LOCUS       NM_006425               3480 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SLU7 homolog, splicing factor (SLU7), transcript
            variant 2, mRNA.
ACCESSION   NM_006425
VERSION     NM_006425.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3480)
  AUTHORS   Garate-Rascon,M., Recalde,M., Rojo,C., Fernandez-Barrena,M.G.,
            Avila,M.A., Arechederra,M. and Berasain,C.
  TITLE     SLU7: A New Hub of Gene Expression Regulation-From Epigenetics to
            Protein Stability in Health and Disease
  JOURNAL   Int J Mol Sci 23 (21), 13411 (2022)
   PUBMED   36362191
  REMARK    GeneRIF: SLU7: A New Hub of Gene Expression Regulation-From
            Epigenetics to Protein Stability in Health and Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3480)
  AUTHORS   Garate-Rascon,M., Recalde,M., Jimenez,M., Elizalde,M., Azkona,M.,
            Uriarte,I., Latasa,M.U., Urtasun,R., Bilbao,I., Sangro,B.,
            Garcia-Ruiz,C., Fernandez-Checa,J.C., Corrales,F.J., Esquivel,A.,
            Pineda-Lucena,A., Fernandez-Barrena,M.G., Avila,M.A.,
            Arechederra,M. and Berasain,C.
  TITLE     Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte
            Nuclear Factor 4alpha Degradation, Preserving Hepatic
            Differentiation and Protecting From Liver Damage
  JOURNAL   Hepatology 74 (5), 2791-2807 (2021)
   PUBMED   34170569
  REMARK    GeneRIF: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated
            Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic
            Differentiation and Protecting From Liver Damage.
REFERENCE   3  (bases 1 to 3480)
  AUTHORS   Recalde,M., Garate-Rascon,M., Elizalde,M., Azkona,M., Latasa,M.U.,
            Barcena-Varela,M., Sangro,B., Fernandez-Barrena,M.G., Avila,M.A.,
            Arechederra,M. and Berasain,C.
  TITLE     The splicing regulator SLU7 is required to preserve DNMT1 protein
            stability and DNA methylation
  JOURNAL   Nucleic Acids Res 49 (15), 8592-8609 (2021)
   PUBMED   34331453
  REMARK    GeneRIF: The splicing regulator SLU7 is required to preserve DNMT1
            protein stability and DNA methylation.
REFERENCE   4  (bases 1 to 3480)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3480)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3480)
  AUTHORS   Shomron,N., Reznik,M. and Ast,G.
  TITLE     Splicing factor hSlu7 contains a unique functional domain required
            to retain the protein within the nucleus
  JOURNAL   Mol Biol Cell 15 (8), 3782-3795 (2004)
   PUBMED   15181151
  REMARK    GeneRIF: The zinc-knuckle motif of hSlu7 determines the cellular
            localization of the protein through a nucleocytoplasmic-sensitive
            shuttling balance.
REFERENCE   7  (bases 1 to 3480)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   8  (bases 1 to 3480)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     An upstream AG determines whether a downstream AG is selected
            during catalytic step II of splicing
  JOURNAL   Mol Cell Biol 21 (5), 1509-1514 (2001)
   PUBMED   11238888
REFERENCE   9  (bases 1 to 3480)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     The RNA splicing factor hSlu7 is required for correct 3'
            splice-site choice
  JOURNAL   Nature 402 (6758), 207-210 (1999)
   PUBMED   10647016
REFERENCE   10 (bases 1 to 3480)
  AUTHORS   Chua,K. and Reed,R.
  TITLE     Human step II splicing factor hSlu7 functions in restructuring the
            spliceosome between the catalytic steps of splicing
  JOURNAL   Genes Dev 13 (7), 841-850 (1999)
   PUBMED   10197984
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA232975.1, DA409854.1,
            CA976106.1, BC010634.1, AC091842.3 and BE221264.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006425.4.
            
            Summary: Pre-mRNA splicing occurs in two sequential
            transesterification steps. The protein encoded by this gene is a
            splicing factor that has been found to be essential during the
            second catalytic step in the pre-mRNA splicing process. It
            associates with the spliceosome and contains a zinc knuckle motif
            that is found in other splicing factors and is involved in
            protein-nucleic acid and protein-protein interactions. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2), as well as variants 3-5,
            encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024875.1, SRR1660803.102334.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297151.9/ ENSP00000297151.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DA232975.1         81-121
            42-537              DA409854.1         48-543
            538-1060            CA976106.1         209-731
            1061-1972           BC010634.1         1067-1978
            1973-3111           AC091842.3         68377-69515         c
            3112-3480           BE221264.1         11-379              c
FEATURES             Location/Qualifiers
     source          1..3480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..3480
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="SLU7 homolog, splicing factor"
                     /db_xref="GeneID:10569"
                     /db_xref="HGNC:HGNC:16939"
                     /db_xref="MIM:605974"
     exon            1..59
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            60..245
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1836
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="isoform b is encoded by transcript variant 2; step
                     II splicing factor SLU7; zinc knuckle motif containing;
                     pre-mRNA-splicing factor SLU7; SLU7 splicing factor
                     homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor SLU7 isoform b"
                     /protein_id="NP_006416.3"
                     /db_xref="CCDS:CCDS4352.1"
                     /db_xref="GeneID:10569"
                     /db_xref="HGNC:HGNC:16939"
                     /db_xref="MIM:605974"
                     /translation="MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRK
                     LGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWY
                     KRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLM
                     FDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKH
                     QWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLR
                     NLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEA
                     YDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLA
                     QTEDYVEYSRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFF
                     KYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKKKKKKKKKH
                     RKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKRPYNSMYETREPTEEEM
                     EAYRMKRQRPDDPMASFLGQ"
     exon            246..399
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            400..480
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            481..645
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            646..714
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            715..762
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            763..894
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            895..992
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1060
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1200
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1362
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1467
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1539
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1656
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..3480
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1949..1954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="hexamer: AATAAA"
     polyA_site      1972
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="major polyA site"
     regulatory      3456..3461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="hexamer: CATAAA"
     polyA_site      3480
                     /gene="SLU7"
                     /gene_synonym="9G8; hSlu7"
                     /note="major polyA site"
ORIGIN      
        1 attacgagat tggcttggat tctgtcggat ggacttgggg ctagctgcgg cggggctgga
       61 ggaggccaga taaccatgtc agccacagtt gtagatgcag ttaatgctgc acccctatcg
      121 gggtccaaag aaatgagttt ggaagaacca aagaagatga ccagagagga ctggagaaag
      181 aagaaggagc tagaagaaca gcgaaaattg ggcaatgctc ctgcagaagt tgatgaagaa
      241 ggaaaagaca tcaaccccca tattcctcag tatatttctt cagtgccatg gtatattgat
      301 ccttcaaaaa gacctacttt aaaacaccag agaccacaac cagaaaaaca aaagcagttc
      361 agctcatctg gagaatggta caagaggggt gtaaaagaga attccataat tactaagtac
      421 cgcaaaggag catgtgaaaa ttgtggggcc atgacacaca aaaagaaaga ctgctttgag
      481 agacctaggc gagttggagc caaatttaca ggtactaata tagctccaga tgaacatgtc
      541 cagcctcaac tgatgtttga ctatgatggg aagagggatc ggtggaatgg ctacaatcca
      601 gaagaacaca tgaaaattgt tgaagagtat gccaaagttg atttggcaaa acgaacattg
      661 aaagcccaga aactccaaga ggaattagcc tcaggaaaat tagtggaaca ggctaattct
      721 ccaaaacacc agtggggaga agaggaacca aattctcaga tggaaaaaga tcataatagt
      781 gaagatgagg atgaagataa atatgcagat gatattgaca tgcctggaca gaattttgac
      841 tccaagagac gaattactgt ccggaatctc aggattcgag aagatattgc aaaatatttg
      901 aggaatttag atccaaattc tgcctactat gatccaaaaa ctagagcaat gagagagaat
      961 ccttatgcca atgcaggaaa gaatccagat gaagtgagtt atgctggaga taactttgtt
     1021 aggtacacag gagataccat ttcaatggct cagacacagt tgtttgcatg ggaagcctat
     1081 gacaagggat ctgaagtgca tctacaggca gatcctacaa agctagagct gttgtataag
     1141 tccttcaaag tcaaaaaaga agatttcaaa gaacagcaga aagaaagcat cctggaaaag
     1201 tatggtggcc aagaacattt ggatgcccct ccagctgaat tgcttttagc ccagactgaa
     1261 gactatgtgg agtactcaag acatgggaca gtcatcaaag gacaggagcg ggctgttgcc
     1321 tgctctaagt atgaggagga tgtgaagatc cacaatcaca cacatatctg gggatcgtac
     1381 tggaaagaag gccgatgggg atacaaatgc tgtcactctt ttttcaagta ttcctattgt
     1441 actggagaag ctgggaagga gattgttaac tctgaggagt gtattataaa tgagataact
     1501 ggggaagaat ctgtgaaaaa acctcaaacc ctcatggagc tgcatcaaga aaaactgaaa
     1561 gaggaaaaga agaagaagaa aaagaaaaag aagaagcatc gaaagagcag ttcagatagt
     1621 gatgatgaag aaaagaagca tgaaaaattg aaaaaggcac tgaacgcaga ggaggcccgc
     1681 cttcttcatg tcaaggagac catgcagatt gatgagagga agcggcctta caatagcatg
     1741 tatgaaactc gagaacctac tgaagaggaa atggaggcat atagaatgaa acgtcagagg
     1801 ccagatgacc ccatggcctc tttccttgga cagtagcaac tagtcagaag accatccaag
     1861 atagatgcag ctgatacatt cttttcagct tcttattgat gattgtagat agaaaaatcc
     1921 ttgtttattc ttcttgctgc ctggctttaa taaatatttc agatgcctca cagtaagttc
     1981 actcctttcc atactgagga aacaagaaaa gaagaagagg cacatgaagt gtgcttttgg
     2041 gaatagaatt taaaattgga ttaagatttt atttccagtt ttttttattt atttattttt
     2101 ttttttgaga cggagtcttg ctctgtcgcc caggctgaag tgcggtggcg cgatctcggc
     2161 tcactgcaag ctccacctcc caggttcacg ccattctcct gcctcagcct ccctagtagt
     2221 tgggactaca ggcgcccgcc accatgctca gctaattttt tgtattttta gtagagacgg
     2281 tttcatcgtg ttagccagga tggtctcgat ctcctgacct tgtgatccac ccgcctcagc
     2341 ctcccaaagt gctgagatta caggcgtgag ccaccgcgcc tggcctattt ccagttttat
     2401 gtgagtcatg taaaaaagcc ttggctctct acctattaag aatgtctctt tctctgtatt
     2461 tattaagctt caaactttat tgcttcgatt tttgtggccc tatatttagt attagcacac
     2521 cttggttttg agaaaaaaac agggctttgt ttttttaaat aattactagc aactctgtga
     2581 ctacatttat ttttattttt tttagagaca ggatcttgct atgttgccca ggctagagag
     2641 cagtggcttt tcacagacaa agtcataatg ccctgcagtc ttgggctcaa gcgattctct
     2701 cttccttggc ctctggagta gactaaatgt gttagtcttt gaatggaaaa caactatttt
     2761 ctcatcattg ggtcaatatt gactgatcag tagtaggtct tttaccattc tggacataag
     2821 tctaggtgta gaaatccttt cctttatcat agaggatatg gtttacatta ccgtttgttt
     2881 tcattgtgat tgcccctatg taacaatcat gaatattaga ttttttaaat tgtagaatat
     2941 cctaatattt atagccagca gctgttactt tgtttgtaaa atttgcaaaa aaacaaaacc
     3001 tgaagttggt ttattgaaag aattataagg atagcttcta gggatattag taatagattg
     3061 ccatgatcct gaagcctctt ctcagaacac tgtgaagata atactgacag tagaatcagt
     3121 gaaaacagcc taacaaaacc tctgacatca gtatatcaac ttttaacagc ccactcactg
     3181 gcttttctaa actaccaaaa accacctgta ggatactgca ttaagtcagc atctcagaaa
     3241 cagtggtgtg agtaactgag tcaaattgtc aagtactttg gatatacata gtgtcgagct
     3301 ttagattggt atgaaattaa acagcaatgc aaatagattt aattcctatt tactttaaga
     3361 atgaaaaaca atgttcattt tcctacctaa acagggtggt tcaacataaa ggctgatgtt
     3421 gtgtccgttt tgtattttat cttttgttaa agatacataa atgacaatac ttaactgtga
//
