LOCUS       NM_005902               6464 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens SMAD family member 3 (SMAD3), transcript variant 1,
            mRNA.
ACCESSION   NM_005902 NM_015400
VERSION     NM_005902.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6464)
  AUTHORS   Lindsay,M.E., Scimone,E.R., Lawton,J., Richa,R., Yonker,L.M.,
            Di,Y.P., Buch,K., Ouyang,W., Mo,X., Lin,A.E. and Mou,H.
  TITLE     Gain-of-function variants in SMAD4 compromise respiratory
            epithelial function
  JOURNAL   J Allergy Clin Immunol 155 (1), 107-119 (2025)
   PUBMED   39243984
REFERENCE   2  (bases 1 to 6464)
  AUTHORS   Miyoshi,Y., Lucena-Cacace,A., Tian,Y., Matsumura,Y., Tani,K.,
            Nishikawa,M., Narita,M., Kimura,T., Ono,K. and Yoshida,Y.
  TITLE     SMAD3 mediates the specification of human induced pluripotent stem
            cell-derived epicardium into progenitors for the cardiac pericyte
            lineage
  JOURNAL   Stem Cell Reports 19 (10), 1399-1416 (2024)
   PUBMED   39332407
  REMARK    GeneRIF: SMAD3 mediates the specification of human induced
            pluripotent stem cell-derived epicardium into progenitors for the
            cardiac pericyte lineage.
REFERENCE   3  (bases 1 to 6464)
  AUTHORS   Fu,Y., Sun,X., He,Q., Gu,Z., Jia,X. and Zhuang,Z.
  TITLE     Connexin 43 controls metastatic behavior in triple negative breast
            cancer through TGFbeta1-Smad3-intergin alphaV signaling axis Based
            on optical image diagnosis
  JOURNAL   SLAS Technol 29 (5), 100190 (2024)
   PUBMED   39299505
  REMARK    GeneRIF: Connexin 43 controls metastatic behavior in triple
            negative breast cancer through TGFbeta1-Smad3-intergin alphaV
            signaling axis Based on optical image diagnosis.
REFERENCE   4  (bases 1 to 6464)
  AUTHORS   Geng,W., An,J., Dong,K., Zhang,H., Zhang,X., Liu,Y., Xu,R., Liu,Y.,
            Huang,X., Song,H., Yan,W., Sun,A., He,F., Wang,J., Gao,H. and
            Tian,C.
  TITLE     ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by
            Recruiting SMYD3 in Breast Cancer
  JOURNAL   Adv Sci (Weinh) 11 (40), e2404904 (2024)
   PUBMED   39225541
  REMARK    GeneRIF: ZNF8 Orchestrates with Smad3 to Promote Lung Metastasis by
            Recruiting SMYD3 in Breast Cancer.
REFERENCE   5  (bases 1 to 6464)
  AUTHORS   Zhang,Y., Feng,X., We,R. and Derynck,R.
  TITLE     Receptor-associated Mad homologues synergize as effectors of the
            TGF-beta response
  JOURNAL   Nature 383 (6596), 168-172 (1996)
   PUBMED   8774881
REFERENCE   6  (bases 1 to 6464)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat Genet 13 (3), 347-349 (1996)
   PUBMED   8673135
REFERENCE   7  (bases 1 to 6464)
  AUTHORS   Beijersbergen,R.L., Kerkhoven,R.M., Zhu,L., Carlee,L.,
            Voorhoeve,P.M. and Bernards,R.
  TITLE     E2F-4, a new member of the E2F gene family, has oncogenic activity
            and associates with p107 in vivo
  JOURNAL   Genes Dev 8 (22), 2680-2690 (1994)
   PUBMED   7958925
REFERENCE   8  (bases 1 to 6464)
  AUTHORS   Ginsberg,D., Vairo,G., Chittenden,T., Xiao,Z.X., Xu,G.,
            Wydner,K.L., DeCaprio,J.A., Lawrence,J.B. and Livingston,D.M.
  TITLE     E2F-4, a new member of the E2F transcription factor family,
            interacts with p107
  JOURNAL   Genes Dev 8 (22), 2665-2679 (1994)
   PUBMED   7958924
REFERENCE   9  (bases 1 to 6464)
  AUTHORS   Loeys,B.L. and Dietz,H.C.
  TITLE     Loeys-Dietz Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301312
REFERENCE   10 (bases 1 to 6464)
  AUTHORS   Milewicz,D.M. and Cecchi,A.C.
  TITLE     Heritable Thoracic Aortic Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301299
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087482.9 and AC012568.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005902.3.
            
            Summary: The SMAD family of proteins are a group of intracellular
            signal transducer proteins similar to the gene products of the
            Drosophila gene 'mothers against decapentaplegic' (Mad) and the C.
            elegans gene Sma. The SMAD3 protein functions in the transforming
            growth factor-beta signaling pathway, and transmits signals from
            the cell surface to the nucleus, regulating gene activity and cell
            proliferation. This protein forms a complex with other SMAD
            proteins and binds DNA, functioning both as a transcription factor
            and tumor suppressor. Mutations in this gene are associated with
            aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3.
            [provided by RefSeq, May 2022].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.67621.1, BC050743.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327367.9/ ENSP00000332973.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-759               AC087482.9         159885-160643
            760-953             AC012568.7         80150-80343
            954-1085            AC012568.7         80508-80639
            1086-1160           AC012568.7         82034-82108
            1161-1211           AC012568.7         85809-85859
            1212-1424           AC012568.7         96496-96708
            1425-1562           AC012568.7         99982-100119
            1563-1707           AC012568.7         102620-102764
            1708-6464           AC012568.7         105668-110424
FEATURES             Location/Qualifiers
     source          1..6464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.33"
     gene            1..6464
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /note="SMAD family member 3"
                     /db_xref="GeneID:4088"
                     /db_xref="HGNC:HGNC:6769"
                     /db_xref="MIM:603109"
     exon            1..759
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             554..1831
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /note="isoform 1 is encoded by transcript variant 1; SMA-
                     and MAD-related protein 3; MAD, mothers against
                     decapentaplegic homolog 3; mad homolog JV15-2; mad protein
                     homolog; MAD homolog 3; mothers against DPP homolog 3;
                     SMAD, mothers against DPP homolog 3"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 3
                     isoform 1"
                     /protein_id="NP_005893.1"
                     /db_xref="CCDS:CCDS10222.1"
                     /db_xref="GeneID:4088"
                     /db_xref="HGNC:HGNC:6769"
                     /db_xref="MIM:603109"
                     /translation="MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKK
                     TGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHE
                     LRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSI
                     PENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNN
                     LDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSN
                     VNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKI
                     PPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTST
                     PCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS"
     exon            760..953
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1085
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1160
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1211
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1424
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1562
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1707
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..6464
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6445..6450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /note="hexamer: AATAAA"
     polyA_site      6464
                     /gene="SMAD3"
                     /gene_synonym="hMAD-3; hSMAD3; HSPC193; HsT17436; JV15-2;
                     LDS1C; LDS3; mad3; MADH3"
                     /note="major polyA site"
ORIGIN      
        1 gaaacacaga ctgggagcgg gcgggagcgg gagcgcggcg cacgccccgg gccggcccag
       61 ccagcgagcg agcgagcggc gagccgggag gaggagggtg gcggggcggt gaggccgcag
      121 aggcggaggg atctgcgcat caaagctagc gaggcgagcg aagtttggcc gggggttgga
      181 ctttccttcc cggaggcggc acccaaacag ctaccccgtg cggaaaccca aacttctgct
      241 gccacttgga gtctcgcggc cgccgcctcc gccccgcgtt cggggccttc ccgaccctgc
      301 actgctgccg tccgcccgcc cggccgctct tctcttcgcc gtgggagccg ctccgggcgc
      361 agggccgcgc gccgagcccc gcaggctgca gcgccgcggc ccggcccggc gccccggcaa
      421 cttcgccgag agttgaggcg aagtttgggc gaccgcggca ggccccggcc gagctcccct
      481 ctgcgccccc ggcgtcccgt cgagcccagc cccgccgggg gcgctcctcg ccgcccgcgc
      541 gccctcccca gccatgtcgt ccatcctgcc tttcactccc ccgatcgtga agcgcctgct
      601 gggctggaag aagggcgagc agaacgggca ggaggagaaa tggtgcgaga aggcggtcaa
      661 gagcctggtc aagaaactca agaagacggg gcagctggac gagctggaga aggccatcac
      721 cacgcagaac gtcaacacca agtgcatcac catccccagg tccctggatg gccggttgca
      781 ggtgtcccat cggaaggggc tccctcatgt catctactgc cgcctgtggc gatggccaga
      841 cctgcacagc caccacgagc tacgggccat ggagctgtgt gagttcgcct tcaatatgaa
      901 gaaggacgag gtctgcgtga atccctacca ctaccagaga gtagagacac cagttctacc
      961 tcctgtgttg gtgccacgcc acacagagat cccggccgag ttccccccac tggacgacta
     1021 cagccattcc atccccgaaa acactaactt ccccgcaggc atcgagcccc agagcaatat
     1081 tccagagacc ccaccccctg gctacctgag tgaagatgga gaaaccagtg accaccagat
     1141 gaaccacagc atggacgcag gttctccaaa cctatccccg aatccgatgt ccccagcaca
     1201 taataacttg gacctgcagc cagttaccta ctgcgagccg gccttctggt gctccatctc
     1261 ctactacgag ctgaaccagc gcgtcgggga gacattccac gcctcgcagc catccatgac
     1321 tgtggatggc ttcaccgacc cctccaattc ggagcgcttc tgcctagggc tgctctccaa
     1381 tgtcaacagg aatgcagcag tggagctgac acggagacac atcggaagag gcgtgcggct
     1441 ctactacatc ggaggggagg tcttcgcaga gtgcctcagt gacagcgcta tttttgtcca
     1501 gtctcccaac tgtaaccagc gctatggctg gcacccggcc accgtctgca agatcccacc
     1561 aggatgcaac ctgaagatct tcaacaacca ggagttcgct gccctcctgg cccagtcggt
     1621 caaccagggc tttgaggctg tctaccagtt gacccgaatg tgcaccatcc gcatgagctt
     1681 cgtcaaaggc tggggagcgg agtacaggag acagactgtg accagtaccc cctgctggat
     1741 tgagctgcac ctgaatgggc ctttgcagtg gcttgacaag gtcctcaccc agatgggctc
     1801 cccaagcatc cgctgttcca gtgtgtctta gagacatcaa gtatggtagg ggagggcagg
     1861 cttggggaaa atggccatgc aggaggtgga gaaaattgga actctactca acccattgtt
     1921 gtcaaggaag aagaaatctt tctccctcaa ctgaaggggt gcacccacct gttttctgaa
     1981 acacacgagc aaacccagag gtggatgtta tgaacagctg tgtctgccaa acacatttac
     2041 cctttggccc cactttgaag ggcaagaaat ggcgtctgct ctggtggctt aagtgagcag
     2101 aacaggtagt attacaccac cggccccctc cccccagact ctttttttga gtgacagctt
     2161 tctgggatgt cacagtccaa ccagaaacac ccctctgtct aggactgcag tgtggagttc
     2221 accttggaag ggcgttctag gtaggaagag cccgcagggc catgcagacc tcatgcccag
     2281 ctctctgacg cttgtgacag tgcctcttcc agtgaacatt cccagcccag ccccgccccg
     2341 ccccgcccca ccactccagc agaccttgcc ccttgtgagc tggatagact tgggatgggg
     2401 agggagggag ttttgtctgt ctccctcccc tctcagaaca tactgattgg gaggtgcgtg
     2461 ttcagcagaa cctgcacaca ggacagcggg aaaaatcgat gagcgccacc tctttaaaaa
     2521 ctcacttacg tttgtccttt ttcactttga aaagttggaa ggatctgctg aggcccagtg
     2581 catatgcaat gtatagtgtc tattatcaca ttaatctcaa agagattcga atgacggtaa
     2641 gtgttctcat gaagcaggag gcccttgtcg tgggatggca tttggtctca ggcagcacca
     2701 cactgggtgc gtctccagtc atctgtaaga gcttgctcca gattctgatg catacggcta
     2761 tattggttta tgtagtcagt tgcattcatt aaatcaactt tatcatatgc tcttttaaat
     2821 gtttggttta tatattttct ttaaaaatcc tgggctggca cattgactgg gaaacctgag
     2881 tgagacccag caactgcttc tctcccttct ctctcctgag gtgaagcttt tccaggtttt
     2941 gttgaagaga tacctgccag cacttctgca agctgaaatt tacagaagca aattcaccag
     3001 aagggaaaca tctcaggcca acataggcaa atgaaaaggg ctattaaaat atttttacac
     3061 ctttgaaaat tgcaggcttg gtacaaagag gtctgtcatc ttccccctgg gatataagat
     3121 gatctagctc ccggtagagg atcaccggtg acaactatag cagttgtatt gtgtaacaag
     3181 tactgctccc agcagcaatt agggagaaaa ctagtctaaa ttatttcaac tggaaaaaag
     3241 aaaaaagagt cctcttcttt tcccagcctt ttgcagaaca cagtagacag aactgccacc
     3301 ttcaattggt actttattct ttgctgctgt ttttgtataa aatgacctat cccacgtttt
     3361 tgcatgaatt tatagcagga aaaatcaagg gatttcctat ggaagtcctg ctttattcca
     3421 ggtgaaggga aggaagtgta tatacttttg gcaagtcata cagctcaaat gtgatgagat
     3481 ttctgatgtt agagggagat ggagaggctt cctgatgcct catctgcagg gtcctgtgcc
     3541 tctgaagttc tagccatgag gtttccaggt aggacagctg ctccccaagc ctcctgagga
     3601 cacaggaaga gacggaagga gcaccttgac agacttgtgt gagtcttctc gaaggagggt
     3661 tgactcagaa cccagagaca atacaaaacc cctcacttcc tctgagaggg ccaaatgctg
     3721 tgagtctgaa gtatgtgcct ggtgtgaaat gatctatggc ctgtttctta cacaggaagc
     3781 cccctgaacc tcctgtacat gtgttcatgt tcccagccag ctctgagacc caggaaccaa
     3841 atattccatt ttggcttctg ctagagcagt catggttcct ctcctaaaag ccatgggcag
     3901 cagtttccga gggcctgcat gatccacctg ctgcacgatc ctatgagggc ttcctgtggc
     3961 acacagccct ctgggtgctt gggaactagc ttcaggcaca gcctgattct ggtgatccag
     4021 tgatctatgg aagtcgtgtc ttactccagg tgaaggggga aaaaaaaagc ctatactttg
     4081 gcaggttatg aactttgaat gtgatgaaat gacacgtttg gctgcatttg gatggtgtct
     4141 tagaaccctc attgctcaga cctgaaggct acttctagga gcatgaagtt tgagttttgt
     4201 gtttttccaa aggatacttc cttggccctt tttctttatt gactagacca ccagaggagg
     4261 atgtgtggga ttgtaggcaa acccacctgt ggcatcactg aaaataaatt tgatcatacc
     4321 taagaggtta ggaaatggtg ccattcccac cttagagtgc tacataggtg ctttgggcgt
     4381 atgtaacatt agtgtccttc cttgaagcca caagctagtt ttcttagttt taaaatcctg
     4441 ttgtatgaat ggcatttgta tattaaaaca cttttttaaa ggacagttga aaagggcaag
     4501 aggaaaccag ggcagttcta gaggagtgct ggtgactgga tagcagtttt aagtggcgtt
     4561 cacctagtca acacgaccgc gtgtgttgcc cctgccctgg gctccccgcc atgacatctt
     4621 caccttgcag cttgtgctga gactgaccca agtgcagcta gcactgggac acagatcctt
     4681 gtcttcagca ccttccaagg agccaacttt tattcccttt cctctctccc ctccccacct
     4741 cgcttcttcc caatttagta acttagatgc ttccagcaca tacgtaggta gctaccccag
     4801 ccggtttgga ttacaggcct gtgctggaac atcatctcag ttggccacct tcctggcagg
     4861 ctgtagacct gacattttga gacaagccta gaggagtcag gagcagggac tttgactctt
     4921 aggaagagca cacatgaggg caaggctgct ggcagacgtc tccattgtcc ttatgttgtc
     4981 tgtgttgtat tttttttttt ttattgacca tggtgattat ttttttaaac catcgttaat
     5041 atactgaagt gagctatagc acatatcatg tgcttagttt gtttattttt ctccatctcc
     5101 ccttggcttc ctagagtttg gacatattcc aggctaaatg cttttactca agactacaga
     5161 aaggtttgaa gtagtgtgtg catggcatgc acgtatgtaa gtaatctggg gaagaagcaa
     5221 agatctgttt cattcttagc ctcaggcctc atgagggtct ccacagggcc ggagctcagg
     5281 ttacaccact ccttcgtcct tacaggagat gtagggagaa gaatctgcag gctgcttgta
     5341 ggactgttca ccaaggggga taccagcagc aagagagtgc acccgtttag ccctggaccc
     5401 tgtttcttac tgtgtgactt ggctagagtt gggagttccc ccaaaataaa cgtgtcccca
     5461 ttttaccaga accaaacctc aacacagcga agctgtactg tctttgtgtg gcaaagatgt
     5521 tcccttgtag gcccctttca ggtaaccgtc ttcacaatgt attttcatca cagtttaagg
     5581 agcatcagcc gcttctcaag tgggtaggga aagcagaaaa acgtacgcaa gaggacatgg
     5641 atccaaaatg atgatgaagc atctcccatg gggaggtgat ggtggggaga tgatgggcta
     5701 aacaggcaac ttttcaaaaa cacagctatc atagaaaaga aacttgcctc atgtaaactg
     5761 gattgagaaa ttctcagtga ttctgcaatg gatttttttt taatgcagaa gtaatgtata
     5821 ctctagtatt ctggtgtttt tatatttatg taataatttc ttaaaaccat tcagacagat
     5881 aactatttaa ttttttttaa gaaagttgga aaggtctctc ctcccaagga cagtggctgg
     5941 aagagttggg gcacagccag ttctgaatgt tggtggaggg tgtagtggct ttttggctca
     6001 gcatccagaa acaccaaacc aggctggcta aacaagtggc cgcgtgtaaa aacagacagc
     6061 tctgagtcaa atctgggccc ttccacaagg gtcctctgaa ccaagcccca ctcccttgct
     6121 aggggtgaaa gcattacaga gagatggagc catctatcca agaagccttc actcaccttc
     6181 actgctgctg ttgcaactcg gctgttctgg actctgatgt gtgtggaggg atggggaata
     6241 gaacattgac tgtgttgatt accttcacta ttcggccagc ctgacctttt aataactttg
     6301 taaaaagcat gtatgtattt atagtgtttt agatttttct aacttttata tcttaaaagc
     6361 agagcacctg tttaagcatt gtacccctat tgttaaagat ttgtgtcctc tcattccctc
     6421 tcttcctctt gtaagtgccc ttctaataaa cttttcatgg aaaa
//
