LOCUS       NM_003064                596 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens secretory leukocyte peptidase inhibitor (SLPI), mRNA.
ACCESSION   NM_003064
VERSION     NM_003064.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 596)
  AUTHORS   Azevedo,P.L., Maradei,S., de Sa Bigni,R., Santos Ramires Aragao,J.,
            Abdelhay,E. and Binato,R.
  TITLE     SLPI overexpression in hMSCs could be implicated in the HSC gene
            expression profile in AML
  JOURNAL   Sci Rep 14 (1), 15550 (2024)
   PUBMED   38969699
  REMARK    GeneRIF: SLPI overexpression in hMSCs could be implicated in the
            HSC gene expression profile in AML.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 596)
  AUTHORS   Chen,F., Wu,Y.Y. and Yang,B.
  TITLE     [The role and mechanism of multifunctional molecule SLPI in
            regulating ischemia-reperfusion induced acute kidney injury and
            repair]
  JOURNAL   Sheng Li Xue Bao 76 (3), 475-486 (2024)
   PUBMED   38939941
  REMARK    GeneRIF: [The role and mechanism of multifunctional molecule SLPI
            in regulating ischemia-reperfusion induced acute kidney injury and
            repair].
            Review article
REFERENCE   3  (bases 1 to 596)
  AUTHORS   Scott,A., Weldon,S. and Taggart,C.C.
  TITLE     SLPI and elafin: multifunctional antiproteases of the WFDC family
  JOURNAL   Biochem Soc Trans 39 (5), 1437-1440 (2011)
   PUBMED   21936829
  REMARK    Review article
REFERENCE   4  (bases 1 to 596)
  AUTHORS   Williams,S.E., Brown,T.I., Roghanian,A. and Sallenave,J.M.
  TITLE     SLPI and elafin: one glove, many fingers
  JOURNAL   Clin Sci (Lond) 110 (1), 21-35 (2006)
   PUBMED   16336202
  REMARK    GeneRIF: SLPI has antiprotease activity and antimicrobial activity
            against bacteria and fungi. SLPI is an important molecule in the
            functioning of the innate immune system.
            Review article
REFERENCE   5  (bases 1 to 596)
  AUTHORS   Abe,T., Kobayashi,N., Yoshimura,K., Trapnell,B.C., Kim,H.,
            Hubbard,R.C., Brewer,M.T., Thompson,R.C. and Crystal,R.G.
  TITLE     Expression of the secretory leukoprotease inhibitor gene in
            epithelial cells
  JOURNAL   J Clin Invest 87 (6), 2207-2215 (1991)
   PUBMED   1674946
REFERENCE   6  (bases 1 to 596)
  AUTHORS   Sallenave,J.M. and Ryle,A.P.
  TITLE     Purification and characterization of elastase-specific inhibitor.
            Sequence homology with mucus proteinase inhibitor
  JOURNAL   Biol Chem Hoppe Seyler 372 (1), 13-21 (1991)
   PUBMED   2039600
REFERENCE   7  (bases 1 to 596)
  AUTHORS   Stetler,G., Brewer,M.T. and Thompson,R.C.
  TITLE     Isolation and sequence of a human gene encoding a potent inhibitor
            of leukocyte proteases
  JOURNAL   Nucleic Acids Res 14 (20), 7883-7896 (1986)
   PUBMED   3640338
REFERENCE   8  (bases 1 to 596)
  AUTHORS   Heinzel,R., Appelhans,H., Gassen,G., Seemuller,U., Machleidt,W.,
            Fritz,H. and Steffens,G.
  TITLE     Molecular cloning and expression of cDNA for human
            antileukoprotease from cervix uterus
  JOURNAL   Eur J Biochem 160 (1), 61-67 (1986)
   PUBMED   3533531
REFERENCE   9  (bases 1 to 596)
  AUTHORS   Thompson,R.C. and Ohlsson,K.
  TITLE     Isolation, properties, and complete amino acid sequence of human
            secretory leukocyte protease inhibitor, a potent inhibitor of
            leukocyte elastase
  JOURNAL   Proc Natl Acad Sci U S A 83 (18), 6692-6696 (1986)
   PUBMED   3462719
REFERENCE   10 (bases 1 to 596)
  AUTHORS   Seemuller,U., Arnhold,M., Fritz,H., Wiedenmann,K., Machleidt,W.,
            Heinzel,R., Appelhans,H., Gassen,H.G. and Lottspeich,F.
  TITLE     The acid-stable proteinase inhibitor of human mucous secretions
            (HUSI-I, antileukoprotease). Complete amino acid sequence as
            revealed by protein and cDNA sequencing and structural homology to
            whey proteins and Red Sea turtle proteinase inhibitor
  JOURNAL   FEBS Lett 199 (1), 43-48 (1986)
   PUBMED   3485543
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC020708.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003064.3.
            
            Summary: This gene encodes a secreted inhibitor which protects
            epithelial tissues from serine proteases. It is found in various
            secretions including seminal plasma, cervical mucus, and bronchial
            secretions, and has affinity for trypsin, leukocyte elastase, and
            cathepsin G. Its inhibitory effect contributes to the immune
            response by protecting epithelial surfaces from attack by
            endogenous proteolytic enzymes. This antimicrobial protein has
            antibacterial, antifungal and antiviral activity. [provided by
            RefSeq, Nov 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020708.1, BM842052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000338380.2/
                                                  ENSP00000342082.2
            Protein has antimicrobial activity :: PMID: 16336202
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-596               BC020708.1         1-596
FEATURES             Location/Qualifiers
     source          1..596
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..596
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /note="secretory leukocyte peptidase inhibitor"
                     /db_xref="GeneID:6590"
                     /db_xref="HGNC:HGNC:11092"
                     /db_xref="MIM:107285"
     exon            1..106
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..420
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /note="secretory leukocyte protease inhibitor
                     (antileukoproteinase); seminal proteinase inhibitor; mucus
                     proteinase inhibitor; HUSI-1; protease inhibitor WAP4; WAP
                     four-disulfide core domain protein 4"
                     /codon_start=1
                     /product="antileukoproteinase precursor"
                     /protein_id="NP_003055.1"
                     /db_xref="CCDS:CCDS13347.1"
                     /db_xref="GeneID:6590"
                     /db_xref="HGNC:HGNC:11092"
                     /db_xref="MIM:107285"
                     /translation="MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCL
                     RYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPP
                     NFCEMDGQCKRDLKCCMGMCGKSCVSPVKA"
     exon            107..265
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            266..415
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /inference="alignment:Splign:2.1.0"
     exon            416..596
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      571..576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /note="hexamer: AATAAA"
     polyA_site      596
                     /gene="SLPI"
                     /gene_synonym="ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4;
                     WFDC4"
                     /note="major polyA site"
ORIGIN      
        1 agagtcactc ctgccttcac catgaagtcc agcggcctct tccccttcct ggtgctgctt
       61 gccctgggaa ctctggcacc ttgggctgtg gaaggctctg gaaagtcctt caaagctgga
      121 gtctgtcctc ctaagaaatc tgcccagtgc cttagataca agaaacctga gtgccagagt
      181 gactggcagt gtccagggaa gaagagatgt tgtcctgaca cttgtggcat caaatgcctg
      241 gatcctgttg acaccccaaa cccaacaagg aggaagcctg ggaagtgccc agtgacttat
      301 ggccaatgtt tgatgcttaa cccccccaat ttctgtgaga tggatggcca gtgcaagcgt
      361 gacttgaagt gttgcatggg catgtgtggg aaatcctgcg tttcccctgt gaaagcttga
      421 ttcctgccat atggaggagg ctctggagtc ctgctctgtg tggtccaggt cctttccacc
      481 ctgagacttg gctccaccac tgatatcctc ctttggggaa aggcttggca cacagcaggc
      541 tttcaagaag tgccagttga tcaatgaata aataaacgag cctatttctc tttgca
//
