LOCUS       NM_177458                583 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens secreted LY6/PLAUR domain containing 2 (SLURP2),
            transcript variant 1, mRNA.
ACCESSION   NM_177458
VERSION     NM_177458.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 583)
  AUTHORS   Lyukmanova,E.N., Bychkov,M.L., Sharonov,G.V., Efremenko,A.V.,
            Shulepko,M.A., Kulbatskii,D.S., Shenkarev,Z.O., Feofanov,A.V.,
            Dolgikh,D.A. and Kirpichnikov,M.P.
  TITLE     Human secreted proteins SLURP-1 and SLURP-2 control the growth of
            epithelial cancer cells via interactions with nicotinic
            acetylcholine receptors
  JOURNAL   Br J Pharmacol 175 (11), 1973-1986 (2018)
   PUBMED   29505672
  REMARK    GeneRIF: SLURPs inhibit growth of epithelial cancer cells in vitro
            and merit further investigation as potential agents for anticancer
            therapy
REFERENCE   2  (bases 1 to 583)
  AUTHORS   Lyukmanova,E.N., Shulepko,M.A., Shenkarev,Z.O., Bychkov,M.L.,
            Paramonov,A.S., Chugunov,A.O., Kulbatskii,D.S., Arvaniti,M.,
            Dolejsi,E., Schaer,T., Arseniev,A.S., Efremov,R.G., Thomsen,M.S.,
            Dolezal,V., Bertrand,D., Dolgikh,D.A. and Kirpichnikov,M.P.
  TITLE     Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and
            Pharmacology of Interactions with Different Types of Acetylcholine
            Receptors
  JOURNAL   Sci Rep 6, 30698 (2016)
   PUBMED   27485575
  REMARK    GeneRIF: Computer modeling revealed possible SLURP-2 binding to the
            'classical' orthosteric agonist/antagonist binding sites at alpha7
            and alpha3beta2-nAChRs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 583)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 583)
  AUTHORS   Moriwaki,Y., Takada,K., Tsuji,S., Kawashima,K. and Misawa,H.
  TITLE     Transcriptional regulation of SLURP2, a psoriasis-associated gene,
            is under control of IL-22 in the skin: A special reference to the
            nested gene LYNX1
  JOURNAL   Int Immunopharmacol 29 (1), 71-75 (2015)
   PUBMED   26033490
REFERENCE   5  (bases 1 to 583)
  AUTHORS   Chernyavsky,A.I., Galitovskiy,V., Shchepotin,I.B. and Grando,S.A.
  TITLE     Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and
            SLURP-2 on human intestinal epithelial cells and immunocytes
  JOURNAL   Biomed Res Int 2014, 609086 (2014)
   PUBMED   24877120
REFERENCE   6  (bases 1 to 583)
  AUTHORS   Arredondo,J., Chernyavsky,A.I. and Grando,S.A.
  TITLE     Overexpression of SLURP-1 and -2 alleviates the tumorigenic action
            of tobacco-derived nitrosamine on immortalized oral epithelial
            cells
  JOURNAL   Biochem Pharmacol 74 (8), 1315-1319 (2007)
   PUBMED   17643396
REFERENCE   7  (bases 1 to 583)
  AUTHORS   Arredondo,J., Chernyavsky,A.I., Jolkovsky,D.L., Webber,R.J. and
            Grando,S.A.
  TITLE     SLURP-2: A novel cholinergic signaling peptide in human
            mucocutaneous epithelium
  JOURNAL   J Cell Physiol 208 (1), 238-245 (2006)
   PUBMED   16575903
REFERENCE   8  (bases 1 to 583)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   9  (bases 1 to 583)
  AUTHORS   Tsuji,H., Okamoto,K., Matsuzaka,Y., Iizuka,H., Tamiya,G. and
            Inoko,H.
  TITLE     SLURP-2, a novel member of the human Ly-6 superfamily that is
            up-regulated in psoriasis vulgaris
  JOURNAL   Genomics 81 (1), 26-33 (2003)
   PUBMED   12573258
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB081838.1, AC083841.9 and
            AY358417.1.
            
            On Nov 23, 2018 this sequence version replaced NM_177458.2.
            
            Summary: This gene encodes a novel, secreted member of the Ly6/uPAR
            (LU) superfamily of proteins containing the unique three-finger LU
            domain. This gene is mainly expressed in epithelial cells,
            including skin and keratinocytes, and is up-regulated in psoriatic
            skin lesions, suggesting its involvement in the pathophysiology of
            psoriasis. Alternatively spliced transcript variants have been
            found for this gene. Read-through transcription from the
            neighboring upstream gene (LYNX1) generates naturally-occurring
            transcripts (LYNX1-SLURP2) that encode a fusion protein comprised
            of sequence sharing identity with each individual gene product.
            [provided by RefSeq, Sep 2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB081838.1, AY358417.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317543.12/ ENSP00000319846.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AB081838.1         1-385
            386-389             AC083841.9         123294-123297
            390-583             AY358417.1         406-599
FEATURES             Location/Qualifiers
     source          1..583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..583
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /note="secreted LY6/PLAUR domain containing 2"
                     /db_xref="GeneID:432355"
                     /db_xref="HGNC:HGNC:25549"
     exon            1..74
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..316
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secreted Ly6/uPAR related protein 2; secreted
                     Ly-6/uPAR-related protein 2; secreted LY6/PLAUR
                     domain-containing protein 2; secreted Ly-6/uPAR
                     domain-containing protein 2"
                     /codon_start=1
                     /product="secreted Ly-6/uPAR domain-containing protein 2
                     isoform 1 precursor"
                     /protein_id="NP_803253.1"
                     /db_xref="CCDS:CCDS34952.1"
                     /db_xref="GeneID:432355"
                     /db_xref="HGNC:HGNC:25549"
                     /translation="MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDS
                     THCVTTATRVLSNTEDLPLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNHD"
     exon            75..179
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..583
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      554..559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /note="hexamer: AATAAA"
     polyA_site      583
                     /gene="SLURP2"
                     /gene_synonym="SLURP-2"
                     /note="major polyA site"
ORIGIN      
        1 agcccgacct caccaggaga acatgcagct cggcactggg ctcctgctgg ccgccgtcct
       61 gagcctgcag ctggctgcag ccgaagccat atggtgtcac cagtgcacgg gcttcggagg
      121 gtgctcccat ggatccagat gcctgaggga ctccacccac tgtgtcacca ctgccacccg
      181 ggtcctcagc aacaccgagg atttgcctct ggtcaccaag atgtgccaca taggctgccc
      241 cgatatcccc agcctgggcc tgggccccta cgtatccatc gcttgctgcc agaccagcct
      301 ctgcaaccat gactgacggc tgccctcctc caggcccccg gacgctcagc ccccacagcc
      361 cccacagcct ggcgccaggg ctcacagctg cccctccctc gagactggcc agcccacctc
      421 tcccggcctc tgcagccacc gtccagcacc gcttgtccta gggaagtcct gcgtggagtc
      481 ttgcctcaat ctgctgccgt ccaagcctgg ggcccatcgt gcctgccgcc ccttcaggtc
      541 ccgacctccc cacaataaaa tgtgattgga tcgtgtggta caa
//
