LOCUS       NM_001281503            4827 bp    mRNA    linear   PRI 16-SEP-2022
DEFINITION  Homo sapiens SLIT and NTRK like family member 1 (SLITRK1),
            transcript variant 2, mRNA.
ACCESSION   NM_001281503
VERSION     NM_001281503.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4827)
  AUTHORS   Ali MZ, Farid A, Ahmad S, Muzammal M, Mohaini MA, Alsalman AJ, Al
            Hawaj MA, Alhashem YN, Alsaleh AA, Almusalami EM, Maryam M and Khan
            MA.
  TITLE     In Silico Analysis Identified Putative Pathogenic Missense nsSNPs
            in Human SLITRK1 Gene
  JOURNAL   Genes (Basel) 13 (4), 672 (2022)
   PUBMED   35456478
  REMARK    GeneRIF: In Silico Analysis Identified Putative Pathogenic Missense
            nsSNPs in Human SLITRK1 Gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4827)
  AUTHORS   Guo Y, Guo XL, Wang S, Chen X, Shi J, Wang J, Wang K, Klempner SJ,
            Wang W and Xiao M.
  TITLE     Genomic Alterations of NTRK, POLE, ERBB2, and Microsatellite
            Instability Status in Chinese Patients with Colorectal Cancer
  JOURNAL   Oncologist 25 (11), e1671-e1680 (2020)
   PUBMED   32627883
  REMARK    GeneRIF: Genomic Alterations of NTRK, POLE, ERBB2, and
            Microsatellite Instability Status in Chinese Patients with
            Colorectal Cancer.
REFERENCE   3  (bases 1 to 4827)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4827)
  AUTHORS   Melo-Felippe FB, Fontenelle LF and Kohlrausch FB.
  TITLE     Gene variations in PBX1, LMX1A and SLITRK1 are associated with
            obsessive-compulsive disorder and its clinical features
  JOURNAL   J Clin Neurosci 61, 180-185 (2019)
   PUBMED   30377043
  REMARK    GeneRIF: Our results indicate an important influence of the
            neurodevelopment genes, PBX1, LMX1A, and SLITRK1 in
            obsessive-compulsive disorder susceptibility
REFERENCE   5  (bases 1 to 4827)
  AUTHORS   Beaubien F, Raja R, Kennedy TE, Fournier AE and Cloutier JF.
  TITLE     Slitrk1 is localized to excitatory synapses and promotes their
            development
  JOURNAL   Sci Rep 6, 27343 (2016)
   PUBMED   27273464
  REMARK    GeneRIF: Altogether, these results demonstrate that Slitrk family
            proteins regulate synapse formation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4827)
  AUTHORS   Wendland,J.R., Kruse,M.R. and Murphy,D.L.
  TITLE     Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and
            susceptibility to obsessive-compulsive disorder
  JOURNAL   Mol Psychiatry 11 (9), 802-804 (2006)
   PUBMED   16936762
  REMARK    GeneRIF: No variation in patients susceptible to
            obsessive-compulsive disorder.(
REFERENCE   7  (bases 1 to 4827)
  AUTHORS   Burton,A.
  TITLE     SLITRK1 trouble in Tourette's syndrome
  JOURNAL   Lancet Neurol 4 (12), 801 (2005)
   PUBMED   16323357
  REMARK    GeneRIF: SLITRK1 trouble in Tourette's syndrome.
REFERENCE   8  (bases 1 to 4827)
  AUTHORS   Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM,
            Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek
            AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer
            HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N and State MW.
  TITLE     Sequence variants in SLITRK1 are associated with Tourette's
            syndrome
  JOURNAL   Science 310 (5746), 317-320 (2005)
   PUBMED   16224024
  REMARK    GeneRIF: findings support the association of rare SLITRK1 sequence
            variants with Tourette's syndrome
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4827)
  AUTHORS   Aruga J, Yokota N and Mikoshiba K.
  TITLE     Human SLITRK family genes: genomic organization and expression
            profiling in normal brain and brain tumor tissue
  JOURNAL   Gene 315, 87-94 (2003)
   PUBMED   14557068
REFERENCE   10 (bases 1 to 4827)
  AUTHORS   Aruga J and Mikoshiba K.
  TITLE     Identification and characterization of Slitrk, a novel neuronal
            transmembrane protein family controlling neurite outgrowth
  JOURNAL   Mol Cell Neurosci 24 (1), 117-129 (2003)
   PUBMED   14550773
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355481.12, HY157227.1,
            DC334447.1, AB067497.1 and AI500170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001281503.1.
            
            Summary: This gene encodes a member of the SLITRK protein family.
            Members of this family are integral membrane proteins that are
            characterized by two N-terminal leucine-rich repeat (LRR) domains
            and a C-terminal region that shares homology with trk neurotrophin
            receptors. However, the protein encoded by this gene lacks the
            region of homology to neurotrophin receptors. This protein is
            thought to be involved in neurite outgrowth. Mutations in this gene
            may be associated with Tourette syndrome. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2013].
            
            Transcript Variant: This variant (2) lacks an internal segment
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.133080.1,
                                           SRR1660809.112857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674365.1/ ENSP00000501349.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL355481.12        19412-19492         c
            82-265              HY157227.1         41-224
            266-836             DC334447.1         1-571
            837-4697            AB067497.1         1198-5058
            4698-4827           AI500170.1         8-137               c
FEATURES             Location/Qualifiers
     source          1..4827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q31.1"
     gene            1..4827
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="SLIT and NTRK like family member 1"
                     /db_xref="GeneID:114798"
                     /db_xref="HGNC:HGNC:20297"
                     /db_xref="MIM:609678"
     exon            1..471
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /inference="alignment:Splign:2.1.0"
     exon            472..4827
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..2615
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="slit and trk like gene 1; leucine-rich
                     repeat-containing protein 12"
                     /codon_start=1
                     /product="SLIT and NTRK-like protein 1 precursor"
                     /protein_id="NP_001268432.1"
                     /db_xref="CCDS:CCDS9464.1"
                     /db_xref="GeneID:114798"
                     /db_xref="HGNC:HGNC:20297"
                     /db_xref="MIM:609678"
                     /translation="MLLWILLLETSLCFAAGNVTGDVCKEKICSCNEIEGDLHVDCEK
                     KGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAF
                     LGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLI
                     LNDNLISTLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTC
                     DLLSLKEWLENIPKNALIGRVVCEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPA
                     QEETFAPGPLPTPFKTNGQEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKP
                     LANSLPCPGGCSCDHIPGSGLKMNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRK
                     SHFVDYKNLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLE
                     YLNVEYNAIQLILPGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMY
                     LPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNFFR
                     KDFMLLSNDEICPQLYARISPTLTSHSKNSTGLAETGTHSNSYLDTSRVSISVLVPGL
                     LLVFVTSAFTVVGMLVFILRNRKRSKRRDANSSASEINSLQTVCDSSYWHNGPYNADG
                     AHRVYDCGSHSLSD"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="hexamer: ATTAAA"
     polyA_site      3790
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="major polyA site"
     regulatory      4802..4807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="hexamer: AATAAA"
     polyA_site      4827
                     /gene="SLITRK1"
                     /gene_synonym="LRRC12; TTM"
                     /note="major polyA site"
ORIGIN      
        1 gtcagatctt tcagagtgca ccaggctgga acgagcagag cttcttagca actctcttct
       61 ccgcccccct cccctcattc tcgcgctctc ttcctccctc agacaactcg ccccccgccc
      121 tccgcccccc tccacgtaat tccgaaagag cagaagaaag agaaggagaa caggaaaaga
      181 agagctagta agcgagagcg agagcacaga aaagaaaaaa aaaagcctta agaggaccga
      241 aggggaggaa aggaaaagga tggacaacca caaaacgcag cgattgcgga aattttccag
      301 cgccattggc tgggcagcgt gagtccttcg gtcgggcgtg atttcagcac cgggggaact
      361 ggacagcacc tcggggggac ttctgggcaa cccgcaacca cagcaagaac tccaccagca
      421 gcctcaacaa cagaagccgc ggaaaaccct gctttgtatc agagaggcaa ggatggtcgc
      481 tgttactttg tgatgagatc ggggatgaat tgctcgcttt aaaaatgctg ctttggattc
      541 tgttgctgga gacgtctctt tgttttgccg ctggaaacgt tacaggggac gtttgcaaag
      601 agaagatctg ttcctgcaat gagatagaag gggacctaca cgtagactgt gaaaaaaagg
      661 gcttcacaag tctgcagcgt ttcactgccc cgacttccca gttttaccat ttatttctgc
      721 atggcaattc cctcactcga cttttcccta atgagttcgc taacttttat aatgcggtta
      781 gtttgcacat ggaaaacaat ggcttgcatg aaatcgttcc gggggctttt ctggggctgc
      841 agctggtgaa aaggctgcac atcaacaaca acaagatcaa gtcttttcga aagcagactt
      901 ttctggggct ggacgatctg gaatatctcc aggctgattt taatttatta cgagatatag
      961 acccgggggc cttccaggac ttgaacaagc tggaggtgct cattttaaat gacaatctca
     1021 tcagcaccct acctgccaac gtgttccagt atgtgcccat cacccacctc gacctccggg
     1081 gtaacaggct gaaaacgctg ccctatgagg aggtcttgga gcaaatccct ggtattgcgg
     1141 agatcctgct agaggataac ccttgggact gcacctgtga tctgctctcc ctgaaagaat
     1201 ggctggaaaa cattcccaag aatgccctga tcggccgagt ggtctgcgaa gcccccacca
     1261 gactgcaggg taaagacctc aatgaaacca ccgaacagga cttgtgtcct ttgaaaaacc
     1321 gagtggattc tagtctcccg gcgccccctg cccaagaaga gacctttgct cctggacccc
     1381 tgccaactcc tttcaagaca aatgggcaag aggatcatgc cacaccaggg tctgctccaa
     1441 acggaggtac aaagatccca ggcaactggc agatcaaaat cagacccaca gcagcgatag
     1501 cgacgggtag ctccaggaac aaacccttag ctaacagttt accctgccct gggggctgca
     1561 gctgcgacca catcccaggg tcgggtttaa agatgaactg caacaacagg aacgtgagca
     1621 gcttggctga tttgaagccc aagctctcta acgtgcagga gcttttccta cgagataaca
     1681 agatccacag catccgaaaa tcgcactttg tggattacaa gaacctcatt ctgttggatc
     1741 tgggcaacaa taacatcgct actgtagaga acaacacttt caagaacctt ttggacctca
     1801 ggtggctata catggatagc aattacctgg acacgctgtc ccgggagaaa ttcgcggggc
     1861 tgcaaaacct agagtacctg aacgtggagt acaacgctat ccagctcatc ctcccgggca
     1921 ctttcaatgc catgcccaaa ctgaggatcc tcattctcaa caacaacctg ctgaggtccc
     1981 tgcctgtgga cgtgttcgct ggggtctcgc tctctaaact cagcctgcac aacaattact
     2041 tcatgtacct cccggtggca ggggtgctgg accagttaac ctccatcatc cagatagacc
     2101 tccacggaaa cccctgggag tgctcctgca caattgtgcc tttcaagcag tgggcagaac
     2161 gcttgggttc cgaagtgctg atgagcgacc tcaagtgtga gacgccggtg aacttcttta
     2221 gaaaggattt catgctcctc tccaatgacg agatctgccc tcagctgtac gctaggatct
     2281 cgcccacgtt aacttcgcac agtaaaaaca gcactgggtt ggcggagacc gggacgcact
     2341 ccaactccta cctagacacc agcagggtgt ccatctcggt gttggtcccg ggactgctgc
     2401 tggtgtttgt cacctccgcc ttcaccgtgg tgggcatgct cgtgtttatc ctgaggaacc
     2461 gaaagcggtc caagagacga gatgccaact cctccgcgtc cgagattaat tccctacaga
     2521 cagtctgtga ctcttcctac tggcacaatg ggccttacaa cgcagatggg gcccacagag
     2581 tgtatgactg tggctctcac tcgctctcag actaagaccc caaccccaat aggggagggc
     2641 agagggaagg cgatacatcc ttccccaccg caggcacccc gggggctgga ggggcgtgta
     2701 cccaaatccc cgcgccatca gcctggatgg gcataagtag ataaataact gtgagctcgc
     2761 acaaccgaaa gggcctgacc ccttacttag ctccctcctt gaaacaaaga gcagactgtg
     2821 gagagctggg agagcgcagc cagctcgctc tttgctgaga gccccttttg acagaaagcc
     2881 cagcacgacc ctgctggaag aactgacagt gccctcgccc tcggccccgg ggcctgtggg
     2941 gttggatgcc gcggttctat acatatatac atatatccac atctatatag agagatagat
     3001 atctattttt cccctgtgga ttagccccgt gatggctccc tgttggctac gcagggatgg
     3061 gcagttgcac gaaggcatga atgtattgta aataagtaac tttgacttct gacaaaaaac
     3121 aaaaagtgct gcatggctcg catggaatcc acgcgctcca gggactctgc ccgcccccgc
     3181 gactggagac ggcatctcgt tcacagcacc caccctctta cctgataagt tccatcgtat
     3241 caaactttct ataaacaaaa tacagtataa tcagaaagtg ccatttcgcc attatttgtg
     3301 atcggtaggc agttcagagc ataagttaac tgtgaaaaaa atgtaaaggt tttatttagg
     3361 acatttgcat ggctagtcat cagtccattt tatgagttaa caatgtattt tgttgaggga
     3421 agtttttagg ggttgttttg ggttctttta ttttgatggt gatgttttat tttattttat
     3481 ttttttcagg gggtcttttt tttaatacat atccaataat gccttccatc tgaatgtaaa
     3541 ataagtaccc atgatttcta ttatagtatc agtgtaatta tttaaaaaat gattttgagg
     3601 cagttaagca tgaccaatta atgtcactct agtgcttagg ctgcgatcct atggtagcaa
     3661 ttctgtgctg gtataaatct tacttataaa gtaggaaaag agaaccgagg aagcacgtga
     3721 aacttactaa ttctattcga ggattttata atggcatatt ttttcagtat taaagcgaaa
     3781 atgttttcaa ctctgggtcc ttaccttttt ccagcttcat atttgcaagt ggtaaattgg
     3841 atttgcggtg gaagagacag gggagggaaa cggttggggt tagatccctt cctgagctac
     3901 attaaggctc tttctctaat cgccttactt agctttttac cctttaagta gctcctcttc
     3961 cctcgccccc accctctacc ccacccccac cttcgctcag actttaccgg ctttccccag
     4021 tccataaagg tcttgcccca acactcaccc cttctttttt tcccctctcc aaatgcagca
     4081 gtgaatccct ttattaatac tggaaatccc tctctgctgc ttttgttggt gctgcccaca
     4141 ctgcagatat attaaggatg ttaggagaga tttgatttaa ttgactctgc ctagataggt
     4201 ctcattaaac agagtggaga tttcattggt cagcactcct caatgaaaga cagacctaat
     4261 gactggcatt tgagatgctg ctggcatttt gaattcaaca tctgctgaaa acggtaaaac
     4321 taattagtgc ccacccaccc tccccgcccc agcaactgca tattgaaatt tgttaaagca
     4381 ctcatcttta tggaaattaa tcattatcct aaagaagtgt ttctctccca tcatccggat
     4441 ttctggttgt ggcccagcaa ttaacaaaaa cagcttcaac tgttcgaatt ttatgaacca
     4501 atgtaactct ggcctcaatc atattcctct gggatttcta aacagcagtt aagctacaaa
     4561 aagcaaacaa aaccacacat attgatggag tctgcattcc accacatatc cacccttgag
     4621 aagtatgtca aaagactgca gactatagat ttttttttaa tataggatta taaatcagct
     4681 agtgaaagac ctcagagcag ttgtaagtag atctgccatc tagaactcat attctaaagg
     4741 gaagtgattt ctcagaacag tgatgttctg gaatatgtat tatttatttt aacacttttt
     4801 taataaaatc tttattataa accatga
//
