LOCUS       NM_003062               9716 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens slit guidance ligand 3 (SLIT3), transcript variant 2,
            mRNA.
ACCESSION   NM_003062
VERSION     NM_003062.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9716)
  AUTHORS   Chen,R., Wang,Y., Zhang,Z., Wang,X., Li,Y., Wang,M., Wang,H.,
            Dong,M., Zhou,Q. and Yang,L.
  TITLE     The Role of SLIT3-ROBO4 Signaling in Endoplasmic Reticulum
            Stress-Induced Delayed Corneal Epithelial and Nerve Regeneration
  JOURNAL   Invest Ophthalmol Vis Sci 65 (5), 8 (2024)
   PUBMED   38700874
  REMARK    GeneRIF: The Role of SLIT3-ROBO4 Signaling in Endoplasmic Reticulum
            Stress-Induced Delayed Corneal Epithelial and Nerve Regeneration.
REFERENCE   2  (bases 1 to 9716)
  AUTHORS   Liu,X., Li,B., Wang,S., Zhang,E., Schultz,M., Touma,M., Monteiro Da
            Rocha,A., Evans,S.M., Eichmann,A., Herron,T., Chen,R., Xiong,D.,
            Jaworski,A., Weiss,S. and Si,M.S.
  TITLE     Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure
            Overload-Induced Cardiac Hypertrophy
  JOURNAL   Circ Res 134 (7), 913-930 (2024)
   PUBMED   38414132
  REMARK    GeneRIF: Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates
            Pressure Overload-Induced Cardiac Hypertrophy.
REFERENCE   3  (bases 1 to 9716)
  AUTHORS   Zhu,Q., Zhao,X., Zhang,D., Xia,W. and Zhang,J.
  TITLE     Abnormal expression of SLIT3 induces intravillous vascularization
            dysplasia in ectopic pregnancy
  JOURNAL   PeerJ 11, e14850 (2023)
   PUBMED   36793891
  REMARK    GeneRIF: Abnormal expression of SLIT3 induces intravillous
            vascularization dysplasia in ectopic pregnancy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9716)
  AUTHORS   Tang,Y., Cai,J. and Lv,B.
  TITLE     LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1
            inhibits colon adenocarcinoma progression via the miR-515-5p/slit
            guidance ligand 3 axis
  JOURNAL   Bioengineered 13 (2), 2308-2320 (2022)
   PUBMED   35034539
  REMARK    GeneRIF: LncRNA ubiquitin-binding protein domain protein 10
            antisense RNA 1 inhibits colon adenocarcinoma progression via the
            miR-515-5p/slit guidance ligand 3 axis.
REFERENCE   5  (bases 1 to 9716)
  AUTHORS   Duan,X., Wang,L., Wang,Z., Wei,W., Wang,M. and Ding,D.
  TITLE     LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by
            Regulating miR-587/SLIT3 Axis
  JOURNAL   Crit Rev Eukaryot Gene Expr 32 (8), 9-22 (2022)
   PUBMED   36017912
  REMARK    GeneRIF: LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer
            by Regulating miR-587/SLIT3 Axis.
REFERENCE   6  (bases 1 to 9716)
  AUTHORS   Patel,K., Nash,J.A., Itoh,A., Liu,Z., Sundaresan,V. and Pini,A.
  TITLE     Slit proteins are not dominant chemorepellents for olfactory tract
            and spinal motor axons
  JOURNAL   Development 128 (24), 5031-5037 (2001)
   PUBMED   11748139
REFERENCE   7  (bases 1 to 9716)
  AUTHORS   Little,M.H., Wilkinson,L., Brown,D.L., Piper,M., Yamada,T. and
            Stow,J.L.
  TITLE     Dual trafficking of Slit3 to mitochondria and cell surface
            demonstrates novel localization for Slit protein
  JOURNAL   Am J Physiol Cell Physiol 281 (2), C486-C495 (2001)
   PUBMED   11443047
REFERENCE   8  (bases 1 to 9716)
  AUTHORS   Holmes,G.P., Negus,K., Burridge,L., Raman,S., Algar,E., Yamada,T.
            and Little,M.H.
  TITLE     Distinct but overlapping expression patterns of two vertebrate slit
            homologs implies functional roles in CNS development and
            organogenesis
  JOURNAL   Mech Dev 79 (1-2), 57-72 (1998)
   PUBMED   10349621
REFERENCE   9  (bases 1 to 9716)
  AUTHORS   Itoh,A., Miyabayashi,T., Ohno,M. and Sakano,S.
  TITLE     Cloning and expressions of three mammalian homologues of Drosophila
            slit suggest possible roles for Slit in the formation and
            maintenance of the nervous system
  JOURNAL   Brain Res Mol Brain Res 62 (2), 175-186 (1998)
   PUBMED   9813312
REFERENCE   10 (bases 1 to 9716)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008479.6, AC008409.5,
            AC094081.3, AC027311.4 and AC011365.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003062.3.
            
            Summary: The protein encoded by this gene is secreted, likely
            interacting with roundabout homolog receptors to effect cell
            migration. Two transcript variants encoding different isoforms have
            been found for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146759.1, AB011538.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519560.6/ ENSP00000430333.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-627               AC008479.6         145118-145744
            628-699             AC008409.5         119795-119866       c
            700-771             AC008409.5         113112-113183       c
            772-843             AC008409.5         61886-61957         c
            844-915             AC094081.3         67248-67319         c
            916-987             AC094081.3         28567-28638         c
            988-1059            AC094081.3         7243-7314           c
            1060-1223           AC027311.4         67511-67674
            1224-1365           AC027311.4         78387-78528
            1366-1437           AC027311.4         89396-89467
            1438-1509           AC011365.5         4368-4439
            1510-1581           AC011365.5         8021-8092
            1582-1725           AC011365.5         19621-19764
            1726-1889           AC011365.5         21055-21218
            1890-2040           AC011365.5         31310-31460
            2041-2115           AC011365.5         33063-33137
            2116-2259           AC011365.5         39992-40135
            2260-2403           AC011365.5         40901-41044
            2404-2567           AC011365.5         44364-44527
            2568-2700           AC011365.5         45565-45697
            2701-2769           AC011365.5         69515-69583
            2770-2841           AC011365.5         70995-71066
            2842-2913           AC011365.5         71672-71743
            2914-2985           AC011365.5         81645-81716
            2986-3149           AC011365.5         82941-83104
            3150-3274           AC011365.5         85899-86023
            3275-3372           AC011365.5         93320-93417
            3373-3512           AC011365.5         97568-97707
            3513-3606           AC011365.5         101299-101392
            3607-3744           AC011365.5         106883-107020
            3745-3985           AC011365.5         108072-108312
            3986-4116           AC011365.5         109903-110033
            4117-4271           AC011365.5         120668-120822
            4272-4557           AC011365.5         122516-122801
            4558-4766           AC011365.5         124008-124216
            4767-9716           AC011365.5         127310-132259
FEATURES             Location/Qualifiers
     source          1..9716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34-q35.1"
     gene            1..9716
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /note="slit guidance ligand 3"
                     /db_xref="GeneID:6586"
                     /db_xref="HGNC:HGNC:11087"
                     /db_xref="MIM:603745"
     exon            1..627
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..5002
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; multiple EGF-like domains protein 5; multiple
                     epidermal growth factor-like domains protein 5; slit
                     homolog 3; multiple EGF like domains 5"
                     /codon_start=1
                     /product="slit homolog 3 protein isoform 2 precursor"
                     /protein_id="NP_003053.2"
                     /db_xref="CCDS:CCDS4369.1"
                     /db_xref="GeneID:6586"
                     /db_xref="HGNC:HGNC:11087"
                     /db_xref="MIM:603745"
                     /translation="MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAAS
                     VDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIER
                     GAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVK
                     NLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY
                     CDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNAN
                     SISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK
                     RIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKIN
                     CLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD
                     YLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEK
                     CRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSN
                     NKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT
                     FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRR
                     IVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSN
                     KGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNM
                     SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGT
                     NPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIV
                     AKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHL
                     SDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL
                     CDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQ
                     CVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCP
                     PGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPL
                     ALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSL
                     GKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKA
                     LPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH
                     HGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQP
                     GFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKR
                     RKYVFQCTDGSSFVEEVERHLECGCLACS"
     exon            628..699
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..771
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..843
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..915
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            916..987
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1059
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1223
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1365
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1437
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1509
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1581
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1725
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1889
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2040
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2115
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2259
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2403
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2567
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2700
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2769
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2841
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2913
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..2985
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            2986..3149
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3274
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3372
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3512
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3606
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3744
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3985
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            3986..4116
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            4117..4271
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4557
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4766
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..9716
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5330..5335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /note="hexamer: AATAAA"
     polyA_site      5352
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /note="major polyA site"
     polyA_site      9716
                     /gene="SLIT3"
                     /gene_synonym="MEGF5; SLIL2; Slit-3; SLIT1; slit2"
                     /note="major polyA site"
ORIGIN      
        1 actgaatgga gagagcgagc gccggccagc tcacccggcc gccccgtgcc ccagccgcag
       61 ccgccgcgct ccccagccca gccccaagcc ggacctcccc gggcgccacg ccccattgcg
      121 ctcgccccag gtccccaacc cggcccgcgg gccagcgggg ccagggggcg ctccgcacct
      181 gggcactccc agcgatgcgc agcggggcag cgccggcccc gccgatggag ctgctgttgc
      241 tgccgccgcc gccgcccgga gcgccccgct ccgcccgcgc cccgtgcgcc tgagcaccga
      301 gctcgcccct cctccgcgct aactccgccg cccgctcccc aggccgcccg cgctccccgc
      361 gcgcctcctc gggctccacg cgtcttgccc cgcagaggca gcctcctcca ggagcggggc
      421 cctgcacacc atggcccccg ggtgggcagg ggtcggcgcc gccgtgcgcg cccgcctggc
      481 gctggccttg gcgctggcga gcgtcctgag tgggcctcca gccgtcgcct gccccaccaa
      541 gtgtacctgc tccgctgcca gcgtggactg ccacgggctg ggcctccgcg cggttcctcg
      601 gggcatcccc cgcaacgctg agcgccttga cctggacaga aataatatca ccaggatcac
      661 caagatggac ttcgctgggc tcaagaacct ccgagtcttg catctggaag acaaccaggt
      721 cagcgtcatc gagagaggcg ccttccagga cctgaagcag ctagagcgac tgcgcctgaa
      781 caagaataag ctgcaagtcc ttccagaatt gcttttccag agcacgccga agctcaccag
      841 actagatttg agtgaaaacc agatccaggg gatcccgagg aaggcgttcc gcggcatcac
      901 cgatgtgaag aacctgcaac tggacaacaa ccacatcagc tgcattgaag atggagcctt
      961 ccgagcgctg cgcgatttgg agatccttac cctcaacaac aacaacatca gtcgcatcct
     1021 ggtcaccagc ttcaaccaca tgccgaagat ccgaactctg cgcctccact ccaaccacct
     1081 gtactgcgac tgccacctgg cctggctctc ggattggctg cgacagcgac ggacagttgg
     1141 ccagttcaca ctctgcatgg ctcctgtgca tttgaggggc ttcaacgtgg cggatgtgca
     1201 gaagaaggag tacgtgtgcc cagcccccca ctcggagccc ccatcctgca atgccaactc
     1261 catctcctgc ccttcgccct gcacgtgcag caataacatc gtggactgtc gaggaaaggg
     1321 cttgatggag attcctgcca acttgccgga gggcatcgtc gaaatacgcc tagaacagaa
     1381 ctccatcaaa gccatccctg caggagcctt cacccagtac aagaaactga agcgaataga
     1441 catcagcaag aatcagatat cggatattgc tccagatgcc ttccagggcc tgaaatcact
     1501 cacatcgctg gtcctgtatg ggaacaagat caccgagatt gtcaagggac tgtttgatgg
     1561 gctggtgtcc ctacagctgc tcctcctcaa tgccaacaag atcaactgcc tgcgggtgaa
     1621 cacgtttcag gacctgcaga acctcaactt gctctccctg tatgacaaca agctgcagac
     1681 catcagcaag gggctcttcg cccctctgca gtccatccag acactccact tagcccaaaa
     1741 cccatttgtg tgcgactgcc acttgaagtg gctggccgac tacctccagg acaaccccat
     1801 cgagacaagc ggggcccgct gcagcagccc gcgccgactc gccaacaagc gcatcagcca
     1861 gatcaagagc aagaagttcc gctgctcagg ctccgaggat taccgcagca ggttcagcag
     1921 cgagtgcttc atggacctcg tgtgccccga gaagtgtcgc tgtgagggca cgattgtgga
     1981 ctgctccaac cagaagctgg tccgcatccc aagccacctc cctgaatatg tcaccgacct
     2041 gcgactgaat gacaatgagg tatctgttct ggaggccact ggcatcttca agaagttgcc
     2101 caacctgcgg aaaataaatc tgagtaacaa taagatcaag gaggtgcgag agggagcttt
     2161 cgatggagca gccagcgtgc aggagctgat gctgacaggg aaccagctgg agaccgtgca
     2221 cgggcgcgtg ttccgtggcc tcagtggcct caaaaccttg atgctgagga gtaacttgat
     2281 cggctgtgtg agtaatgaca cctttgccgg cctgagttcg gtgagactgc tgtccctcta
     2341 tgacaatcgg atcaccacca tcacccctgg ggccttcacc acgcttgtct ccctgtccac
     2401 cataaacctc ctgtccaacc ccttcaactg caactgccac ctggcctggc tcggcaagtg
     2461 gttgaggaag aggcggatcg tcagtgggaa ccctaggtgc cagaagccat ttttcctcaa
     2521 ggagattccc atccaggatg tggccatcca ggacttcacc tgtgatggca acgaggagag
     2581 tagctgccag ctgagcccgc gctgcccgga gcagtgcacc tgtatggaga cagtggtgcg
     2641 atgcagcaac aaggggctcc gcgccctccc cagaggcatg cccaaggatg tgaccgagct
     2701 gtacctggaa ggaaaccacc taacagccgt gcccagagag ctgtccgccc tccgacacct
     2761 gacgcttatt gacctgagca acaacagcat cagcatgctg accaattaca ccttcagtaa
     2821 catgtctcac ctctccactc tgatcctgag ctacaaccgg ctgaggtgca tccccgtcca
     2881 cgccttcaac gggctgcggt ccctgcgagt gctaaccctc catggcaatg acatttccag
     2941 cgttcctgaa ggctccttca acgacctcac atctctttcc catctggcgc tgggaaccaa
     3001 cccactccac tgtgactgca gtcttcggtg gctgtcggag tgggtgaagg cggggtacaa
     3061 ggagcctggc atcgcccgct gcagtagccc tgagcccatg gctgacaggc tcctgctcac
     3121 caccccaacc caccgcttcc agtgcaaagg gccagtggac atcaacattg tggccaaatg
     3181 caatgcctgc ctctccagcc cgtgcaagaa taacgggaca tgcacccagg accctgtgga
     3241 gctgtaccgc tgtgcctgcc cctacagcta caagggcaag gactgcactg tgcccatcaa
     3301 cacctgcatc cagaacccct gtcagcatgg aggcacctgc cacctgagtg acagccacaa
     3361 ggatgggttc agctgctcct gccctctggg ctttgagggg cagcggtgtg agatcaaccc
     3421 agatgactgt gaggacaacg actgcgaaaa caatgccacc tgcgtggacg ggatcaacaa
     3481 ctacgtgtgt atctgtccgc ctaactacac aggtgagcta tgcgacgagg tgattgacca
     3541 ctgtgtgcct gagctgaacc tctgtcagca tgaggccaag tgcatccccc tggacaaagg
     3601 attcagctgc gagtgtgtcc ctggctacag cgggaagctc tgtgagacag acaatgatga
     3661 ctgtgtggcc cacaagtgcc gccacggggc ccagtgcgtg gacacaatca atggctacac
     3721 atgcacctgc ccccagggct tcagtggacc cttctgtgaa caccccccac ccatggtcct
     3781 actgcagacc agcccatgcg accagtacga gtgccagaac ggggcccagt gcatcgtggt
     3841 gcagcaggag cccacctgcc gctgcccacc aggcttcgcc ggccccagat gcgagaagct
     3901 catcactgtc aacttcgtgg gcaaagactc ctacgtggaa ctggcctccg ccaaggtccg
     3961 accccaggcc aacatctccc tgcaggtggc cactgacaag gacaacggca tccttctcta
     4021 caaaggagac aatgaccccc tggcactgga gctgtaccag ggccacgtgc ggctggtcta
     4081 tgacagcctg agttcccctc caaccacagt gtacagtgtg gagacagtga atgatgggca
     4141 gtttcacagt gtggagctgg tgacgctaaa ccagaccctg aacctagtag tggacaaagg
     4201 aactccaaag agcctgggga agctccagaa gcagccagca gtgggcatca acagccccct
     4261 ctaccttgga ggcatcccca cctccaccgg cctctctgcc ttgcgccagg gcacggaccg
     4321 gcctctaggc ggcttccacg gatgcatcca tgaggtgcgc atcaacaacg agctgcagga
     4381 cttcaaggcc ctcccaccac agtccctggg ggtgtcacca ggctgcaagt cctgcaccgt
     4441 gtgcaagcac ggcctgtgcc gctccgtgga gaaggacagc gtggtgtgcg agtgccgccc
     4501 aggctggacc ggcccactct gcgatcagga ggcccgggac ccctgcctcg gccacagatg
     4561 ccaccatgga aaatgtgtgg caactgggac ctcatacatg tgcaagtgtg ccgagggcta
     4621 tggaggggac ttgtgtgaca acaagaatga ctctgccaat gcctgctcag ccttcaagtg
     4681 tcaccatggg cagtgccaca tctcagacca aggggagccc tactgcctgt gccagcccgg
     4741 ctttagcggc gagcactgcc aacaagagaa tccgtgcctg ggacaagtag tccgagaggt
     4801 gatccgccgc cagaaaggtt atgcatcatg tgccacagcc tccaaggtgc ccatcatgga
     4861 atgtcgtggg ggctgtgggc cccagtgctg ccagcccacc cgcagcaagc ggcggaaata
     4921 cgtcttccag tgcacggacg gctcctcgtt tgtagaagag gtggagagac acttagagtg
     4981 cggctgcctc gcgtgttcct aagcccctgc ccgcctgcct gccacctctc ggactccagc
     5041 ttgatggagt tgggacagcc atgtgggacc ccctggtgat tcagcatgaa ggaaatgaag
     5101 ctggagagga aggtaaagaa gaagagaata ttaagtatat tgtaaaataa acaaaaaata
     5161 gaacttattt ttattatgga aagtgactat tttcatcttt tattatataa atatattaca
     5221 ccatctgcgt atatgtacca tatagtgagt tatttttacc aagttttgtg ttgtgtattt
     5281 gttgtgtttt taaaaatagc tgtttaaaaa tttaagaaaa aaatagacta ataaaaatgc
     5341 tttaaaacaa aaggataaga ataaagaatg atagcctgtc tgaggaagga ggaagatgtt
     5401 ttcatgttta tgaaacggta ttatgtcggc agtagaccaa gagctgctca ttgagatcag
     5461 aaaaaggaat aagaggaaga gagagaagga aaagaccttt gtttcttgtt ttttaactcc
     5521 cttttatttt tcctccccta aaattaccca gcttttcgga gtcctggatg tcagtgccca
     5581 aaatgcccag ttcttccagg aaaagctgct gagccctggc cttctcagtc tcactgccac
     5641 tcaaaaatat tgctgtccct gtctgtccca gacccccctt cagggtatct gaacccactg
     5701 ggggacccct cttctccttc ctgggtggcc ctggcttccg tatctgaacc cactggggga
     5761 cccctcttct ccttcctggc tggccctggc ttccaatcga ggactgacta ttgaagtctg
     5821 ctacaggtgt catttggaac tgtcttacca aattttaaaa cagctgctat ttttcctgct
     5881 cctccccagg agaggggtct tcctagagga ggcgagggaa gagaatatca tggtgtctcc
     5941 tcaggaccca tgcactggcc ctctctcctc cttccaggta atttttcatt ggaatgtatc
     6001 ccagtagaga aggtagtcag cccttcttgg aagcggaagg ctgggagcca agtcaagtct
     6061 gcccacagcg ctagatgtcc aactctggaa ggttcttgga ggctcttgtt gtaagacagg
     6121 cctctgccac ctgatcctcc aggtcaccag catgacgata gagactcctt gcccatctgt
     6181 gacactttcc aatgcatatc caaactttac cttattttat ctatgcaacc cctgcctccc
     6241 tgggaaggat aagggagtag agctgggttc actaagaagg aagtttaggc cctcacaggc
     6301 tctggaactt gccttaagcc acacaccaga taagtggagg agccagacca gaagtccaga
     6361 cccaaagctt gagattcttc ctctagaatg ggtgagcaca ggtgattcag gcggcttaaa
     6421 tccatcagag cagccctgcc ggaaaaggaa ataatatgat gttttttcct gctcttgttc
     6481 tgccttgctc actccttctc cctccgcagt atctggaaag attctggaga ccagggctta
     6541 tgcatctagg gaaagtgacc aagggcagcc tatccagcct ctgcctccat tcctgaaggg
     6601 gacttccctg cccctgtttc tttccatgtc tctccctccc tcactcccat ttgccccctt
     6661 ccaccccatc aggttagcca catatcttcc agggctcagc tgttcacacc aactccctgg
     6721 ctcttatcat ccatccctcc ttcccccagg agcttccact gtaggagttt cagggagaag
     6781 agtttggaat tcattggacc tttcagccct caggttccct agaggagcct agttgatctg
     6841 tgagtaccaa tggtgggcca aagacgcagg gaataatgaa gggagaaaga aaagaaagga
     6901 agatggagga aaacgaggca actggaagaa ggaaggaagg aaagaaggaa gggatggagg
     6961 ggatgaagag aagggagaga gggatatagc tgaggaattt atctaaaaat gtgcatgtaa
     7021 atctccatta tgttccaggt actgtgcctt atgatggctt tgttttttgt tgtcattaga
     7081 gacaaggtct tgctttgtca cccaggctgg agtagagtgg ttcgatcata gctcaccgca
     7141 gcctcaacct cctaggctca agccatcttc ctgcctcagt ctcccaaaat gctgggatta
     7201 caggtgtgag ccactatgct cagcctgttt caaacattat tataatagca gatttattta
     7261 gtactttatt atacatcaga taccactcta attgtgaaat agatatatat tcatttaatt
     7321 attgaaacaa ccatgtagtt aaaacactat taactcattt tacagttgag tagactgaga
     7381 cacagagaag ttaaagaact tgcccaagag taaatgtcta ataaaccgta gagccaggat
     7441 ctgggcccag gctgtctgac tccagaactt gctcactcaa ccactaaacc atcctgcttc
     7501 tcatgggaaa gaaacacatc ctgcctttga ggatcctaca gcctgtgaca aaaacagtca
     7561 taaaaatgga caattgcctt attacacaag gagctcttaa gtggcaatac aagcaatgga
     7621 agtggctgtc cagaggaggg aacttctagt cctaggtctt taaggatgaa taggagtttg
     7681 ccagagtgag aaagggaatt gaactttcct gggagtggcc ttttaaaaag caatgagata
     7741 tggccaggcc tggcttgttt ggggaagagt caaaatctag ggtggcaaga gtatgggaag
     7801 cacactgagg agcagagaga aatggggtag gtaggaaggt agggttttga ccacaaagag
     7861 ctgtgcatgc taaactgggc cacaggtgcc agcagggttg tttgaggaag ggaagagcaa
     7921 gacaagctct ggtttaggaa gagagctgtg gcagcataaa ggcctgaaag aggagacaga
     7981 gctgtcaccc aaaatggact tgagagctcc ctgtggttta ctctgtggct agaaaacact
     8041 gccggccaga tggatcacaa atgtctatgg tagcttagaa gctctgctct tgaagaggat
     8101 cctgggatct gcccaacacc cttcccaacc tccatttccc catccccacc tccattgccc
     8161 catcccccct ctccccctag gcaggtggat ctgagcctta tcccaccacc aatgcccctg
     8221 ctagcctctc cccacccagc ccagagccta ctcagcctgc catctcaaga gccccaccga
     8281 gggtcactgg cttcctggga ggagtcacca ggctgccagc tttccctctg cctccccaag
     8341 gaacctgaga cctccctctg ctcatcaccc tgggcccaat cctgaatcca gcccccatca
     8401 accaagacag caaaagggcc aggtctgtcc cttataattt tgagccttct ccctcaagtt
     8461 tggaagccct gactttaaga aatgccaaat gcaaggacca ttaagaaaat tctccccgaa
     8521 atgaggctcc tctaacaaat gatgattaaa acgctctctc cttgagcagt cacattctag
     8581 aaacaggaca ttccatgagg caggaagagt tcagttaatt tgctcctgaa aaagtgtggt
     8641 tcagtgtttg tgtggcaatg tacgtgggca gaagaggccg ctcaagctgt gtcccccctg
     8701 agcaggattc aggaaaggga aaagaagttc tcttcaactc agccaagggg ccgtacgatg
     8761 gccgatgaga ttatgtattt aaaagttctt tgtaaagtgt aaactaaaaa ccttaaatgt
     8821 aagatgctgt tgttattatt actgttgttg ttgctgttat ggacatgcca aaaggccctt
     8881 gttagaagac agttttgcct tttcaatctc atagcaagga actcaagtct gatgcttcaa
     8941 aaagatgaga agaagggcaa gaagagggat aactcccaag ctcagaggga aaaaaaaggt
     9001 gggggaaaag agccccaggg tgaccttcag gaaaggccag gaccaggatg atctaacctt
     9061 tcccttcacc agaaacaaag ctattgccag actgaaccct aaagtcaagc agtcacccac
     9121 tgcctttgct gggagcagaa gcccatagca acaagtgacc tgcccctcag actcaagatc
     9181 ccagatacca gagctggagg agtcataggg cattactggt aggcaggaaa actgagggtc
     9241 gaacaaatgg aagaatgcgg tgatcataga ccaaagacac acagataatt aaccccatgt
     9301 gtccacccag gccaaagttc ttcctgctac cccacagtgg atgtccaggc agatggtccc
     9361 cacatgatgg ggaagcagag ggcatagtgt ggttttgtgg gacttgttca tgttttgtag
     9421 tgtgggctca acagtgccaa aggaaacact agggaaaagt tggtgaaaca tgccagctag
     9481 caggaccagt aaaggcataa tcaggcattt ggcaaagctt gcttttctaa ttcaatgata
     9541 ggttctaata ggaaattttt gaagattttt taaaacaatg ttatagtggc acttccccag
     9601 tatggaataa ataacatgca ttcttttttc aatatactgt catattcaga tgtcattaaa
     9661 ataaatggat gagtcacaga ggagctatca gatgctctca tgactaccat aactca
//
