LOCUS       NM_001003688            2880 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens SMAD family member 1 (SMAD1), transcript variant 2,
            mRNA.
ACCESSION   NM_001003688
VERSION     NM_001003688.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2880)
  AUTHORS   Que,X., Ren,L., Yang,L., Wang,L., Li,J., Wu,R. and Chen,Q.
  TITLE     Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2
            affects the decidualization in endometriosis patients through the
            SMAD1/5/9 pathway
  JOURNAL   FASEB J 38 (9), e23622 (2024)
   PUBMED   38703029
  REMARK    GeneRIF: Long noncoding RNA BMPR1B-AS1 stability regulated by
            IGF2BP2 affects the decidualization in endometriosis patients
            through the SMAD1/5/9 pathway.
REFERENCE   2  (bases 1 to 2880)
  AUTHORS   Chen,J., Zhang,Z., Feng,L., Liu,W., Wang,X., Chen,H. and Zou,H.
  TITLE     Lrg1 silencing attenuates ischemia-reperfusion renal injury by
            regulating autophagy and apoptosis through the TGFbeta1- Smad1/5
            signaling pathway
  JOURNAL   Arch Biochem Biophys 753, 109892 (2024)
   PUBMED   38246328
  REMARK    GeneRIF: Lrg1 silencing attenuates ischemia-reperfusion renal
            injury by regulating autophagy and apoptosis through the TGFbeta1-
            Smad1/5 signaling pathway.
REFERENCE   3  (bases 1 to 2880)
  AUTHORS   Wang,L., Li,T., Ma,X., Li,Y., Li,Z., Li,Z., Yu,N., Huang,J., Han,Q.
            and Long,X.
  TITLE     Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis
  JOURNAL   J Dermatol Sci 112 (1), 31-38 (2023)
   PUBMED   37743142
  REMARK    GeneRIF: Exosomes from human adipose-derived mesenchymal stem cells
            attenuate localized scleroderma fibrosis by the
            let-7a-5p/TGF-betaR1/Smad axis.
REFERENCE   4  (bases 1 to 2880)
  AUTHORS   Chen,W., Hu,J., He,Y., Yu,L., Liu,Y., Cheng,Y., Jia,B., Li,X.,
            Yu,G. and Wang,Y.
  TITLE     The Interaction Between SMAD1 and YAP1 Is Correlated with Increased
            Resistance of Gastric Cancer Cells to Cisplatin
  JOURNAL   Appl Biochem Biotechnol 195 (10), 6050-6067 (2023)
   PUBMED   36418715
  REMARK    GeneRIF: The Interaction Between SMAD1 and YAP1 Is Correlated with
            Increased Resistance of Gastric Cancer Cells to Cisplatin.
REFERENCE   5  (bases 1 to 2880)
  AUTHORS   Nakatsu,D., Kunishige,R., Taguchi,Y., Shinozaki-Narikawa,N.,
            Osaka,K., Yokomizo,K., Ishida,M., Takei,S., Yamasaki,S., Hagiya,K.,
            Hattori,K., Tsukamoto,T., Murata,M. and Kano,F.
  TITLE     BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and
            oligodendrogenesis in Alzheimer's patients' iPSCs in
            senescence-related conditions
  JOURNAL   Stem Cell Reports 18 (3), 688-705 (2023)
   PUBMED   36764297
  REMARK    GeneRIF: BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits
            neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs
            in senescence-related conditions.
            Erratum:[Stem Cell Reports. 2023 May 9;18(5):1246. doi:
            10.1016/j.stemcr.2023.03.017.. PMID: 37163982]
REFERENCE   6  (bases 1 to 2880)
  AUTHORS   Zhang,Y., Feng,X., We,R. and Derynck,R.
  TITLE     Receptor-associated Mad homologues synergize as effectors of the
            TGF-beta response
  JOURNAL   Nature 383 (6596), 168-172 (1996)
   PUBMED   8774881
REFERENCE   7  (bases 1 to 2880)
  AUTHORS   Lechleider,R.J., de Caestecker,M.P., Dehejia,A.,
            Polymeropoulos,M.H. and Roberts,A.B.
  TITLE     Serine phosphorylation, chromosomal localization, and transforming
            growth factor-beta signal transduction by human bsp-1
  JOURNAL   J Biol Chem 271 (30), 17617-17620 (1996)
   PUBMED   8663601
REFERENCE   8  (bases 1 to 2880)
  AUTHORS   Riggins,G.J., Thiagalingam,S., Rozenblum,E., Weinstein,C.L.,
            Kern,S.E., Hamilton,S.R., Willson,J.K., Markowitz,S.D.,
            Kinzler,K.W. and Vogelstein,B.
  TITLE     Mad-related genes in the human
  JOURNAL   Nat Genet 13 (3), 347-349 (1996)
   PUBMED   8673135
REFERENCE   9  (bases 1 to 2880)
  AUTHORS   Liu,F., Hata,A., Baker,J.C., Doody,J., Carcamo,J., Harland,R.M. and
            Massague,J.
  TITLE     A human Mad protein acting as a BMP-regulated transcriptional
            activator
  JOURNAL   Nature 381 (6583), 620-623 (1996)
   PUBMED   8637600
REFERENCE   10 (bases 1 to 2880)
  AUTHORS   Hoodless,P.A., Haerry,T., Abdollah,S., Stapleton,M., O'Connor,M.B.,
            Attisano,L. and Wrana,J.L.
  TITLE     MADR1, a MAD-related protein that functions in BMP2 signaling
            pathways
  JOURNAL   Cell 85 (4), 489-500 (1996)
   PUBMED   8653785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U59912.1, BC001878.1,
            BI772689.1, CB956339.1, BI792941.1 and BE644607.1.
            
            Summary: The protein encoded by this gene belongs to the SMAD, a
            family of proteins similar to the gene products of the Drosophila
            gene 'mothers against decapentaplegic' (Mad) and the C. elegans
            gene Sma. SMAD proteins are signal transducers and transcriptional
            modulators that mediate multiple signaling pathways. This protein
            mediates the signals of the bone morphogenetic proteins (BMPs),
            which are involved in a range of biological activities including
            cell growth, apoptosis, morphogenesis, development and immune
            responses. In response to BMP ligands, this protein can be
            phosphorylated and activated by the BMP receptor kinase. The
            phosphorylated form of this protein forms a complex with SMAD4,
            which is important for its function in the transcription
            regulation. This protein is a target for SMAD-specific E3 ubiquitin
            ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination
            and proteasome-mediated degradation. Alternatively spliced
            transcript variants encoding the same protein have been observed.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. All eight variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U54826.1, U59912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2467143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1792              U59912.1           2-1793
            1793-1798           BC001878.1         1894-1899
            1799-1821           BI772689.1         427-449
            1822-2309           CB956339.1         204-691
            2310-2444           BI792941.1         437-571             c
            2445-2880           BE644607.1         1-436               c
FEATURES             Location/Qualifiers
     source          1..2880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..2880
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="SMAD family member 1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
     exon            1..64
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            65..640
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1638
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="Mad-related protein 1; mothers against DPP homolog
                     1; TGF-beta signaling protein 1; transforming growth
                     factor-beta signaling protein 1; MAD, mothers against
                     decapentaplegic homolog 1; SMAD, mothers against DPP
                     homolog 1"
                     /codon_start=1
                     /product="mothers against decapentaplegic homolog 1"
                     /protein_id="NP_001003688.1"
                     /db_xref="CCDS:CCDS3765.1"
                     /db_xref="GeneID:4086"
                     /db_xref="HGNC:HGNC:6767"
                     /db_xref="MIM:601595"
                     /translation="MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKK
                     KGAMEELEKALSCPGQPSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHE
                     LKPLECCEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLG
                     QNEPHMPLNATFPDSFQQPNSHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQM
                     PADTPPPAYLPPEDPMTQDGSQPMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVY
                     YELNNRVGEAFHASSTSVLVDGFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGV
                     HLYYVGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLL
                     AQSVNHGFETVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKV
                     LTQMGSPHNPISSVS"
     exon            641..898
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1015
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1237
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1494
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..2880
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="hexamer: AATAAA"
     polyA_site      2880
                     /gene="SMAD1"
                     /gene_synonym="BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1"
                     /note="major polyA site"
ORIGIN      
        1 cactgcatgt gtattcgtga gttcgcggtt gaacaactgt tcctttactc tgctccctgt
       61 ctttgtgctg actgggttac ttttttaaac actaggaatg gtaatttcta ctcttctgga
      121 cttcaaacta agaagttaaa gagacttctc tgtaaataaa caaatctctt ctgctgtcct
      181 tttgcatttg gagacagctt tatttcacca tatccaagga gtataactag tgctgtcatt
      241 atgaatgtga caagtttatt ttcctttaca agtccagctg tgaagagact tcttgggtgg
      301 aaacagggcg atgaagaaga aaaatgggca gagaaagctg ttgatgcttt ggtgaaaaaa
      361 ctgaagaaaa agaaaggtgc catggaggaa ctggaaaagg ccttgagctg cccagggcaa
      421 ccgagtaact gtgtcaccat tccccgctct ctggatggca ggctgcaagt ctcccaccgg
      481 aagggactgc ctcatgtcat ttactgccgt gtgtggcgct ggcccgatct tcagagccac
      541 catgaactaa aaccactgga atgctgtgag tttccttttg gttccaagca gaaggaggtc
      601 tgcatcaatc cctaccacta taagagagta gaaagccctg tacttcctcc tgtgctggtt
      661 ccaagacaca gcgaatataa tcctcagcac agcctcttag ctcagttccg taacttagga
      721 caaaatgagc ctcacatgcc actcaacgcc acttttccag attctttcca gcaacccaac
      781 agccacccgt ttcctcactc tcccaatagc agttacccaa actctcctgg gagcagcagc
      841 agcacctacc ctcactctcc caccagctca gacccaggaa gccctttcca gatgccagct
      901 gatacgcccc cacctgctta cctgcctcct gaagacccca tgacccagga tggctctcag
      961 ccgatggaca caaacatgat ggcgcctccc ctgccctcag aaatcaacag aggagatgtt
     1021 caggcggttg cttatgagga accaaaacac tggtgctcta ttgtctacta tgagctcaac
     1081 aatcgtgtgg gtgaagcgtt ccatgcctcc tccacaagtg tgttggtgga tggtttcact
     1141 gatccttcca acaataagaa ccgtttctgc cttgggctgc tctccaatgt taaccggaat
     1201 tccactattg aaaacaccag gcggcatatt ggaaaaggag ttcatcttta ttatgttgga
     1261 ggggaggtgt atgccgaatg ccttagtgac agtagcatct ttgtgcaaag tcggaactgc
     1321 aactaccatc atggatttca tcctactact gtttgcaaga tccctagtgg gtgtagtctg
     1381 aaaattttta acaaccaaga atttgctcag ttattggcac agtctgtgaa ccatggattt
     1441 gagacagtct atgagcttac aaaaatgtgt actatacgta tgagctttgt gaagggctgg
     1501 ggagcagaat accaccgcca ggatgttact agcaccccct gctggattga gatacatctg
     1561 cacggccccc tccagtggct ggataaagtt cttactcaaa tgggttcacc tcataatcct
     1621 atttcatctg tatcttaaat ggccccaggc atctgcctct ggaaaactat tgagccttgc
     1681 atgtacttga aggatggatg agtcagacac gattgagaac tgacaaagga gccttgataa
     1741 tacttgacct ctgtgaccaa ctgttggatt cagaaattta aacaaaaaaa aaaaaaaaca
     1801 cacacacctt ggtaacatac tgttgatatc aagaacctgt ttagtttaca ttgtaacatt
     1861 ctattgtaaa atcaactaaa attcagactt ttagcaggac tttgtgtaca gttaaaggag
     1921 agatggccaa gccagggaca aattgtctat tagaaaacgg tcctaagaga ttctttggtg
     1981 tttggcactt taaggtcatc gttgggcaga agtttagcat taatagttgt tctgaaacgt
     2041 gttttatcag gtttagagcc catgttgagt cttcttttca tgggttttca taatatttta
     2101 aaactatttg tttagcgatg gttttgttcg tttaagtaaa ggttaatctt gatgatatac
     2161 ataataatct ttctaaaatt gtatgctgac catacttgct gtcagaataa tgctaggcat
     2221 atgctttttg ctaaatatgt atgtacagag tatttggaag ttaagaattg attagactag
     2281 tgaatttagg agtatttgag gtgggtgggg ggaagaggga aatgacaact gcaaatgtag
     2341 actatactgt aaaaattcag tttgttgctt taaagaaaca aactgatacc tgaattttgc
     2401 tgtgtttcca ttttttagag atttttatca tttttttctc tctcggcatt cttttttctc
     2461 atactcttca aaaagcagtt ctgcagctgg ttaattcatg taactgtgag agcaaatgaa
     2521 taattcctgc tattctgaaa ttgcctacat gtttcaatac cagttatatg gagtgcttga
     2581 atttaataag cagtttttac ggagtttaca gtacagaaat aggctttaat tttcaagtga
     2641 attttttgcc aaacttagta actctgttaa atatttggag gatttaaaga acatcccagt
     2701 ttgaattcat ttcaaacttt ttaaattttt ttgtactatg tttggtttta ttttccttct
     2761 gttaatcttt tgtattcact tatgctctcg tacattgagt acttttattc caaaactagt
     2821 gggttttctc tactggaaat tttcaataaa cctgtcatta ttgcttactt tgattaaaaa
//
