatat cttttgtaag acatttcctt ttttaaaaaa atttttgcaa ataactgatc
     2461 tcaagtatat gtcatttact caaaatctgt cataagcatt actttatagc tagtgacagt
     2521 gcatgcacag ccttgttcaa ctatgtttgc tgcttttgga caatgttgca agaactctat
     2581 ttttgacatg cattaatctt ttattttgca cttttatggg tgacagtttt tagcataacc
     2641 tttgataaaa tacactcaag tgacttggac ttagatgctt atccttacgt ccttggtacc
     2701 ttttttgtat taacaaacac tgcaatttat agattacatt tgtaggaagt tatgcttttt
     2761 tctggttttt gttttacttt caacctaggt tataagactg ttattctata gctccaactt
     2821 aaggtgcctt tttaattccc tacagtttta tgggtgttat cagtgctgga gaatcatgta
     2881 gttaatccca ttgctcttac aagtgtcagc ttacttgtat cagcctccct acgcaaggac
     2941 ctatgcactg gagccgtagg aggctcttca gttgggcccc aaggataagg ctactgattt
     3001 gatactaaat gaatcagcag tggatgtagg gatagctgat tttaaaacac tcggctgggc
     3061 acagtggctc acacctgtaa tcccagcact ttgggaggct gaggcaggca gatcatgatg
     3121 tcaggagttt gagaccagcc tggccaatat ggtgaaaccc tgtctctaca aaaaatacaa
     3181 aaattagctg ggcatggtgg tgcgtgcctg aagtcccagc tactcgggaa gctgaggcag
     3241 aagaatcact tgaacctggg aggcggaggt tgtggtgagc cgagatcgca ccactgcact
     3301 ccagcctggg cgacagagcg agactctgcc tcaaaaaaca aaacaaaaca aaacactcac
     3361 ccatcaacga atatagactc ttctctcatt tatcgatgat cctctttttc cattttttaa
     3421 gtacttatgt ggaagctagt ctcccaaaac acaatcttta gagagaaaag acatgaacga
     3481 actccaaaat atccatttaa tcaatcatgt ttttggcttt ggataaagaa ctttgaacca
     3541 gtttttttct caggagctgt caaatggaca cttaattatg acatgagaat gaagaaatta
     3601 ttttggaaaa aaaaaatgac ctaatttacc tatcagtgaa agctttattt tctggtgcct
     3661 tttgaaagta tatggagtca tatcattctt ctgtttaaaa tgttagtttg gtttgacttt
     3721 ccactttgtc ctttctgctc ttgtgaagaa aaaaaaaagc attttcgagg aaagaattat
     3781 gcaatttctt ttgttttctg tgtcattatt tattgctttt tcaatgtgca gccagtggat
     3841 ggttttagtt ctttcagatg aactgccatt tgtgtttcag ctcacagttc tttgctgggt
     3901 aaaagaaata ctttctgaca gtcacctgag ccttaaatgt aagtattaca tgacatgcat
     3961 tctgtttctt ccagagttct gtctgccaca cgaaagagaa tatttgctta cttgatagaa
     4021 ctttggcatt ttcatcattc ttttacttaa ccaggcttat ggcatgatct ctggaacaaa
     4081 tttgtaggaa aaaattactc caattgaatg actgatgtat gtaatcaact tcattgggct
     4141 gcagtaaact agtggaaatt agagagttgt tttattggtg ttttctactg tgagttaatt
     4201 aaaaattgtt tttatttggg gtcattatgt cacagtcttg agttaacaag atcttacgtg
     4261 attggccttt tctttgtttt ctcttaggag ttgtgtctca tgaatgacag tactaaagct
     4321 attaacaact aagagtttga cagagaacta taagcctgtt gtatctccta aaagttgtca
     4381 actccccacc cttggacttt aaatgaaaat tttattcagt ccagctattc ttacagtccc
     4441 taaggatttt catatatcta tgtataggag ataaaatttg ctagtaagat ttttaaaaac
     4501 tggctagtga aaggaaagta cctctgaaag aaaccatttt agcaaattat ggttatatgt
     4561 tttaatttaa tctacagaat gttttatagt aaaattctag caccactaga ataatcacat
     4621 agcatgtaca atatatttat gctggctgaa aagacagaat ctgggaataa taaaattgca
     4681 accagtttgg taatgcaaac agcagaatag aatgaaatct cagtaatgaa ttaaagcaac
     4741 aaaaagatat tgattggcaa aaagcaagat ataagagatt catttgctta acatttctac
     4801 ataatattta tggtctggtc agtattggtc tggtcagtat tgcctggctg acgtgaaatg
     4861 taaactagta ggcgtgttat tgatctgcta aaactaaccc tctttttaag aggagattta
     4921 aggaagacgt caatcaaaat gtcaaatatg tgtgtcagaa tataaataat ttttcacatt
     4981 gtattgttgc tatataaaaa aaataataga attggttggg tttctgaggt gaaatccaga
     5041 gtaagagtac tagacagttc aacaagccac atctaatggc acagatagag gatgtagcta
     5101 ttttatacct ttcataacat ttgagagtaa gatatccttc aggatgtgaa gtgattatta
     5161 agtactcata cctgaaatct gttgtcaaga ttagaactgg ggttcatgtt aaaaaccttc
     5221 catattacct gagggtacct gtggggaaca gttccttccc ctgtgtggta gtattttgtt
     5281 ggaagagaat gtttatacaa aaaatgaaat tcttccaaca gcagagaaac tctaaaaagt
     5341 ttgatagtac ctatcaaagt gctgtacttc tgtgatagag aacatctgat gtaccaattt
     5401 agatctattt ctttatactt tttctaatca attgcttaat agtactttgg atgattatca
     5461 cctttgccac ttaaaatata taaatatcct ttttacttca tgaggaagga agaatttttt
     5521 gataattact gagttcagcc ttttgtgatg acttatattt tggacttaca ttttaacttt
     5581 aaagaatgtc agatcccttc tttgtcttac tagttaaatc ctcacctaat ctcttgggta
     5641 tgaatataaa tgtgtgtcat cgttatattg ttcagctaga tgagcaagta tcttagggta
     5701 gtaggtagcc tggtggtttt agaagtgttt ggtgattttt atggagagag ttttcctaag
     5761 tggtggttta taggtggtat cagatattat tagggcagct ttttggggag taatctcagg
     5821 tctcccagag cagcagcatt tttctcattg atataagtaa gattcttagg agcttttctt
     5881 atcacacaag atgcctgaat cgaatgtgag aattgaaggc atttcttctg cataaacaaa
     5941 gaattctacc tgctggacag aaacctggaa agttctttgg aattcgctga attacagttt
     6001 agtatgtcct gattacagag tgacaatatt tatcaagcct ttgttatatt ggattatctt
     6061 ctctcttaaa atacaactgt attataattg aaatgacagc ccaaaattgg atggtttacc
     6121 aaaaccaatg aaagggattt cacacatcaa tttttatttc tgttttgaag agcacatgct
     6181 atataataat tgctagtagc aactgcagta aaacaggtga taagttattt tctctgaaaa
     6241 gatccagtcc tagagcagga ttcttcgatc attcatggca gagtgaaaaa ggtttgtatg
     6301 gttcttgtcc aaataactca gttcttaaaa ttcttaaaat gatcgtaaac cattatcctt
     6361 taaaggttta tttgaagatg ctgttaaagt acagaatttt gtgtacaggt agatttttcc
     6421 gtccctcatt aatagtgcct tcttaattaa tacagactgg tgttagctat aacaaaactc
     6481 cagtaaggcc aaagaatccc aagttctttg tggaaaaaaa aaaaaaatct tttagggtca
     6541 gattttccct tctaatatca ttgaagatga tgttgcattg atttattcat aaagtatttt
     6601 aactatagga actctagaag ataatggtta ggcaagtgat ttttttttta aatatggttg
     6661 gcgtaagttg tattttgaaa ttcacttatt ttaaaatcga agaggattgt aatcatggaa
     6721 atagaatgtt tgtatctacc tgcccacatt ttcttaaaaa gatatttcat atacagataa
     6781 tgaagaccaa gctagtggct gcactgtagg tctgctgctt atttgtattt gttgtgcttc
     6841 tgtttatgtt gtagaagctg aaattctagc aacatgcttc aattctgtta ttttgatact
     6901 tatgaaaatg tattaggttt tactatattg tgcttttgaa agccataact cttaagaact
     6961 ttgtttttgc atattgtttg ctaattcttt actttaataa acctcaaaac ctg
//
