LOCUS       NM_001376007            5139 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens schlafen family member 11 (SLFN11), transcript variant
            6, mRNA.
ACCESSION   NM_001376007 XM_017025299
VERSION     NM_001376007.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5139)
  AUTHORS   Zhang,P., Hu,X., Li,Z., Liu,Q., Liu,L., Jin,Y., Liu,S., Zhao,X.,
            Wang,J., Hao,D., Chen,H. and Liu,D.
  TITLE     Schlafen 11 triggers innate immune responses through its
            ribonuclease activity upon detection of single-stranded DNA
  JOURNAL   Sci Immunol 9 (96), eadj5465 (2024)
   PUBMED   38875319
  REMARK    GeneRIF: Schlafen 11 triggers innate immune responses through its
            ribonuclease activity upon detection of single-stranded DNA.
REFERENCE   2  (bases 1 to 5139)
  AUTHORS   Wang,H.X., Zhao,Z.P., Du,X.Y., Peng,S.L., Xu,H.Y., Tang,W. and
            Yang,L.
  TITLE     SLFN11 promotes clear cell renal cell carcinoma progression via the
            PI3K/AKT signaling pathway
  JOURNAL   Med Oncol 41 (2), 54 (2024)
   PUBMED   38206539
  REMARK    GeneRIF: SLFN11 promotes clear cell renal cell carcinoma
            progression via the PI3K/AKT signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5139)
  AUTHORS   Alvi,E., Mochizuki,A.L., Katsuki,Y., Ogawa,M., Qi,F., Okamoto,Y.,
            Takata,M. and Mu,A.
  TITLE     Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11
            during the replication stress response
  JOURNAL   Commun Biol 6 (1), 1038 (2023)
   PUBMED   37833372
  REMARK    GeneRIF: Mouse Slfn8 and Slfn9 genes complement human cells lacking
            SLFN11 during the replication stress response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5139)
  AUTHORS   Metzner,F.J., Wenzl,S.J., Kugler,M., Krebs,S., Hopfner,K.P. and
            Lammens,K.
  TITLE     Mechanistic understanding of human SLFN11
  JOURNAL   Nat Commun 13 (1), 5464 (2022)
   PUBMED   36115853
  REMARK    GeneRIF: Mechanistic understanding of human SLFN11.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5139)
  AUTHORS   Fischietti,M., Eckerdt,F., Perez,R.E., Guillen Magana,J.N.,
            Mazewski,C., Ho,S., Gonzalez,C., Streich,L.D., Beauchamp,E.M.,
            Heimberger,A.B., Baran,A.H., Yue,F., James,C.D. and Platanias,L.C.
  TITLE     SLFN11 negatively regulates non-canonical NFkB signaling to promote
            glioblastoma progression
  JOURNAL   Cancer Res Commun 2 (9), 966-978 (2022)
   PUBMED   36382088
  REMARK    GeneRIF: SLFN11 negatively regulates non-canonical NFkB signaling
            to promote glioblastoma progression.
REFERENCE   6  (bases 1 to 5139)
  AUTHORS   Mavrommatis,E., Fish,E.N. and Platanias,L.C.
  TITLE     The schlafen family of proteins and their regulation by interferons
  JOURNAL   J Interferon Cytokine Res 33 (4), 206-210 (2013)
   PUBMED   23570387
REFERENCE   7  (bases 1 to 5139)
  AUTHORS   Li,M., Kao,E., Gao,X., Sandig,H., Limmer,K., Pavon-Eternod,M.,
            Jones,T.E., Landry,S., Pan,T., Weitzman,M.D. and David,M.
  TITLE     Codon-usage-based inhibition of HIV protein synthesis by human
            schlafen 11
  JOURNAL   Nature 491 (7422), 125-128 (2012)
   PUBMED   23000900
  REMARK    GeneRIF: SLFN11 selectively inhibits viral protein synthesis in
            HIV-infected cells by means of codon-bias discrimination
REFERENCE   8  (bases 1 to 5139)
  AUTHORS   Zoppoli,G., Regairaz,M., Leo,E., Reinhold,W.C., Varma,S.,
            Ballestrero,A., Doroshow,J.H. and Pommier,Y.
  TITLE     Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer
            cells to DNA-damaging agents
  JOURNAL   Proc Natl Acad Sci U S A 109 (37), 15030-15035 (2012)
   PUBMED   22927417
  REMARK    GeneRIF: SLFN11 expression is causally associated with the activity
            of DNA-damaging agents in cancer cells, and has a broad expression
            range in colon and ovarian adenocarcinomas.
REFERENCE   9  (bases 1 to 5139)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 5139)
  AUTHORS   Schwarz,D.A., Katayama,C.D. and Hedrick,S.M.
  TITLE     Schlafen, a new family of growth regulatory genes that affect
            thymocyte development
  JOURNAL   Immunity 9 (5), 657-668 (1998)
   PUBMED   9846487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC060766.8.
            
            On Nov 7, 2019 this sequence version replaced XM_017025299.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2096431.1,
                                           SRR14038192.847681.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685675.1/ ENSP00000510787.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC060766.8         64079-64226
            149-246             AC060766.8         70000-70097
            247-363             AC060766.8         70637-70753
            364-1451            AC060766.8         73874-74961
            1452-1580           AC060766.8         77329-77457
            1581-2304           AC060766.8         83641-84364
            2305-5139           AC060766.8         84561-87395
FEATURES             Location/Qualifiers
     source          1..5139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..5139
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /note="schlafen family member 11"
                     /db_xref="GeneID:91607"
                     /db_xref="HGNC:HGNC:26633"
                     /db_xref="MIM:614953"
     exon            1..148
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     exon            149..246
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     exon            247..363
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     exon            364..1451
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     CDS             383..3088
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /codon_start=1
                     /product="schlafen family member 11"
                     /protein_id="NP_001362936.1"
                     /db_xref="CCDS:CCDS11294.1"
                     /db_xref="GeneID:91607"
                     /db_xref="HGNC:HGNC:26633"
                     /db_xref="MIM:614953"
                     /translation="MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKE
                     RVMRAACALLNSGGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRC
                     FYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKRKPKI
                     LEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPESQLVEFKQF
                     STKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQ
                     AIYKLPCVHFCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIV
                     EDKYVCSLTTEKWVGMMTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKE
                     LQQLLFSVPPGYLRYTPESLWRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLN
                     LQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKV
                     CVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLS
                     DQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEA
                     HRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYG
                     KAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKY
                     LQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQGVQGTLRIKKYLTVEQIMTCVADTCRR
                     FFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRR
                     FSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH"
     exon            1452..1580
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..2304
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..5139
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4847..4852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /note="hexamer: AATAAA"
     polyA_site      4874
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /note="major polyA site"
     regulatory      5098..5103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /note="hexamer: AATAAA"
     polyA_site      5139
                     /gene="SLFN11"
                     /gene_synonym="SLFN8/9"
                     /note="major polyA site"
ORIGIN      
        1 gaaacgctaa gggggcttcg gaagcgctgg agcttgagag gtcagagagg gtccttgccc
       61 ccagcctggg actccggagt tgcgtttcta cccgtgcttc agggtctagc ccagccgaat
      121 ccgcgtcggg ctgtaactcg agtgccaggt ttctgtatac atagccttca ggactgcttt
      181 tggtggaaag agatagcagg tggtgctaat tcactgtgtt ggtgggaact ctggctacac
      241 tgaaagattc ttactttgac ccccaggctg gagtgcagtg gcacgatctt ggttcaccac
      301 aatctcgtct cgaaggctca ggtgattctc tcacctcagc cgcctgagta gctgggacca
      361 cagtttcagc tgtgagttca acatggaggc aaatcagtgc cccctggttg tggaaccatc
      421 ttacccagac ctggtcatca atgtaggaga agtgactctt ggagaagaaa acagaaaaaa
      481 gctgcagaaa attcagagag accaagagaa ggagagagtt atgcgggctg catgtgcttt
      541 attaaactca ggaggaggag tgattcgaat ggccaagaag gttgagcatc ccgtggagat
      601 gggactggat ttagaacagt ctttgagaga gcttattcag tcttcagatc tgcaggcttt
      661 ctttgagacc aagcaacaag gaaggtgttt ttacattttt gttaaatctt ggagcagtgg
      721 ccctttccct gaagatcgct ctgtcaagcc ccgcctttgc agcctcagtt cttcattata
      781 ccgtagatct gagacctctg tgcgttccat ggactcaaga gaggcattct gtttcctgaa
      841 gaccaaaagg aagccaaaaa tcttggaaga aggacctttt cacaaaattc acaagggtgt
      901 ataccaagag ctccctaact cggatcctgc tgacccaaac tcggatcctg ctgacctaat
      961 tttccaaaaa gactatcttg aatatggtga aatcctgcct tttcctgagt ctcagttagt
     1021 agagtttaaa cagttctcta caaaacactt ccaagaatat gtaaaaagga caattccaga
     1081 atacgtccct gcatttgcaa acactggagg aggctatctt tttattggag tggatgataa
     1141 gagtagggaa gtcctgggat gtgcaaaaga aaatgttgac cctgactctt tgagaaggaa
     1201 aatagaacaa gccatataca aactaccttg tgttcatttt tgccaacccc aacgcccgat
     1261 aaccttcaca ctcaaaattg tgaatgtgtt aaaaagggga gagctctatg gctatgcttg
     1321 catgatcaga gtaaatccct tctgctgtgc agtgttctca gaagctccca attcatggat
     1381 agtggaggac aagtacgtct gcagcctgac aaccgagaaa tgggtaggca tgatgacaga
     1441 cacagatcca gatcttctac agttgtctga agattttgaa tgtcagctga gtctatctag
     1501 tgggcctccc cttagcagac cagtgtactc caagaaaggc ctggaacata aaaaggaact
     1561 ccagcaactt ttattttcag tcccaccagg atatttgcga tatactccag agtcactctg
     1621 gagggacctg atctcagagc acagaggact agaggagtta ataaataagc aaatgcaacc
     1681 tttctttcgg ggaattttga tcttctctag aagttgggct gtggacctga acttgcagga
     1741 gaagccagga gtcatctgtg atgctctgct gatagcacag aacagcaccc ccattctcta
     1801 caccattctc agggagcaag atgcagaggg ccaggactac tgcactcgca ccgcctttac
     1861 tttgaagcag aagctagtga acatgggggg ctacaccggg aaggtgtgtg tcagggccaa
     1921 ggtcctctgc ctgagtcctg agagcagcgc agaggccttg gaggctgcag tgtctccgat
     1981 ggattaccct gcgtcctata gccttgcagg cacccagcac atggaagccc tgctgcagtc
     2041 cctcgtgatt gtcttactcg gcttcaggtc tctcttgagt gaccagctcg gctgtgaggt
     2101 tttaaatctg ctcacagccc agcagtatga gatattctcc agaagcctcc gcaagaacag
     2161 agagttgttt gtccacggct tacctggctc agggaagacc atcatggcca tgaagatcat
     2221 ggagaagatc aggaatgtgt ttcactgtga ggcacacaga attctctacg tttgtgaaaa
     2281 ccagcctctg aggaacttta tcagtgatag aaatatctgc cgagcagaga cccggaaaac
     2341 tttcctaaga gaaaactttg aacacattca acacatcgtc attgacgaag ctcagaattt
     2401 ccgtactgaa gatggggact ggtatgggaa ggcaaaaagc atcactcgga gagcaaaggg
     2461 tggcccagga attctctgga tctttctgga ttactttcag accagccact tggattgcag
     2521 tggcctccct cctctctcag accaatatcc aagagaagag ctcaccagaa tagttcgcaa
     2581 tgcagatcca atagccaagt acttacaaaa agaaatgcaa gtaattagaa gtaatccttc
     2641 atttaacatc cccactgggt gcctcgaggt atttcctgaa gccgaatggt cccagggtgt
     2701 tcagggaacc ttacgaatta agaaatactt gactgtggag caaataatga cctgtgtggc
     2761 agacacgtgc aggcgcttct ttgatagggg ctattctcca aaggatgttg ctgtgcttgt
     2821 cagcaccgca aaagaagtgg agcactataa gtatgagctc ttgaaagcaa tgaggaagaa
     2881 aagggtggtg cagctcagtg atgcatgtga tatgttgggt gatcacattg tgttggacag
     2941 tgttcggcga ttctcaggcc tggaaaggag catagtgttt gggatccatc caaggacagc
     3001 tgacccagct atcttaccca atgttctgat ctgtctggct tccagggcaa aacaacacct
     3061 gtatattttt ccgtggggtg gccattagga agaactccaa atcaaaatgc tatgtaaatg
     3121 tctatgggtg acagtctgct gatggtagaa acctttcttt ttagttcaca agtcagagat
     3181 ttggacggag ctgacacaaa gagtttggag ctcccccatt tctggctctc ctttcagggg
     3241 ttccttcccc aaccctttca gcagcggtgg ctgcccccca ttctgacccc tgactcttcc
     3301 agccagaaag atggtggttt tctaaaggaa ctttagctgt cctgcacaat gccgatctgt
     3361 gtcttgcatt ttgggtaaaa gccataaaaa taagaaactc agcctgtggc ctttctttct
     3421 tccaaggctg ggcttctttt tttaagtgac ttcatgcagt ttgttgcttt taaaaatttg
     3481 tccagaatcg ttttctgcag aagcatggtc tgttaggagc ttactggccg tagcagaagc
     3541 aattgtttcc tgaattcttg acatttatct ttgctgtatt catttagggc ttgggagagt
     3601 ccgaagataa ttcagtcact gtcagattaa taattttgtc aggacaaaga ataccgttat
     3661 gattatttaa tcctttaaaa ttgtggtctc cagagcttgt tctcagaatg gcccagacca
     3721 agccttaatt gtgatagtga atattaatgg tcactttaag gagaaattat aggccaagat
     3781 gaaatgaaca taaacctgtt tgccctggct ttcagtggaa gatgatatta gagaccaaaa
     3841 tctggttctg aaggtgtgta tcagccctaa ggtgaaccag acttgggaaa gattgtcttt
     3901 aaaaatcaat gagtttatgt tttaacttct cagcttagtt ctatgcattg ctctataaca
     3961 cacctagtta agttttatgt tattcttgaa ctgtgatttt ttttctattt actttcatgg
     4021 tttggtgggc cattgttatg gactgaatgt ttgtgtccca cccttcaccc ccaaattccc
     4081 gtgttgaagc cccaacctgc actgtggagc tggggctgct aaggaagtaa ttaaggttac
     4141 atgaagtcat ggtggggctc tgatctgcta aggttggtgt ccttataggg agagacccca
     4201 gagagcttgt tccctccctc cctgtgcatg caaacaagag ggcatgggag cacacagaga
     4261 gatggcagcc acctacaagc caagaggaga agcctcacaa tcaaactctc gctgctggcg
     4321 agagtcttgg actctgtctt ggacttccag cctccagact gtgagaaaca aatttctgtt
     4381 gtttcagctt ctcagtctct ggtgttttgt tattgcagcc tgagaacaca gctgtacgat
     4441 tatttgtcaa acagaaaaca ctgatactta acaatgctaa tgcaattatt tatttgcttt
     4501 tcagtctcta caaaacgttc taaaacacta atctaaatat taacagtaaa atatttgcat
     4561 aactaatgga aactaagaaa tcatatgacc aatatttcac ttattggtaa tcttactcta
     4621 ctgatttccc cccagactgt gatttttgaa cttccttgcc tttctcctgt ctttctgtgt
     4681 ttattcatgg aattccagtt atctgggctt gaaattgcag gctctcctaa cttaagcaaa
     4741 atctgacaga tcagcaaaat gagataaatg tttctttttt ctttctgact gcattaaatc
     4801 agatacaact cagcattaaa aagctatctt tgtaaatgtt gttactaata aattagtctt
     4861 ataagatccc tggactttgg agttgttgca atgtctttga gagtaattct ttaaaagtct
     4921 aatttcgact ggttgtatct ctttatgatt tattgcccca ctaacaatat ttgaaacaat
     4981 ataatatttt aaaatgtata aataattatg aatttttgtt tagaacaaag aggattactg
     5041 atatttgttt ccctatgaat ggcaaaaggt ttagcttact actgcatttc tgttttaaat
     5101 aaaaagttga gagtttgtgt ctcattaaac tgaaaaaaa
//
