LOCUS       NM_001009608            6056 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SLX4 interacting protein (SLX4IP), mRNA.
ACCESSION   NM_001009608 XM_059267
VERSION     NM_001009608.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6056)
  AUTHORS   Mangosh,T.L., Awadallah,W.N., Grabowska,M.M. and Taylor,D.J.
  TITLE     SLX4IP Promotes Telomere Maintenance in Androgen
            Receptor-Independent Castration-Resistant Prostate Cancer through
            ALT-like Telomeric PML Localization
  JOURNAL   Mol Cancer Res 19 (2), 301-316 (2021)
   PUBMED   33188147
  REMARK    GeneRIF: SLX4IP Promotes Telomere Maintenance in Androgen
            Receptor-Independent Castration-Resistant Prostate Cancer through
            ALT-like Telomeric PML Localization.
REFERENCE   2  (bases 1 to 6056)
  AUTHORS   Robinson,N.J., Morrison-Smith,C.D., Gooding,A.J., Schiemann,B.J.,
            Jackson,M.W., Taylor,D.J. and Schiemann,W.P.
  TITLE     SLX4IP and telomere dynamics dictate breast cancer metastasis and
            therapeutic responsiveness
  JOURNAL   Life Sci Alliance 3 (4), e201900427 (2020)
   PUBMED   32071280
  REMARK    GeneRIF: SLX4IP and telomere dynamics dictate breast cancer
            metastasis and therapeutic responsiveness.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6056)
  AUTHORS   Zhang,H., Chen,Z., Ye,Y., Ye,Z., Cao,D., Xiong,Y., Srivastava,M.,
            Feng,X., Tang,M., Wang,C., Tainer,J.A. and Chen,J.
  TITLE     SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand
            crosslink repair
  JOURNAL   Nucleic Acids Res 47 (19), 10181-10201 (2019)
   PUBMED   31495888
  REMARK    GeneRIF: The binding of SLX4IP to both SLX4 and XPF-ERCC1 not only
            is vital for maintaining the stability of SLX4IP protein, but also
            promotes the interaction between SLX4 and XPF-ERCC1, especially
            after DNA damage. Collectively, these results demonstrate a new
            regulatory role for SLX4IP in maintaining an efficient
            SLX4-XPF-ERCC1 complex in interstrand crosslinks (ICLs) repair.
REFERENCE   4  (bases 1 to 6056)
  AUTHORS   Panier,S., Maric,M., Hewitt,G., Mason-Osann,E., Gali,H., Dai,A.,
            Labadorf,A., Guervilly,J.H., Ruis,P., Segura-Bayona,S., Belan,O.,
            Marzec,P., Gaillard,P.L., Flynn,R.L. and Boulton,S.J.
  TITLE     SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance
  JOURNAL   Mol Cell 76 (1), 27-43 (2019)
   PUBMED   31447390
  REMARK    GeneRIF: SLX4IP antagonizes promiscuous BLM Activity during
            alternative lengthening of telomeres maintenance in osteosarcoma
            cells.
REFERENCE   5  (bases 1 to 6056)
  AUTHORS   Meissner,B., Bartram,T., Eckert,C., Trka,J., Panzer-Grumayer,R.,
            Hermanova,I., Ellinghaus,E., Franke,A., Moricke,A., Schrauder,A.,
            Teigler-Schlegel,A., Dorge,P., von Stackelberg,A., Basso,G.,
            Bartram,C.R., Kirschner-Schwabe,R., Bornhauser,B., Bourquin,J.P.,
            Cazzaniga,G., Hauer,J., Attarbaschi,A., Izraeli,S., Zaliova,M.,
            Cario,G., Zimmermann,M., Avigad,S., Sokalska-Duhme,M., Metzler,M.,
            Schrappe,M., Koehler,R., Te Kronnie,G. and Stanulla,M.
  TITLE     Frequent and sex-biased deletion of SLX4IP by illegitimate
            V(D)J-mediated recombination in childhood acute lymphoblastic
            leukemia
  JOURNAL   Hum Mol Genet 23 (3), 590-601 (2014)
   PUBMED   24045615
  REMARK    GeneRIF: The association of SLX4IP deletion with male sex suggest
            that differential illegitimate V(D)J-mediated recombination events
            contribute to the higher incidence rates of childhood acute
            lymphoblastic leukemia in boys compared with girls.
REFERENCE   6  (bases 1 to 6056)
  AUTHORS   Svendsen,J.M., Smogorzewska,A., Sowa,M.E., O'Connell,B.C.,
            Gygi,S.P., Elledge,S.J. and Harper,J.W.
  TITLE     Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and
            is required for DNA repair
  JOURNAL   Cell 138 (1), 63-77 (2009)
   PUBMED   19596235
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC026094.1, AL035456.26 and CA416447.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001009608.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020787.1, SRR5189661.147636.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2163623
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334534.10/ ENSP00000335557.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1374              BC026094.1         7-1380
            1375-5765           AL035456.26        14908-19298
            5766-6056           CA416447.1         21-311              c
FEATURES             Location/Qualifiers
     source          1..6056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.2"
     gene            1..6056
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /note="SLX4 interacting protein"
                     /db_xref="GeneID:128710"
                     /db_xref="HGNC:HGNC:16225"
                     /db_xref="MIM:615958"
     exon            1..149
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            150..205
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1405
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /codon_start=1
                     /product="protein SLX4IP"
                     /protein_id="NP_001009608.1"
                     /db_xref="CCDS:CCDS33439.1"
                     /db_xref="GeneID:128710"
                     /db_xref="HGNC:HGNC:16225"
                     /db_xref="MIM:615958"
                     /translation="MASKKFAVKCGNFAVLVDLHILPQGSNKDTSWFSEQKKEEVCLL
                     LKETIDSRVQEYLEVRKQHRPSNAEFTRSNPLSLKGYGFQITAYFLKRGIRLRCIRST
                     QNAELCVFPDRFVVCVSQLAFSRDLLASQNEDLTERVLHGVSDYFAECAESSLPPSAK
                     LRRNALKEIVKRTETKSSVTSKSQTRRDTVETSSDSVIAEIARRRNDGQASSSPPSES
                     MGQAKDSIKAAESHWGLPVQKLEKVNQTQPEDTSGQQKPHPGERLKTGLLSRSPVCSC
                     ESASPCPKQSPRVAKTQQKRRNCSSAEDFDHHGRVSLGSDRLVPREIIVEKSKAVRVL
                     PASELSDPGLLLKQDLAKTTSKEELHVLESLSSRHLMKNNPGQAQQTGLATNTERLST
                     IQNSPTKKRKKYERGH"
     exon            206..295
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            296..416
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            417..494
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            495..583
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..684
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..6056
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6037..6042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /note="hexamer: AGTAAA"
     polyA_site      6056
                     /gene="SLX4IP"
                     /gene_synonym="bA204H22.1; bA254M13.1; C20orf94;
                     dJ1099D15.3"
                     /note="major polyA site"
ORIGIN      
        1 gaaagtgctt cccttaagct tctgaaggtt ggctgcagtt ccggctacct gtgtagtccg
       61 agtttccaca gccaggtact actccgccag tgaccctgga cagtaacaaa acatataaag
      121 cccgagccca aaccccgcca ccatcatagg tctgtagtta ctgtggaatc aataagccat
      181 ggcatctaag aaatttgctg ttaaatgtgg gaattttgct gtcctcgtgg atcttcatat
      241 cttgccacaa ggttcaaaca aagatacaag ctggttttct gaacagaaga aagaggaagt
      301 ctgtttactg ttaaaagaaa ccattgattc aagagttcag gagtacttgg aagttcgcaa
      361 acagcacagg ccatcaaatg cagaattcac aagatccaat cccttgtcct taaaaggtta
      421 tggctttcaa atcacagcct atttcctcaa gagagggata cgccttcgct gcatcaggag
      481 cacacagaat gctgaactct gtgtattccc tgacagattt gtggtttgtg tcagtcagct
      541 tgcattcagt cgtgatcttt tagcaagtca gaatgaagat ttgacagaaa gagttctcca
      601 tggagtgtct gattactttg ctgagtgtgc agagagttca cttcctccca gtgcaaagct
      661 ccggagaaat gctctgaaag aaattgtgaa aagaactgaa acaaaaagca gtgtcacgag
      721 caaatcgcag accagaagag acactgtgga aacatctagt gactcagtga ttgcagagat
      781 agcaaggagg aggaatgatg gtcaggcttc ctccagtccc ccatcagaat ccatgggaca
      841 agcaaaggat tccataaagg cagctgagag ccactggggg cttcctgttc aaaagctgga
      901 aaaagttaat cagacccagc cagaagacac tagtggccag caaaaacctc atcctgggga
      961 gcggttaaag acagggcttc taagcaggag ccccgtctgt agctgtgagt cagcatcacc
     1021 atgtccaaaa caaagtccac gagtggccaa aacccaacag aaacgcagga actgcagctc
     1081 tgcggaagac ttcgaccacc acgggagagt ttctcttgga agtgatcgat tagtcccgag
     1141 agaaataata gtggaaaaaa gcaaagctgt cagggttttg ccagcttcag agttgtcaga
     1201 tccagggtta cttttgaaac aagatttggc aaaaaccacg tctaaggaag agttgcatgt
     1261 tttggaaagt ctctcctcca gacatcttat gaaaaataac ccagggcagg cacagcaaac
     1321 cggcttagcc acaaacactg aaagattatc tacaattcag aacagcccaa ccaagaaaag
     1381 aaagaaatac gaaagaggcc attaacaccg aagaggtttg taccgttgga gttgaggaca
     1441 tagtggccaa acctgtgaca agagagctgc gaatatagat gccgggattt taaaggaatt
     1501 aattagaatg actaatttaa ataggaagtg tgttatctgt gttatggcta tggtttgttt
     1561 tcaaagcatt tcaaaccggg aggctatatg cttgttctaa cagcgttgct tctttatcat
     1621 tgtattttat gactgtcttc agagaattag taatgacaaa gagccatcca ccttgtcagg
     1681 gaggagactg tgcaaggact gcatgaagaa actgatcatg agccccttct tggcacatca
     1741 ctgtgcagac cacacaatgg accgtgcaaa gacagtgctg ccgtgctgcc tttcagctcc
     1801 aggggtacaa tccatccccc tgctcctcag cctgagtagg agggcagtga aagaacaagc
     1861 tagtggttct tagcgcgtgg tcctgggacc agcttcgttg tctggaaatg tgctagaaat
     1921 gtggttattg ggccctgccc catgctgagt aactgccttt gggtgattct gaaacatgct
     1981 cgcgtttgag aaccactgga ctaatagaac actccccagt gcttcctgca gcctggttgc
     2041 catggcctcc agctcaccag ttggggccag atgtgcacat gcatcccctc ggactccctc
     2101 aaactcgtaa aacacttggg tttggtgtat gggtcactct cttccgggtt ctacagtatg
     2161 gcagccatgg cacccatgaa ggtgttactt tcccttataa ttgttgaagt cgatgggcga
     2221 ttctgcccaa ccttaggaga agacatcaga gaggctcgtt gttgcctgta gctcaagcat
     2281 gtcccagtcc ctgctcttgc acccacctcc aggattttgg tttgggacag actataacct
     2341 aacaggaact cagtgaccag gttccagttt cccagttgga aggcttcgca ggcagttcaa
     2401 atttcaagat gggagccttc cctttacaat gtcacccact gtctccagtg ggcttgatga
     2461 aatgtcacat agtgaattgt agcaatgact tattttggat ggacacccgc taaaagtttc
     2521 caataaccga atttcactct aaaagaggaa agaaacaata ttcaaggtcc attcattcaa
     2581 tacatctttt ttttttttct gttcaacatg gggtggtcct ttgaaatggc acctccccta
     2641 agtaataagg aaaaccaagt atattcccta aagtgttgaa gttagcagaa aaatcaccca
     2701 gaaaagccca aaacaatgac aagagtacag aaacaggcat agtgtaggtt catgcttgag
     2761 atggattagt ggtttattcc atcccgttct atcctttccc gtatctcctg tccccacttg
     2821 ttaagaccag taagactcat gaagcagcag ctatatttca tggcaccatt ttgggtcatg
     2881 aaattccatc ttggtcacca agcctgactg tggtggtaga tactgttact ttaatgttcc
     2941 aaaccctgcc tagaaacctg ttcctgtccc atgatcccag cctcaccacc cccacttgaa
     3001 acagcccttc ctactggtat cctgtcctct tccctcttgg cttttttcct gctcccagcg
     3061 gaacccagtc aggggattct ataggagaag agggagccca acagaatact aacttcagtg
     3121 gagctgactc tgcttataca ataggggtgg gctgcacaga gtggaaaccg agtacctggt
     3181 agaatgtgca tttccatggc ccactgtagg cgcctctctt agagcaaaca gtattttagg
     3241 tgtgctcttt attgaacaca ggaccacagt gtgtcactga atcttcttaa acagaagcaa
     3301 ttagaacgat ttagatatag ggagggcaca agtaataagt aacccagggg atagaccaag
     3361 aagcagctct ctggaagagt ctggaattaa aaagacggct gtactagaac agtagccact
     3421 gcctgctcca gaactagggg ggagatattt gagctggagc caccagagaa catttctatt
     3481 gagaagtttt tatttgtttg ttctgttggt tttttgttat ttctgttttc ttctaatctt
     3541 tctctgaagt atcactctgg tattgagaaa tttttatttc attagctaac ctgggcttgg
     3601 tggttaaggc tagtacttgt acttagaatg attctctgtc aggaaaagtc ttggctttag
     3661 agtttgttat agttggggat ataacaatta ctgtgatcga agagaaaaaa tagcaccttt
     3721 ggttgtagat agatgtagtt ttcctcacag ccctcacgtc ccttcatgta aaagggattt
     3781 taacaggatt tacagaggga atggctctca gttcccacac tgtgacatgt gtttgaggaa
     3841 ttttgccttt aagcattttt cttgcacatg gctgaaacac ccctggctct cttgttattt
     3901 gagtggttgc atgattcttt ggatatttgg aagtacaaag gggtaaatgg atgccagggg
     3961 ttttttgttg ttgttgctta ttaggtagga tatgaagagt tctcactgtt gggaatggta
     4021 tgtgttttga cattcttttt tttttttttt ttttttttga gacagagtct cgctctgtcg
     4081 cccaggctgg agtgcagtgg ggcgatcttg gctcactgca agctccgcct cctgggttca
     4141 cgtcattctc ctgtctcagc ctcctgagta gctgggacta cagacgctcg ccaccacgcc
     4201 cggctaattt tttgtatttt tttttttttt tttttttttt tagcagaaac gggttttcac
     4261 cgtgttggcc agggtggtct cgatctcctg actcgtgatc cgcccgcctc ggcctcccaa
     4321 agtgctggga ttacaggtga gagccaccgc acccggcctg ttttgacatt cttaatgatc
     4381 ttaataattt ggcatctgaa agtctgaaac agtgtcagta ttgttagtca aaaagaacaa
     4441 gttcttcaac cacttgcgta gtaccccaaa ttatattcaa gtccctgtga ctccaatgct
     4501 tggagaagtc attgatatga tttgattaat gttataactt tgaatttcct aactttctca
     4561 gcggcataga ttctaagcca cttccatgtg ctttcagatg gcatcttaat agattggtgt
     4621 tgaggttatt ttaatgtcca taaacaagaa aggtctggga acaatctgta tgatttttct
     4681 ttcacatttt cttatctttg ccactggagg ttaactgtcg tccagatatg catatgaatt
     4741 gtgaaatgca aagaagcaaa catttggggg taggggagta agtgctgtag ttcttttgtt
     4801 cacttatttt aatactatag aagtgtattt cattttataa aaagcaagaa tcataaaaac
     4861 cctctgtatt ttgatttatg aagaatatag cttctctctg aagtatctca agatatatct
     4921 tggggaccac aatgggatca cagtgtaatt gtttgctgtt ggtgtcatgt ttggatttta
     4981 gcatggtttg ttatgcatgt cagtggcctc tgatttcaga aagagcttgg cgagggcaga
     5041 acacataagg gaaggaaacc tctgctcaag agagtggcct gggatcacag tgtcgtcatt
     5101 cccaatttcc ttgaattcct tcttggcaga ccttactgta atattacaca aaactgtaat
     5161 gagtggccct cctttggagg taacagatgc ctttcctaag aactcaaagt tctcttttca
     5221 gcgtgctgtg acttgaatat ggaaatcatt ttaatttctt cttttctctt atggggaaat
     5281 ttccatgctt ggtttgtcaa gacaagagaa ttcattcctt attattgaaa cattaatgaa
     5341 ctgaaacacg ttgaagcaag taaaaaatca aaattaggtt ggtttatctt aaatagttaa
     5401 aagccttcct tagtacaaaa taaattaagc attgtaaaac gaagttaatt caggtaatta
     5461 ctcagtacag aaatctaacc gtatatatca ttggtattgc aatttaaggg tataattaaa
     5521 ttctcagaaa tctgcaggac tcactctaat ttgctttcta tatttattta caagacaggg
     5581 aacaaatatg tgtcaatgtg cagcttaaca gaggggactt gaatggataa aattatcttt
     5641 aattatctag agctacccag tactgggctt gaatttaatc atagtcaaat gtttcctctg
     5701 gcagcataat attaccatac accatattac cttataattg ccattacagt tccttatcaa
     5761 aaatgttaat tctttgcttg agcaaaaatc aataaaacct tatgtttgac cctaaagtat
     5821 ttgatcaggg aacagaaggt gtgaattgga cagatccccc gaataacttt cttcaatcaa
     5881 gttgaaaaac caaacagcta tgtaagtccc caggagagct ctttttccct tatcttctca
     5941 tttgttttgt tataaactgt ttaaatagtt caaatggttg tgcatgccta ggggatgaaa
     6001 cctatgtaat agaaatgtac tgttttatga ataaggagta aaattgtttt aaaaaa
//
