LOCUS       NM_003063                722 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sarcolipin (SLN), mRNA.
ACCESSION   NM_003063 NM_032697
VERSION     NM_003063.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 722)
  AUTHORS   Cao,Y., Yang,R., Sun,J., Zhang,W., Lee,I., Wang,W. and Meng,X.
  TITLE     Effects of amino acid modifications on the permeability of the
            pentameric sarcolipin channel
  JOURNAL   Proteins 89 (4), 427-435 (2021)
   PUBMED   33244801
  REMARK    GeneRIF: Effects of amino acid modifications on the permeability of
            the pentameric sarcolipin channel.
REFERENCE   2  (bases 1 to 722)
  AUTHORS   Morales-Alamo,D., Martinez-Canton,M., Gelabert-Rebato,M.,
            Martin-Rincon,M., de Pablos-Velasco,P., Holmberg,H.C. and
            Calbet,J.A.L.
  TITLE     Sarcolipin expression in human skeletal muscle: Influence of energy
            balance and exercise
  JOURNAL   Scand J Med Sci Sports 30 (3), 408-420 (2020)
   PUBMED   31674694
  REMARK    GeneRIF: Sarcolipin protein is more abundantly expressed in leg
            than arm skeletal muscles in humans. Sarcolipin protein expression
            is not altered by short-term low-intensity exercise but is reduced
            by repeated sprint exercise. Expression in human skeletal muscle is
            not associated with adiposity nor resting energy expenditure in
            overweight men.
REFERENCE   3  (bases 1 to 722)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 722)
  AUTHORS   Zhao,Y.G., Chen,Y., Miao,G., Zhao,H., Qu,W., Li,D., Wang,Z.,
            Liu,N., Li,L., Chen,S., Liu,P., Feng,D. and Zhang,H.
  TITLE     The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA
            Activity to Control ER-Isolation Membrane Contacts for
            Autophagosome Formation
  JOURNAL   Mol Cell 67 (6), 974-989 (2017)
   PUBMED   28890335
REFERENCE   5  (bases 1 to 722)
  AUTHORS   Gorski,P.A., Ceholski,D.K. and Young,H.S.
  TITLE     Structure-Function Relationship of the SERCA Pump and Its
            Regulation by Phospholamban and Sarcolipin
  JOURNAL   Adv Exp Med Biol 981, 77-119 (2017)
   PUBMED   29594859
  REMARK    GeneRIF: Structure-Function Relationship of the SERCA Pump and Its
            Regulation by Phospholamban and Sarcolipin.
            Review article
REFERENCE   6  (bases 1 to 722)
  AUTHORS   Mascioni,A., Karim,C., Barany,G., Thomas,D.D. and Veglia,G.
  TITLE     Structure and orientation of sarcolipin in lipid environments
  JOURNAL   Biochemistry 41 (2), 475-482 (2002)
   PUBMED   11781085
REFERENCE   7  (bases 1 to 722)
  AUTHORS   Smith,W.S., Broadbridge,R., East,J.M. and Lee,A.G.
  TITLE     Sarcolipin uncouples hydrolysis of ATP from accumulation of Ca2+ by
            the Ca2+-ATPase of skeletal-muscle sarcoplasmic reticulum
  JOURNAL   Biochem J 361 (Pt 2), 277-286 (2002)
   PUBMED   11772399
REFERENCE   8  (bases 1 to 722)
  AUTHORS   Odermatt,A., Becker,S., Khanna,V.K., Kurzydlowski,K., Leisner,E.,
            Pette,D. and MacLennan,D.H.
  TITLE     Sarcolipin regulates the activity of SERCA1, the fast-twitch
            skeletal muscle sarcoplasmic reticulum Ca2+-ATPase
  JOURNAL   J Biol Chem 273 (20), 12360-12369 (1998)
   PUBMED   9575189
REFERENCE   9  (bases 1 to 722)
  AUTHORS   Odermatt,A., Taschner,P.E., Scherer,S.W., Beatty,B., Khanna,V.K.,
            Cornblath,D.R., Chaudhry,V., Yee,W.C., Schrank,B., Karpati,G.,
            Breuning,M.H., Knoers,N. and MacLennan,D.H.
  TITLE     Characterization of the gene encoding human sarcolipin (SLN), a
            proteolipid associated with SERCA1: absence of structural mutations
            in five patients with Brody disease
  JOURNAL   Genomics 45 (3), 541-553 (1997)
   PUBMED   9367679
REFERENCE   10 (bases 1 to 722)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res 6 (1), 35-42 (1996)
   PUBMED   8681137
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP233121.1, BC094685.1 and
            AP002353.4.
            
            On Nov 22, 2018 this sequence version replaced NM_003063.2.
            
            Summary: Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane
            proteins that catalyze the ATP-dependent transport of Ca(2+) from
            the cytosol into the lumen of the sarcoplasmic reticulum in muscle
            cells. This gene encodes a small proteolipid that regulates several
            sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein
            interacts with Ca(2+)-ATPases and reduces the accumulation of
            Ca(2+) in the sarcoplasmic reticulum without affecting the rate of
            ATP hydrolysis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005261.1, SRR5189652.254065.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305991.3/ ENSP00000304707.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BP233121.1         6-18
            14-104              BC094685.1         1-91
            105-105             AP002353.4         46123-46123         c
            106-722             BC094685.1         93-709
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..722
                     /gene="SLN"
                     /note="sarcolipin"
                     /db_xref="GeneID:6588"
                     /db_xref="HGNC:HGNC:11089"
                     /db_xref="MIM:602203"
     exon            1..94
                     /gene="SLN"
                     /inference="alignment:Splign:2.1.0"
     exon            95..722
                     /gene="SLN"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..265
                     /gene="SLN"
                     /codon_start=1
                     /product="sarcolipin"
                     /protein_id="NP_003054.1"
                     /db_xref="CCDS:CCDS31667.1"
                     /db_xref="GeneID:6588"
                     /db_xref="HGNC:HGNC:11089"
                     /db_xref="MIM:602203"
                     /translation="MGINTRELFLNFTIVLITVILMWLLVRSYQY"
     regulatory      698..703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLN"
                     /note="hexamer: AATAAA"
     polyA_site      722
                     /gene="SLN"
                     /note="major polyA site"
ORIGIN      
        1 agacagcctg ggaggggaga aggagttgga gctcaagttg gagacagcga ggagaaacct
       61 gccatagcca gggtgtgtct ttgatcctct tcaggaggtg aggagaagcc agaggtcctt
      121 ggtgtgccct cagaaatctg cctgcagttc tcaccaagcc gctgtgaaaa tggggataaa
      181 cacccgggag ctgtttctca acttcactat tgtcttgatt acggttattc ttatgtggct
      241 ccttgtgagg tcctatcagt actgagaggc catgccatgg tcctgggatt gactgagatg
      301 ctccggagct gcctgctcta tgccctgaga ccccactgct gtcattgtca caggatgcca
      361 ttctccatcc gagggcacct gtgacctgca ctcacaatat ctgctatgct gtagtgctag
      421 gattgattat gtgttctcca aagatgctgc tcccaagggc tgccaagtgt ttgccaggga
      481 acggtagatt tattccccaa ctcttaactg aaaatgtgtt agacaagcca caaagttaaa
      541 attaaactgg attcatgatg atgtaggatt gttacaagcc cctgatctgt ctcaccacac
      601 atcccttcaa cccacacggt ctgcaaccaa actctaattc aacctgccag aaggaatgtt
      661 agaggaagtc tttgtcagcc cttatagcta tcatgtgaat aaagttaagt caacttcaaa
      721 aa
//
