LOCUS       NM_144990               1961 bp    mRNA    linear   PRI 07-JUN-2022
DEFINITION  Homo sapiens schlafen like 1 (SLFNL1), transcript variant 1, mRNA.
ACCESSION   NM_144990
VERSION     NM_144990.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB046748.1, BC022037.2 and AL391730.13.
            
            On Jun 2, 2019 this sequence version replaced NM_144990.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022037.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302946.13/ ENSP00000304401.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DB046748.1         32-41
            11-609              BC022037.2         3-601
            610-610             AL391730.13        86846-86846         c
            611-1961            BC022037.2         603-1953
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1961
                     /gene="SLFNL1"
                     /note="schlafen like 1"
                     /db_xref="GeneID:200172"
                     /db_xref="HGNC:HGNC:26313"
     exon            1..103
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            104..110
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..663
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1452
                     /gene="SLFNL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     schlafen-like protein 1; testicular tissue protein Li 173"
                     /codon_start=1
                     /product="schlafen-like protein 1 isoform 1"
                     /protein_id="NP_659427.3"
                     /db_xref="CCDS:CCDS460.1"
                     /db_xref="GeneID:200172"
                     /db_xref="HGNC:HGNC:26313"
                     /translation="MTPMKRSVQTQVSEPFMESWGEESLPELPAEQSLTEYSDLEEAP
                     SAHTLYVGHLNPQFSVPVLACLLRDTLERLEMPVAREHIEVVRRPRKAYALVQVTVHR
                     DTLASLPWRLQTALEEHLILKELAARGKDLLLSEAQGPFSHREEKEEEEEDSGLSPGP
                     SPGSGVPLPTWPTHTLPDRPQAQQLQSCQGRPSGVCSDSAIVHQQIVGKDQLFQGAFL
                     GSETRNMEFKRGSGEYLSLAFKHHVRRYVCAFLNSEGGSLLVGVEDSGLVQGIRCSHR
                     DEDRARLLVDSILQGFKPQIFPDAYTLTFIPVISTSETSVPLKVIRLTVHTPKAQSQP
                     QLYQTDQGEVFLRRDGSIQGPLSASAIQEWCRQRWLVELGKLEEKMKALMMEKEQLQQ
                     QLQQHGPVSCTCCVL"
     exon            664..1185
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1329
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1961
                     /gene="SLFNL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFNL1"
                     /note="hexamer: AATAAA"
     polyA_site      1961
                     /gene="SLFNL1"
                     /note="major polyA site"
ORIGIN      
        1 aagcctccaa gttccctgag agctaccggc caggggtcgg gaggctatgg gagctcaggg
       61 caggcacctc ccatgctccc gcgggagcca ccaggacatg aaggcctcag gagccgggac
      121 actccctgag tcctctggga gcccttaagc cacactgaga acacagaccc tgggagaagc
      181 agccagcagt gaggaatcct ggaacccctt cccagggaga gccttcccat gacccccatg
      241 aagagatcag tgcaaacaca ggtgtcagag cccttcatgg agtcctgggg tgaggagtcc
      301 ctgccggagc tacccgcaga gcagtccctg acggagtact ctgacctcga ggaggctccc
      361 tcggcgcaca ctctctatgt gggccatctg aacccccagt tctcagtgcc ggtgcttgcc
      421 tgcctgctgc gagacaccct ggagcggctg gagatgccgg tggcgcggga gcacattgaa
      481 gtggtgaggc ggccgcggaa ggcctatgca ctggtgcagg tgactgtcca cagggacacc
      541 ctggcctccc tcccctggcg cctgcagacg gccctggagg agcacctaat cctcaaggag
      601 ctggcagccc gtgggaagga cctgctattg agtgaggccc aagggccctt cagccacaga
      661 gaggagaagg aggaggagga ggaggacagt ggcctgagcc ctggccccag tccaggctct
      721 ggtgtcccgc tgcccacctg gcctacacac acgctgcctg ataggcccca ggcccagcag
      781 ctgcagagct gccagggccg gcccagcggc gtgtgctccg acagtgccat tgtgcaccag
      841 cagatcgtgg gcaaggacca gctcttccag ggtgccttcc tgggcagcga gacccgcaat
      901 atggagttca agcggggtag cggcgagtac ctcagcctgg ccttcaagca ccacgtgcgg
      961 cgctacgtgt gcgccttcct caacagcgag ggcggcagcc tgctcgtggg agtagaggac
     1021 agcggcctgg tgcagggcat ccgctgcagc caccgtgacg aggaccgcgc acgcctgctg
     1081 gtggactcca tcctgcaggg cttcaagcct cagatctttc ccgatgccta cactctcacc
     1141 ttcatccctg tgatcagtac ctcggagacc agcgtccccc tcaaggtgat ccgcctgacc
     1201 gtgcacaccc ccaaggccca gagccagccg caactctacc agacagacca gggggaggtg
     1261 tttctgcggc gcgacgggag catccagggc ccgctgtctg ccagcgccat ccaggagtgg
     1321 tgcaggcaga ggtggctggt ggagctgggc aagctggaag agaagatgaa ggcgctgatg
     1381 atggagaagg agcagctcca gcagcagctg cagcagcacg ggcctgtgtc ctgcacctgc
     1441 tgtgtcctgt gagggccctg gggagcaggc aggacggcac ggcactctcc acctgagacc
     1501 cagggatttc ctgtttgagt gtaaggccaa ccagtaaagc ccatgcgggc tgctgagagg
     1561 cggacaggga ctccttcaac atggcacatg agcaggcacc catgtggctt caaccctgac
     1621 agacccatct gtgtagccaa gaaactgctc tcagccctgt ccccaaatga ccttactttc
     1681 agaaagaatg tgtaaaaccc tgcccagagc tcccctaggg ctaagctata agggattgtc
     1741 cttctcccta aaatgctcat ttggcccagg ctgaggtctg tgactccagt tggctacaca
     1801 gtgccagaaa ggaatctgtc atctcaggaa agcccctcaa agatggcgag gcatatttga
     1861 tgactgtggt tacagggcaa gaggccaccc tgcagccccc acccctgact tgctggaact
     1921 tgtgactgtc aaagctccat taataaatta catgcacctg g
//
