LOCUS       NM_001363830           13219 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens schlafen family member 12 like (SLFN12L), transcript
            variant 1, mRNA.
ACCESSION   NM_001363830 XM_017024005
VERSION     NM_001363830.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13219)
  AUTHORS   Chaturvedi,L.S., Wang,Q., More,S.K., Vomhof-DeKrey,E.E. and
            Basson,M.D.
  TITLE     Schlafen 12 mediates the effects of butyrate and repetitive
            mechanical deformation on intestinal epithelial differentiation in
            human Caco-2 intestinal epithelial cells
  JOURNAL   Hum Cell 32 (3), 240-250 (2019)
   PUBMED   30875077
  REMARK    GeneRIF: Schlafen 12 (SLFN12) is a cytosolic protein that
            stimulates sucrase-isomaltase (SI) expression.
REFERENCE   2  (bases 1 to 13219)
  AUTHORS   Ding,L., Hayes,M.M., Photenhauer,A., Eaton,K.A., Li,Q.,
            Ocadiz-Ruiz,R. and Merchant,J.L.
  TITLE     Schlafen 4-expressing myeloid-derived suppressor cells are induced
            during murine gastric metaplasia
  JOURNAL   J Clin Invest 126 (8), 2867-2880 (2016)
   PUBMED   27427984
  REMARK    GeneRIF: in the stomachs of H. pylori-infected patients, the human
            SLFN4 ortholog SLFN12L colocalized to cells that expressed
            myeloid-derived suppressor cell surface markers CD15+CD33+HLA-DRlo
REFERENCE   3  (bases 1 to 13219)
  AUTHORS   Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
            Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
            Jr.
  TITLE     Genome-wide association scan of trait depression
  JOURNAL   Biol Psychiatry 68 (9), 811-817 (2010)
   PUBMED   20800221
REFERENCE   4  (bases 1 to 13219)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   5  (bases 1 to 13219)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015911.8.
            
            On May 7, 2021 this sequence version replaced NM_001363830.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR18074968.4324435.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03267768 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000628453.4/
                                                ENSP00000487397.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC015911.8         125143-125248       c
            107-797             AC015911.8         109849-110539       c
            798-1876            AC015911.8         66687-67765         c
            1877-1987           AC015911.8         65645-65755         c
            1988-13219          AC015911.8         51824-63055         c
FEATURES             Location/Qualifiers
     source          1..13219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..13219
                     /gene="SLFN12L"
                     /note="schlafen family member 12 like"
                     /db_xref="GeneID:100506736"
                     /db_xref="HGNC:HGNC:33920"
                     /db_xref="MIM:614956"
     exon            1..106
                     /gene="SLFN12L"
                     /inference="alignment:Splign:2.1.0"
     exon            107..797
                     /gene="SLFN12L"
                     /inference="alignment:Splign:2.1.0"
     CDS             712..2550
                     /gene="SLFN12L"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="schlafen family member 12-like isoform 1"
                     /protein_id="NP_001350759.2"
                     /db_xref="CCDS:CCDS86591.2"
                     /db_xref="GeneID:100506736"
                     /db_xref="HGNC:HGNC:33920"
                     /db_xref="MIM:614956"
                     /translation="MEKIRNVFHCEAHRILYICESQFLRNFIRKEFLRGNGLAAGKMN
                     ISIDLDTNYAELVLNVGRVTLGENNRKKMKDCQLRKQQNENVSRAVCALLNSGGGVIK
                     AEVENKGYSYKKDGIGLDLENSFSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQ
                     IATLSSSLYKRDVTSAKVMNASAALEFLKDMEKTGGRAYLRPEFPAKRACVDVQEESN
                     MEALAADFFNRTELGYKEKLTFTESTHVEIKNFSTEKLLQRITEILPQYVSAFANTDG
                     GYLFVGLNEDKEVIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGTINYLCKFLGV
                     YDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQLTEKEWIQFMVDSEPVCEE
                     LPSPASTSSPVSQSYPLREYINFKIQPLRYHLPGLSEKITCAPKTFCRNLFSQHEGLK
                     QLICEEMGSVNKGSLIFSRSWSLDLGLQENHKVLCDALLISQDKPPVLYTFHMVQDEE
                     FKDYSTQTAQTLKQKLAKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYY
                     WTTAQTMKDLEKALSNILPKENQIFLFVCLFRFCLFVCWFVCFFLR"
     exon            798..1876
                     /gene="SLFN12L"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..1987
                     /gene="SLFN12L"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..13219
                     /gene="SLFN12L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13191..13196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFN12L"
                     /note="hexamer: AATAAA"
     polyA_site      13219
                     /gene="SLFN12L"
                     /note="major polyA site"
ORIGIN      
        1 accactgtcc tcagccaaac tgcagggact cctaagtaga tcagagctcc tggaactttc
       61 tcatcttttc agcatctcaa ccctgtggaa tcttttaact cccaagtgct accaggatat
      121 ttgcgatgta ctctggaatc cctctggaag gagctgtcct cacagaatga aggattagag
      181 gagttaataa ataagcaaac ccaacctttc tcctggggaa ttgtgatcct ctctagaagc
      241 taggctgtgg acctgaattt gcaggagaag ccaggagtca tctgtgatgc tctgctgata
      301 gcatagaaca gccctggcag ggccaggact actgcacttg cactgccctt actttgaagc
      361 agaagctggt gaacatgggg ggctacactg gggaggtgtg tgtcagggcc aaggtcctct
      421 gcctgagtcc tgagagcagc gcagaggctt tggaggctgc agtgtctccg atggattacc
      481 ctgcgtccta tagttttgca ggcacccagc acattggaag ccctgctgca gtccctcgtg
      541 attgtcttgc tcggcttcag gtctctcttg agtgacctgt gcagctatga ggttttaaat
      601 ctgctcacag cccagcagta tgagatattc tccagaagct tccacaagaa cagagaattg
      661 tttgtccatg gcttacctgg cttaggaaag accatcatgg ccatgaagat catggagaag
      721 atcaggaatg tgtttcactg tgaggcacac agaattctct acatttgtga aagtcagttt
      781 ctgaggaatt tcatcagaaa agaatttctg cgtggaaatg gcttagctgc tgggaaaatg
      841 aacatcagta ttgatttaga cacaaactat gctgagctgg ttctaaatgt gggaagagtc
      901 actcttggag agaacaatag aaaaaaaatg aaggattgtc aactgagaaa acagcagaat
      961 gaaaatgtct cacgagctgt gtgtgctctg ctgaattctg gagggggagt gatcaaggct
     1021 gaagttgaga ataaaggcta tagttataaa aaagatggaa tagggctaga tttggaaaat
     1081 tcttttagta acatgctgcc atttgttcct aatttcctgg acttcatgca gaatggtaac
     1141 tactttcaca tttttgtgaa atcatggagc ttggaaacct ctggtccgca gattgccacg
     1201 ttgagctcca gtttgtacaa gagagatgta acgtctgcaa aagtcatgaa tgcttctgct
     1261 gcactggagt tcctcaaaga catggaaaaa actggaggga gagcatattt aagaccagaa
     1321 ttccctgcaa aaagggcctg tgttgatgta caagaagaaa gtaacatgga agccttggct
     1381 gctgattttt ttaacagaac agaacttggt tataaagaaa aattgacctt tactgaatcc
     1441 acacacgttg aaataaaaaa cttctcgact gaaaagttgt tacaacgaat tacagagatt
     1501 ctccctcaat atgtttctgc atttgcaaat actgatggag gatatttatt cgttggtcta
     1561 aatgaagata aagaagtaat tggctttaaa gcagagaaga gttatcttac taagttagaa
     1621 gaagtaacaa aaaattccat tgggaaactg cctgtgcatc acttctgtgt ggagaagggg
     1681 acgataaatt acttatgcaa attccttgga gtatatgata aaggaaggct ttgtggatat
     1741 gtgtatgcac tcagagtgga acgcttctgc tgtgcagtgt ttgctaaaaa gcctgattcc
     1801 tggcacgtga aagataacag agttaagcag ttgaccgaga aggaatggat ccagttcatg
     1861 gtggattcag aaccagtatg tgaggaactg ccctctccag caagtacatc atcacctgtc
     1921 tcccagagtt atcctcttcg tgaatatatt aacttcaaaa ttcagccact gagatatcac
     1981 cttccagggc tatcagaaaa gataacttgt gctccaaaaa ccttctgcag aaatctgttc
     2041 tcacaacatg aaggacttaa gcaattaata tgtgaagaaa tgggctctgt caataagggc
     2101 tcactgatct tctctaggag ctggtctttg gatctgggct tgcaagagaa ccacaaagtc
     2161 ctctgtgatg ctcttctgat ttcccaggac aagcctccag tcctatacac cttccacatg
     2221 gtacaggatg aggagtttaa agactattct acacaaactg cccaaacttt aaaacagaag
     2281 ctggcaaaaa ttggtggtta cactaaaaaa gtgtgtgtca tgacaaagat cttctacttg
     2341 agccctgaag gcaagacaag ctgccagtat gatttaaact cgcaagtaat ttaccctgaa
     2401 tcctactatt ggacaacagc tcaaacaatg aaagacttgg aaaaggccct ttcaaatatc
     2461 ttacctaagg agaatcaaat ctttttgttt gtttgtttgt ttcgtttttg tttgtttgtt
     2521 tgttggtttg tttgtttttt cttgagatga gtctcactct gtcacccaga ctggagtgta
     2581 gtgacacgat ctcgactcac tgcaacctct gcctcctggg ttcaagcaat tccctgcctc
     2641 agcctcccga gtagctggga ttacatgtgc ctgccaccac acctggctaa tttttttttt
     2701 tttgtatttt tagcagagat ggggtttcac cgtcttggcc aggctggtct tgaactcctg
     2761 acctcgtgat tcaacccccc cccccggtct cccaaagtgc taggagtaca gatgtgagcc
     2821 accgcgcccg gctggagaat caattctttt atagaccaat tagcctttga catttccagc
     2881 atctcccaga taatcagtat agataaggat gtttaaatct tgtccaaggc tcacttgaat
     2941 catggaagat ggactgggct acagagatat ttttcattat atatttggta acattctcta
     3001 attctctaaa aatacgtctt tgaaaacatt gcaagttagg caacttgacg tgatgttgga
     3061 aaactgggat tagcctatgt tcgcttcttc ctaagttctt tatagatatt ccttaaggga
     3121 aattagaaaa attaattacc tacacatgtt ttgccatacc aagatgtcat ttgactataa
     3181 aggaaatatc agacattctt atccaatgga catggaaaac atagttctct aatatcttct
     3241 tgaaaactat attgcaatga aatgcagcca atgaagagat gaatcaaaat ggagaacttg
     3301 ccgagttgga tggatcactt gaggtcagga gttgaagacc agcctgggca acatggtgaa
     3361 acccagtctc tactaaaaat ataaaaatta gccaagtgtg gtggcacaca catgtagtcc
     3421 cagctactcg ggaggctgag gcatgagaat tgcttgaacg caggaagtgg aggttacagt
     3481 gagccaagac cacaccactg cactccagct tgggcaagag agcaagactc tgtcatctct
     3541 atgcaaataa actagaaaat ctagaagaaa tggataaatt cctgaacaca tgcaacctcc
     3601 caagactgag ccagggagaa gtcaaatccc tgaacaggtc aataacaagt tctgaaattg
     3661 aggcagtaat tactaaccaa aaaaagccca ggaccagaca gattcacagc tgaattctac
     3721 cagaggtaca aagaggagct ggtaccattt ctactgaaac tattccaaac aataaaagag
     3781 gaaagaatcc tgcctaactc attttatgaa gccagtatca tcctgatacc aaaacctggt
     3841 agggacacaa taaaaaaagg aaaacttcag gccaatatcc ctgatgaaca tcattgcaaa
     3901 aatcatcaat aaaatactgg caaaccgaat ccagtggcat gtcagaaaag cttatccacc
     3961 acgatcaagt gggcctcatc cctgggatgc aaggctgatt caacaaacac aaatcaataa
     4021 atgtaattca tcacataaac agaaacaatg acaaaaacca tatgattatc tcaatagatg
     4081 cagaaaaaga ctctgacaaa attcaacatc cctttatgtt aaaaactctc aataaactgg
     4141 gtattgatga aacatatctc aaaacaataa gagctattca tgacaaaccc acagccaata
     4201 tcatactgaa tgggcaaaac ctggaagcat tccctttgaa aattggcaca agacaagaat
     4261 gccctctctc accactccta ttcaacatag tattggaagt tccggccagg gcaatcaggc
     4321 aagagaaaga aataaaggta ttcgaatagg aagagaggaa gtcaaattgt ctttatttgt
     4381 agatgagatg attttatatc tagaaaatcc catcatctca gcctccaaat tccttaagct
     4441 gataagcaac ttcagcaaag tctcaggata caaaatcaat gtgcaaaagt cacaagcatt
     4501 ccattacacc aacaatagac aagcagagag ccaaatcatg agtgaactca cattcacaat
     4561 cgctaaaaag agaataaaat acctagaaat acagctaaca agggatgtga aggacctctt
     4621 caaggagaac tacaaaccac tgctcaagga aacaagagaa gacacaaaca aatggaaaaa
     4681 cattccatcc tcataaacag gaagaatcaa tatcatgaaa atggccatat tgcccaaagt
     4741 aatttataga ttcaatgtta ttcccatcaa actaccattg acattcttca cagaatttca
     4801 tatggaatca aatcagaatt aaatgaaatt aaatttcata tggaatcaaa gaagaccttg
     4861 tatagctaag ataatcctaa acaaaaagaa caaagctgga ggcattatgc tacctgactt
     4921 caaactacac tacatggcta cagtaaccaa aacagcatgg tactggcata aaaagagaca
     4981 tatagaccaa tggaacagaa cagagacctc agaaataaca ccacacatct ataaccatct
     5041 gatcttctac aaacttgaca aaaacaagca atggggaaag gatcttctat tcaataaatg
     5101 gtgctgggag aactggctag ccatatgcag aaaactgaaa ctggatccct tccttacacc
     5161 ttatacaaaa attaacccaa gatggactaa agactcaaac tgaaaactga aactggatcc
     5221 cttccttaca ctttatacaa aaattaactc aagatagatt aaagacttaa atgcaaaact
     5281 caaaaccata aaaactctag aagaaaacct aggcaatacc attcaggaca taggcatggg
     5341 caaagacttc atgacaaaaa caccaaaagc aattgcaacg aaagccaaag ttgacaaacg
     5401 ggatctaatt aaactaaaga gcttctgtac agggaaagaa accaccatca gagtgaacgg
     5461 acaacctaca gaatgggaga aaatttttgc aatctaccca tctgacaaag gtctaatacc
     5521 cagaatgtac aaggaactta aacaaattta caaggaaaaa acaaccccat tgaaaagtgg
     5581 ataaaggata tgaatagaca tttctcaaaa gaagacattt atacagccaa caaacgtatg
     5641 aaaaaaaact caacatcact tatcattaga gaaatgcaaa tcaaaaccac aatgagacac
     5701 catctcacac aagtcaaatg gtgattattg aaaagtcaag ataaaagatt atttaaaact
     5761 tttaaataat cttttattaa aagaatattt aaaactttta aataatcttt tattaaaaga
     5821 aagattatta aaaagtctcc actgcacggc gaggctgtgg agaaatagga atgcttttac
     5881 actgttggtg ggaatgtaaa ttagttcaac cattgtggaa gacagtgtgg cgattcctca
     5941 aggatctaga accagaaata ccatttgacc caggaatccc attactgggt atatacccaa
     6001 aggaatgtaa atcattctac tataaagata catgcaggcg tggcgcggtg gctcatgcct
     6061 gtaatcccag cactttggga ggctgaggcg ggtggatcac ctgaggccag gagtttgaga
     6121 ccagcctggc caacatggtg aaaccccatt tctactaaaa atacaagaat tagctgggag
     6181 tggtggtagg cgtctgtaat cccagctact tgggaggctg agacatgaaa attgcttgaa
     6241 cccgggaggc agaggttgca gtgagccaag atcaccccat tgcactccag cctgggtgac
     6301 aagagcaaaa ctctgtctca gaaaaaaaaa aaaaaagaca catgcacaca tatgtttatt
     6361 gccccactat ttacaatagc aaaggcatgg aaccaaccca aatgcccatc agtgatagac
     6421 tggataaaga aaatgtggta catatacacc atggaatact gtgcagccat aaaaaggaat
     6481 gagatcatga cctttgcagg gacatggatg aagctggaag ccatcatcct cagcaaacta
     6541 acatgggaac agaaaatgaa acactacatg ttctcactca taagtgggag ctgaacaatg
     6601 agaacacatg gacacaggga aaggattaac acacaccagg gcctgttgtg gggtggggag
     6661 agtgagggga gggaactcag aggatgggtc aataggtgca gcaaaccacc atggcacatg
     6721 tatacctatg taacaaacct gcacattctg cacgtgtatc ccagagctta aagtataata
     6781 aaaattaaaa aaaaaaaaaa gaacttaaaa cagtgggagc atgttcacac tcttggagtc
     6841 tttccagccc tgaacctcag gcagcctgta tcagctgctg gtgatgggtg acctgggcat
     6901 ggggaagacc accatcatca aacagtgagt gcaccagaac tcctcctggc tggcaccctg
     6961 aagccaccac tgtgtgaact gtgcattcaa ggtgctacac tgggacccag aggccttggc
     7021 acacctacag ctgtggaaca ttgcaatgag gaaagattgg gaaaatgaca agagcctgtt
     7081 atctggaact tacaggcgca tttattgtct ccagtatcac caggccagcc ccatttgaag
     7141 cagagctaaa gtggaaaaat gatttggact aaacgttaac acatggcaga ccaatttcta
     7201 tggttctgtt ggccaagaaa tgtgaccatg ggaggatgaa cgcaggaaca atagcctcaa
     7261 gatgggccag atctacatgg aacatagttt tgcagtagga aaatataaac tttggtgaaa
     7321 ccttcagatg cctgataaaa tattatatga aaatgtactc ttgaagtttt gatttatgga
     7381 ggtgactgag tgtcaacaca gatggactag cgccattgaa aaaagacttt attacttata
     7441 gttccaagag aaggggactt gctctgtcat gcagggtcat gtggtaaagc atccagttgg
     7501 ttaaggaaag aggagcagaa gtgaggggaa aatctaattc ggaaccttta ttattagggt
     7561 ttctgtggga aaggtccagc tgggcagggg gaacagctta ggactcaata gtttgaataa
     7621 ttctgatggg ctttggggcc tagggacggt ccccagttgt ctgttacatg gccctgggtt
     7681 tatgtagggt agggaaaata ttggctcgat gtgtgagtag cttagagtat gagctctggg
     7741 tcacagcggg gatgtaaaga atgttggcca ttagtttggc cctgtgatta atggatgcca
     7801 aatagacaag tacagaacct aggaaaacac agtaagaccc attgcccctg ggcctatttg
     7861 gcatcatcgt aagaaacctg gggtggtaat agtggactta tttaaaggat ggggtacagt
     7921 tgccctaaat agcctagaaa atattttatt gtaagagtaa gatagaagaa caatgtggaa
     7981 gtataaagag cccttgtagg ctggtccata actaagttct tcatttgcat gtcattagtc
     8041 aagaaagtag atctgaaatt tttggaggtt tttactatta tcttggtgga gttttaaagt
     8101 gggttaaaag tttgaaatac atatatatat atattatata tatatttata tatataatat
     8161 atatatattt tatatatata tattttatat aaaacaggtc ctgcagtcag gttgttgggg
     8221 gataggaact aatacattaa taatgcatgt gtagactagc gtgtgtgtat aaccaaggag
     8281 gagtggtcat ggtcagagac acagggcagg aagtcacggg ggaaagcttg agggggtagt
     8341 aggggtaggc actggggagt tagtggtcct cttcccagtg ggttgaggga ttgactcagg
     8401 aggcaacagc cttcagagaa aggcaatact atccattaat ttttgttatc tttttagaca
     8461 cagggtcttg cccttgtcac cgaggctgga gtgcagtggt gtggtcatag ctcattacag
     8521 ccttgacctc ccgacatcaa gagattctcc tgcctcagac tcttgagtag ctgggactac
     8581 aggtgtacac caccatgccc agctaacttt tatatgtttt gtagagatgg ggtctcccca
     8641 tgttgcccag gctggtttga actcctggga ttaagcagtc ctgcctcagc ctcccaaagt
     8701 gctggaatta taggcatgag tcactgtgct tggccctcca ttaattctta gaatgacgta
     8761 ggtagtggta actactatta aattttcctt caggcatagg agtgcggggt gtatgttttg
     8821 gcagagagca aggagtatgc caggatgata ggctaagcag acagcacact cagaaacaca
     8881 atagaatccc tgatatcaaa ggaaaaaagg ccaaatgttc ggtgtgcagt ttgtgcctga
     8941 gaagaggcag tccatgggtg tcactggggt gaaggttttt gtgtttaggg tgacgccatg
     9001 tctggtgcag gggtaaattc atctctgacg gtaagctgga tcgatgtcat ctgaggcagc
     9061 ataatctcca gcagtgagtg cctatccagg aaaatgtcat ctaggatatg ggtcttgagt
     9121 atttctttta agtaaataca gactcaggtt gatgtgggtc ttagcatttg ccatgattga
     9181 ttaaaacaat ggcttgtatg gagggttggt gcctccagat gataaaacaa caaaagcacc
     9241 cataccagca gtaagatcag caggctgagc atggcagctc atgcctgtaa tcccagcact
     9301 ttgagaggcc aaagcaggtg cattgcttga gctcaggcat tcaagaccag cctgggcaac
     9361 atggtaaaac cctgtctcta caaaaaacat aaaaaattag ctgggcgtgg tagtgtgtgc
     9421 ctgtggtcgc agcttctcag gaggctgagg tgagaggatt gtctgaaccc aggaagtaga
     9481 gtggggagtg aatcgtgatc acgccactgc actccagcct gggtaacaga gtgagacctt
     9541 gtctcagacc aaaacaaaaa gcaaaaacaa acaaacaaaa caaaaaagat aaacagaaaa
     9601 cagaatggtg tgcagctgca tttgacagag ttttggtttt tgcttgcttg cttgcttgct
     9661 tcatggttga agtttaggct caaacgggtc ccatatcaga taagcagctg cctagcccat
     9721 tggacaatca ctattaattg gaccccagag aatatacaca cctgctgtgg cctcctgatg
     9781 gggggggttt gatattgaaa atctataaaa ataggttaag gcctggggca agataaagac
     9841 ccattgagag gtccatttgt tggactggaa ctttaaaaga agttgtttgg ggagactctt
     9901 atgtctctct gttaaactgg ctatttggga cctattaggg tcatgaaagt tttattgaat
     9961 gcctgtttgt ttcgggagcc cattcagtgt gtattttgca atgtgaaatg tgtgccttgg
    10021 ttattacctt ggtaattgta aggcctcata tggtggcctt aatatacata gacacgtgat
    10081 tttgggtatc taagaggaaa gaggttctta gtgttcctta atctgaaagg gacaattcat
    10141 taggcaatgg ctcaattgtt caaaaggaat atggagatgg ggccatttgt tggccagggc
    10201 atccagcatt cggtaatatt ccacctagct ccatcatgta tggtggttgg cagtgccatt
    10261 catatagtcc gtgaacttct attgctgttc actcagtcaa tccaaaggag ctttccaggt
    10321 aaccaagggg tctggaggag aggtgacctc ctccagcact atggcatctg gcaagggacc
    10381 aaggactggg gacgtcactc ccttctgcgt gtgaatatgc tagagagccc aggacttggt
    10441 agcctccttg agacaggtta gagacaaacc tgggccctct gagaggctga gcttgcaggg
    10501 tgctgtttcc atgactgaaa gcataacagg tagccaggta tggagggtca cagactcaga
    10561 atctgtgaaa gcctctatgt ccaggagagc ccagtatgga gctagtcatt tgtggtttta
    10621 atggcatata gcatgaggct gagagccctc aggcaattcg tagccatcac aggtggtcta
    10681 gactttagga ggcatgagta gagcttgtta aagtctcttc agtaaaggaa tcaatgcagg
    10741 caccaatggg tctgtctgtt ggtattaatt tggatagatt ttagagcctt tttgtttgag
    10801 gctgccacat ttaaagtggg ttcatttgtg agttacagct caatgagatt aagtaaaatt
    10861 tgtaagtgaa gaatattttg ccatgaaaac ccaaaaagga tgaaaagatg ttggactctt
    10921 atgtccatat gagtagatta agtgacatct ccttggagga ggttattaat gtaatatcat
    10981 atctgtgctc ccagaggaag gtgcatgcac ttaagatctt gtctgtccct gtctctttaa
    11041 aaagaaggcc atctgaaaag gctatatact gtatgattcc aactatatga cattctgtaa
    11101 aaggcaagat tatggagaca gtaaaatgat cggtggtttc caaggattaa gggagtggga
    11161 ggaatgaata gttgaaccac agaggattct taaggccatg aaaatcctgt gtttgatact
    11221 atatagtaga tatatgtcat tatacatttg tctgaaccca taaaatgtac aagaagaatg
    11281 aacgctaatg taaaagtcgc aatggatttt gagtgattat gatgtattaa tttagattaa
    11341 tcaattgtaa caaatgtacc acactaatgg gagatgttgc taatggggga ggctatgcat
    11401 gagtgcgggc agtgggtata tggaaaatct ttgtactttc cgctcaattt tgctgtgaat
    11461 ctgctctaga aaaattaagt attaaaaaag atcttgtctg taagatgtgt gcatgatggc
    11521 aaaattgtga aggtactgag gtgtagcctg caagaggtat attgtgtctc ttcagcaatg
    11581 gaggcaaact acagtggagt ctgttgaaat aggcacggaa ttgaacatat tgaacatatt
    11641 agccaagtct gtaagaacag agtatttagc agttattgat tggatagagt taataatgtt
    11701 aatcatacta gatactggct atgaggccct agtcgacaag accacagcaa taatgttgta
    11761 gtcctccacc gtgaggtgcc tgctgcttat tattttccag gtttaagaac aggcaacact
    11821 gggctgttaa acggacaagc agcagggaat acttatctcc tttatccctt ttatgttata
    11881 taaatgaggt tttatgtaac aactttcaat ccttcaaggg cctattttaa cttacattga
    11941 accatattaa ctattttaat gggatttata taatcctatt ttatcaagcc aatttttgag
    12001 tgccaaaaat ttaattttaa tttattattt attgtgacat ggagtctatg ttcaatacga
    12061 gatactttaa ggcactgagt acaacaacta tgagcaattc aatcaagata taaaataagg
    12121 catagctatt tttaaaaagc tatttagcta ccttttaaaa ttatatgggg tacaatgttt
    12181 aaatttgttg gaacctcagg cataagtata atttgagtat ttattaagtc cacgaggttt
    12241 ctcaattggt gcattttggc aaatgttaaa gttaatttag agctttcagt tctggccagg
    12301 cgtggtggct cacgcctgta atcccagcac tttgggaggc cgagacaggc ggatcacttg
    12361 aggccaggag ttcgagacca gcctggcgaa catatagtga aacctcatct ctactaaaaa
    12421 atacaaaaat tagctggatg tggtggtgtg ctcccgtagt cccagctact tgggaagctg
    12481 aggcaggaga atcacttgaa cctgggaggc gggggttgca gtgagccaag atggcaccac
    12541 cgcactccag cctgggtgac agagcaagac tttatctctc tctaaaaaaa gcaaaaaaca
    12601 gaaaacaaaa aaccttacag ttctaaaccc aatcacgacc ttagctatct ttttgttata
    12661 taaattcttt ggtatacaaa ttttcgattt ccaattgggt gaaattatgg atgtttgttt
    12721 taatttagat atacgtttga tatctttatc tatgtacatg tacaatctat tcattatgtc
    12781 tatattaacc taaatgctca tcaatgacag attagataaa gaaaatgtgg tacatataca
    12841 ccatgggcta ctacacagcc ataaaaaaga acaagatcat gtcttttgca ggaacatgga
    12901 tggaactgga ggccattacc cttagcaaac taacttaaga acagaaaacc aagtccagca
    12961 tcttctcact gataaatggg agctaaacga aagaacttat gaacacaaag aaggaaacag
    13021 cagacactgg ggtctatttg agggggggag ggtgggagga gggagaggag cagaaaagtt
    13081 aactattggg tatgggctta atacctgggt gatgaaataa tatgtataac aaaaccccat
    13141 gacacatgtt tacctgtgta atgagccttc acatgcgccc ccaaacctaa aataaaaatt
    13201 aacaaaaatt ttatctaca
//
