LOCUS       NM_003061               7964 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens slit guidance ligand 1 (SLIT1), mRNA.
ACCESSION   NM_003061
VERSION     NM_003061.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7964)
  AUTHORS   Zheng,Y., Xiao,M., Zhang,J. and Chang,F.
  TITLE     Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by
            Restraining the Activation of Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Br J Biomed Sci 79, 10067 (2022)
   PUBMED   35996510
  REMARK    GeneRIF: Micro RNA-640 Targeting SLIT1 Enhances Glioma
            Radiosensitivity by Restraining the Activation of Wnt/beta-Catenin
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7964)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7964)
  AUTHORS   Hosokawa,K., Mizumaki,H., Elbadry,M.I., Saito,C., Espinoza,J.L.,
            Thi Thanh Dao,A., Katagiri,T., Harashima,A., Kikuchi,A., Kanai,A.,
            Matsui,H., Inaba,T., Taniwaki,M., Yamamoto,Y. and Nakao,S.
  TITLE     Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due
            to a breakdown of the autocrine loop involving Slit1 in acquired
            aplastic anemia
  JOURNAL   Leukemia 33 (11), 2732-2766 (2019)
   PUBMED   31186493
  REMARK    GeneRIF: SLIT1-mutated hematopoietic stem cells have a role in
            clonal hematopoiesis in acquired aplastic anemia
REFERENCE   4  (bases 1 to 7964)
  AUTHORS   Shuai,W., Wu,J., Chen,S., Liu,R., Ye,Z., Kuang,C., Fu,X., Wang,G.,
            Li,Y., Peng,Q., Shi,W., Li,Y., Zhou,Q. and Huang,W.
  TITLE     SUV39H2 promotes colorectal cancer proliferation and metastasis via
            tri-methylation of the SLIT1 promoter
  JOURNAL   Cancer Lett 422, 56-69 (2018)
   PUBMED   29458143
  REMARK    GeneRIF: Findings show that SLIT1 is a direct target of SUV39H2
            which binds to its promoter and catalyzes H3K9 tri-methylation to
            silence SLIT1 expression.
REFERENCE   5  (bases 1 to 7964)
  AUTHORS   Simino,J., Sung,Y.J., Kume,R., Schwander,K. and Rao,D.C.
  TITLE     Gene-alcohol interactions identify several novel blood pressure
            loci including a promising locus near SLC16A9
  JOURNAL   Front Genet 4, 277 (2013)
   PUBMED   24376456
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7964)
  AUTHORS   Yuan,W., Zhou,L., Chen,J.H., Wu,J.Y., Rao,Y. and Ornitz,D.M.
  TITLE     The mouse SLIT family: secreted ligands for ROBO expressed in
            patterns that suggest a role in morphogenesis and axon guidance
  JOURNAL   Dev Biol 212 (2), 290-306 (1999)
   PUBMED   10433822
REFERENCE   7  (bases 1 to 7964)
  AUTHORS   Wu,W., Wong,K., Chen,J., Jiang,Z., Dupuis,S., Wu,J.Y. and Rao,Y.
  TITLE     Directional guidance of neuronal migration in the olfactory system
            by the protein Slit
  JOURNAL   Nature 400 (6742), 331-336 (1999)
   PUBMED   10432110
REFERENCE   8  (bases 1 to 7964)
  AUTHORS   Liang,Y., Annan,R.S., Carr,S.A., Popp,S., Mevissen,M.,
            Margolis,R.K. and Margolis,R.U.
  TITLE     Mammalian homologues of the Drosophila slit protein are ligands of
            the heparan sulfate proteoglycan glypican-1 in brain
  JOURNAL   J Biol Chem 274 (25), 17885-17892 (1999)
   PUBMED   10364234
REFERENCE   9  (bases 1 to 7964)
  AUTHORS   Itoh,A., Miyabayashi,T., Ohno,M. and Sakano,S.
  TITLE     Cloning and expressions of three mammalian homologues of Drosophila
            slit suggest possible roles for Slit in the formation and
            maintenance of the nervous system
  JOURNAL   Brain Res Mol Brain Res 62 (2), 175-186 (1998)
   PUBMED   9813312
REFERENCE   10 (bases 1 to 7964)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512424.14, BC146761.1, BC028105.1 and CD671648.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003061.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146761.1, AB017167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266058.9/ ENSP00000266058.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AL512424.14        155722-155754       c
            34-580              BC146761.1         1-547
            581-1370            BC028105.1         542-1331
            1371-1595           BC146761.1         1338-1562
            1596-1615           AL512424.14        18885-18904         c
            1616-7168           BC146761.1         1583-7135
            7169-7501           CD671648.1         192-524
            7502-7964           BC146761.1         7469-7931
FEATURES             Location/Qualifiers
     source          1..7964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..7964
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /note="slit guidance ligand 1"
                     /db_xref="GeneID:6585"
                     /db_xref="HGNC:HGNC:11085"
                     /db_xref="MIM:603742"
     exon            1..482
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..4890
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /note="multiple EGF-like domains protein 4; multiple
                     epidermal growth factor-like domains protein 4; slit
                     homolog 1; multiple EGF like domains 4"
                     /codon_start=1
                     /product="slit homolog 1 protein precursor"
                     /protein_id="NP_003052.2"
                     /db_xref="CCDS:CCDS7453.1"
                     /db_xref="GeneID:6585"
                     /db_xref="HGNC:HGNC:11085"
                     /db_xref="MIM:603742"
                     /translation="MALTPGWGSSAGPVRPELWLLLWAAAWRLGASACPALCTCTGTT
                     VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVER
                     GAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLK
                     NLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLF
                     CDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCT
                     LSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK
                     LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANK
                     INCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWL
                     ADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECN
                     SDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTH
                     LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNR
                     ISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWL
                     GGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECAC
                     LDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISS
                     LSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVT
                     SLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKKFEC
                     QGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGP
                     CENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQ
                     CPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCR
                     DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQG
                     NRPVCQCLPGFGGPECEKLLSVNFVDRDTYLQFTDLQNWPRANITLQVSTAEDNGILL
                     YNGDNDHIAVELYQGHVRVSYDPGSYPSSAIYSAETINDGQFHTVELVAFDQMVNLSI
                     DGGSPMTMDNFGKHYTLNSEAPLYVGGMPVDVNSAAFRLWQILNGTGFHGCIRNLYIN
                     NELQDFTKTQMKPGVVPGCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD
                     GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASG
                     TKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAICQTTRPLSWVECRGSCPG
                     QGCCQGLRLKRRKFTFECSDGTSFAEEVEKPTKCGCALCA"
     exon            483..554
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..626
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..698
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..770
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..842
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..914
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1078
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1226
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1298
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1370
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1442
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1586
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1750
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1774
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1919
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1994
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1995..2138
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2282
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2449
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2582
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2651
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2723
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2795
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2867
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3031
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3156
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3254
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3394
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3488
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3626
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3864
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3865..3995
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4150
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4439
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4440..4651
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..7964
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5144..5149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
     polyA_site      7964
                     /gene="SLIT1"
                     /gene_synonym="MEGF4; SLIL1; SLIT-1; SLIT3"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcgcag cagtcagttg ggagctggag ggagggagag ggagacgcag gcggcgaaac
       61 ggcagaggag ccgagccccc tccgcccaag gcgccctccc tccgtccgcg cacaggcgcc
      121 gtcgcttgga ggagcaaggt gcctcccagc ccgcaggggc gccgcgcgca agcccgcggg
      181 ctcttcggtg gctctgcccc gggactgcac ctggaggcgg ccccggacgg ggatggtcag
      241 cggctgctgc cgtctggctc gcgagcggga cgctgtgagg gcaccatggc gctgactccc
      301 gggtgggggt cctcggcggg gccggtccgg ccggagctct ggctgctgct gtgggcagcc
      361 gcgtggcgcc tgggtgcctc ggcgtgcccc gccctctgca cctgcaccgg aaccacggtg
      421 gactgccacg gcacggggct gcaggccatt cccaagaata tacctcggaa caccgagcgc
      481 ctggaactca atggcaacaa catcactcgg atccataaga atgactttgc ggggctcaag
      541 cagctgcggg tgctgcagct gatggagaac cagattggag cagtggaacg tggtgctttt
      601 gatgacatga aggagctgga gcggctgcga ctgaaccgaa accagctgca catgttaccg
      661 gaactgctgt tccagaacaa ccaggctttg tcaagactgg acttgagtga gaacgccatc
      721 caggccatcc ccaggaaagc ttttcgggga gctacggacc ttaaaaattt acagctggac
      781 aagaaccaga tcagctgcat tgaggaaggg gccttccgtg ctctgcgggg gctggaggtg
      841 ctgaccctga acaacaacaa tatcaccacc atccccgtgt ccagcttcaa ccatatgccc
      901 aagctacgga ccttccgcct gcactccaac cacctgtttt gcgactgcca cctggcctgg
      961 ctctcgcagt ggctgaggca gcggccaacc atcgggctct tcacccagtg ctcgggccca
     1021 gccagcctgc gtggcctcaa tgtggcagag gtccagaaga gtgagttcag ctgctcaggc
     1081 cagggagaag cggggcgcgt gcccacctgc accctgtcct ccggctcctg cccggccatg
     1141 tgcacctgca gcaatggcat cgtggactgt cgtggaaaag gcctcactgc catcccggcc
     1201 aacctgcccg agaccatgac ggagatacgc ctggagctga acggcatcaa gtccatccct
     1261 cctggagcct tctcacccta cagaaagcta cggaggatag acctgagcaa caatcagatc
     1321 gctgagattg cacccgacgc cttccagggc ctccgctccc tgaactcgct ggtcctctat
     1381 ggaaacaaga tcacagacct cccccgtggt gtgtttggag gcctatacac cctacagctc
     1441 ctgctcctga atgccaacaa gatcaactgc atccggcccg atgccttcca ggacctgcag
     1501 aacctctcac tgctctccct gtatgacaac aagatccaga gcctcgccaa gggcactttc
     1561 acctccctgc gggccatcca gactctgcac ctggcgcaga accctttcat ttgcgactgt
     1621 aacctcaagt ggctggcaga cttcctgcgc accaatccca tcgagacgag tggtgcccgc
     1681 tgtgccagtc cccggcgcct cgccaacaag cgcatcgggc agatcaagag caagaagttc
     1741 cggtgctcag ccaaagagca gtacttcatt ccaggcacgg aggattacca gctgaacagc
     1801 gagtgcaaca gcgacgtggt ctgtccccac aagtgccgct gtgaggccaa cgtggtggag
     1861 tgctccagcc tgaagctcac caagatccct gagcgcatcc cccagtccac ggcagaactg
     1921 cgattgaata acaatgagat ttccatcctg gaggccactg ggatgtttaa aaaacttaca
     1981 catctgaaga aaatcaatct gagcaacaac aaggtgtcag aaattgaaga tggggccttc
     2041 gagggcgcag cctctgtgag cgagctgcac ctaactgcca accagctgga gtccatccgg
     2101 agcggcatgt tccggggtct ggatggcttg aggaccctaa tgctgcggaa caaccgcatc
     2161 agctgcatcc acaacgacag cttcacgggc ctgcgcaacg tccggctcct ctcgctctac
     2221 gacaaccaga tcaccaccgt atccccagga gccttcgaca ccctccagtc cctctccaca
     2281 ctgaatctcc tggccaaccc tttcaactgc aactgccagc tggcctggct aggaggctgg
     2341 ctacggaagc gcaagatcgt gacggggaac ccgcgatgcc agaaccctga ctttttgcgg
     2401 cagattcccc tgcaggacgt ggccttccct gacttcaggt gtgaggaagg ccaggaggag
     2461 gggggctgcc tgccccgccc acagtgccca caggagtgcg cctgcctgga caccgtggtc
     2521 cgatgcagca acaagcacct gcgggccctg cccaagggca ttcccaagaa tgtcacagaa
     2581 ctctatttgg acgggaacca gttcacgctg gttccgggac agctgtctac cttcaagtac
     2641 ctgcagctcg tggacctgag caacaacaag atcagttcct taagcaattc ctccttcacc
     2701 aacatgagcc agctgaccac tctgatcctc agctacaatg ccctgcagtg catcccgcct
     2761 ttggccttcc agggactccg ctccctgcgc ctgctgtctc tccacggcaa tgacatctcc
     2821 accctccaag agggcatctt tgcagacgtg acctccctgt ctcacctggc cattggtgcc
     2881 aaccccctat actgtgactg ccacctccgc tggctgtcca gctgggtgaa gactggctac
     2941 aaggaaccgg gcattgctcg ttgtgctggg ccccaggaca tggagggcaa gctgctcctc
     3001 accacgcctg ccaagaagtt tgaatgccaa ggtcctccaa cgctggctgt ccaggccaag
     3061 tgtgatctct gcttgtccag tccgtgccag aaccagggca cctgccacaa cgaccccctt
     3121 gaggtgtaca ggtgcgcctg ccccagcggc tataagggtc gagactgtga ggtgtccctg
     3181 gacagctgtt ccagtggccc ctgtgaaaat gggggcacct gccatgcaca ggagggcgag
     3241 gatgccccgt tcacgtgctc ctgtcccacc ggctttgaag gaccaacctg tggggtgaac
     3301 acagatgact gtgtggatca tgcctgtgcc aatgggggcg tctgtgtgga tggtgtgggc
     3361 aactacacct gccagtgccc cctgcagtat gagggaaagg cctgtgagca gctggtggac
     3421 ttgtgctctc cggatctgaa cccatgtcaa cacgaggccc agtgtgtggg caccccggat
     3481 gggcccaggt gtgagtgcat gccaggttat gcaggtgaca actgcagtga gaaccaggat
     3541 gactgcaggg accaccgctg ccagaatggg gcccagtgta tggatgaagt caacagctac
     3601 tcctgcctct gtgctgaggg ctacagtgga cagctctgtg agatccctcc ccatctgcct
     3661 gcccccaaga gcccctgtga ggggactgag tgccagaatg gggccaactg tgtggaccag
     3721 ggcaacaggc ctgtgtgcca gtgcctccca ggcttcggtg gccctgagtg tgagaagttg
     3781 ctcagtgtca actttgtgga tcgggacact tacctgcagt tcactgacct gcaaaactgg
     3841 ccacgggcca acatcacgtt gcaggtctcc acggcagagg acaatgggat ccttctgtac
     3901 aacggggaca acgaccacat tgcagttgag ctgtaccagg gccatgtgcg tgtcagctac
     3961 gacccaggca gctaccccag ctctgccatc tacagtgctg agacgatcaa cgatgggcaa
     4021 ttccacaccg ttgagctggt tgcctttgac cagatggtga atctctccat tgatggcggg
     4081 agccccatga ccatggacaa ctttggcaaa cattacacgc tcaacagcga ggcgccactc
     4141 tatgtgggag ggatgcccgt ggatgtcaac tcagctgcct tccgcctgtg gcagatcctc
     4201 aacggcaccg gcttccacgg ttgcatccga aacctgtaca tcaacaacga gctgcaggac
     4261 ttcaccaaga cgcagatgaa gccaggcgtg gtgccaggct gcgaaccctg ccgcaagctc
     4321 tactgcctgc atggcatctg ccagcccaat gccaccccag ggcccatgtg ccactgcgag
     4381 gctggctggg tgggcctgca ctgtgaccag cccgctgacg gcccctgcca tggccacaag
     4441 tgtgtccatg ggcaatgcgt gcccctcgac gctctttcct acagctgcca gtgccaggat
     4501 gggtactcgg gggcactgtg caaccaggcc ggggccctgg cagagccctg cagaggcctg
     4561 cagtgcctgc atggccactg ccaggcctca ggcaccaagg gggcacactg tgtgtgtgac
     4621 cccggctttt cgggcgagct gtgtgagcaa gagtccgagt gccgggggga ccctgtccgg
     4681 gactttcacc aggtccagag gggctatgcc atctgccaga ccacgcgccc cctgtcatgg
     4741 gtggagtgcc ggggctcgtg cccaggccag ggctgctgcc agggccttcg gctgaagcgg
     4801 aggaagttca cctttgagtg cagcgatggg acctcttttg ccgaggaggt ggaaaagccc
     4861 accaagtgtg gctgtgccct ctgcgcatag cgctgggcgt ggacaggccg gtgagggcgg
     4921 gcaaggggcc ccagccgctg cagcagcgga gacagtcgcc agcagctggg ctggggtgca
     4981 ggtcatcaca ggacggctcc tgggcagctg ggccctcctg ggtggggtgg tgccagagca
     5041 gccttttaaa agcaaattgc gccatagctg ggggcagcgg gggtgggcga ggcctgagct
     5101 gcgggctgcc ctctccggaa gtgccttgca caaataggcg cttaataaat atttgttgag
     5161 tgaatgtgtg cgtgaggtca ggccaagaag tgcagaacga tgacacccct ccttacctgc
     5221 tatctgaatc tggagaagaa aaatgacagc cttccaaacc aacccttccc tttggcctgt
     5281 ggcccaggct ggcttggaac tgggtctgtg gccccagaag cctcttaccc ctctgcgggc
     5341 aaccatgaag tactgtcagc ctccccggga agccagcctg gttcattctg ctgctacaga
     5401 atctgctggt ggtaggccag gctctggagc gggggtgccg cctcctgctg gccagggagg
     5461 gtcggaccct tgccccctgg gctgactggc agctctgcag ccacggcttg ggaacgaggc
     5521 tgtgggtgga ggtggttctt aggaccaggc ctctgaatcc taaagttcta gcatgactac
     5581 tgtagctgcg agggcttatg tggaggaaac agtcacaggg gctgctcagg gtggcagacc
     5641 ccactaaaga gggcagaggg ttctttgctc tagataaaca aacatcatct gcctccagac
     5701 actggccaca gtaggagtat tggtcctggg cttccccagc caccagtcag ccacaagctg
     5761 tcggtgacct attggtagag ggactgggtg tgagggtctg ggccagggtg cttgacctgg
     5821 gagcagctgg ttcagagtcc ttcacaccgc aggccagtag ggagcagtgg aagggacagt
     5881 gctccaggca ttgggaagtc cctgctggct ctatcactcg gggcaaactt ctccccacct
     5941 gggccttggg ttcttcagct ataaaatggc cagaggtggg gggcgggatg actaaaggaa
     6001 cagtgcagac tcccccactg tggtcttggg aggccagagg agttagaaga cctatctatc
     6061 tatctatcta tctacattga tcacatcaaa agtatttatg tgcctaaccc ggggctgggg
     6121 attgtggacg ttctggccta atggacagat gtgaactcat cccagagcat cgcaggaatg
     6181 accaggatgc ccgggaagag ttgagctgag tgggggctcc agccacagac agcggcccag
     6241 gccagggagt tgctggcaac gaaggagcca gtggtggaag aagaagaggc cctgaatata
     6301 cgattgcctg cccacgttgt cttctcttcc atacacagtg aaaatgtaga aagatggttt
     6361 gtgaggccaa actgtgaatg ggctaaaggg aggcaaagtt gcactctcct tccccagagg
     6421 gctcaccaag agggcacacc cccgggggtt ctggtgggca acgggggtga gcatgtccct
     6481 gccctggctc cctccatctg tgaccaggag gcatggctgg gtgtatgttc aggtgaggct
     6541 cagagtggca ttgtgtccct gtcccctgcc cagggcagtg aggggagccc ttgatgctga
     6601 ttagaaggct agaactgggg tagaggtgcc tggcatgtct catgccatgg ggactcaatc
     6661 tagcaactgt gagtcctggg gtccctgtga tgggaagagg gcagtgccct gcccaatgtg
     6721 gcaggtgtcc tcatggcagg atctgcccct caccaggggg ctgggatcta cttgcttgga
     6781 gctctgagca aggccacaat gcccgccccc acccccaagt agactgcagc ctgggcctca
     6841 tggggcttct cccaggccca catggcatcc ctctctgagt ttccaggcca ccgtgggacc
     6901 ctgcagagca tctgcaccgg gctggatagg gcagaaaagc tcaagggcag ctagcttgcc
     6961 tcttccctgg aagaaaggtg ctctgggact caccaaccct gagaaagata gctttcctgg
     7021 ccaccaccat tccccaccac cctggagaag ccaattccca ggcttgaagg gcactggctg
     7081 gcaggaggcc tcttcattct gcaggaggtg gaaaggacac ctgtagacag gtgatgctca
     7141 cccctcacct ggcgccatgg ggctgggagg tgagcggctg gcatgtttgt tcctagggag
     7201 caccatgtga gcttaaggct cccctgaccg gccccaccac atggcccagc ctcctagcac
     7261 agcagcgctg acctcagtgc agtctgagga ttggaatcca ccatgagatg atgtgagagc
     7321 tgtgtgcccc aggatcaact ttttctccaa cttggccatc agccagcgag ttgctaagga
     7381 cctgagtcag cactcacgtt gcctattcac actccgcttg aaagtccgga aggtggctac
     7441 tgcaaaatca cccctctgag aagtcctctc tccacatctt gtcccccttt gtgaagaccc
     7501 ctagttcgct ctgcatttta ggcatgaaga gatacagcag ggtgcgtccg gagggagctg
     7561 tggccttgca acaccactgg caacagggcc ggggctcccg gtgaaggtgt caggaagtgg
     7621 aaaaggctgg actttgtctc ctctttgcct gctggtagcc taaccgcaaa agtatctctt
     7681 tatacagaat acttacagat tctaatatat atttgtattt cattttgtta cagtattttt
     7741 atatgttaaa gtcaacatcc agcgtcttgt tttgcctttc agatgctatg tggtcgtggc
     7801 acgttttgtt gggggtttct gtagtcgtct tgtttggatc aactcctaga ggctggttta
     7861 gaacaggccc atgagggagc tgcacctgcc ctggaagtat tgttttagac tatgtcgata
     7921 ttgtctgttg tcttccatgt gaacatgaca ttgagtcact ctgc
//
