LOCUS       NM_018121               6892 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SMC5-SMC6 complex localization factor 2 (SLF2),
            transcript variant 1, mRNA.
ACCESSION   NM_018121
VERSION     NM_018121.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6892)
  AUTHORS   Zhang,L., Wirth,M., Patra,U., Stroh,J., Isaakidis,K., Rieger,L.,
            Kossatz,S., Milanovic,M., Zang,C., Demel,U., Keiten-Schmitz,J.,
            Wagner,K., Steiger,K., Rad,R., Bassermann,F., Muller,S., Keller,U.
            and Schick,M.
  TITLE     Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs
            the DNA damage response
  JOURNAL   EMBO Mol Med 15 (9), e16431 (2023)
   PUBMED   37485814
  REMARK    GeneRIF: Actionable loss of SLF2 drives B-cell lymphomagenesis and
            impairs the DNA damage response.
REFERENCE   2  (bases 1 to 6892)
  AUTHORS   Oravcova,M., Nie,M., Zilio,N., Maeda,S., Jami-Alahmadi,Y.,
            Lazzerini-Denchi,E., Wohlschlegel,J.A., Ulrich,H.D., Otomo,T. and
            Boddy,M.N.
  TITLE     The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral
            replication centers
  JOURNAL   Elife 11, e79676 (2022)
   PUBMED   36373674
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6892)
  AUTHORS   Grange,L.J., Reynolds,J.J., Ullah,F., Isidor,B., Shearer,R.F.,
            Latypova,X., Baxley,R.M., Oliver,A.W., Ganesh,A., Cooke,S.L.,
            Jhujh,S.S., McNee,G.S., Hollingworth,R., Higgs,M.R., Natsume,T.,
            Khan,T., Martos-Moreno,G.A., Chupp,S., Mathew,C.G., Parry,D.,
            Simpson,M.A., Nahavandi,N., Yuksel,Z., Drasdo,M., Kron,A., Vogt,P.,
            Jonasson,A., Seth,S.A., Gonzaga-Jauregui,C., Brigatti,K.W.,
            Stegmann,A.P.A., Kanemaki,M., Josifova,D., Uchiyama,Y., Oh,Y.,
            Morimoto,A., Osaka,H., Ammous,Z., Argente,J., Matsumoto,N.,
            Stumpel,C.T.R.M., Taylor,A.M.R., Jackson,A.P., Bielinsky,A.K.,
            Mailand,N., Le Caignec,C., Davis,E.E. and Stewart,G.S.
  TITLE     Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes
            and mosaic variegated hyperploidy
  JOURNAL   Nat Commun 13 (1), 6664 (2022)
   PUBMED   36333305
  REMARK    GeneRIF: Pathogenic variants in SLF2 and SMC5 cause segmented
            chromosomes and mosaic variegated hyperploidy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6892)
  AUTHORS   Scott,W.A., Dhanji,E.Z., Dyakov,B.J.A., Dreseris,E.S., Asa,J.S.,
            Grange,L.J., Mirceta,M., Pearson,C.E., Stewart,G.S., Gingras,A.C.
            and Campos,E.I.
  TITLE     ATRX proximal protein associations boast roles beyond histone
            deposition
  JOURNAL   PLoS Genet 17 (11), e1009909 (2021)
   PUBMED   34780483
  REMARK    GeneRIF: ATRX proximal protein associations boast roles beyond
            histone deposition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6892)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6892)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   7  (bases 1 to 6892)
  AUTHORS   Potts,P.R. and Yu,H.
  TITLE     The SMC5/6 complex maintains telomere length in ALT cancer cells
            through SUMOylation of telomere-binding proteins
  JOURNAL   Nat Struct Mol Biol 14 (7), 581-590 (2007)
   PUBMED   17589526
REFERENCE   8  (bases 1 to 6892)
  AUTHORS   Potts,P.R., Porteus,M.H. and Yu,H.
  TITLE     Human SMC5/6 complex promotes sister chromatid homologous
            recombination by recruiting the SMC1/3 cohesin complex to
            double-strand breaks
  JOURNAL   EMBO J 25 (14), 3377-3388 (2006)
   PUBMED   16810316
REFERENCE   9  (bases 1 to 6892)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6892)
  AUTHORS   Nikali,K., Saharinen,J. and Peltonen,L.
  TITLE     cDNA cloning, expression profile and genomic structure of a novel
            human transcript on chromosome 10q24, and its analyses as a
            candidate gene for infantile onset spinocerebellar ataxia
  JOURNAL   Gene 299 (1-2), 111-115 (2002)
   PUBMED   12459258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF460991.1, BC030565.1 and AI282394.1.
            
            On Nov 24, 2018 this sequence version replaced NM_018121.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.180591.1, AF460991.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238961.9/ ENSP00000238961.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1769              AF460991.1         395-2163
            1770-3634           BC030565.1         1754-3618
            3635-6890           AF460991.1         4029-7284
            6891-6892           AI282394.1         6-7                 c
FEATURES             Location/Qualifiers
     source          1..6892
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.31"
     gene            1..6892
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /note="SMC5-SMC6 complex localization factor 2"
                     /db_xref="GeneID:55719"
                     /db_xref="HGNC:HGNC:17814"
                     /db_xref="MIM:610348"
     exon            1..288
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..3670
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM178A; family with sequence similarity 178,
                     member A; smc5/6 localization factor 1; SMC5-SMC6 complex
                     localization factor protein 2"
                     /codon_start=1
                     /product="SMC5-SMC6 complex localization factor protein 2
                     isoform 1"
                     /protein_id="NP_060591.3"
                     /db_xref="CCDS:CCDS7500.1"
                     /db_xref="GeneID:55719"
                     /db_xref="HGNC:HGNC:17814"
                     /db_xref="MIM:610348"
                     /translation="MTRRCMPARPGFPSSPAPGSSPPRCHLRPGSTAHAAAGKRTESP
                     GDRKQSIIDFFKPASKQDRHMLDSPQKSNIKYGGSRLSITGTEQFERKLSSPKESKPK
                     RVPPEKSPIIEAFMKGVKEHHEDHGIHESRRPCLSLASKYLAKGTNIYVPSSYHLPKE
                     MKSLKKKHRSPERRKSLFIHENNEKNDRDRGKTNADSKKQTTVAEADIFNNSSRSLSS
                     RSSLSRHHPEESPLGAKFQLSLASYCRERELKRLRKEQMEQRINSENSFSEASSLSLK
                     SSIERKYKPRQEQRKQNDIIPGKNNLSNVENGHLSRKRSSSDSWEPTSAGSKQNKFPE
                     KRKRNSVDSDLKSTRESMIPKARESFLEKRPDGPHQKEKFIKHIALKTPGDVLRLEDI
                     SKEPSDETDGSSAGLAPSNSGNSGHHSTRNSDQIQVAGTKETKMQKPHLPLSQEKSAI
                     KKASNLQKNKTASSTTKEKETKLPLLSRVPSAGSSLVPLNAKNCALPVSKKDKERSSS
                     KECSGHSTESTKHKEHKAKTNKADSNVSSGKISGGPLRSEYGTPTKSPPAALEVVPCI
                     PSPAAPSDKAPSEGESSGNSNAGSSALKRKLRGDFDSDEESLGYNLDSDEEEETLKSL
                     EEIMALNFNQTPAATGKPPALSKGLRSQSSDYTGHVHPGTYTNTLERLVKEMEDTQRL
                     DELQKQLQEDIRQGRGIKSPIRIGEEDSTDDEDGLLEEHKEFLKKFSVTIDAIPDHHP
                     GEEIFNFLNSGKIFNQYTLDLRDSGFIGQSAVEKLILKSGKTDQIFLTTQGFLTSAYH
                     YVQCPVPVLKWLFRMMSVHTDCIVSVQILSTLMEITIRNDTFSDSPVWPWIPSLSDVA
                     AVFFNMGIDFRSLFPLENLQPDFNEDYLVSETQTTSRGKESEDSSYKPIFSTLPETNI
                     LNVVKFLGLCTSIHPEGYQDREIMLLILMLFKMSLEKQLKQIPLVDFQSLLINLMKNI
                     RDWNTKVPELCLGINELSSHPHNLLWLVQLVPNWTSRGRQLRQCLSLVIISKLLDEKH
                     EDVPNASNLQVSVLHRYLVQMKPSDLLKKMVLKKKAEQPDGIIDDSLHLELEKQAYYL
                     TYILLHLVGEVSCSHSFSSGQRKHFVLLCGALEKHVKCDIREDARLFYRTKVKDLVAR
                     IHGKWQEIIQNCRPTQGQLHDFWVPDS"
     exon            289..332
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            333..1063
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1121
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..2119
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2190
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2313
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2481
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2584
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2585..2660
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2802
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2905
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3082
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3180
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3268
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3400
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3401..3478
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3565
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3566..3634
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..6892
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6866..6871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /note="hexamer: ATTAAA"
     polyA_site      6892
                     /gene="SLF2"
                     /gene_synonym="ATELS1; C10orf6; FAM178A"
                     /note="major polyA site"
ORIGIN      
        1 acttccgaag agagaaccgc catgaagaga gaagggggtg ccgcccacct ctgctccgac
       61 agcctcccgg agtcccagca gcaagacggc aaccacgcac ccaacttctc cagccacggc
      121 tcatgccgcc gtcgccagcg gcgccgacat gacaaggcgc tgcatgcccg ctaggccagg
      181 tttcccctca tccccagccc cggggtcgtc gcccccgcgc tgccatctga gacccggtag
      241 taccgcccat gctgcagcgg gaaagagaac agagagtcct ggggacagga agcagtcaat
      301 tatagatttc ttcaaaccag cttcaaaaca agacagacac atgttggatt caccacaaaa
      361 atcaaacatc aaatatggag gaagtagatt gtctatcact gggacagagc agtttgaaag
      421 gaaactatcc tcaccaaaag aatctaaacc caaaagggtg ccaccagaaa agagccctat
      481 tatagaagct ttcatgaaag gtgttaaaga gcaccatgaa gatcatggta tacatgagtc
      541 acgtcggcct tgtctgtcac tagcctccaa atatttagcc aaaggaacaa atatctatgt
      601 tccttcttca tatcacttgc caaaggagat gaagtcacta aagaaaaaac atcgatcccc
      661 agagagaagg aagtcactat tcattcatga aaataatgag aagaatgata gagatcgagg
      721 caaaaccaat gcagactcca aaaagcagac cacagtggca gaagctgaca tcttcaataa
      781 cagctccaga agccttagca gcaggagcag cctgtccagg caccacccgg aagaaagccc
      841 actgggagct aaattccagt tgtcactagc ttcttactgc agagaacgag aactaaagag
      901 gttgagaaag gagcaaatgg agcagagaat caactccgag aattctttct cagaagcaag
      961 cagtctttcc ttaaaatcta gtatagaaag aaaatataaa ccaaggcagg aacaaaggaa
     1021 acagaatgac atcatacctg gaaaaaataa tctgtcaaat gtggaaaatg gacatctctc
     1081 aagaaaaaga tcctcttctg attcatggga acctacttca gcaggctcta agcagaataa
     1141 attccctgaa aaaagaaaaa ggaactctgt ggactcagat ctgaaaagca caagagaatc
     1201 tatgatacca aaagcaagag agtccttcct tgagaagcgt cctgatggac cacatcagaa
     1261 agaaaaattt ataaaacata ttgcactgaa gacacctggt gatgtgttgc gcttagaaga
     1321 tatatccaag gaaccgagtg atgaaactga tggctcttct gcaggcttgg caccttcaaa
     1381 ttctggcaat tctggccacc attctaccag gaatagtgac caaatccaag tggcaggtac
     1441 caaggagact aagatgcaga aaccccactt acctttatct caggaaaagt ctgcaattaa
     1501 aaaagctagc aaccttcaga aaaataaaac cgctagctcc acgacaaagg agaaggagac
     1561 aaaactacct ttactttccc gtgttccaag tgctggttcc tctctagtac cattaaatgc
     1621 taaaaattgt gctcttccag tttctaaaaa agataaagag cgttcctcat ctaaagaatg
     1681 ttctgggcat tctacagaat ccaccaaaca caaggaacac aaagcaaaga ctaataaggc
     1741 cgattctaat gtatcttcag ggaaaatttc tgggggacct ttgcgctcag aatatggcac
     1801 tcctacaaag tctccccctg ctgctttgga agttgtgcca tgtatcccaa gccctgcagc
     1861 accttcagat aaagcccctt cagaaggaga gagttcagga aattccaatg caggtagcag
     1921 tgcactgaaa agaaaactaa ggggtgattt tgatagtgat gaagaaagtt taggttacaa
     1981 cctagacagt gatgaggaag aggaaacatt aaagtcactg gaagaaataa tggctttgaa
     2041 cttcaatcag actcctgcag ctacaggaaa gcctcctgct ctttccaagg ggcttagatc
     2101 tcagtcatca gactatacag gacatgttca tcctggaact tacacaaata ccttagaacg
     2161 tctagtgaag gaaatggaag acacacaaag gctagatgaa ctgcagaagc aactacaaga
     2221 agacataagg caaggccgag gcattaaatc cccaatcaga attggagaag aagacagtac
     2281 agatgatgag gatggcctct tagaagagca caaggaattt ctaaagaaat tttcagttac
     2341 aattgatgct attcctgatc atcatccagg tgaagaaata tttaatttcc tcaattctgg
     2401 aaaaattttc aatcagtata ccttggattt aagagactct ggttttattg gacaaagtgc
     2461 tgtagaaaaa cttattctta aatcgggaaa aacagatcag atttttttga caacacaagg
     2521 tttccttacg tctgcttatc actatgtcca gtgtcctgtc cctgtgttaa agtggctgtt
     2581 tcggatgatg tcagttcata cagactgtat tgtgtcagtg cagattttaa gtacattgat
     2641 ggaaataaca attagaaatg ataccttcag tgactcacca gtttggccat ggatcccatc
     2701 attgtctgat gtagcagctg tgtttttcaa tatggggatt gattttagat ctttgtttcc
     2761 cctggagaat cttcagccag actttaatga agactatcta gtttctgaaa cacagacaac
     2821 atcaaggggg aaagaaagtg aagattcatc ttataagcca attttttcaa cacttcctga
     2881 aaccaacatt ttaaatgtgg ttaagtttct aggcttgtgt acatctatac atccagaagg
     2941 ttaccaggat cgtgaaataa tgttgctgat tttaatgtta tttaaaatga gtttggaaaa
     3001 acagctgaaa cagattcctt tagtagactt tcaaagcctc ctgataaacc tgatgaaaaa
     3061 catcagagat tggaacacaa aggtgcctga actctgtctg ggcataaatg aactctccag
     3121 tcatccccac aacctcctgt ggttggtaca gctggtccct aattggacat cacgtggaag
     3181 gcaactgaga cagtgcctca gtctagtgat tatttcaaag cttttggatg agaaacacga
     3241 agatgttcct aatgccagta atctgcaggt atcagtccta catcgctatc ttgtgcagat
     3301 gaagccttct gatttgttaa agaaaatggt cttgaagaaa aaggctgaac aaccagatgg
     3361 cattattgat gacagtcttc atttagaact tgaaaagcag gcatattacc tgacctacat
     3421 tcttcttcat ttagtcggtg aagttagttg ttctcattct ttttcttctg gacaacggaa
     3481 acactttgtg ctactctgtg gggctttgga aaagcatgtt aaatgtgata ttagggaaga
     3541 tgcaagactt ttttacagaa ctaaggtgaa agacttggtc gccaggatac atggaaaatg
     3601 gcaggaaata atccagaact gtcggcctac tcaggggcag cttcatgact tctgggtacc
     3661 agattcttaa taggagttgc agcagcaaaa atatgaacca agagaaattc aataagagcc
     3721 tttcatagag gagtagaaag gattattaca gaatccaatg aatgccaaga aaatgtacag
     3781 caaatgtgcc acttgaatat ctagtatgaa gctggtaatg aagaaattgc catttctgaa
     3841 gcagatatga aatatgatct gcttaattgt taaggcaact gacctttcaa aagtgcagag
     3901 tcttattaaa agaggggagg ggtagaagca gaataatagt catatgtcta acctgcccca
     3961 gttaactcct cttgttaaat tataagccag ttatcttttt tagatagtat ttttgtcact
     4021 tggataatca caggaaatat ataagaaaag agcttggact aacttgagaa gttggacatg
     4081 gaaagcaaga ccaagttcca gttgggttta attttccctc ttggttattt tcggacacaa
     4141 agggaatgct taaaactgag tttagtaata aaaagcataa atctcttctg taacttttat
     4201 aaaccacagg gaggtttcaa tccatgcatt ttccttcatt actcaagatt ataaatctgt
     4261 ttttaaaata catctaaaca aacagttgag aaacaaaagt ttggcatgtt gtcagatccc
     4321 cttaagagga agaggttaag ctgtaaagta gtggccctgt tttgatgcca gaacattcat
     4381 atgctgtttg ttctggattt cttttaaatg catgtatttt aaatactggt taaatcttag
     4441 aatcttggct atatcttaga attctggctc ttggtaacca tattacagaa gtctatattg
     4501 taaaagccta aagatctgga caagtttcca acaaccttgt ttccatgagt atataatttt
     4561 ggcagacacc tgaattcttt gggacactgt gtctgtgtat gtgtgtgtgt gtgtgtgtgt
     4621 gtgtgtgcgc ttgtatcttg aagttgttgc acttcaaaac cacagctgct gtaaattctt
     4681 aaacactgga gagccatcct ttggtttaaa tggtagaggg ttagtggaag tgcacacgtt
     4741 gtttttagcc caggggtagt aacaaactct tactagccaa ctagaaaatt attttgttga
     4801 cgagatgtcc cttttaggag ggtttgtttc ctgaaagaat gccaactttt tttgttgttc
     4861 tttcagtatt ggcttgagtg acctgttctc ctgagtgctc tagtgtctcc agttgtgggg
     4921 gggaaagatg atggagggga acagaaactg gacttgatgt ttgcggtttg agaggcaaga
     4981 aaataaaata actttctacc tctaaattga ggcttaggag taaaaagcat tttgtcctaa
     5041 atttatcatt taaaatagca tcagtaactt ttgagctcat gtcaatcaag cattggcagt
     5101 cagagatttt atagggaaga ctaagtaaat ccagtttcca agaacctaaa ctgattgagg
     5161 ctccaagagt cagaccaaca aaagttttat tctgtgttgt ttactggtaa gaatattatt
     5221 atcttgatac tacctctcaa gggtattgtt acaaaatgcc acttatggtt aaagagatag
     5281 atacaaagag ttctatttga cagaagcttg aaactctggc atctatctgc ccaacgatgg
     5341 gggctttcgt tctgtaattt aatcctttgt agatacatta tttgtgtgta attttatacg
     5401 tgttcatatt tttctcattt tgcattgtgt aaagtgtaca aaatctcaaa gtataaaata
     5461 ctgcttatat tgcttgtaat ttacagtgtg taaatatttt ctaattgtgt acattgatgg
     5521 gggggacaag tgggttattc aggttttttt ttaatgaccc ttttgtattg cagtttcaac
     5581 agataactgt ccatcaaatt taaaaccact ttgatacatt tttatttaac agttccaata
     5641 agaaaaaaat ctctattttt aattatattt ctcctttaga aaaaaaatac ttcatggtcc
     5701 ctctaaaata aatggccaga cctcagttta ggcccttgta tttatgactc tggtagaggt
     5761 cttcagactc caggtcatag tccagtcagt atttgcattt gggttctcat gaaaactttg
     5821 tgactctctt ttagcacaag tagcccatgg tttttcttcc aaatcaagta ttttacttct
     5881 cccttgagtc cccatgcttt gtctccctcc tgctgctatt gcccggtgaa tgggatggta
     5941 gagagggaga aatgttcatt gcacagagaa tgtcaggcca ctttggggac ttggcaaacg
     6001 aagcttgcac tgagtggtgg tgtgtttggc aatattactg tgccaaaaat caccttgtct
     6061 aattttatgg atatgtatgg caaacttatt acccttcttg caagctgcac attaaggtac
     6121 ttgtaagtgt ttatgctttt gtgtgtaact gtttgccttt tctaactgct tttcttgtta
     6181 ctgaaaatat aattctacta gttttatcac attaagaggc tctccatgca caaaatgcat
     6241 tgatgtagcc gtaaagtaac agcatttgta cattttctat ctcctgatgg cagtggtgcc
     6301 tttgtcacct tttggaaggt ttgcattttg tttctgcttt caagcgcaaa tagtagcttg
     6361 ctttcagctt cacaaaaatc tcctcaaatg taaaagatac aaaatggcgt gttatcatcc
     6421 aggcttagtt ggagtatttg catttttatt tttatcaaaa caaatataat tggtggggac
     6481 tggccagtaa taatgtgtgg cgtctttaag ccaagagtaa tttttaaatt aaaaatgaaa
     6541 attttaagag gtagcccatt aaacaagcta ctgagttgga gaattagggg atgactgtgg
     6601 tggtttgtcg ctaaggaggc aacagtaggg tccaggcggc ggggcacgta gagcagttag
     6661 catgatccat ggttattcct tactcatgaa cagtgtcggc gcacctcatt atctgtgcat
     6721 ttgtttttcc tgggcagtcc tgtcagccag ttaatccacc agctcttagg aagtaaatac
     6781 agattttttt ctttcctttt tttttttttt aaagatttta tactacatct tgttaaagtc
     6841 ctatgaatgt gtgtgtgtgt gtgctattaa aactgctttt tctcagtttg aa
//
