LOCUS       NM_001014999            1133 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SLX1 homolog A, structure-specific endonuclease
            subunit (SLX1A), transcript variant 1, mRNA.
ACCESSION   NM_001014999
VERSION     NM_001014999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Garribba,L., Bjerregaard,V.A., Goncalves Dinis,M.M., Ozer,O.,
            Wu,W., Sakellariou,D., Pena-Diaz,J., Hickson,I.D. and Liu,Y.
  TITLE     Folate stress induces SLX1- and RAD51-dependent mitotic DNA
            synthesis at the fragile X locus in human cells
  JOURNAL   Proc Natl Acad Sci U S A 117 (28), 16527-16536 (2020)
   PUBMED   32601218
  REMARK    GeneRIF: Folate stress induces SLX1- and RAD51-dependent mitotic
            DNA synthesis at the fragile X locus in human cells.
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Zhou,X., DeLucia,M. and Ahn,J.
  TITLE     SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein
            by HIV-1 Viral Protein R (Vpr)
  JOURNAL   J Biol Chem 291 (33), 16936-16947 (2016)
   PUBMED   27354282
  REMARK    GeneRIF: SLX4-SLX1 Protein-independent Down-regulation of
            MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).
REFERENCE   3  (bases 1 to 1133)
  AUTHORS   Wyatt,H.D., Sarbajna,S., Matos,J. and West,S.C.
  TITLE     Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday
            junction resolution in human cells
  JOURNAL   Mol Cell 52 (2), 234-247 (2013)
   PUBMED   24076221
  REMARK    GeneRIF: Data show that three structure-selective endonucleases,
            SLX1-SLX4, MUS81-EME1, and GEN1, define two pathways of Holliday
            junctions (HJs) resolution in HeLa cells.
REFERENCE   4  (bases 1 to 1133)
  AUTHORS   Wan,B., Yin,J., Horvath,K., Sarkar,J., Chen,Y., Wu,J., Wan,K.,
            Lu,J., Gu,P., Yu,E.Y., Lue,N.F., Chang,S., Liu,Y. and Lei,M.
  TITLE     SLX4 assembles a telomere maintenance toolkit by bridging multiple
            endonucleases with telomeres
  JOURNAL   Cell Rep 4 (5), 861-869 (2013)
   PUBMED   24012755
REFERENCE   5  (bases 1 to 1133)
  AUTHORS   Fekairi,S., Scaglione,S., Chahwan,C., Taylor,E.R., Tissier,A.,
            Coulon,S., Dong,M.Q., Ruse,C., Yates,J.R. 3rd, Russell,P.,
            Fuchs,R.P., McGowan,C.H. and Gaillard,P.H.L.
  TITLE     Human SLX4 is a Holliday junction resolvase subunit that binds
            multiple DNA repair/recombination endonucleases
  JOURNAL   Cell 138 (1), 78-89 (2009)
   PUBMED   19596236
REFERENCE   6  (bases 1 to 1133)
  AUTHORS   Svendsen,J.M., Smogorzewska,A., Sowa,M.E., O'Connell,B.C.,
            Gygi,S.P., Elledge,S.J. and Harper,J.W.
  TITLE     Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and
            is required for DNA repair
  JOURNAL   Cell 138 (1), 63-77 (2009)
   PUBMED   19596235
REFERENCE   7  (bases 1 to 1133)
  AUTHORS   Andersen,S.L., Bergstralh,D.T., Kohl,K.P., LaRocque,J.R.,
            Moore,C.B. and Sekelsky,J.
  TITLE     Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with
            DNA structure-specific endonucleases in DNA repair and
            recombination
  JOURNAL   Mol Cell 35 (1), 128-135 (2009)
   PUBMED   19595722
REFERENCE   8  (bases 1 to 1133)
  AUTHORS   Munoz,I.M., Hain,K., Declais,A.C., Gardiner,M., Toh,G.W.,
            Sanchez-Pulido,L., Heuckmann,J.M., Toth,R., Macartney,T.,
            Eppink,B., Kanaar,R., Ponting,C.P., Lilley,D.M. and Rouse,J.
  TITLE     Coordination of structure-specific nucleases by human SLX4/BTBD12
            is required for DNA repair
  JOURNAL   Mol Cell 35 (1), 116-127 (2009)
   PUBMED   19595721
REFERENCE   9  (bases 1 to 1133)
  AUTHORS   Hildebrandt,M.A., Salavaggione,O.E., Martin,Y.N., Flynn,H.C.,
            Jalal,S., Wieben,E.D. and Weinshilboum,R.M.
  TITLE     Human SULT1A3 pharmacogenetics: gene duplication and functional
            genomic studies
  JOURNAL   Biochem Biophys Res Commun 321 (4), 870-878 (2004)
   PUBMED   15358107
REFERENCE   10 (bases 1 to 1133)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI757439.1, CD673028.1,
            BC144462.1 and AI885276.1.
            
            On Nov 27, 2019 this sequence version replaced NM_001014999.2.
            
            Summary: This gene encodes a protein that is an important regulator
            of genome stability. The protein represents the catalytic subunit
            of the SLX1-SLX4 structure-specific endonuclease, which can resolve
            DNA secondary structures that are formed during repair and
            recombination processes. Two identical copies of this gene are
            located on the p arm of chromosome 16 due to a segmental
            duplication; this record represents the more centromeric copy.
            Alternative splicing results in multiple transcript variants.
            Read-through transcription also occurs between this gene and the
            downstream SULT1A3 (sulfotransferase family, cytosolic, 1A,
            phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ066696.1, AL523681.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251303.11/ ENSP00000251303.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               BI757439.1         34-216
            184-829             CD673028.1         1-646
            830-1088            BC144462.1         465-723
            1089-1133           AI885276.1         8-52                c
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1133
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /note="SLX1 homolog A, structure-specific endonuclease
                     subunit"
                     /db_xref="GeneID:548593"
                     /db_xref="HGNC:HGNC:20922"
                     /db_xref="MIM:615822"
     exon            1..398
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1038
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GIY-YIG domain-containing protein 1; SLX1
                     structure-specific endonuclease subunit homolog A"
                     /codon_start=1
                     /product="structure-specific endonuclease subunit SLX1
                     isoform 1"
                     /protein_id="NP_001014999.1"
                     /db_xref="CCDS:CCDS32431.1"
                     /db_xref="GeneID:548593"
                     /db_xref="HGNC:HGNC:20922"
                     /db_xref="MIM:615822"
                     /translation="MGPAGVAARPGRFFGVYLLYCLNPRYRGRVYVGFTVNTARRVQQ
                     HNGGRKKGGAWRTSGRGPWEMVLVVHGFPSSVAALRFEWAWQHPHASRRLAHVGPRLR
                     GETAFAFHLRVLAHMLRAPPWARLPLTLRWVRPDLRQDLCLPPPPHVPLAFGPPPPQA
                     PAPRRRAGPFDDAEPEPDQGDPGACCSLCAQTIQDEEGPLCCPHPGCLLRAHVICLAE
                     EFLQEEPGQLLPLEGQCPCCEKSLLWGDLIWLCQMDTEKEVEDSELEEAHWTDLLET"
     exon            399..450
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..792
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..920
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1008
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1133
                     /gene="SLX1A"
                     /gene_synonym="GIYD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctggctt ccgcggtcgg acttctacac ccgcctccag acaggagagg ggcacgtacc
       61 ggcgctacgg cttcctgcag gctgcctccg gatagtcccc gagagcttgt tccgaagcaa
      121 gcaccctgca gccctagcga tccagccctc ccctggaccc taggtcacgg caatcaaccc
      181 cctgctgtgg ttcccgaacc ccaaggcccg atgggtcccg cgggggtcgc ggcgaggcca
      241 gggcgctttt tcggcgtcta cctgctctac tgcctgaacc cccggtaccg gggccgcgtc
      301 tacgtggggt tcactgtcaa cactgctcgt cgggtccagc agcacaatgg gggccgcaaa
      361 aaaggcgggg cctggcggac cagcgggcga gggccctggg agatggtgct cgtcgtgcac
      421 ggcttcccgt cctccgtggc cgcccttcgg tttgagtggg cttggcagca cccgcacgcc
      481 tcgcgccgcc tggcgcacgt ggggcctcgc ctgcgaggag agacagcctt cgctttccac
      541 ctgcgcgtgc tggcgcacat gctgcgcgca ccgccctggg ctcgcctccc gctcacgctg
      601 cgctgggtgc gcccagacct ccgccaggac ctctgcctcc cgccgccgcc gcacgtgcct
      661 ctggccttcg ggcctccacc gccccaggcc ccggccccaa ggcgccgcgc aggtcccttt
      721 gatgacgcgg agcctgagcc agaccagggg gatccagggg cctgctgctc cctgtgcgcc
      781 cagaccatcc aggatgaaga ggggcccttg tgttgccccc accctggctg cctgctaagg
      841 gcccatgtga tctgcctggc agaggagttt cttcaggaag aaccagggca gcttctgccc
      901 ctagagggcc aatgcccttg ctgtgagaag tcactgcttt ggggagacct gatctggctg
      961 tgccagatgg acactgagaa agaagtagaa gactcagaat tagaagaggc acactggaca
     1021 gacctgctgg agacctgatc ctcagtgtcc ttaccccctc ctacctcttt tctgtgccac
     1081 ctgctgtggg tccagcaggt ttttacttga gtacaataaa aagtctgagt caa
//
