LOCUS       NM_014720               7827 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens STE20 like kinase (SLK), transcript variant 1, mRNA.
ACCESSION   NM_014720
VERSION     NM_014720.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7827)
  AUTHORS   Wang,Y., Wang,R. and Tang,D.D.
  TITLE     Ste20-like Kinase-mediated Control of Actin Polymerization Is a New
            Mechanism for Thin Filament-associated Regulation of Airway Smooth
            Muscle Contraction
  JOURNAL   Am J Respir Cell Mol Biol 62 (5), 645-656 (2020)
   PUBMED   31913659
  REMARK    GeneRIF: SLK-mediated actin cytoskeletal reorganization may
            facilitate force transmission between the contractile units and the
            extracellular matrix.
REFERENCE   2  (bases 1 to 7827)
  AUTHORS   Wang,K., Hong,R.L., Lu,J.B. and Wang,D.L.
  TITLE     Ste20-like kinase is upregulated in glioma and induces glioma
            invasion
  JOURNAL   Neoplasma 65 (2), 185-191 (2018)
   PUBMED   29534578
  REMARK    GeneRIF: The inhibition of SLK by RNA interference significantly
            suppressed the invasion ability of glioma, and on protein level,
            knock- down of SLK leaded to an up-regulation of E-cadherin and a
            down-regulation of Vimentin in glioma cells.
REFERENCE   3  (bases 1 to 7827)
  AUTHORS   Fokin,A.I., Klementeva,T.S., Nadezhdina,E.S. and Burakov,A.V.
  TITLE     SLK/LOSK kinase regulates cell motility independently of
            microtubule organization and Golgi polarization
  JOURNAL   Cytoskeleton (Hoboken) 73 (2), 83-92 (2016)
   PUBMED   26818812
REFERENCE   4  (bases 1 to 7827)
  AUTHORS   Jaberi,A., Hooker,E., Guillemette,J., Papillon,J., Kristof,A.S. and
            Cybulsky,A.V.
  TITLE     Identification of Tpr and alpha-actinin-4 as two novel
            SLK-interacting proteins
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2539-2552 (2015)
   PUBMED   26094769
  REMARK    GeneRIF: SLK interacts with Tpr and alpha-actinin-4 in cells, and
            these protein-protein interactions may control the subcellular
            localization and the biological activity of SLK.
REFERENCE   5  (bases 1 to 7827)
  AUTHORS   Baron,K.D., Al-Zahrani,K., Conway,J., Labreche,C., Storbeck,C.J.,
            Visvader,J.E. and Sabourin,L.A.
  TITLE     Recruitment and activation of SLK at the leading edge of migrating
            cells requires Src family kinase activity and the LIM-only protein
            4
  JOURNAL   Biochim Biophys Acta 1853 (7), 1683-1692 (2015)
   PUBMED   25882817
  REMARK    Erratum:[Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2754]
REFERENCE   6  (bases 1 to 7827)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   7  (bases 1 to 7827)
  AUTHORS   Dan,I., Watanabe,N.M. and Kusumi,A.
  TITLE     The Ste20 group kinases as regulators of MAP kinase cascades
  JOURNAL   Trends Cell Biol 11 (5), 220-230 (2001)
   PUBMED   11316611
REFERENCE   8  (bases 1 to 7827)
  AUTHORS   Eichmuller,S., Usener,D., Dummer,R., Stein,A., Thiel,D. and
            Schadendorf,D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 629-634 (2001)
   PUBMED   11149944
REFERENCE   9  (bases 1 to 7827)
  AUTHORS   Yamada,E., Tsujikawa,K., Itoh,S., Kameda,Y., Kohama,Y. and
            Yamamoto,H.
  TITLE     Molecular cloning and characterization of a novel human STE20-like
            kinase, hSLK
  JOURNAL   Biochim Biophys Acta 1495 (3), 250-262 (2000)
   PUBMED   10699464
REFERENCE   10 (bases 1 to 7827)
  AUTHORS   Sabourin,L.A., Tamai,K., Seale,P., Wagner,J. and Rudnicki,M.A.
  TITLE     Caspase 3 cleavage of the Ste20-related kinase SLK releases and
            activates an apoptosis-inducing kinase domain and an
            actin-disassembling region
  JOURNAL   Mol Cell Biol 20 (2), 684-696 (2000)
   PUBMED   10611247
  REMARK    Erratum:[Mol Cell Biol 2000 Apr;20(8):2949]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360170.23, BC047885.1, AF273048.1 and AL138761.12.
            
            On Nov 22, 2018 this sequence version replaced NM_014720.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF273048.1, SRR7346977.1823209.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369755.4/ ENSP00000358770.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AL360170.23        48832-48876
            46-572              BC047885.1         1-527
            573-5133            AF273048.1         1-4561
            5134-7827           AL138761.12        49979-52672
FEATURES             Location/Qualifiers
     source          1..7827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.33-q25.1"
     gene            1..7827
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="STE20 like kinase"
                     /db_xref="GeneID:9748"
                     /db_xref="HGNC:HGNC:11088"
                     /db_xref="MIM:616563"
     exon            1..756
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..4314
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; Long
                     Ste20-like Kinase; Ste20-related serine/threonine kinase;
                     STE20-like serine/threonine-protein kinase; CTCL tumor
                     antigen se20-9; hSLK; STE20-related kinase;
                     serine/threonine-protein kinase 2; STE20-related
                     serine/threonine-protein kinase; SNF1 sucrose
                     nonfermenting like kinase; SNF1 (sucrose nonfermenting,
                     yeast, homolog)-like kinase, SNF1 sucrose nonfermenting
                     like kinase"
                     /codon_start=1
                     /product="STE20-like serine/threonine-protein kinase
                     isoform 1"
                     /protein_id="NP_055535.2"
                     /db_xref="CCDS:CCDS7553.1"
                     /db_xref="GeneID:9748"
                     /db_xref="HGNC:HGNC:11088"
                     /db_xref="MIM:616563"
                     /translation="MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGA
                     FGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYEN
                     NLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGN
                     ILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADV
                     WSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKN
                     VDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIP
                     ASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEK
                     AVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEG
                     KENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGE
                     KEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSA
                     EDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSS
                     ENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKE
                     KKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPES
                     ENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKF
                     IVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQR
                     EQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKE
                     LSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELD
                     GSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQ
                     YFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKK
                     SLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELH
                     QLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFF
                     KMTGESECLNPSTQSRISKFYPIPSLHSTGS"
     exon            757..921
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..970
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1120
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1193
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1388
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1470
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1599
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..2955
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3086
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3210
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3211..3390
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3483
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3613
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3738
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3927
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4053
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4167
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..7827
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6156..6161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="hexamer: GATAAA"
     polyA_site      6178
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="major polyA site"
     regulatory      7806..7811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="hexamer: AATAAA"
     polyA_site      7827
                     /gene="SLK"
                     /gene_synonym="bA16H23.1; LOSK; se20-9; STK2"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcggcg tcggcgcgcg ctccaggccg aggctgtgtg ggctggggag ggagacaggc
       61 ggcggcggcg gcgccccaga cccgagggga cgcgcgggcc ttgcgccgcg ggagcggacg
      121 gcggcggagg agaccctagg ctcgcggccc gaggcgggag ggctcggctt ctcgactgcc
      181 cgcctccgag gccgccggcc gcttctctct cccagagtgg ccgccgcccc tggagactcg
      241 ccgtgacacg ggcctaagcc gccgccgcgg gagtcctgac cgctcggacc cgtcggatca
      301 ggccgggtgg gagcgagctt gcgggcaggt gccgctcccg gagggtgggc cggaggcgag
      361 gcgcccaccg cgcggctcgc gggccgggct cggcggaggg gccgctcgcg cagcaccccc
      421 accgcgggcc ggagcccggg tcgccgcccc gccttctccc gggaccgccc ggccggagct
      481 gcgggggccg agggacgccg cgcccgccgc cgccagccgg gctcgcgcgg gagagcaggg
      541 aagagaaact ttgcctttta ttgtttttag tccttaagtg caaggaactc tgtgttggga
      601 ggaaaaatgt ccttcttcaa tttccgtaag atcttcaagt tggggagcga gaagaagaag
      661 aagcagtacg aacacgtgaa gagggacctg aaccccgaag acttttggga gattatagga
      721 gaactgggcg acggagcctt tgggaaagtg tacaaggccc agaataaaga gaccagtgtt
      781 ttagctgctg caaaagtgat tgacactaaa tctgaagaag aacttgaaga ttacatggta
      841 gagattgaca tattagcatc ttgtgatcac ccaaatatag tcaagcttct agatgccttc
      901 tattatgaga acaatctttg gatcctcatt gaattttgtg caggtggagc agtagatgct
      961 gtgatgcttg aacttgagag accattaact gagtcccaaa tacaagtagt ttgcaagcag
     1021 actttagatg cattgaacta cttacatgat aataagatca tccacagaga tctgaaggct
     1081 ggcaacattc tctttacctt agatggagat atcaaattgg cggattttgg agtatcagct
     1141 aaaaacacga ggacaattca aagaagagat tcctttattg gtacaccata ttggatggct
     1201 cctgaagtag tcatgtgtga aacatctaag gacagaccct atgactacaa agctgatgtt
     1261 tggtccctgg gtatcacttt aatagaaatg gctgagatag aaccacctca tcatgaatta
     1321 aatccaatgc gagtgctgct aaaaatagca aaatctgagc cacctacatt agcacagcca
     1381 tccagatggt cttcaaattt taaggacttt ctaaagaaat gcttagaaaa gaatgtggat
     1441 gccaggtgga ctacatctca gctgctgcag catccctttg ttactgttga ttccaacaaa
     1501 cccatccgag aattgattgc agaggcgaag gctgaagtaa cagaagaagt tgaagatggc
     1561 aaagaggaag atgaagagga ggaaacagaa aattctctgc caatacctgc aagtaagcgt
     1621 gcatcttctg accttagtat cgccagctct gaagaagata aactttcaca aaatgcttgt
     1681 attttggagt ctgtctcaga aaaaacagaa cgtagtaact ctgaagataa actcaacagc
     1741 aaaattctta atgaaaaacc caccactgat gaacctgaaa aggctgtgga ggatattaat
     1801 gaacatatta ccgatgctca gttagaagca atgactgaac tccatgacag aacagcagta
     1861 atcaaggaga atgaaagaga gaagaggccc aagcttgaaa atctgcctga cacagaagac
     1921 caagaaactg tggacattaa ttcagtcagt gaaggaaaag agaataatat aatgataacc
     1981 ttagaaacaa atattgaaca taatctaaaa tctgaggaag aaaaggatca ggaaaagcaa
     2041 cagatgtttg aaaataagct tataaaatct gaagaaatta aagatactat tttgcaaaca
     2101 gtagatttag tttctcaaga gactggagaa aaagaggcaa atattcaggc agttgatagt
     2161 gaagttgggc ttacaaagga agacacccaa gagaaattgg gggaagacga caaaactcaa
     2221 aaagatgtga tcagcaatac aagtgatgtg ataggaacat gtgaggcagc agatgtggct
     2281 cagaaagtgg atgaagacag tgctgaggat acgcagagta atgatgggaa agaagtggtc
     2341 gaagtaggcc agaaattaat taataagccc atggtgggtc ctgaggctgg tggtactaag
     2401 gaagttccta ttaaagaaat agttgaaatg aatgaaatag aagaaggtaa aaataaggaa
     2461 caagcaataa acagttcaga gaacataatg gacatcaatg aggaaccagg aacaactgaa
     2521 ggtgaagaaa tcactgagtc aagtagcact gaagaaatgg aggtcagaag tgtggtggct
     2581 gatactgacc aaaaggcttt aggaagtgaa gttcaggatg cttctaaagt cactactcag
     2641 atagataaag agaaaaaaga aattccagtg tcaattaaaa aagagcctga agttactgta
     2701 gtttcacagc ccactgaacc tcagcctgtt ctaataccca gtattaatat caactctgac
     2761 agtggagaaa ataaagaaga aataggttct ttatcaaaaa ctgaaactat tctgccacca
     2821 gaatctgaga atccaaagga aaatgataat gattcaggca ctggttccac tgctgatact
     2881 agcagtattg acttgaattt atccatctct agctttctaa gtaaaactaa agacagtgga
     2941 tcgatatctt tacaagaaac aagaagacaa aagaaaacat tgaagaaaac acgcaaattt
     3001 attgttgatg gtgtagaagt gagtgtaaca acatcaaaga tagttacaga tagtgattcc
     3061 aaaactgaag aattgcggtt tcttagacgt caggaacttc gggaattaag atttcttcag
     3121 aaagaagagc aaagagccca acaacagctc aatagcaaac tacagcaaca acgagaacaa
     3181 attttccggc gctttgagca ggaaatgatg agtaaaaagc gacaatatga ccaggaaatt
     3241 gagaatctag aaaaacagca gaaacagact atcgaacgcc tggaacaaga gcacacaaat
     3301 cgcttgcgag atgaagccaa acgcatcaaa ggagaacaag agaaagagtt gtccaaattt
     3361 cagaatatgc tgaagaaccg aaagaaggag gttataaatg aagtggagaa agcacccaaa
     3421 gagctgagaa aagagctcat gaaacgcagg aaagaggagc ttgcacaaag ccagcatgct
     3481 caggaacaag agtttgttca gaaacaacag caagaattag atggctctct gaaaaagatc
     3541 atccagcagc agaaggcaga gttagctaat attgagagag agtgcctgaa taacaagcaa
     3601 cagctcatga gagctcgaga agctgcaatt tgggagctcg aagaacgaca cttacaagaa
     3661 aaacaccagc tgctcaaaca gcagcttaaa gatcagtatt tcatgcaaag acatcagcta
     3721 cttaagcgcc acgagaagga aacagagcaa atgcagcgtt acaatcaaag acttattgag
     3781 gaattgaaaa acagacagac tcaagaaaga gcaagactgc ccaagattca gcgcagtgaa
     3841 gccaagactc gaatggccat gtttaagaag agtttgagaa ttaactcaac agccacacca
     3901 gatcaggacc gtgataaaat taaacagttt gctgcacaag aagaaaagag gcagaaaaat
     3961 gagagaatgg ctcagcatca gaaacatgag aatcaaatgc gagatcttca gttgcagtgt
     4021 gaagccaatg tccgcgaact gcatcagctg cagaatgaaa aatgccactt gttggttgag
     4081 catgagactc agaaactgaa ggagttagat gaggaacata gccaagaatt aaaggagtgg
     4141 agagagaaat tgagacctag gaaaaagaca ctggaagaag agtttgccag gaaactacag
     4201 gaacaggaag tattctttaa aatgactggg gagtctgaat gccttaaccc atcaacacag
     4261 agccggattt ccaaatttta tcctattccc agcttgcatt ccaccggatc ataacaaagg
     4321 gaagcattct gtgcgtgggt ttggctcttt cagtatgtca ttctgttctc atcttctgcc
     4381 acagtctctc agatagctca tgaagacaat cacctgcctc accttctagg tgttttcctt
     4441 ttttgttttt tttgttttgt tttgttttta agcaaagatg aagggaaaac gaactaagac
     4501 agacgctagg ccatgttggc aaagtagcat cttggtgact aaggtgactt tgtatattca
     4561 tcttaaaaat tatgttcttt agacactgct acctgaaaac tgttggagaa ataatgttta
     4621 aagttattta agaaaaactg ttacatcact aagtattaat aaattcttct tacctgacgt
     4681 aacttctcaa tgcctaaatt ctgtagttga agctctgctg cagagagttg ggataatttt
     4741 cttttggtgg atcagctctc ataaaaaagc tatgatttgc tcaaatatgc tgttgactca
     4801 gtaaatgaat atattttttt ctttaaatag gaacaacctc ttttaaaaga gaaaaattat
     4861 ttcagtgatt tgtcaaaacg aattacctct tttggcatga gctaataatt gagggtgcta
     4921 attttcttaa gatagtgcct aaaacactaa atttcagtca agtcgtaagt aggattttct
     4981 ttttgatcaa cagggacaaa aacatcttta gaattaaaaa catggttgtt ttggaatttt
     5041 tgcttctctt accgtttgat agaaattttc atcctaaaat acatgtacaa agtttggaaa
     5101 gatgaaaaaa agaggtagct tttagattgc aaactggaaa tgtaaaactc atgaaattta
     5161 agcaatatag gtttagctat ctgtgtttat tttctaaaat aatacctgag ctggttaaat
     5221 gatttctctc catcttagct aattctgttt aaaactctgt cagaggcctg caggctgtga
     5281 gttatattta taaatatatc ttcagaaatt aatcttaaaa gaggcattag ttcagaatac
     5341 ttttttaaaa gtttaaatta aatatttagg cacgtcagga attacttttc cttattttga
     5401 aatgaggcta cttatgtctt ggttttattt tgttccatgt ttaaatcatt cactttgatt
     5461 tgagtgggaa aagcctgaag cctttatcat gtggttgctg gtgtgtgtaa ttattaatga
     5521 aatgttcact cctagtccct tatgaggctt agaatttcaa ccacgtgtca ggtcagacag
     5581 tattataaac tgtactttgc tgtctgagac agcacatttg tgaatgatgc ttgctgcctg
     5641 ccattttcaa cctattctct cttaagagtg ctaggtacca aattgtgaaa gtttgttttc
     5701 agttatatta cttttgaggc tggtgaaaaa tttaaatgta actttgtggg aacactgatt
     5761 catatttaga aaatgtaaat gtctgtagca ctttcttgca gttaatttga aaactttgga
     5821 tgctgaacct tgtttgtcag tgatttagat gatttaaaaa tgcatgtgtg atttgaattt
     5881 tataattgtt ttgacaagca taatttactt ggacaacttc gtaggtagcc ttaacttctg
     5941 gccaagtttg ttttttatat aaatatatat acatatatac atattatgta tggttgtaaa
     6001 ttcatacact tatcacatga atgtgttact gtatacaaaa ctcttaatgc tttattctca
     6061 aatgctgggt tgaaaaatgt tttgaaagcc ttttaaaata tatatcttta taaagtaata
     6121 ttcaggatga tgataaaaat tgtttatatt gttatgataa aaatgacagt ataatgttgc
     6181 ccagtgtatt taatgattta tttgaagagg gattgggaag gaacgtcttc ataccacttt
     6241 ctcctttgaa attttcagtt tattgacttt taaaaaatga atacctcagg cagtagacat
     6301 tttttttcta gtatcattta attgataccc tgtgcgctaa atagtgtgtg gtgcctgatt
     6361 aatttggtct gaatatttga ttctttctgt tcctttcaac ttgacattca gattattgac
     6421 tcaaggagag aggctcagag tggaatggtt ggcgctgtgg gtaaggttgg atctccctta
     6481 aaactgcctt ttggattcag tgtttgtgct tgagttcgct ttcaaatatg accataatcg
     6541 tgtgggtgca agactgtaca gtgatacata tgtagaggta aagcattcat tttaatactt
     6601 aaagttatat aaatcttttc aaaaagtgtt ttgttataaa atacgctgtt tgtacccata
     6661 ccagcccacc tcttctgagg ccctgtattc aaatagatga tagtgatcta tctttcctgc
     6721 atgaagtgta ggtggcgagt gggcgagggg cgcagacttc tttgaaatcg aagggtacag
     6781 tcaaatctac tgctgatttg gttgttttgt tgctgtggca gaatatgcca tgaaacacat
     6841 acagacttct ccgaacgtgc accctcatca gccacctcct cccctctttc cctgagtgct
     6901 gtgaacacag cagacctgca cacttctgca gatccagctc ctacagcttg gggcactagg
     6961 ctgcctttcc tagtcctgtc aacaaccata cagtgcgaat tgctgaatta gctgctattc
     7021 tatgtggagt cacattaagc tttttcttat ctttttctat ggggaagcta tagggtgggt
     7081 aaggaaaaaa tgttgaatgc ttttactttg ctgaaaatat tagaactctc ttgtgacagg
     7141 atacagcaaa ttataattaa atataaatta ccagaaccag agctacctct aagtcatact
     7201 tcctcaagca caaagctctc aggcatatga gacccacctt aatgaagggt ctctgatttc
     7261 ttgagcatca gcgagtttca gaagtgacta tttttttgta ctcttctagt ttccttgtaa
     7321 ctatacactt tttcccattc cacactgtgc ttaaatgaca aagactcttc tgagaagcca
     7381 aattctgtcc aagtattaac tagagatatt gttgattaaa gaaaatctag aactgaagtg
     7441 aaagaagaga gttccagttc taatagtctt ttgattaaca attcttttct gagaaatgat
     7501 ttttataaga aatggggtga ttctttaaat gcttttctta agttgaaggc acaacagtta
     7561 atggctgtat tgttgctatt ccgttgctga catgtttttg ataaagcttt aacattcctg
     7621 ctactaattt tggcggagag tgtttgccag gtttcaatgt gggctgcagc tttttgtgct
     7681 ccttctctgg tttgcagtgt aatgagttca taagctaaat tttcagaaag aattttgttt
     7741 aagattatgc ctcttatcta cttgagagca acatgtcttt tcaatcatgg gattgacaca
     7801 tgaaaaataa agttatttct taatcaa
//
