LOCUS       NM_058190                892 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SLX9 ribosome biogenesis factor (SLX9), transcript
            variant 1, mRNA.
ACCESSION   NM_058190
VERSION     NM_058190.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 892)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 892)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 892)
  AUTHORS   Wyler,E., Zimmermann,M., Widmann,B., Gstaiger,M., Pfannstiel,J.,
            Kutay,U. and Zemp,I.
  TITLE     Tandem affinity purification combined with inducible shRNA
            expression as a tool to study the maturation of macromolecular
            assemblies
  JOURNAL   RNA 17 (1), 189-200 (2011)
   PUBMED   21097556
  REMARK    GeneRIF: FAM207A/C21orf70 is a putative trans-acting factor
            involved in biogenesis of the 40S ribosomal subunit.
REFERENCE   4  (bases 1 to 892)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   5  (bases 1 to 892)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 892)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 892)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY097926.1 and BC009341.2.
            
            On Nov 23, 2018 this sequence version replaced NM_058190.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009341.2, BU902128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291634.11/ ENSP00000291634.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                HY097926.1         36-46
            12-892              BC009341.2         1-881
FEATURES             Location/Qualifiers
     source          1..892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..892
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /note="SLX9 ribosome biogenesis factor"
                     /db_xref="GeneID:85395"
                     /db_xref="HGNC:HGNC:15811"
     exon            1..158
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..722
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM207A; family with sequence similarity 207
                     member A; ribosome biogenesis protein SLX9 homolog"
                     /codon_start=1
                     /product="ribosome biogenesis protein SLX9 homolog isoform
                     1"
                     /protein_id="NP_478070.1"
                     /db_xref="CCDS:CCDS13718.1"
                     /db_xref="GeneID:85395"
                     /db_xref="HGNC:HGNC:15811"
                     /translation="MGKVRGLRARVHQAAVRPKGEAAPGPAPPAPEATPPPASAAGKD
                     WAFINTNIFARTKIDPSALVQKLELDVRSVTSVRRGEAGSSARSVPSIRRGAEAKTVL
                     PKKEKMKLRREQWLQKIEAIKLAEQKHREERRRRATVVVGDLHPLRDALPELLGLEAG
                     SRRQARSRESNKPRPSELSRMSAAQRQQLLEEERTRFQELLASPAYRASPLVAIGQTL
                     ARQMQLEDGGQL"
     exon            159..312
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     exon            313..381
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     exon            382..529
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     exon            530..598
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     exon            599..892
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /note="hexamer: AATAAA"
     polyA_site      892
                     /gene="SLX9"
                     /gene_synonym="C21orf70; FAM207A; PRED56"
                     /note="major polyA site"
ORIGIN      
        1 ccgcacgttt gccgtgctcc gccgggaaga tggggaaagt gagggggttg cgcgcccgag
       61 tgcaccaggc tgccgtgagg ccgaaagggg aggccgcccc cggccccgcg ccccctgccc
      121 cggaggcgac ccctccgccg gcctcggccg cggggaagga ctgggcgttc atcaacacca
      181 acatctttgc caggaccaag atagacccca gcgccttggt gcagaagctg gagctggacg
      241 tgaggagtgt cacttccgtc aggagaggtg aggcaggctc gagtgcacgg agcgtccctt
      301 ccatcaggag aggtgcagag gccaagaccg ttttgcccaa gaaggagaaa atgaagctga
      361 ggcgtgagca atggttgcag aaaatcgaag ccataaaact ggctgagcag aagcacaggg
      421 aggagcggag gcggagggcc acggtggtgg tgggggacct gcaccctctc agggatgccc
      481 tgcccgagct gctggggctc gaggctggca gccggcgcca agcccgcagc agggagagca
      541 acaagccccg gccctcagag ctcagccgga tgagcgcagc ccagagacag cagcttctcg
      601 aggaagaaag gacccggttt caggagctgc tggccagtcc ggcctacaga gccagccccc
      661 tggtggccat cgggcagacg ctggcccggc agatgcagct ggaagatggc ggccagctct
      721 gaccagggca gcgggcatgc cacaactcct caggacacat gtgggccaag tagagagcgc
      781 cggcccctca aggaccatgg cctgagcctg gtggacgccc ttccctctgg tcggttgtgg
      841 ggctcaataa atggctctgt gaacttcccc tgcactgcca gggccgttcc ca
//
