LOCUS       NM_001354817            3188 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SMAD family member 1 (SMAD1), transcript variant 8,
            mRNA.
ACCESSION   NM_001354817
VERSION     NM_001354817.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Que,X., Ren,L., Yang,L., Wang,L., Li,J., Wu,R. and Chen,Q.
  TITLE     Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2
            affects the decidualization in endometriosis patients through the
            SMAD1/5/9 pathway
  JOURNAL   FASEB J 38 (9), e23622 (2024)
   PUBMED   38703029
  REMARK    GeneRIF: Long noncoding RNA BMPR1B-AS1 stability regulated by
            IGF2BP2 affects the decidualization in endometriosis patients
            through the SMAD1/5/9 pathway.
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Wang,L., Li,T., Ma,X., Li,Y., Li,Z., Li,Z., Yu,N., Huang,J., Han,Q.
            and Long,X.
  TITLE     Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis
  JOURNAL   J Dermatol Sci 112 (1), 31-38 (2023)
   PUBMED   37743142
  REMARK    GeneRIF: Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis.
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Chen,W., Hu,J., He,Y., Yu,L., Liu,Y., Cheng,Y., Jia,B., Li,X.,
            Yu,G. and Wang,Y.
  TITLE     The Interaction Between SMAD1 and YAP1 Is Correlated with Increased
            Resistance of Gastric Cancer Cells to Cisplatin
  JOURNAL   Appl Biochem Biotechnol 195 (10), 6050-6067 (2023)
   PUBMED   36418715
  REMARK    GeneRIF: The Interaction Between SMAD1 and YAP1 Is Correlated with
            Increased Resistance of Gastric Cancer Cells to Cisplatin.
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Nakatsu,D., Kunishige,R., Taguchi,Y., Shinozaki-Narikawa,N.,
            Osaka,K., Yokomizo,K., Ishida,M., Takei,S., Yamasaki,S., Hagiya,K.,
            Hattori,K., Tsukamoto,T., Murata,M. and Kano,F.
  TITLE     BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and
            oligodendrogenesis in Alzheimer's patients' iPSCs in
            senescence-related conditions
  JOURNAL   Stem Cell Reports 18 (3), 688-705 (2023)
   PUBMED   36764297
  REMARK    GeneRIF: BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits
            neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs
            in senescence-related conditions.
            Erratum:[Stem Cell Reports. 2023 May 9;18(5):1246. doi:
            10.1016/j.stemcr.2023.03.017.. PMID: 37163982]
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Zhang,Y., Feng,X., We,R. and Derynck,R.
  TITLE     Receptor-associated Mad homologues synergize as effectors of the
            TGF-beta response
  JOURNAL   Nature 383 (6596), 168-172 (1996)
   PUBMED   8774881
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Lechleider,R.J., de Caestecker,M.P., Dehejia,A.,
            Polymeropoulos,M.H. and Roberts,A.B.
  TITLE     Serine phosphorylation, chromosomal localization, and transforming
            growth factor-beta signal transduction by human bsp-1
  JOURNAL   J Biol Chem 271 (30), 17617-17620 (1996)
   PUBMED   8663601
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat Genet 13 (3), 347-349 (1996)
   PUBMED   8673135
REFERENCE   9  (bases 1 to 3188)
  AUTHORS   Liu,F., Hata,A., Baker,J.C., Doody,J., Carcamo,J., Harland,R.M. and
            Massague,J.
  TITLE     A human Mad protein acting as a BMP-regulated transcriptional
            activator
  JOURNAL   Nature 381 (6583), 620-623 (1996)
   PUBMED   8637600
REFERENCE   10 (bases 1 to 3188)
  AUTHORS   Hoodless,P.A., Haerry,T., Abdollah,S., Stapleton,M., O'Connor,M.B.,
            Attisano,L. and Wrana,J.L.
  TITLE     MADR1, a MAD-related protein that functions in BMP2 signaling
            pathways
  JOURNAL   Cell 85 (4), 489-500 (1996)
   PUBMED   8653785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093796.3 and AK293055.1.
            
            Summary: The protein encoded by this gene belongs to the SMAD, a
            family of proteins similar to the gene products of the Drosophila
            gene 'mothers against decapentaplegic' (Mad) and the C. elegans
            gene Sma. SMAD proteins are signal transducers and transcriptional
            modulators that mediate multiple signaling pathways. This protein
            mediates the signals of the bone morphogenetic proteins (BMPs),
            which are involved in a range of biological activities including
            cell growth, apoptosis, morphogenesis, development and immune
            responses. In response to BMP ligands, this protein can be
            phosphorylated and activated by the BMP receptor kinase. The
            phosphorylated form of this protein forms a complex with SMAD4,
            which is important for its function in the transcription
            regulation. This protein is a target for SMAD-specific E3 ubiquitin
            ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination
            and proteasome-mediated degradation. Alternatively spliced
            transcript variants encoding the same protein have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (8) differs in the 5' UTR compared
            to variant 3. All eight variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.20849.1, AK293055.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC093796.3         64861-64866
            7-1944              AK293055.1         1-1938
            1945-3188           AC093796.3         139989-141232
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..3188
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="SMAD family member 1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
     exon            1..372
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..948
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             549..1946
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="Mad-related protein 1; mothers against DPP homolog
                     1; TGF-beta signaling protein 1; transforming growth
                     factor-beta signaling protein 1; MAD, mothers against
                     decapentaplegic homolog 1; SMAD, mothers against DPP
                     homolog 1"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 1"
                     /protein_id="NP_001341746.1"
                     /db_xref="CCDS:CCDS3765.1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
                     /translation="MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKK
                     KGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHE
                     LKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG
                     QNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM
                     PADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLL
                     AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPHNPISSVS"
     exon            949..1206
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1323
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1545
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1802
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..3188
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="hexamer: AATAAA"
     polyA_site      3188
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="major polyA site"
ORIGIN      
        1 cactgcatgt gtattcgtga gttcgcggtt gaacaactgt tcctttactc tgctccctgt
       61 ctttgttagt gtttctcggg gttgtttctg taggaaggtg ggggtggtgg gcgtgagaga
      121 cagatgtggg cttgtttttc tagttgctga aactgtatga aggctttaaa gggagaacgt
      181 tttcttgatg tgctttagga ggggaggagg aacaaatgcc tgccagatct cacagctaca
      241 gtagctgagc ttttgtttat tttgaagagc atgcaatttt taaatacacg gtgcaagata
      301 accagtaaag gcgcgttcct tctgaaaatt gaggccggtc tcagaaccat ctcctgagaa
      361 agcatccttt tcgtgctgac tgggttactt ttttaaacac taggaatggt aatttctact
      421 cttctggact tcaaactaag aagttaaaga gacttctctg taaataaaca aatctcttct
      481 gctgtccttt tgcatttgga gacagcttta tttcaccata tccaaggagt ataactagtg
      541 ctgtcattat gaatgtgaca agtttatttt cctttacaag tccagctgtg aagagacttc
      601 ttgggtggaa acagggcgat gaagaagaaa aatgggcaga gaaagctgtt gatgctttgg
      661 tgaaaaaact gaagaaaaag aaaggtgcca tggaggaact ggaaaaggcc ttgagctgcc
      721 cagggcaacc gagtaactgt gtcaccattc cccgctctct ggatggcagg ctgcaagtct
      781 cccaccggaa gggactgcct catgtcattt actgccgtgt gtggcgctgg cccgatcttc
      841 agagccacca tgaactaaaa ccactggaat gctgtgagtt tccttttggt tccaagcaga
      901 aggaggtctg catcaatccc taccactata agagagtaga aagccctgta cttcctcctg
      961 tgctggttcc aagacacagc gaatataatc ctcagcacag cctcttagct cagttccgta
     1021 acttaggaca aaatgagcct cacatgccac tcaacgccac ttttccagat tctttccagc
     1081 aacccaacag ccacccgttt cctcactctc ccaatagcag ttacccaaac tctcctggga
     1141 gcagcagcag cacctaccct cactctccca ccagctcaga cccaggaagc cctttccaga
     1201 tgccagctga tacgccccca cctgcttacc tgcctcctga agaccccatg acccaggatg
     1261 gctctcagcc gatggacaca aacatgatgg cgcctcccct gccctcagaa atcaacagag
     1321 gagatgttca ggcggttgct tatgaggaac caaaacactg gtgctctatt gtctactatg
     1381 agctcaacaa tcgtgtgggt gaagcgttcc atgcctcctc cacaagtgtg ttggtggatg
     1441 gtttcactga tccttccaac aataagaacc gtttctgcct tgggctgctc tccaatgtta
     1501 accggaattc cactattgaa aacaccaggc ggcatattgg aaaaggagtt catctttatt
     1561 atgttggagg ggaggtgtat gccgaatgcc ttagtgacag tagcatcttt gtgcaaagtc
     1621 ggaactgcaa ctaccatcat ggatttcatc ctactactgt ttgcaagatc cctagtgggt
     1681 gtagtctgaa aatttttaac aaccaagaat ttgctcagtt attggcacag tctgtgaacc
     1741 atggatttga gacagtctat gagcttacaa aaatgtgtac tatacgtatg agctttgtga
     1801 agggctgggg agcagaatac caccgccagg atgttactag caccccctgc tggattgaga
     1861 tacatctgca cggccccctc cagtggctgg ataaagttct tactcaaatg ggttcacctc
     1921 ataatcctat ttcatctgta tcttaaatgg ccccaggcat ctgcctctgg aaaactattg
     1981 agccttgcat gtacttgaag gatggatgag tcagacacga ttgagaactg acaaaggagc
     2041 cttgataata cttgacctct gtgaccaact gttggattca gaaatttaaa caaaaaaaaa
     2101 aaaaaacaca cacaccttgg taacatactg ttgatatcaa gaacctgttt agtttacatt
     2161 gtaacattct attgtaaaat caactaaaat tcagactttt agcaggactt tgtgtacagt
     2221 taaaggagag atggccaagc cagggacaaa ttgtctatta gaaaacggtc ctaagagatt
     2281 ctttggtgtt tggcacttta aggtcatcgt tgggcagaag tttagcatta atagttgttc
     2341 tgaaacgtgt tttatcaggt ttagagccca tgttgagtct tcttttcatg ggttttcata
     2401 atattttaaa actatttgtt tagcgatggt tttgttcgtt taagtaaagg ttaatcttga
     2461 tgatatacat aataatcttt ctaaaattgt atgctgacca tacttgctgt cagaataatg
     2521 ctaggcatat gctttttgct aaatatgtat gtacagagta tttggaagtt aagaattgat
     2581 tagactagtg aatttaggag tatttgaggt gggtgggggg aagagggaaa tgacaactgc
     2641 aaatgtagac tatactgtaa aaattcagtt tgttgcttta aagaaacaaa ctgatacctg
     2701 aattttgctg tgtttccatt ttttagagat ttttatcatt tttttctctc tcggcattct
     2761 tttttctcat actcttcaaa aagcagttct gcagctggtt aattcatgta actgtgagag
     2821 caaatgaata attcctgcta ttctgaaatt gcctacatgt ttcaatacca gttatatgga
     2881 gtgcttgaat ttaataagca gtttttacgg agtttacagt acagaaatag gctttaattt
     2941 tcaagtgaat tttttgccaa acttagtaac tctgttaaat atttggagga tttaaagaac
     3001 atcccagttt gaattcattt caaacttttt aaattttttt gtactatgtt tggttttatt
     3061 ttccttctgt taatcttttg tattcactta tgctctcgta cattgagtac ttttattcca
     3121 aaactagtgg gttttctcta ctggaaattt tcaataaacc tgtcattatt gcttactttg
     3181 attaaaaa
//
