LOCUS       NM_024755               4168 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SAFB like transcription modulator (SLTM), transcript
            variant 1, mRNA.
ACCESSION   NM_024755
VERSION     NM_024755.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4168)
  AUTHORS   Chen,R., Tong,Y., Hu,X., Wang,W. and Liao,F.
  TITLE     circSLTM knockdown attenuates chondrocyte inflammation, apoptosis
            and ECM degradation in osteoarthritis by regulating the
            miR-515-5p/VAPB axis
  JOURNAL   Int Immunopharmacol 138, 112435 (2024)
   PUBMED   38981227
  REMARK    GeneRIF: circSLTM knockdown attenuates chondrocyte inflammation,
            apoptosis and ECM degradation in osteoarthritis by regulating the
            miR-515-5p/VAPB axis.
REFERENCE   2  (bases 1 to 4168)
  AUTHORS   Feng,X., He,S., Chen,Y. and Zhang,L.
  TITLE     Deubiquitinase BRCC3 promotes the migration, invasion and EMT
            progression of colon adenocarcinoma by stabilizing MET expression
  JOURNAL   Genes Genomics 46 (5), 637-646 (2024)
   PUBMED   38470543
  REMARK    GeneRIF: Deubiquitinase BRCC3 promotes the migration, invasion and
            EMT progression of colon adenocarcinoma by stabilizing MET
            expression.
REFERENCE   3  (bases 1 to 4168)
  AUTHORS   Liang,Q., Hu,Y., Yuan,Q., Yu,M., Wang,H. and Zhao,B.
  TITLE     MET exon 14 skipping mutation drives cancer progression and
            recurrence via activation of SMAD2 signalling
  JOURNAL   Br J Cancer 130 (3), 380-393 (2024)
   PUBMED   38110666
  REMARK    GeneRIF: MET exon 14 skipping mutation drives cancer progression
            and recurrence via activation of SMAD2 signalling.
REFERENCE   4  (bases 1 to 4168)
  AUTHORS   Gong,D.A., Zhou,P., Chang,W.Y., Yang,J.Y., Zhang,Y.L., Huang,A.L.,
            Tang,N. and Wang,K.
  TITLE     SPOP promotes CREB5 ubiquitination to inhibit MET signaling in
            liver cancer
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (2), 119642 (2024)
   PUBMED   37996058
  REMARK    GeneRIF: SPOP promotes CREB5 ubiquitination to inhibit MET
            signaling in liver cancer.
REFERENCE   5  (bases 1 to 4168)
  AUTHORS   Tsujio,G., Yashiro,M., Sakuma,T., Aoyama,R., Maruo,K., Yamamoto,Y.
            and Maeda,K.
  TITLE     Impact of SMAD2 and MET Expression on Lymph Node Metastasis of
            HER2-positive Gastric Cancer Cells
  JOURNAL   Anticancer Res 43 (10), 4359-4364 (2023)
   PUBMED   37772583
  REMARK    GeneRIF: Impact of SMAD2 and MET Expression on Lymph Node
            Metastasis of HER2-positive Gastric Cancer Cells.
REFERENCE   6  (bases 1 to 4168)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 4168)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 4168)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 4168)
  AUTHORS   Salyakina,D., Ma,D.Q., Jaworski,J.M., Konidari,I., Whitehead,P.L.,
            Henson,R., Martinez,D., Robinson,J.L., Sacharow,S., Wright,H.H.,
            Abramson,R.K., Gilbert,J.R., Cuccaro,M.L. and Pericak-Vance,M.A.
  TITLE     Variants in several genomic regions associated with asperger
            disorder
  JOURNAL   Autism Res 3 (6), 303-310 (2010)
   PUBMED   21182207
REFERENCE   10 (bases 1 to 4168)
  AUTHORS   Gratacos,M., Costas,J., de Cid,R., Bayes,M., Gonzalez,J.R.,
            Baca-Garcia,E., de Diego,Y., Fernandez-Aranda,F.,
            Fernandez-Piqueras,J., Guitart,M., Martin-Santos,R., Martorell,L.,
            Menchon,J.M., Roca,M., Saiz-Ruiz,J., Sanjuan,J., Torrens,M.,
            Urretavizcaya,M., Valero,J., Vilella,E., Estivill,X. and
            Carracedo,A.
  CONSRTM   Psychiatric Genetics Network Group
  TITLE     Identification of new putative susceptibility genes for several
            psychiatric disorders by association analysis of regulatory and
            non-synonymous SNPs of 306 genes involved in neurotransmission and
            neurodevelopment
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 150B (6), 808-816 (2009)
   PUBMED   19086053
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025918.7, DA215437.1, BC140851.1 and BC046119.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024755.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.51521.1,
                                           SRR1660807.146606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380516.7/ ENSP00000369887.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC025918.7         115417-115419       c
            4-36                DA215437.1         1-33
            37-3459             BC140851.1         1-3423
            3460-4168           BC046119.1         1752-2460
FEATURES             Location/Qualifiers
     source          1..4168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.1"
     gene            1..4168
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /note="SAFB like transcription modulator"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
     exon            1..276
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..3219
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /note="isoform a is encoded by transcript variant 1;
                     modulator of estrogen-induced transcription"
                     /codon_start=1
                     /product="SAFB-like transcription modulator isoform a"
                     /protein_id="NP_079031.2"
                     /db_xref="CCDS:CCDS10168.2"
                     /db_xref="GeneID:79811"
                     /db_xref="HGNC:HGNC:20709"
                     /db_xref="MIM:620992"
                     /translation="MAAATGAVAASAASGQAEGKKITDLRVIDLKSELKRRNLDITGV
                     KTVLISRLKQAIEEEGGDPDNIELTVSTDTPNKKPTKGKGKKHEADELSGDASVEDDA
                     FIKDCELENQEAHEQDGNDELKDSEEFGENEEENVHSKELLSAEENKRAHELIEAEGI
                     EDIEKEDIESQEIEAQEGEDDTFLTAQDGEEEENEKDIAGSGDGTQEVSKPLPSEGSL
                     AEADHTAHEEMEAHTTVKEAEDDNISVTIQAEDAITLDFDGDDLLETGKNVKITDSEA
                     SKPKDGQDAIAQSPEKESKDYEMNANHKDGKKEDCVKGDPVEKEARESSKKAESGDKE
                     KDTLKKGPSSTGASGQAKSSSKESKDSKTSSKDDKGSTSSTSGSSGSSTKNIWVSGLS
                     SNTKAADLKNLFGKYGKVLSAKVVTNARSPGAKCYGIVTMSSSTEVSRCIAHLHRTEL
                     HGQLISVEKVKGDPSKKEMKKENDEKSSSRSSGDKKNTSDRSSKTQASVKKEEKRSSE
                     KSEKKESKDTKKIEGKDEKNDNGASGQTSESIKKSEEKKRISSKSPGHMVILDQTKGD
                     HCRPSRRGRYEKIHGRSKEKERASLDKKRDKDYRRKEILPFEKMKEQRLREHLVRFER
                     LRRAMELRRRREIAERERRERERIRIIREREERERLQRERERLEIERQKLERERMERE
                     RLERERIRIEQERRKEAERIAREREELRRQQQQLRYEQEKRNSLKRPRDVDHRRDDPY
                     WSENKKLSLDTDARFGHGSDYSRQQNRFNDFDHRERGRFPESSAVQSSSFERRDRFVG
                     QSEGKKARPTARREDPSFERYPKNFSDSRRNEPPPPRNELRESDRREVRGERDERRTV
                     IIHDRPDITHPRHPREAGPNPSRPTSWKSEGSMSTDKRETRVERPERSGREVSGHSVR
                     GAPPGNRSSASGYGSREGDRGVITDRGGGSQHYPEERHVVERHGRDTSGPRKEWHGPP
                     SQGPSYHDTRRMGDGRAGAGMITQHSSNASPINRIVQISGNSMPRGSGSGFKPFKGGP
                     PRRF"
     exon            277..364
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            365..429
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            430..627
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            628..675
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            676..703
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1172
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1222
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1341
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1491
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1595
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1762
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1848
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..2012
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2193
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2318
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2489
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2804
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2949
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3110
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..4168
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4148..4153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /note="hexamer: AATAAA"
     polyA_site      4168
                     /gene="SLTM"
                     /gene_synonym="Met"
                     /note="major polyA site"
ORIGIN      
        1 attgtgcgca gcgctgcgcg gcgccggcgg ccgccgaggc ctgggtggaa gttggcgctg
       61 ctgccgccgc cctgcagccc actcgctgcc tcggcagcgc gctgctcttc taagatggct
      121 gccgctaccg gtgcggtggc agcctcggcc gcctcgggtc aggcggaagg taaaaagatc
      181 accgatctgc gggtcatcga tctgaagtcc gagctgaagc ggcggaactt agacatcacc
      241 ggagtcaaga ccgtgctcat ctcccgactc aagcaggcta ttgaagagga aggaggcgat
      301 ccagataata ttgaattaac tgtttcaact gatactccaa acaagaaacc aactaaaggc
      361 aaaggtaaaa aacatgaagc agatgagttg agtggagatg cttctgtgga agatgatgct
      421 tttatcaagg actgtgaatt ggagaatcaa gaggcacatg agcaagatgg aaatgatgaa
      481 ctaaaggact ctgaagaatt tggtgaaaat gaagaagaaa atgtgcattc caaggagtta
      541 ctctctgcag aagaaaacaa gagagctcat gaattaatag aggcagaagg aatagaagat
      601 atagaaaaag aggacatcga aagtcaggaa attgaagctc aagaaggtga agatgatacc
      661 tttctaacag cccaagatgg tgaggaagaa gaaaatgaga aagatatagc aggttctggt
      721 gatggtacac aagaagtatc taaacctctt ccttcagaag ggagcctagc tgaggctgat
      781 cacacagctc atgaagagat ggaagctcat acgactgtga aagaagctga ggatgacaac
      841 atctcggtca caatccaggc tgaagatgcc atcactctgg attttgatgg tgatgacctc
      901 ctagaaacag gtaaaaatgt gaaaattaca gattctgaag caagtaagcc aaaagatggg
      961 caggacgcca ttgcacagag cccggagaag gaaagcaagg attatgagat gaatgcgaac
     1021 cataaagatg gtaagaagga agactgcgtg aagggtgacc ctgtcgagaa ggaagccaga
     1081 gaaagttcta agaaagcaga atctggagac aaagaaaagg atactttgaa gaaagggccc
     1141 tcgtctactg gggcctctgg tcaagcaaag agctcttcaa aggaatctaa agacagcaag
     1201 acatcatcta aagatgacaa aggaagtaca agtagtacta gtggtagcag tggaagctca
     1261 actaaaaata tctgggttag tggactttca tctaatacca aagctgctga tttgaagaac
     1321 ctctttggca aatatggaaa ggttctgagt gcaaaagtag ttacaaatgc tcgaagtcct
     1381 ggggcaaaat gctatggcat tgtaactatg tcttcaagca cagaggtgtc caggtgtatt
     1441 gcacatcttc atcgcactga gctgcatgga cagctgattt ctgttgaaaa agtaaaaggt
     1501 gatccctcta agaaagaaat gaagaaagaa aatgatgaaa agagtagttc aagaagttct
     1561 ggagataaaa aaaatacgag tgatagaagt agcaagacac aagcctctgt caaaaaagaa
     1621 gagaaaagat cgtctgagaa atctgaaaaa aaagaaagca aggatactaa gaaaatagaa
     1681 ggtaaagatg agaagaatga taatggagca agtggccaaa catcagaatc gattaaaaaa
     1741 agtgaagaaa agaagcgaat aagttccaag agtccaggac atatggtaat actagaccaa
     1801 actaaaggag atcattgtag accatcaaga agaggaagat atgagaaaat tcatggaaga
     1861 agtaaggaaa aggagagagc tagtctagat aaaaaaagag ataaagacta cagaaggaaa
     1921 gagatcttgc cttttgaaaa gatgaaggaa caaaggttga gagaacattt agttcgtttt
     1981 gaaaggctgc gacgagcaat ggaacttcga agacgaagag agattgcaga gagagagcgt
     2041 cgagagcgag aacgcattag aataattcgt gaacgggaag aacgggaacg cttacagaga
     2101 gagagagagc gcctagaaat tgaaaggcaa aaactagaga gagagagaat ggaacgcgaa
     2161 cgcttggaaa gggaacgcat tcgtattgaa caggaacgtc gtaaggaagc tgaacggatt
     2221 gctcgagaaa gagaggaact cagaaggcaa caacagcagc ttcgttatga acaagaaaaa
     2281 aggaattcct tgaaacgccc acgtgatgta gatcataggc gagatgatcc ttactggagc
     2341 gagaataaaa agttgtctct agatacagat gcacgatttg gccatggatc cgactactct
     2401 cgccaacaga acagatttaa tgactttgat caccgagaga ggggcaggtt tcctgagagt
     2461 tcagcagtac agtcttcatc ttttgaaagg cgggatcgct ttgttggtca aagtgagggg
     2521 aaaaaagcac gacctactgc acgaagggaa gatccaagct tcgaaagata tcccaaaaat
     2581 ttcagtgact ccagaagaaa tgagcctcca ccaccaagaa atgaacttag agaatcagac
     2641 aggcgagaag tacgagggga gcgagacgaa aggagaacgg tgattattca tgacaggcct
     2701 gatatcactc atcctagaca tcctcgagag gcagggccca atccttccag acccaccagc
     2761 tggaaaagtg aaggaagcat gtccactgac aaacgggaaa caagagttga aaggccagaa
     2821 cgatctggga gagaagtatc agggcacagt gtgagaggcg ctccccctgg gaatcgtagc
     2881 agcgcttcgg ggtacgggag cagagaggga gacagaggag tcatcacaga ccgaggaggt
     2941 ggatcacagc actatcctga ggagcgacat gtggttgaac gccatggacg ggacacaagc
     3001 ggaccaagga aagagtggca tggtccaccc tctcaagggc ctagctatca tgatacgagg
     3061 cgaatgggtg acggccgggc aggagcaggc atgataaccc aacattcaag taacgcatcc
     3121 ccaattaata gaattgtaca aatcagtggc aattccatgc caagaggaag tggctccgga
     3181 tttaagccat ttaagggtgg acctccgcga cgattctgaa aatgagctct ctgccaaggt
     3241 tttaagataa tttattgaaa tctcctgtaa actttacttg actacttatg aagaggacct
     3301 ctgacttgct tgagagttct gtcagacttt tctttttaaa aatttaacat gattgctttt
     3361 ctcaattttg gagaagatgt ttaaatagtt ctgttgtaac ttttaatagt tttgtgtatc
     3421 attcaacttt ttttcttgca gcaccgaggc acatttgaaa agatggaatt gaagtcgttt
     3481 tgtttaacgc tgtgtgaata taaagagtag tttgcagctg tgtggtagtg gtttaatttg
     3541 cagccttagc tctgtggtgt ctggctctag agttacttct ttttaccaag cattttcagc
     3601 ctccattttg aaggctgtct acacttaaga agtcttagct gtctaatttt tagagaataa
     3661 gattgttcat tgcatttctg agtattatgt aacctatttt tgcagaaggt actgttacat
     3721 taagtgcatc tgtgtatcct ggtttaaaaa aatgtaatct tttttgaaat aaaccttcat
     3781 attctgtata gttgctaaag tgttgagaac ctttttaatt gtaaaatgag aaccgatttt
     3841 cagtttagtg tagcagcaca cttgttcagg tttgcatggt atgaaaccaa atagattcat
     3901 gaaaccttgg ccatgaggtt tgtttcacaa ggttcttaga ccgagttgtg caggtaagtg
     3961 cacttttagg taatctgcac tgtttgtttg atggataaat tccatctctg ggaattgtgt
     4021 gggtattaat gtttccatgt tcccaactat gttgagaagt ggaaaaaaac ccaggttcta
     4081 gatgggtgaa tcagttgggt tttgtaaata cttgtatgtg gggaagacat tgttgtcttt
     4141 ttgtgaaaat aaaaatccac acctggaa
//
