LOCUS       NM_144682               8398 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens schlafen family member 13 (SLFN13), mRNA.
ACCESSION   NM_144682
VERSION     NM_144682.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8398)
  AUTHORS   Yang,J.Y., Deng,X.Y., Li,Y.S., Ma,X.C., Feng,J.X., Yu,B., Chen,Y.,
            Luo,Y.L., Wang,X., Chen,M.L., Fang,Z.X., Zheng,F.X., Li,Y.P.,
            Zhong,Q., Kang,T.B., Song,L.B., Xu,R.H., Zeng,M.S., Chen,W.,
            Zhang,H., Xie,W. and Gao,S.
  TITLE     Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting
            RNase engaged in translational control
  JOURNAL   Nat Commun 9 (1), 1165 (2018)
   PUBMED   29563550
  REMARK    GeneRIF: The cytoplasmically localized SLFN13 inhibits protein
            synthesis in 293T cells and restricts HIV replication in a
            nucleolytic activity-dependent manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8398)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA720331.1, CR749630.1, AC015911.8 and AC060766.8.
            
            On Nov 22, 2018 this sequence version replaced NM_144682.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749630.1, AL832726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285013.11/ ENSP00000285013.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-494               DA720331.1         72-565
            495-3104            CR749630.1         483-3092
            3105-5794           AC015911.8         25270-27959         c
            5795-8398           AC060766.8         1-2604
FEATURES             Location/Qualifiers
     source          1..8398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8398
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /note="schlafen family member 13"
                     /db_xref="GeneID:146857"
                     /db_xref="HGNC:HGNC:26481"
                     /db_xref="MIM:614957"
     exon            1..45
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     exon            46..192
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     exon            193..1271
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2899
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /note="schlafen-13"
                     /codon_start=1
                     /product="schlafen family member 13"
                     /protein_id="NP_653283.3"
                     /db_xref="CCDS:CCDS32620.1"
                     /db_xref="GeneID:146857"
                     /db_xref="HGNC:HGNC:26481"
                     /db_xref="MIM:614957"
                     /translation="MEANHCSLGVYPSYPDLVIDVGEVTLGEENRKKLQKTQRDQERA
                     RVIRAACALLNSGGGVIQMEMANRDERPTEMGLDLEESLRKLIQYPYLQAFFETKQHG
                     RCFYIFVKSWSGDPFLKDGSFNSRICSLSSSLYCRSGTSVLHMNSRQAFDFLKTKERQ
                     SKYNLINEGSPPSKIMKAVYQNISESNPAYEVFQTDTIEYGEILSFPESPSIEFKQFS
                     TKHIQQYVENIIPEYISAFANTEGGYLFIGVDDKSRKVLGCAKEQVDPDSLKNVIARA
                     ISKLPIVHFCSSKPRVEYSTKIVEVFCGKELYGYLCVIKVKAFCCVVFSEAPKSWMVR
                     EKYIRPLTTEEWVEKMMDADPEFPPDFAEAFESQLSLSDSPSLCRPVYSKKGLEHKAD
                     LQQHLFPVPPGHLECTPESLWKELSLQHEGLKELIHKQMRPFSQGIVILSRSWAVDLN
                     LQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKV
                     CVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLS
                     DQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEA
                     HRILYVCENQPLRNFISDRNICRAETRETFLREKFEHIQHIVIDEAQNFRTEDGDWYR
                     KAKTITQREKDCPGVLWIFLDYFQTSHLGHSGLPPLSAQYPREELTRVVRNADEIAEY
                     IQQEMQLIIENPPINIPHGYLAILSEAKWVPGVPGNTKIIKNFTLEQIVTYVADTCRC
                     FFERGYSPKDVAVLVSTVTEVEQYQSKLLKAMRKKMVVQLSDACDMLGVHIVLDSVRR
                     FSGLERSIVFGIHPRTADPAILPNILICLASRAKQHLYIFL"
     exon            1272..1403
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..2127
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..8398
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4488..4493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /note="hexamer: AATAAA"
     polyA_site      4511
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /note="major polyA site"
     regulatory      8375..8380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
                     /note="hexamer: AATAAA"
     polyA_site      8398
                     /gene="SLFN13"
                     /gene_synonym="hSLFN13; SLFN10"
ORIGIN      
        1 ggaaacgcgg agtgtcctgg agcttgacgc gctggagctt gagaggtctt tcaggactga
       61 ttttggtgga agaagacagc aggcggtggg cattcactgt gctggtggga agtctggtta
      121 cattaagaaa ggaattctag caaagttatt ctgtaaatac aacagaatca gttgcttttg
      181 ttaaatatat tggtgcaagt tcaacatgga ggcaaatcac tgctccctgg gtgtgtatcc
      241 atcttaccca gacctggtca tcgatgtcgg agaagtgact ctgggagaag aaaacagaaa
      301 aaagctacag aaaactcaga gagaccaaga gagggcgaga gttatacggg ccgcgtgtgc
      361 tttattaaac tcaggaggag gagtgattca gatggaaatg gccaacaggg atgagcgtcc
      421 cacagagatg ggactggatt tagaagaatc cttgagaaag cttattcagt atccatattt
      481 gcaggctttc tttgagacta agcaacacgg aaggtgtttt tatatttttg ttaaatcttg
      541 gagtggtgat cctttcctta aagatggttc tttcaattcc cgcatttgca gccttagttc
      601 ttcattatac tgtagatctg gcacctctgt gcttcacatg aattcaagac aggcattcga
      661 tttcctgaag accaaggaaa gacagtccaa atataatctg attaatgaag ggtctccacc
      721 tagtaaaatt atgaaagctg tataccagaa catatctgag tcaaatcctg catatgaagt
      781 tttccaaact gacactattg aatatggtga aatcctatct tttcctgagt ctccatccat
      841 agagtttaaa cagttctcta caaaacatat ccaacaatat gtagaaaata taattccaga
      901 gtacatctct gcatttgcaa acactgaggg aggctatctt tttattggag tggatgataa
      961 gagtaggaaa gtcctgggat gtgccaaaga acaggttgac cctgactctt tgaaaaatgt
     1021 aattgcaaga gcaatttcta agttgcccat tgttcatttt tgctcttcaa aacctcgggt
     1081 agagtacagc accaaaatcg tagaagtgtt ttgtgggaaa gagttgtatg gctatctctg
     1141 tgtgattaaa gtgaaggcat tctgttgtgt ggtgttctcg gaagctccca agtcatggat
     1201 ggtgagggag aagtacatcc gccccttgac aactgaggaa tgggtagaga aaatgatgga
     1261 cgcagatcca gagtttcctc cagactttgc tgaggccttt gagtctcagt tgagtctatc
     1321 tgacagtcct tcactttgca gaccagtgta ttctaagaaa ggtctggaac acaaagctga
     1381 tctacaacaa catttatttc cagttccacc aggacatttg gaatgtactc cagagtccct
     1441 ctggaaggag ctgtctttac agcatgaagg actaaaggag ttaatacaca agcaaatgcg
     1501 acctttctcc cagggaattg tgatcctctc tagaagctgg gctgtggacc tgaacttgca
     1561 ggagaagcca ggagtcatct gtgatgctct gctgatagca cagaacagca cccccattct
     1621 ctacaccatt ctcagggagc aggatgcaga gggccaggac tactgcactc gcaccgcctt
     1681 tactttgaag cagaagctag tgaacatggg gggctacacc gggaaggtgt gtgtcagggc
     1741 caaggtcctc tgcctgagtc ctgagagcag cgcagaggcc ttggaggctg cagtgtctcc
     1801 gatggattac cctgcgtcct atagccttgc aggcacccag cacatggaag ccctgctgca
     1861 gtccctcgtg attgtcttac tcggcttcag gtctctcttg agtgaccagc tcggctgtga
     1921 ggttttaaat ctgctcacag cccagcagta tgagatattc tccagaagcc tccgcaagaa
     1981 cagagagttg tttgtccacg gcttacctgg ctcagggaag accatcatgg ccatgaagat
     2041 catggagaag atcaggaatg tgtttcactg tgaggcacac agaattctct acgtttgtga
     2101 aaaccagcct ctgaggaact ttatcagtga tagaaatatc tgccgagcag agacccggga
     2161 aactttccta agagaaaaat ttgaacacat tcaacacatc gtcattgacg aagctcagaa
     2221 tttccgtact gaagatgggg actggtatag gaaggcaaaa accatcactc agagagaaaa
     2281 ggattgtcca ggagttctct ggatctttct ggactacttt cagaccagtc acttgggtca
     2341 cagtggcctt ccccctctct cagcacagta tccaagagaa gagctcacca gagtagttcg
     2401 caatgcagat gaaatagccg agtacataca acaagaaatg caactaatta tagaaaatcc
     2461 tccaattaat atcccccatg ggtatctggc aattctcagt gaagctaaat gggttccagg
     2521 tgttccaggc aacacaaaga ttattaaaaa ctttactttg gagcaaatag tgacctatgt
     2581 ggcagacacc tgcaggtgct tctttgaaag gggctattct ccaaaggatg ttgctgtgct
     2641 tgtcagcacc gtgacagaag tggagcagta tcagtctaag ctcttgaaag caatgaggaa
     2701 gaaaatggtg gtgcagctca gtgatgcatg tgatatgttg ggtgtgcaca ttgtgttgga
     2761 cagtgtccgg cgattctcag gcctggaaag gagcatagtg tttgggatcc atccaaggac
     2821 agctgaccca gctatcttac ccaatattct gatctgtctg gcttccaggg caaaacagca
     2881 cctatatatt tttctgtgaa gtgactatta ggaagaactc caaaccaaaa tactgtgtaa
     2941 atgtctatgg gtgacagtct gctgatggta gaaacctttc tttttagttc acaagtcagt
     3001 tagagatttg gacagagctg acacaaagag tttggagctc ccccatttct ggctctcctt
     3061 tcaggggttc ctcccccaac tcttttcagc agtggtggct gccccccatt ctgacccctg
     3121 actcttgcag ccagaaagat ggtggttttc taaaggaact ttagctgtgc tgcacaatgc
     3181 agacctgtgt cttgctctct gggtaaaagc cataaaaata agaaactcag cctgtggcct
     3241 ttcttccaag gctggagttc tcgagttctt ttatgtgact tcgtgtagtt tgttgcttta
     3301 aaaaatttgt ccagaattgt tttctgcaga agcatggtct gttaggagct tacaggccat
     3361 aggagaagca gttgtttcct gaatttatct ttgctgtatt catttagggc ttgggagagt
     3421 cccaagataa ttcagtcact gtcagattaa tcatttcggc agaacaaaca atattgttat
     3481 gattatttaa tccttaaaat tgtgatctcc agagtttgtt atcagaataa cccagaccaa
     3541 ggcttaattg taatagtgaa cattaatggt acctttacag agaaattata ggccaagaga
     3601 aaatgctggc tttcagtaga agttaatatt agaaacccaa atctggttct gaaagtgtgt
     3661 atcagatgta cggtgaacaa acttgggaaa gattttcttt aaaaatcaat gagcgttggc
     3721 caggcacggt ggctcacacc tgtaatccca gctgtttggg aggctgaggc aggtggatca
     3781 cctgaggtca ggagttcaag accagcctgg ccaacatgga gaaaccccat ctctactaaa
     3841 aatacaaaaa ttagcagggc atggtggtgc atgcctgtat cccagctact tgggaggctg
     3901 aagcatgaga atcacttgaa tcctggaggc agaggttgca gtgagctgag atcatgtcac
     3961 tgtactccag cctgggcaac agagtgagac tgtctcaaaa agaagaagaa gaaaaaaaat
     4021 gcagtgagtt tatgttgtta cattgtaaca tctcagcgta gctgtatgca ttactctata
     4081 gcataactac ttaagtttta tgtcattctt gaactgtgat ttttttttct atttgctttc
     4141 atagtttggt gggccattgt tatggactga atgtttgtgt cccatcctca cccctaaatt
     4201 cccatgttga agccccaacc ttcactgtgg agctggggct gctaaggaag taattaaggt
     4261 tacacgaagt cacagtggag aatctgatct gctaagactg gtgtccttat agggagagac
     4321 cccagagagc ttgttccctt cctccctgtg cacacaaaca agagggcatg ggagcacaca
     4381 gagagatggc agccacctac aagccaagag gagaagcctc acaatgaacc ccccccccca
     4441 ccctgctggc acctatgtct tcgacttcca gcccccagac tgtgagaaat aaatttctgt
     4501 tggttcagcc atccagtctc tagtgttttg ttattgcagc ctgagaacac agctgtatga
     4561 tcattcatca aactaaaaac actgatactt aacaatgcta atgcaattac ttatttgctt
     4621 ttcagtctct acaaaacatt ctaaaacact aatctaaata ctaacaataa aatatttgca
     4681 taactaatga aaattaagaa accacatgcc caatattcca tttataagta atcctatttg
     4741 gctgatttcc ctccatattg taagttttga acttttctgc cagtctttct cctatttgtg
     4801 ttaactcatg gaattccagt tgtctagcct tgaaattgta ggctcttcta acttgagcaa
     4861 aatctgacag atcagcaaaa taaggagaaa aatatttctt ctttctttct ggctgcatta
     4921 aatgagatac agctcagcac caaaaagcta tctttgtaaa tgttcttagt aaactccctg
     4981 gtctttggag ttatttcagc ctttgagagt aattctttaa aagtctaatt ctgactggtt
     5041 gaatctctct atatgattta ttgccctagt aatatttgaa acagtatcat attttaaaat
     5101 atataaatat ttatgaattt ttgttcagcc caaagaggat tactgatgct ttcttctttt
     5161 tccatatgat gaggaaatgt ttagcttata tatttattgc atttctgttt taaataaaaa
     5221 attgagagtt tgtgtttcat taaactgaaa aaaaaggttc tgtaaaataa atgattaaat
     5281 ggaggaaaag gagaagactg aggccagcaa ctccatgata cagccaaaaa tgagccagta
     5341 aaagattaag caagattaac tgtaaatttt tttttttttt ttttttaaag agaaaaggtc
     5401 tcactgtgtt tcccaggctg gagggtagtg gtgtgatcat agttcactag agccctgaac
     5461 tcctgggctc aagtgatcct cttgccttag cctcccattg ctgggattat aggcatgagc
     5521 cactgtgtca ggcttaattg ggttttgatg ggtacctgcc tatctctgta atttggctct
     5581 agtcatatag gacctgcttc attaaagatc tgaaaatcta tccagccatt gtaaaatgaa
     5641 acaaaatgtt ttgaaaattt aaattagcct tttattttag ttcagacata tagaaaagtt
     5701 gcaagcatag tacagaaagt tcctatatac cccacttagt gccctccttt ttaaaatttt
     5761 tttaaaccta gcttatttcc tttaagattt ctgagaattc caggaatgct cacagatctg
     5821 tccttgtagt ctcctgccac ttcttgctat ggagtgctgt accaaggtct ctgctagttt
     5881 ctagttggct tgacataatg actttcctaa acttcttctg ctctgaatct caagcatgga
     5941 aagcggtcac atcttttgtt tcacgaatta acagtcaaca cctggcccta cttttaacaa
     6001 aacttagtaa agccttgagc atagtgaaag acaaatattt aaattatata ttagcaggag
     6061 gctgaggtgg gaggatcata tgaggccagc ctgggcagca tagcatgacc cccccctcga
     6121 gaagacaaca aaaaattatc tgggtgtggt ggtgtgctcc tgcagtccta gctattccag
     6181 aggccgaggc gagaggatcg cttgattcca ggagttcaag gctgtagtta gcgataatcg
     6241 tgtcactgaa tcctagcctg ggcaacagaa taagacccca tgtctaacaa aataataata
     6301 aaacaatcaa aagtttaaaa ttagttatta aatgtcagtg tgcccagagt cctttgacca
     6361 cagatgatcc tgatggcctt ctctcgcctt gtccctgtgc ctccttctac catttttctt
     6421 cctgagattc aaaagtaagt agcggacagg gttcccattt accactaaat acttcagtgg
     6481 gtgtttccta aaaggacatt tatagtacca tcatcaaaat cagtaaatta accctgatac
     6541 tattatctaa tctgtagact ttattgaatt atatcagttg tgcctcaagt gtctttatgt
     6601 ttttttctca aaagagaaaa agttctggtc caggatttga tctaagatca tgcattgtat
     6661 tgagctttcc tttcttttaa gtctcattta atctggagat gttaatctgt ctttgtcata
     6721 tctttgacac tattgaagag gactggccta ttattttgca gagtatctga ttttgggtca
     6781 tttcatgtgt tctcatgatt agattcaggt tatgcatttt tggcatgaat tccatagaag
     6841 ggctgttacg gttctcagtt cacggtatta gaaggcactt gatagtgatt agttccattc
     6901 ctgatgatgt taactctgat catttggata aagtggcgtc tgccaggttt ccctactgtg
     6961 cagttacaat ttgctttttg taattaataa agtgtgtgtg tgtgtgtgtg tggagggggg
     7021 gtgtttttgc ttctgaacgc ataatatttg agattttttt ctaattaaaa agtaattatt
     7081 caaagagttc agagaactga tactgatcac attctttgac cccacatgca aatacattat
     7141 aaactagtaa taaaacggta actagaaaaa tgttcatatc ttttggaatt aaaaaagtgt
     7201 ttaactcgtg gatcaaagca gaaattctgt aaccattgtc acagcaggtt ctaacaagca
     7261 agtttaagga ggagagaatt tcagtcctag agaatttcag tcttattcaa atgctttcct
     7321 agaaagagga aacagttcct aactaatttc atgaggctgg cataatcttg ataacaagtc
     7381 tgataggtaa agtatgaaag gaaaattgca ggtcactcaa ttatcactca aatatctaca
     7441 tgaaaaattc taaacaaaat tttagcaaac aaaatccaac aatttgtaaa agtgataata
     7501 caccacgacc aaggtggttc aagtcaggaa ttcaacgttg attttggcgt taaaaaatca
     7561 atcatcaggc ccagtgaggt ggctcactcc tgtaatccca gactttctgg aggctgaagg
     7621 aggaaagatc cttcaggcca gaagtttgag tctgcactga gctgtgactg catcaccgca
     7681 ctctagcctg ggtgccagtt tgagaccctg tctccaagaa aaaaaaatta atcagtgtaa
     7741 ttcaccacag attaagagtt caaaagagaa aaatcacatg atcatctgaa tagaggaaaa
     7801 agcttttgat aaagttcaac atccattcat aataaggact ctcagcaact tagaagtata
     7861 aaaacacttt tggaaatcaa caaagggaat ttacagcatg aacaaacagc aagccagcat
     7921 ggtggctcac acctgtaatc tcagcacttc cagaggccaa ggcaggagaa tcacttgagc
     7981 ccaggggtta gagacaagcc ttggcaacat agcaagatcc tggctctaca aaaaataaaa
     8041 taaaatgaaa taaaatttaa aaattagctg ggtttggtgg tgtgtgcctg tagtcccagc
     8101 tactgggagg ctgaggtgag aggatcactg gagcccagga ggtgaaggct gcagtgggct
     8161 aaaaacaacc agaacaaccc cccaaccccc tccccgcaaa acactataaa gaatagcaac
     8221 acaaggttca atgtaaactt tgatatggtg ttttacctct gaggagaggc ttattgttaa
     8281 tattctttag ccgtgtaagg ggttcacaga tgttcatact tttgttcttt ataccttata
     8341 tgtattctat aaatattgtt tctactcaat agttaataaa aacataattt aaaagttc
//
