LOCUS       NM_001377540            6381 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens sarcolemma associated protein (SLMAP), transcript
            variant 10, mRNA.
ACCESSION   NM_001377540 XM_017007146
VERSION     NM_001377540.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6381)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 6381)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 6381)
  AUTHORS   Tang,Y., Chen,M., Zhou,L., Ma,J., Li,Y., Zhang,H., Shi,Z., Xu,Q.,
            Zhang,X., Gao,Z., Zhao,Y., Cheng,Y., Jiao,S. and Zhou,Z.
  TITLE     Architecture, substructures, and dynamic assembly of STRIPAK
            complexes in Hippo signaling
  JOURNAL   Cell Discov 5, 3 (2019)
   PUBMED   30622739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6381)
  AUTHORS   Bae,S.J., Ni,L., Osinski,A., Tomchick,D.R., Brautigam,C.A. and
            Luo,X.
  TITLE     SAV1 promotes Hippo kinase activation through antagonizing the PP2A
            phosphatase STRIPAK
  JOURNAL   Elife 6, e30278 (2017)
   PUBMED   29063833
  REMARK    GeneRIF: Here, the authors discover SAV1-mediated inhibition of the
            PP2A complex STRIPAK(SLMAP) as a key mechanism of MST1/2
            activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6381)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   6  (bases 1 to 6381)
  AUTHORS   Guzzo,R.M., Salih,M., Moore,E.D. and Tuana,B.S.
  TITLE     Molecular properties of cardiac tail-anchored membrane protein
            SLMAP are consistent with structural role in arrangement of
            excitation-contraction coupling apparatus
  JOURNAL   Am J Physiol Heart Circ Physiol 288 (4), H1810-H1819 (2005)
   PUBMED   15591093
REFERENCE   7  (bases 1 to 6381)
  AUTHORS   Guzzo,R.M., Wigle,J., Salih,M., Moore,E.D. and Tuana,B.S.
  TITLE     Regulated expression and temporal induction of the tail-anchored
            sarcolemmal-membrane-associated protein is critical for myoblast
            fusion
  JOURNAL   Biochem J 381 (Pt 3), 599-608 (2004)
   PUBMED   15086317
REFERENCE   8  (bases 1 to 6381)
  AUTHORS   Wielowieyski,P.A., Sevinc,S., Guzzo,R., Salih,M., Wigle,J.T. and
            Tuana,B.S.
  TITLE     Alternative splicing, expression, and genomic structure of the 3'
            region of the gene encoding the sarcolemmal-associated proteins
            (SLAPs) defines a novel class of coiled-coil tail-anchored membrane
            proteins
  JOURNAL   J Biol Chem 275 (49), 38474-38481 (2000)
   PUBMED   10986292
REFERENCE   9  (bases 1 to 6381)
  AUTHORS   Wigle,J.T., Demchyshyn,L., Pratt,M.A., Staines,W.A., Salih,M. and
            Tuana,B.S.
  TITLE     Molecular cloning, expression, and chromosomal assignment of
            sarcolemmal-associated proteins. A family of acidic amphipathic
            alpha-helical proteins associated with the membrane
  JOURNAL   J Biol Chem 272 (51), 32384-32394 (1997)
   PUBMED   9405447
REFERENCE   10 (bases 1 to 6381)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC114480.2 and AC099777.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 21, 2020 this sequence version replaced XM_017007146.2.
            
            Summary: This gene encodes a component of a conserved
            striatin-interacting phosphatase and kinase complex. Striatin
            family complexes participate in a variety of cellular processes
            including signaling, cell cycle control, cell migration, Golgi
            assembly, and apoptosis. The protein encoded by this gene is a
            coiled-coil, tail-anchored membrane protein with a single
            C-terminal transmembrane domain that is posttranslationally
            inserted into membranes. Mutations in this gene are associated with
            Brugada syndrome, a cardiac channelopathy. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1308741.1,
                                           SRR18074969.2894476.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000671191.1/ ENSP00000499458.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC114480.2         193451-193484
            35-1336             AC114480.2         193690-194991
            1337-1484           AC099777.2         133649-133796       c
            1485-1557           AC099777.2         123808-123880       c
            1558-1594           AC099777.2         117946-117982       c
            1595-1657           AC099777.2         115363-115425       c
            1658-1753           AC099777.2         107351-107446       c
            1754-1825           AC099777.2         107020-107091       c
            1826-1966           AC099777.2         104340-104480       c
            1967-2104           AC099777.2         103093-103230       c
            2105-2273           AC099777.2         100463-100631       c
            2274-2324           AC099777.2         100322-100372       c
            2325-2375           AC099777.2         99887-99937         c
            2376-2438           AC099777.2         93481-93543         c
            2439-2498           AC099777.2         75079-75138         c
            2499-2579           AC099777.2         68588-68668         c
            2580-2639           AC099777.2         68247-68306         c
            2640-2762           AC099777.2         57173-57295         c
            2763-2837           AC099777.2         56029-56103         c
            2838-3158           AC099777.2         52478-52798         c
            3159-3276           AC099777.2         51904-52021         c
            3277-3448           AC099777.2         48102-48273         c
            3449-3583           AC099777.2         42156-42290         c
            3584-3673           AC099777.2         39245-39334         c
            3674-6381           AC099777.2         35176-37883         c
FEATURES             Location/Qualifiers
     source          1..6381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p14.3"
     gene            1..6381
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="sarcolemma associated protein"
                     /db_xref="GeneID:7871"
                     /db_xref="HGNC:HGNC:16643"
                     /db_xref="MIM:602701"
     exon            1..34
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            35..1336
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             1139..3667
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="isoform j is encoded by transcript variant 10;
                     sarcolemmal membrane-associated protein"
                     /codon_start=1
                     /product="sarcolemmal membrane-associated protein isoform
                     j"
                     /protein_id="NP_001364469.1"
                     /db_xref="CCDS:CCDS93296.1"
                     /db_xref="GeneID:7871"
                     /db_xref="HGNC:HGNC:16643"
                     /db_xref="MIM:602701"
                     /translation="MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNA
                     TFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDI
                     IQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSM
                     YSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLE
                     VMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVE
                     RSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQK
                     GQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKEC
                     SSLGIQVDDFLPKINGSTEKEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETK
                     LSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQS
                     EIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQ
                     AQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQE
                     ELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKE
                     WNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVG
                     SLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDE
                     LKQCKNNLKLLREKGNNPSILQPVPAVFIGLFLAFLFWCFGPLW"
     exon            1337..1484
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1557
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1594
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1657
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1753
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1825
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1966
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2104
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2273
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2324
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2375
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2438
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2498
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2579
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2639
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2762
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2837
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..3158
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3276
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3448
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3449..3583
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3673
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..6381
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5523..5528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="hexamer: AATAAA"
     polyA_site      5546
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="major polyA site"
     regulatory      6236..6241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="hexamer: ATTAAA"
     polyA_site      6261
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
     regulatory      6363..6368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
                     /note="hexamer: AATGAA"
     polyA_site      6381
                     /gene="SLMAP"
                     /gene_synonym="SLAP"
ORIGIN      
        1 agtcagagtc actatggcgg ccggcgctgg caaggtcgga aagtttcctg cctcgtcggg
       61 cgcagcttga gcttgcccca tcggccgcga tcggtggagg ctgcggcgga tccagcccgg
      121 ggcctcaagg cctctcccca acctccgggc cagtctccct cccccacctt ctcgtccgcc
      181 gggagctgcg gctgccgtcc ctgagatgcg accctcgcgg gggcgaccct gaggggaggc
      241 ggcccatgtg ctgagcggcg gcccagaagc ctaggcgtcc ggggaccaac ttcctgccgc
      301 ctgggaactc gagcctcccg gtgtcgcgcc tcgctcggtc cgcaccggcc tgcggagccg
      361 ggtccccgcc ctggtcgcgg ggacgctcgc caggtgccca ggagtcccga cttggccact
      421 gcccgcgccc cgccggcctc cacgcctcgc gcggagaacc tcagccaccg ccgtctcgga
      481 tcgtgccagg ccggggaccg cgtccccctt cccggggcgg cctccgctca gcaggggcga
      541 tgcagactgt cccgccggcc gtctagagcc cctccgtctc cgtcacctct cgccccttca
      601 ctccgggcga ggactggcgg tggctgccca gaggtgccca gccacacctt ccttcggccc
      661 aaaaggactt tcctggccgc gccgaaccga cccttcattc atgctgcagt gctgcaacgt
      721 ttccgccacc aagggggaaa agcggccgcg atctcaaacc aaacacaaga attggcgtgt
      781 gactcatctg cttggatacc tccagtcccc aaactgtgtt ccaggagttt tcttggccga
      841 agctgcccga tgtttgagcc ttttcttccc agagaagaag atggactgaa agctgccagt
      901 tggggacttt ttgtgatcac ggcgttgcag cgttttaaag gaggtgatgg ggcttgcgct
      961 ggcttgtctt cccacccaag tgaagagttg atgttcactg gttatgctta gacaatgtgc
     1021 agtttgtgtt aatttaaaat tttgggtggg ataggggcat aggcttgtga agggcagtcc
     1081 ggatccggag gaactcctct ttgtccctgg taggagagac acccccagtc tatcctcgat
     1141 gccgtcagcc ttggccatct tcacttgccg cccgaactcg cacccgtttc aggagcgtca
     1201 tgtctacctg gacgagccca tcaaaatcgg ccgctcagtg gcccgctgtc gaccagcgca
     1261 gaataatgcc acttttgatt gcaaagtgct atcaaggaac cacgctctcg tctggtttga
     1321 tcacaagacg ggcaagtttt atcttcaaga cactaaaagt agtaatggta cttttataaa
     1381 tagccagaga ttgagtcgag gctctgaaga aagtccacca tgtgaaattc tttccggtga
     1441 cattatccag tttggagtag acgtgacaga gaatacacgg aaagttaccc atgggtgtat
     1501 tgtttccaca ataaaacttt ttctaccaga tggtatggaa gcccggctcc gctcagatgt
     1561 catccatgca ccattaccaa gtcctgttga caaagttgct gctaacactc caagtatgta
     1621 ctctcaggaa ctattccagc tttctcagta tctacaggag gccttacatc gggaacaaat
     1681 gttggaacag aagttagcca cgcttcagcg gctactagcc atcacccaag aggcttcaga
     1741 taccagttgg caggctttaa tagatgaaga tagactctta tcacggttag aagttatggg
     1801 aaaccaatta caggcatgct ccaaaaatca aacagaagat agtttacgaa aggaacttat
     1861 agcattacaa gaggataaac ataactatga gacaacagcc aaagagtccc tgaggcgggt
     1921 tcttcaggag aaaattgaag tggttagaaa actttcagaa gttgagcgaa gtctgagtaa
     1981 tactgaagat gaatgtaccc atctgaaaga aatgaatgaa aggactcagg aagaattaag
     2041 agaattagcc aacaaatata atggagcagt taatgagatt aaagatttat ctgataaatt
     2101 aaaggtagca gagggaaaac aagaggaaat ccaacagaag ggacaggctg agaaaaaaga
     2161 attacaacat aaaatagatg aaatggaaga aaaagaacag gagctccagg caaaaataga
     2221 agctttgcaa gctgataatg atttcaccaa tgaaaggcta acagctttac aagtacggtt
     2281 agaacatctt caggagaaaa ctcttaaaga atgcagcagc ttggggatac aagttgatga
     2341 cttcttacct aaaataaatg ggagcacaga aaaagagcac ttgctttcaa agagtggcgg
     2401 ggactgcact tttattcatc aattcataga atgccagaag aagctgatcg tcgaagggca
     2461 tctaaccaaa gcggtagaag aaacaaagct ttcaaaagaa aatcagacaa gagcaaaaga
     2521 atctgatttt tcagatactc tgagtccaag caaggaaaaa agcagtgacg acactacaga
     2581 cgcccaaatg gatgagcaag acctaaatga gcctcttgcc aaagtgtccc ttttaaaaga
     2641 tgacttgcag ggtgcacagt cagaaattga ggcaaagcaa gaaatacagc atcttcgaaa
     2701 ggaattgatc gaagcccagg agctagctag aacaagtaaa caaaaatgct ttgaacttca
     2761 agctcttttg gaagaagaaa gaaaagccta tcgaaatcaa gttgaggaat ccactaaaca
     2821 aatacaggtt cttcaagccc aattgcagag gttacacatc gatactgaga atctccggga
     2881 ggagaaggac agtgaaatca caagtactag agatgaattg cttagtgccc gagatgaaat
     2941 tttgctcctt catcaagcag cagcaaaggt tgcctctgag cgggacactg acattgcttc
     3001 tttacaagaa gagcttaaga aggtgagagc tgagcttgag cggtggcgga aagcagcgtc
     3061 tgaatatgag aaagaaatca caagtctgca aaacagtttt cagcttagat gtcaacagtg
     3121 tgaggaccag cagagagaag aagcaacaag gttgcaaggt gaactagaga agttgagaaa
     3181 ggaatggaat gcattggaaa ccgaatgcca ttctctaaaa agggaaaatg ttttgctatc
     3241 atcagaactg caacggcaag aaaaagaatt gcacaattct cagaagcaga gtttagagct
     3301 taccagtgat ctcagcatcc ttcaaatgtc taggaaagaa cttgagaatc aagtgggatc
     3361 cttgaaagaa cagcatcttc gggattcagc tgatttaaaa actcttctca gtaaggcaga
     3421 aaaccaagca aaggatgtgc agaaagagta tgaaaagaca cagactgtac tctcagaact
     3481 gaagttgaag tttgaaatga ctgagcagga aaagcagtca atcacagatg agctcaaaca
     3541 gtgtaaaaac aacctgaagc tgctccgaga gaaaggaaat aatccttcca tattacaacc
     3601 cgtcccagcc gtattcatcg gcctattcct ggctttcctg ttttggtgtt tcggtccatt
     3661 gtggtagaga aagaaaccct ggccctggat gcccatgttg gctgccctgg ttgcagtaac
     3721 agccatcgtg ctgtacgtgc caggtctggc cagagcttct ccatgagagc gttccttgag
     3781 tccgtacacc gtcctccctc tagaagctgg catcacactc atgctgggga caaacagaac
     3841 cattttcttc ctctttacct cttaaaacag cagaagtaca agaatacagc tgtagggtca
     3901 ttgctttaaa ttatataaaa tgtatctgtc tataaagaag atataaaatt gtgactttat
     3961 tctactgtaa gcaataattt gcttgcaatt tttcatgtaa tttttaaatt agtatgttaa
     4021 gattctgaat attatggtgg cctaaagtag gcttcttggt acaccagatt atttataaca
     4081 ttaaatttat gagtatttta ctctgaattc tgatcaccag ataattcatt tttctgattt
     4141 gataactacc caaaccaaac aaccaataca tacatgggaa gagaggccct gtgtgctcag
     4201 tgcctatcag tttgaaatat atacacatat atatattttt tacatattta cgccattttt
     4261 acttgttatg aaaccactga gctattggga acaagactta gagacaacta tttgcgtgga
     4321 tttttttttt tttaaggaaa aatacgtttg gaaaataaac tgttatggtg ataatttggg
     4381 gaatatgtgc acgcttgttc agccttaatg tgacttgaag atgtggagga catcaacttt
     4441 gaaaaacttt ccatgagagt gtattttctt gagcaaactg aagtatttct gggagcaaaa
     4501 acatagtaat tacacaattt cagtgcagtc aaccaaaatg ttgagtcaat tggaatgtaa
     4561 tttattaaac catgtattta aagagatatt tttctttaaa agccaagtta ctttctcata
     4621 tacagcattt taggaagcat gatttttttt ttctatcatc tattcctcca agcatgttta
     4681 attgaagaaa gtattaatat ctctttagat aagcttgtat tgacctaatt tggtttatga
     4741 tgtgtcagag ctaattcatg ttcagggtga gcgttgtacc taccaacaaa tttcctggtt
     4801 gggtatgcaa atggttattt tctttttatt gttgttaatt gggactttct gttaatgaaa
     4861 agcactattc ccaagattaa tagtgttcta tgcacaatga agcacctaaa aacactgctt
     4921 gatattataa atttaaaaca caagtgaaag tttagccatg gttttgtgcg gcatcatagt
     4981 tatgtcaata aagtttattt aggtcataga atatcctaaa gtatcacata gttaaatttt
     5041 tcagtcagtg aagaccggga gggaatgtca gtgaattggc ttgaatgttc tgtggcaatc
     5101 cacaggtcta gccaaatatt gaaataggag tttagggtat aatttgcctt gtgatgtttg
     5161 gcagtcactg tttatacttt aaaggttata ttttaagcta tttgagattg cttttgggaa
     5221 gatcactaga tttatggagg aattagtcac aaatgacttg tagaaaatac tgtcatatag
     5281 ttcatttcat cattttctgt tgcaggaagc cactccacca cagaatgcta atatgccagt
     5341 ggtacccagt acctcttgta tataggttat tgcaaatatt gttctgaaat gcttaacttc
     5401 agaattacat tttttaaagt aaataattgt tttaaatcta ttttgtaaag atataaagta
     5461 caatagaatt tctggagtac agattaaact atttgcacta acacacgtga cgtgcatgat
     5521 ttaataaaat aactttactc tccctacgca tgtttgagtt gaatatcatt gaagttctta
     5581 atgctgactc tactattggg ttgttaatag tcttctcttg acatgactct ttatgcaaca
     5641 taacatacat ttggtattct tcagggttta aaagaaaaca ctgagctgtt tcctccaagt
     5701 tttattaacc ttttatttaa cttactgctt tatttttttc tcttttaata tggttattgt
     5761 taaaatgaga gtcacttgct agactggtct ctttaaatgt aaggtctagt atcaatattt
     5821 acttcattca agtggaataa atggcttttt gtagttactt ccagttttcc tcaagaatag
     5881 aaataagtct gttcataagc aataccttca gttttgttca gttcacttcc acgttaaata
     5941 aagaatagga ttattcactg gtaataatag agtcattaag aaatattaag cattgcagct
     6001 aaaaattgaa caaccctgta atgatacatt taagaattat tcaaaggtgc tacatggcag
     6061 ggttagagaa taaaaagaac gtggtgtttg aagcaaaaca gatctgtatt ggcatcttgg
     6121 ttctaccttt tatcagatgt tgttgccttg tgcaaatcac attttctctg agtctccatt
     6181 ttctcattta taacatgcgg agaataatac ttatatttgt ggtagtagtg tgaacattaa
     6241 aaagataatg tatgtgaagt accattcgag tggtgaatac gtttttatga gaatgtcata
     6301 ctgaaaaaat attgcaaata ttaaagtttt aggtaagcct aaactttaat ctactttaat
     6361 taaatgaatt gattgactca a
//
