LOCUS       NM_005900               3002 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SMAD family member 1 (SMAD1), transcript variant 1,
            mRNA.
ACCESSION   NM_005900 NM_015583
VERSION     NM_005900.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3002)
  AUTHORS   Que,X., Ren,L., Yang,L., Wang,L., Li,J., Wu,R. and Chen,Q.
  TITLE     Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2
            affects the decidualization in endometriosis patients through the
            SMAD1/5/9 pathway
  JOURNAL   FASEB J 38 (9), e23622 (2024)
   PUBMED   38703029
  REMARK    GeneRIF: Long noncoding RNA BMPR1B-AS1 stability regulated by
            IGF2BP2 affects the decidualization in endometriosis patients
            through the SMAD1/5/9 pathway.
REFERENCE   2  (bases 1 to 3002)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   3  (bases 1 to 3002)
  AUTHORS   Wang,L., Li,T., Ma,X., Li,Y., Li,Z., Li,Z., Yu,N., Huang,J., Han,Q.
            and Long,X.
  TITLE     Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis
  JOURNAL   J Dermatol Sci 112 (1), 31-38 (2023)
   PUBMED   37743142
  REMARK    GeneRIF: Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis.
REFERENCE   4  (bases 1 to 3002)
  AUTHORS   Chen,W., Hu,J., He,Y., Yu,L., Liu,Y., Cheng,Y., Jia,B., Li,X.,
            Yu,G. and Wang,Y.
  TITLE     The Interaction Between SMAD1 and YAP1 Is Correlated with Increased
            Resistance of Gastric Cancer Cells to Cisplatin
  JOURNAL   Appl Biochem Biotechnol 195 (10), 6050-6067 (2023)
   PUBMED   36418715
  REMARK    GeneRIF: The Interaction Between SMAD1 and YAP1 Is Correlated with
            Increased Resistance of Gastric Cancer Cells to Cisplatin.
REFERENCE   5  (bases 1 to 3002)
  AUTHORS   Nakatsu,D., Kunishige,R., Taguchi,Y., Shinozaki-Narikawa,N.,
            Osaka,K., Yokomizo,K., Ishida,M., Takei,S., Yamasaki,S., Hagiya,K.,
            Hattori,K., Tsukamoto,T., Murata,M. and Kano,F.
  TITLE     BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and
            oligodendrogenesis in Alzheimer's patients' iPSCs in
            senescence-related conditions
  JOURNAL   Stem Cell Reports 18 (3), 688-705 (2023)
   PUBMED   36764297
  REMARK    GeneRIF: BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits
            neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs
            in senescence-related conditions.
            Erratum:[Stem Cell Reports. 2023 May 9;18(5):1246. doi:
            10.1016/j.stemcr.2023.03.017.. PMID: 37163982]
REFERENCE   6  (bases 1 to 3002)
  AUTHORS   Zhang,Y., Feng,X., We,R. and Derynck,R.
  TITLE     Receptor-associated Mad homologues synergize as effectors of the
            TGF-beta response
  JOURNAL   Nature 383 (6596), 168-172 (1996)
   PUBMED   8774881
REFERENCE   7  (bases 1 to 3002)
  AUTHORS   Lechleider,R.J., de Caestecker,M.P., Dehejia,A.,
            Polymeropoulos,M.H. and Roberts,A.B.
  TITLE     Serine phosphorylation, chromosomal localization, and transforming
            growth factor-beta signal transduction by human bsp-1
  JOURNAL   J Biol Chem 271 (30), 17617-17620 (1996)
   PUBMED   8663601
REFERENCE   8  (bases 1 to 3002)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat Genet 13 (3), 347-349 (1996)
   PUBMED   8673135
REFERENCE   9  (bases 1 to 3002)
  AUTHORS   Liu,F., Hata,A., Baker,J.C., Doody,J., Carcamo,J., Harland,R.M. and
            Massague,J.
  TITLE     A human Mad protein acting as a BMP-regulated transcriptional
            activator
  JOURNAL   Nature 381 (6583), 620-623 (1996)
   PUBMED   8637600
REFERENCE   10 (bases 1 to 3002)
  AUTHORS   Hoodless,P.A., Haerry,T., Abdollah,S., Stapleton,M., O'Connor,M.B.,
            Attisano,L. and Wrana,J.L.
  TITLE     MADR1, a MAD-related protein that functions in BMP2 signaling
            pathways
  JOURNAL   Cell 85 (4), 489-500 (1996)
   PUBMED   8653785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U59423.1, BC001878.1,
            BQ962660.1, BI772689.1, CB956339.1, BI792941.1 and BE644607.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005900.2.
            
            Summary: The protein encoded by this gene belongs to the SMAD, a
            family of proteins similar to the gene products of the Drosophila
            gene 'mothers against decapentaplegic' (Mad) and the C. elegans
            gene Sma. SMAD proteins are signal transducers and transcriptional
            modulators that mediate multiple signaling pathways. This protein
            mediates the signals of the bone morphogenetic proteins (BMPs),
            which are involved in a range of biological activities including
            cell growth, apoptosis, morphogenesis, development and immune
            responses. In response to BMP ligands, this protein can be
            phosphorylated and activated by the BMP receptor kinase. The
            phosphorylated form of this protein forms a complex with SMAD4,
            which is important for its function in the transcription
            regulation. This protein is a target for SMAD-specific E3 ubiquitin
            ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination
            and proteasome-mediated degradation. Alternatively spliced
            transcript variants encoding the same protein have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. All eight variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.193707.1,
                                           SRR1803617.243152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302085.9/ ENSP00000305769.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               U59423.1           71-171
            102-160             BC001878.1         81-139
            161-209             BQ962660.1         107-155
            210-1920            BC001878.1         189-1899
            1921-1943           BI772689.1         427-449
            1944-2431           CB956339.1         204-691
            2432-2566           BI792941.1         437-571             c
            2567-3002           BE644607.1         1-436               c
FEATURES             Location/Qualifiers
     source          1..3002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..3002
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="SMAD family member 1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
     exon            1..186
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..762
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..1760
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="Mad-related protein 1; mothers against DPP homolog
                     1; TGF-beta signaling protein 1; transforming growth
                     factor-beta signaling protein 1; MAD, mothers against
                     decapentaplegic homolog 1; SMAD, mothers against DPP
                     homolog 1"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 1"
                     /protein_id="NP_005891.1"
                     /db_xref="CCDS:CCDS3765.1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
                     /translation="MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKK
                     KGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHE
                     LKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG
                     QNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM
                     PADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLL
                     AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPHNPISSVS"
     exon            763..1020
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1137
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1359
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1616
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..3002
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="hexamer: AATAAA"
     polyA_site      3002
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="major polyA site"
ORIGIN      
        1 agatcaatcc aggctccagg agaaagcagg cgggcgggcg gagaaaggag aggccgagcg
       61 gctcaacccg ggccgaggct cggggagcgg agagtggcgc agcgcccggc cgtccggacc
      121 cgggccgcga gaccccgctc gcccggccac tcgtgctccc acacggacgg gcgcgccgcc
      181 aacccggtgc tgactgggtt acttttttaa acactaggaa tggtaatttc tactcttctg
      241 gacttcaaac taagaagtta aagagacttc tctgtaaata aacaaatctc ttctgctgtc
      301 cttttgcatt tggagacagc tttatttcac catatccaag gagtataact agtgctgtca
      361 ttatgaatgt gacaagttta ttttccttta caagtccagc tgtgaagaga cttcttgggt
      421 ggaaacaggg cgatgaagaa gaaaaatggg cagagaaagc tgttgatgct ttggtgaaaa
      481 aactgaagaa aaagaaaggt gccatggagg aactggaaaa ggccttgagc tgcccagggc
      541 aaccgagtaa ctgtgtcacc attccccgct ctctggatgg caggctgcaa gtctcccacc
      601 ggaagggact gcctcatgtc atttactgcc gtgtgtggcg ctggcccgat cttcagagcc
      661 accatgaact aaaaccactg gaatgctgtg agtttccttt tggttccaag cagaaggagg
      721 tctgcatcaa tccctaccac tataagagag tagaaagccc tgtacttcct cctgtgctgg
      781 ttccaagaca cagcgaatat aatcctcagc acagcctctt agctcagttc cgtaacttag
      841 gacaaaatga gcctcacatg ccactcaacg ccacttttcc agattctttc cagcaaccca
      901 acagccaccc gtttcctcac tctcccaata gcagttaccc aaactctcct gggagcagca
      961 gcagcaccta ccctcactct cccaccagct cagacccagg aagccctttc cagatgccag
     1021 ctgatacgcc cccacctgct tacctgcctc ctgaagaccc catgacccag gatggctctc
     1081 agccgatgga cacaaacatg atggcgcctc ccctgccctc agaaatcaac agaggagatg
     1141 ttcaggcggt tgcttatgag gaaccaaaac actggtgctc tattgtctac tatgagctca
     1201 acaatcgtgt gggtgaagcg ttccatgcct cctccacaag tgtgttggtg gatggtttca
     1261 ctgatccttc caacaataag aaccgtttct gccttgggct gctctccaat gttaaccgga
     1321 attccactat tgaaaacacc aggcggcata ttggaaaagg agttcatctt tattatgttg
     1381 gaggggaggt gtatgccgaa tgccttagtg acagtagcat ctttgtgcaa agtcggaact
     1441 gcaactacca tcatggattt catcctacta ctgtttgcaa gatccctagt gggtgtagtc
     1501 tgaaaatttt taacaaccaa gaatttgctc agttattggc acagtctgtg aaccatggat
     1561 ttgagacagt ctatgagctt acaaaaatgt gtactatacg tatgagcttt gtgaagggct
     1621 ggggagcaga ataccaccgc caggatgtta ctagcacccc ctgctggatt gagatacatc
     1681 tgcacggccc cctccagtgg ctggataaag ttcttactca aatgggttca cctcataatc
     1741 ctatttcatc tgtatcttaa atggccccag gcatctgcct ctggaaaact attgagcctt
     1801 gcatgtactt gaaggatgga tgagtcagac acgattgaga actgacaaag gagccttgat
     1861 aatacttgac ctctgtgacc aactgttgga ttcagaaatt taaacaaaaa aaaaaaaaaa
     1921 cacacacacc ttggtaacat actgttgata tcaagaacct gtttagttta cattgtaaca
     1981 ttctattgta aaatcaacta aaattcagac ttttagcagg actttgtgta cagttaaagg
     2041 agagatggcc aagccaggga caaattgtct attagaaaac ggtcctaaga gattctttgg
     2101 tgtttggcac tttaaggtca tcgttgggca gaagtttagc attaatagtt gttctgaaac
     2161 gtgttttatc aggtttagag cccatgttga gtcttctttt catgggtttt cataatattt
     2221 taaaactatt tgtttagcga tggttttgtt cgtttaagta aaggttaatc ttgatgatat
     2281 acataataat ctttctaaaa ttgtatgctg accatacttg ctgtcagaat aatgctaggc
     2341 atatgctttt tgctaaatat gtatgtacag agtatttgga agttaagaat tgattagact
     2401 agtgaattta ggagtatttg aggtgggtgg ggggaagagg gaaatgacaa ctgcaaatgt
     2461 agactatact gtaaaaattc agtttgttgc tttaaagaaa caaactgata cctgaatttt
     2521 gctgtgtttc cattttttag agatttttat catttttttc tctctcggca ttcttttttc
     2581 tcatactctt caaaaagcag ttctgcagct ggttaattca tgtaactgtg agagcaaatg
     2641 aataattcct gctattctga aattgcctac atgtttcaat accagttata tggagtgctt
     2701 gaatttaata agcagttttt acggagttta cagtacagaa ataggcttta attttcaagt
     2761 gaattttttg ccaaacttag taactctgtt aaatatttgg aggatttaaa gaacatccca
     2821 gtttgaattc atttcaaact ttttaaattt ttttgtacta tgtttggttt tattttcctt
     2881 ctgttaatct tttgtattca cttatgctct cgtacattga gtacttttat tccaaaacta
     2941 gtgggttttc tctactggaa attttcaata aacctgtcat tattgcttac tttgattaaa
     3001 aa
//
