LOCUS       NM_020427                527 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens secreted LY6/PLAUR domain containing 1 (SLURP1), mRNA.
ACCESSION   NM_020427
VERSION     NM_020427.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 527)
  AUTHORS   Wang,T., Tang,Z., Xiao,T., Ren,J., He,S., Liu,Y., Xiao,S. and
            Wang,X.
  TITLE     Identification of a novel compound heterozygous mutation and a
            homozygous mutation of SLURP1 in Chinese families with Mal de
            Meleda
  JOURNAL   BMC Med Genomics 16 (1), 152 (2023)
   PUBMED   37393290
  REMARK    GeneRIF: Identification of a novel compound heterozygous mutation
            and a homozygous mutation of SLURP1 in Chinese families with Mal de
            Meleda.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 527)
  AUTHORS   He,X., Wang,L., Liu,L., Gao,J., Long,B., Chi,F., Hu,T., Wan,Y.,
            Gong,Z., Li,L., Zhen,P., Zhang,T., Cao,H. and Huang,S.H.
  TITLE     Endogenous alpha7 nAChR Agonist SLURP1 Facilitates Escherichia coli
            K1 Crossing the Blood-Brain Barrier
  JOURNAL   Front Immunol 12, 745854 (2021)
   PUBMED   34721415
  REMARK    GeneRIF: Endogenous alpha7 nAChR Agonist SLURP1 Facilitates
            Escherichia coli K1 Crossing the Blood-Brain Barrier.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 527)
  AUTHORS   Shulepko,M.A., Bychkov,M.L., Shenkarev,Z.O., Kulbatskii,D.S.,
            Makhonin,A.M., Paramonov,A.S., Chugunov,A.O., Kirpichnikov,M.P. and
            Lyukmanova,E.N.
  TITLE     Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants
            Differently Affect Keratinocyte Proliferation and Apoptosis
  JOURNAL   J Invest Dermatol 141 (9), 2229-2237 (2021)
   PUBMED   33741389
  REMARK    GeneRIF: Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1
            Mutants Differently Affect Keratinocyte Proliferation and
            Apoptosis.
REFERENCE   4  (bases 1 to 527)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 527)
  AUTHORS   Paramonov,A.S., Kocharovskaya,M.V., Tsarev,A.V., Kulbatskii,D.S.,
            Loktyushov,E.V., Shulepko,M.A., Kirpichnikov,M.P., Lyukmanova,E.N.
            and Shenkarev,Z.O.
  TITLE     Structural Diversity and Dynamics of Human Three-Finger Proteins
            Acting on Nicotinic Acetylcholine Receptors
  JOURNAL   Int J Mol Sci 21 (19), 7280 (2020)
   PUBMED   33019770
  REMARK    GeneRIF: Structural Diversity and Dynamics of Human Three-Finger
            Proteins Acting on Nicotinic Acetylcholine Receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 527)
  AUTHORS   Eckl,K.M., Stevens,H.P., Lestringant,G.G.,
            Westenberger-Treumann,M., Traupe,H., Hinz,B., Frossard,P.M.,
            Stadler,R., Leigh,I.M., Nurnberg,P., Reis,A. and Hennies,H.C.
  TITLE     Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in
            patients from Germany, Turkey, Palestine, and the United Arab
            Emirates
  JOURNAL   Hum Genet 112 (1), 50-56 (2003)
   PUBMED   12483299
  REMARK    GeneRIF: Our findings indicate that the MDM type of transgressive
            PPK is caused by SLURP-1 mutations in patients from various origins
            and demonstrate allelic heterogeneity for mutations in SLURP-1.
REFERENCE   7  (bases 1 to 527)
  AUTHORS   Fischer,J., Bouadjar,B., Heilig,R., Huber,M., Lefevre,C.,
            Jobard,F., Macari,F., Bakija-Konsuo,A., Ait-Belkacem,F.,
            Weissenbach,J., Lathrop,M., Hohl,D. and Prud'homme,J.F.
  TITLE     Mutations in the gene encoding SLURP-1 in Mal de Meleda
  JOURNAL   Hum Mol Genet 10 (8), 875-880 (2001)
   PUBMED   11285253
REFERENCE   8  (bases 1 to 527)
  AUTHORS   Adermann,K., Wattler,F., Wattler,S., Heine,G., Meyer,M.,
            Forssmann,W.G. and Nehls,M.
  TITLE     Structural and phylogenetic characterization of human SLURP-1, the
            first secreted mammalian member of the Ly-6/uPAR protein
            superfamily
  JOURNAL   Protein Sci 8 (4), 810-819 (1999)
   PUBMED   10211827
REFERENCE   9  (bases 1 to 527)
  AUTHORS   Fischer,J., Bouadjar,B., Heilig,R., Fizames,C., Prud'homme,J.F. and
            Weissenbach,J.
  TITLE     Genetic linkage of Meleda disease to chromosome 8qter
  JOURNAL   Eur J Hum Genet 6 (6), 542-547 (1998)
   PUBMED   9887370
REFERENCE   10 (bases 1 to 527)
  AUTHORS   Ridge,R.J. and Sloane,N.H.
  TITLE     Partial N-terminal amino acid sequence of the anti-neoplastic
            urinary protein (ANUP) and the anti-tumour effect of the N-terminal
            nonapeptide of the unique cytokine present in human granulocytes
  JOURNAL   Cytokine 8 (1), 1-5 (1996)
   PUBMED   8742060
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC083841.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_020427.2.
            
            Summary: The protein encoded by this gene is a member of the
            Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is
            thought that this secreted protein contains antitumor activity.
            Mutations in this gene have been associated with Mal de Meleda, a
            rare autosomal recessive skin disorder. This gene maps to the same
            chromosomal region as several members of the Ly6/uPAR family of
            glycoprotein receptors. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105135.1, BQ027886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246515.2/ ENSP00000246515.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC083841.9         145423-145501
            80-199              AC083841.9         145907-146026
            200-527             AC083841.9         146553-146880
FEATURES             Location/Qualifiers
     source          1..527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..527
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /note="secreted LY6/PLAUR domain containing 1"
                     /db_xref="GeneID:57152"
                     /db_xref="HGNC:HGNC:18746"
                     /db_xref="MIM:606119"
     exon            1..79
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..333
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /note="lymphocyte antigen 6-like secreted; anti-neoplastic
                     urinary protein; ARS(component B)-81/S; secreted Ly6/uPAR
                     related protein 1; secreted Ly-6/uPAR-related protein 1;
                     SLURP-1"
                     /codon_start=1
                     /product="secreted Ly-6/uPAR-related protein 1 precursor"
                     /protein_id="NP_065160.1"
                     /db_xref="CCDS:CCDS6387.1"
                     /db_xref="GeneID:57152"
                     /db_xref="HGNC:HGNC:18746"
                     /db_xref="MIM:606119"
                     /translation="MASRWAVQLLLVAAWSMGCGEALKCYTCKEPMTSASCRTITRCK
                     PEDTACMTTLVTVEAEYPFNQSPVVTRSCSSSCVATDPDSIGAAHLIFCCFRDLCNSE
                     L"
     exon            80..199
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /inference="alignment:Splign:2.1.0"
     exon            200..527
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      505..510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /note="hexamer: TATAAA"
     polyA_site      527
                     /gene="SLURP1"
                     /gene_synonym="ANUP; ARS; ArsB; LY6-MT; LY6LS; MDM"
                     /note="major polyA site"
ORIGIN      
        1 atcacttctg agcacggagc aatggcctct cgctgggctg tgcagctgct gctcgtggca
       61 gcctggagca tgggctgtgg tgaggccctc aagtgctaca cctgcaagga gcccatgacc
      121 agtgcttcct gcaggaccat tacccgctgc aagccagagg acacagcctg catgaccacg
      181 ctggtgacgg tggaggcaga gtaccccttc aaccagagcc ccgtggtgac ccgctcctgc
      241 tccagctcct gtgtggccac cgaccccgac agcatcgggg ccgcccacct gatcttctgc
      301 tgcttccgag acctctgcaa ctcggaactc tgaacccagg gcggcagggc ggaaggtgct
      361 cctcaggcac ctcctctctg acggggcctg gctccacctg tgatcacctc cccctgcttc
      421 ctgctgctgt ggcacagctc actcatgggg tctgagggga gagaagcaca ccaggggcgc
      481 cctctgcctt ccatacccca cgcttataaa acataactaa gccaaga
//
