LOCUS       NM_030958               8991 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            5A1 (SLCO5A1), transcript variant 1, mRNA.
ACCESSION   NM_030958
VERSION     NM_030958.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8991)
  AUTHORS   Tang,L., Zhu,Q., Wang,Z., Shanahan,C.M., Bensen,J.T.,
            Fontham,E.T.H., Smith,G.J., Pop,E.A., Azabdaftari,G., Mohler,J.L.
            and Wu,Y.
  TITLE     Differential Associations of SLCO Transporters with Prostate Cancer
            Aggressiveness between African Americans and European Americans
  JOURNAL   Cancer Epidemiol Biomarkers Prev 30 (5), 990-999 (2021)
   PUBMED   33619025
  REMARK    GeneRIF: Differential Associations of SLCO Transporters with
            Prostate Cancer Aggressiveness between African Americans and
            European Americans.
REFERENCE   2  (bases 1 to 8991)
  AUTHORS   Brenner,S., Klameth,L., Riha,J., Scholm,M., Hamilton,G., Bajna,E.,
            Ausch,C., Reiner,A., Jager,W., Thalhammer,T. and Buxhofer-Ausch,V.
  TITLE     Specific expression of OATPs in primary small cell lung cancer
            (SCLC) cells as novel biomarkers for diagnosis and therapy
  JOURNAL   Cancer Lett 356 (2 Pt B), 517-524 (2015)
   PUBMED   25301452
  REMARK    GeneRIF: High OATP5A1 expression is associated with small cell lung
            cancer.
REFERENCE   3  (bases 1 to 8991)
  AUTHORS   Sebastian,K., Detro-Dassen,S., Rinis,N., Fahrenkamp,D.,
            Muller-Newen,G., Merk,H.F., Schmalzing,G., Zwadlo-Klarwasser,G. and
            Baron,J.M.
  TITLE     Characterization of SLCO5A1/OATP5A1, a solute carrier transport
            protein with non-classical function
  JOURNAL   PLoS One 8 (12), e83257 (2013)
   PUBMED   24376674
  REMARK    GeneRIF: SLCO5A1 is an organic anion transporting polypeptide which
            is involved in biological processes that require the reorganization
            of the cell shape, such as differentiation and migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8991)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   5  (bases 1 to 8991)
  AUTHORS   Kindla,J., Rau,T.T., Jung,R., Fasching,P.A., Strick,R., Stoehr,R.,
            Hartmann,A., Fromm,M.F. and Konig,J.
  TITLE     Expression and localization of the uptake transporters OATP2B1,
            OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
  JOURNAL   Cancer Biol Ther 11 (6), 584-591 (2011)
   PUBMED   21278488
  REMARK    GeneRIF: tissue-specific localization of OATP2B1, OATP3A1 and
            OATP5A1 has been analyzed in normal mammary tissue and
            corresponding breast cancer tissues.
REFERENCE   6  (bases 1 to 8991)
  AUTHORS   Isidor,B., Pichon,O., Redon,R., Day-Salvatore,D., Hamel,A.,
            Siwicka,K.A., Bitner-Glindzicz,M., Heymann,D., Kjellen,L.,
            Kraus,C., Leroy,J.G., Mortier,G.R., Rauch,A., Verloes,A., David,A.
            and Le Caignec,C.
  TITLE     Mesomelia-synostoses syndrome results from deletion of SULF1 and
            SLCO5A1 genes at 8q13
  JOURNAL   Am J Hum Genet 87 (1), 95-100 (2010)
   PUBMED   20602915
  REMARK    GeneRIF: Haploinsufficiency of SULF1 combined with
            haploinsufficiency of SLCO5A1 (or the altered expression of a
            neighboring gene through position effect) could be necessary in the
            pathogenesis of MSS.
REFERENCE   7  (bases 1 to 8991)
  AUTHORS   Fellay,J., Ge,D., Shianna,K.V., Colombo,S., Ledergerber,B.,
            Cirulli,E.T., Urban,T.J., Zhang,K., Gumbs,C.E., Smith,J.P.,
            Castagna,A., Cozzi-Lepri,A., De Luca,A., Easterbrook,P.,
            Gunthard,H.F., Mallal,S., Mussini,C., Dalmau,J.,
            Martinez-Picado,J., Miro,J.M., Obel,N., Wolinsky,S.M.,
            Martinson,J.J., Detels,R., Margolick,J.B., Jacobson,L.P.,
            Descombes,P., Antonarakis,S.E., Beckmann,J.S., O'Brien,S.J.,
            Letvin,N.L., McMichael,A.J., Haynes,B.F., Carrington,M., Feng,S.,
            Telenti,A. and Goldstein,D.B.
  CONSRTM   NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Common genetic variation and the control of HIV-1 in humans
  JOURNAL   PLoS Genet 5 (12), e1000791 (2009)
   PUBMED   20041166
REFERENCE   8  (bases 1 to 8991)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     The superfamily of organic anion transporting polypeptides
  JOURNAL   Biochim Biophys Acta 1609 (1), 1-18 (2003)
   PUBMED   12507753
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK096879.1, BC137424.1,
            AC091047.10 and CA449383.1.
            
            On Nov 22, 2018 this sequence version replaced NM_030958.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205075.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260126.9/ ENSP00000260126.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AK096879.1         87-205
            120-3462            BC137424.1         1-3343
            3463-3644           AC091047.10        73330-73511
            3645-3704           CA449383.1         17-76               c
            3705-8991           AC091047.10        73572-78858
FEATURES             Location/Qualifiers
     source          1..8991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.3"
     gene            1..8991
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="solute carrier organic anion transporter family
                     member 5A1"
                     /db_xref="GeneID:81796"
                     /db_xref="HGNC:HGNC:19046"
                     /db_xref="MIM:613543"
     exon            1..125
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            126..1528
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..3168
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 (organic anion transporter),
                     member 15; organic anion transporter polypeptide-related
                     protein 4; solute carrier family 21 member 15"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 5A1 isoform 1"
                     /protein_id="NP_112220.2"
                     /db_xref="CCDS:CCDS6205.1"
                     /db_xref="GeneID:81796"
                     /db_xref="HGNC:HGNC:19046"
                     /db_xref="MIM:613543"
                     /translation="MDEGTGLQPGAGEQLEAPATAEAVQERCEPETLRSKSLPVLSSA
                     SCRPSLSPTSGDANPAFGCVDSSGHQELKQGPNPLAPSPSAPSTSAGLGDCNHRVDLS
                     KTFSVSSALAMLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIERRY
                     SLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPHFI
                     SPPYQIQELNASAPNDGLCQGGNSTATLEPPACPKDSGGNNHWVYVALFICAQILIGM
                     GSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPV
                     HLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKKKFSVDAVSDD
                     DVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTA
                     FITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAM
                     ICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEY
                     EPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQSRQVITPPTVGQRSQLRVV
                     IVKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEER
                     PFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGSCWEYNVTSFRFVYFG
                     LAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRQREFPLSTVSERVGHPDNARTRSCPAF
                     STQGEFHEETGLQKGIQCAAQTYPGPFPEAISSSADPGLEESPAALEPPS"
     exon            1529..1661
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1879
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2044
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2243
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2403
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2645
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2710
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..8991
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="hexamer: AATAAA"
     polyA_site      3698
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="major polyA site"
     regulatory      8970..8975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="hexamer: AATAAA"
     polyA_site      8991
                     /gene="SLCO5A1"
                     /gene_synonym="OATP-J; OATP-RP4; OATP5A1; OATPJ; OATPRP4;
                     SLC21A15"
                     /note="major polyA site"
ORIGIN      
        1 attcactgat ttctcttcgg ctggacggag gctgcctcct cacgcggctc ccaactattc
       61 ccgtagctca gtgcccccct cccgccgctc tactcagcca ggcagacaga ctgacagact
      121 cgctagtcgg cagcttcact cccgagggtg ccgcgagccc aggcggcgaa cacccggtac
      181 ccctggcgca gcgaggtggg atgctgtacg gacagcagcg ctaagtgccc ccccaccccc
      241 ggcgcagggt gcactcgctc ctggccgcgg gcccagcggc ggcggcggcg gcggcggcgg
      301 aggggatgag cccgggacgc gcgaggcgcc tgcctcaagc taccgcccgg agagggacgc
      361 cgagtagggc tcatcgcagt accgcgcgga cccctgcccc ctgtggcacg cggctgcgga
      421 gccttgaagc cgtgtctgtg atcaggatgc actgggcgcc tcgcagctgg tgaggatgcc
      481 ctgctgcgcg gccctgcgcc cccagcccca gtcccaggtg ggcaagactg actgggcccg
      541 gcttcggccc ctcgtgccgg tggatgaaac gtgccggagt gcttgggtgc catcagctat
      601 caaatctgaa ttctaagcgc catggacgaa ggcactggac tgcagcccgg ggcgggagag
      661 cagctggagg cgccggccac tgcagaagct gtccaagaga ggtgcgagcc ggagaccctc
      721 aggtctaaga gtttaccggt cctcagcagc gcctcctgcc ggccaagcct cagtcccact
      781 agtggagacg ccaacccggc ctttggctgt gtggattctt cgggccacca ggagttgaag
      841 caaggcccga acccgttggc ccccagtccc tctgccccgt ccacttcggc ggggctcggg
      901 gactgtaacc acagggtgga cctcagcaaa accttctcgg tgtcctccgc cttggccatg
      961 ctccaggaga gaaggtgcct ctacgtggtc ctcacggatt cccgttgctt cctggtgtgc
     1021 atgtgctttc tgaccttcat ccaggcgtta atggtctctg ggtacctgag cagcgtaatt
     1081 accaccattg aaaggcgcta cagtctgaag agttccgagt cggggctgct ggtcagctgc
     1141 tttgacatcg ggaacctggt ggtggtggtg ttcgtcagct acttcggcgg ccggggtcgg
     1201 cggcccctgt ggctggccgt gggtggactc ctcatcgcct tcggggcagc cctcttcgcc
     1261 ttacctcact tcatctcgcc cccctaccag atccaagagt tgaacgcctc ggcccccaac
     1321 gacggcctgt gtcagggtgg caactccacc gccactttgg agcctccggc ctgtccgaag
     1381 gactcgggag gaaataatca ctgggtctac gtggctttat tcatttgcgc gcagattctc
     1441 attggaatgg gctccacacc tatttatacc ctgggaccaa cctacttaga tgacaatgtc
     1501 aagaaagaaa actcctcctt gtacctagcc atcatgtatg tcatgggagc acttggccct
     1561 gcagtgggat atttattagg tggacttctt attggttttt atgttgatcc cagaaatcct
     1621 gttcaccttg accagaatga ccctcgtttc attggaaact ggtggagtgg attcctcctt
     1681 tgtgccattg caatgtttct tgtgatattc ccaatgttta ctttcccaaa aaagcttcca
     1741 cctcgacaca agaaaaagaa aaagaaaaaa ttttctgttg atgctgttag tgatgacgat
     1801 gttctgaagg agaaatcaaa caacagtgaa caagcggaca aaaaagtttc ttcgatggga
     1861 tttggaaagg atgtcagaga cctaccaaga gcagctgtca ggatcttaag caacatgaca
     1921 ttcctttttg tgagtttgtc atacacagct gagagtgcca ttgtaactgc tttcattacc
     1981 ttcattccca agttcatcga gtcacagttt ggtatcccag cctccaatgc cagcatctac
     2041 actggggtta ttatcgtccc cagtgctggt gttggtattg tcctcggagg ctacattata
     2101 aaaaaattga aacttggtgc cagagaatct gcaaaactag caatgatctg cagtggtgtg
     2161 tctttactat gtttttcaac cctatttatt gttggatgtg aaagcattaa tctagggggc
     2221 ataaacatcc cttatacaac aggaccttct ctcaccatgc cccataggaa tctgacagga
     2281 agctgcaacg ttaattgtgg ttgtaaaata cacgagtatg agccagtctg tggatcagat
     2341 ggaattacat actttaaccc ttgtctggct ggctgtgtta atagtggtaa tcttagcact
     2401 gggatacgga attatacaga atgcacctgt gtccaaagtc gccaagtgat cactccaccc
     2461 accgtgggac agcgaagtca gctccgtgtg gttattgtca agacttatct caatgagaac
     2521 ggctatgctg tgtctgggaa atgtaaacgg acctgcaata ctcttatccc attcttagtt
     2581 tttcttttca tagtcacctt catcacagca tgtgcccaac catcagctat catagtaaca
     2641 ctcaggtccg tagaagatga ggagagacct tttgcactgg gaatgcagtt tgttttgttg
     2701 cgaacacttg catacattcc tactccaatc tactttggag cagtcattga caccacctgc
     2761 atgctctggc aacaggaatg tggtgtgcag ggttcttgct gggagtacaa cgtgacgtcg
     2821 tttcgttttg tgtattttgg tttggctgcc ggcctcaaat tcgttgggtt tatttttatt
     2881 tttctggcct ggtactccat aaaatacaag gaggatggac tgcagaggcg gaggcagaga
     2941 gaatttcccc tgagcaccgt gagtgagaga gtgggacacc ccgacaatgc ccggactaga
     3001 tcttgcccag ctttcagcac ccagggagaa ttccacgaag agactggcct gcaaaaaggg
     3061 atccagtgcg cagcacagac ctacccgggg cccttcccag aagcaataag ttcctctgcg
     3121 gacccggggc tggaagagag ccccgctgcc ttggagccgc cctcctgaag cttgaaaatg
     3181 gaagaattta gttttgttgg ttgaattgaa aatggcgact tgagaaacaa ctgtgccttc
     3241 ttttctttct ttcttttttt taacctctac agacacaatc ctcaaaccaa caaaactcag
     3301 tatacacagc cgctattcat tgagggctgg atacctcaac aagactgaga gcctttcccc
     3361 gcttctctcc aagaaggaga cgttcagcta gatttgttcc catttccgtt gtgttaattc
     3421 aaagctcatg ctcccctacg gtacaggctg aggtacacgg ttagcaaaac catgggaagg
     3481 ggaatggcgg tgcatatcat taactaacac tccaaacaaa ggtgagcttg cccaggactt
     3541 ggcatttcca aatcaaagtt tttagatatg aacacctact gtgagttctg ctacaaagca
     3601 caaatgaatt tgtctcaact atgcaatttg attggaaaaa tgtatgtgca gcatgttaca
     3661 tttactttca cggaataaag cagatatgtt tctgaaaaga ggaagctgaa ctttccatcc
     3721 agtactgttg atagcatttt aagccatagc agttataaat caggtagagt ttttcaaatg
     3781 cttcagagga accataggca tagtgtgata gaaggaacag ctacttcagg tcgtaggaca
     3841 cattctcttt cagtctgcct gccccatcct aagataaaga ggctgctgaa tcataaatct
     3901 gatagcttaa atataaactc cagtattctt ttgtaaggag cattaaaact agtgtgctaa
     3961 acaatatggc tagaaactgt aatttgaaat gcataatagg gaaagaaaat gacagctttc
     4021 tcatccaaga aaattgttgc agaaattttc tttagctcta cgggcccaca aagtcactgg
     4081 gaaaagtccc acctgagtat tttagttaca tcttgaaagc actggcaaat ctgtgtggtt
     4141 ttcttttttt ctggacagaa aattgctgtg gttgctcctg aaaatgcata cttatatcag
     4201 gaaatctgtg cctgggatat gaaaatcact tagaatacag gaggagggag atctgtgttc
     4261 tggaacagaa tatgatctta agtaattgtt gaaaattatg taaaataaac cagtccatcc
     4321 gaaagaaccc tactttatca gagatagaat cgttttacac taccctttga ttccccctta
     4381 ctgtaagttt ctggcagtga ttctgagaga ggatttttct gttcctaaat gcactttggg
     4441 ttcattaccc atcattcttt tcagtacctc ccagcacatc actttgaagt aagcatcata
     4501 gagaatgctt tctacatggc tcttaagata gatgcttcct gacggcgcta acggattgac
     4561 agcaagttag ctcaggggtt ctggctgcca gggagtgtaa gggccaaatg ctgatataat
     4621 tgtgaacttt ttctgccaag gagcctatgg tcatggaggg ctaattaggg aaatgttttt
     4681 ctcttctggt ttacccttat ccccagaaga gatgtgattg acagactgtt ccatgattca
     4741 ggcttctgct ctccaacctt gcttgactgc acaggtggaa ttgtgcaaat actcctgggt
     4801 ataaggctgt ttccctctct tcctaggaat gacattggtc aaacagttct cttggttgca
     4861 tacagtttgt gttaacactg ttagactgaa caatgtctac aaggggtgga gctagtggtc
     4921 tcaggggcta aggacttccc tctggttcct gggcttggct ctcggggagg tgaggattct
     4981 tgcttggtta agactgtaat tgcactggta attgtcagac tctggccaat gtggcatata
     5041 ttggaagtat tcaaaaaatc ttgctgatta agaaaacctt gctgattgaa ctagtgtctc
     5101 ctttggggcc tcagggttcc cctttaccct ctatgggaga gctctgatcc tttaaaggag
     5161 aaattttcct ttggtgtggg agttaaagat atgtagattg gagaggtgtg gtgttttctt
     5221 aattttcttc tgatcattaa gatactgcat tgagagaatt ttggtgggat tggcactttt
     5281 tctggtagct aagattgctg gactcagcac ggagtagtta gagagccccc ttactccctt
     5341 tgctgccatg aacagtcatc cagtttggcg atcactgatc aggtgccagg tatcttcagg
     5401 tgtcatatta cctgattacc atctgccact ccataaaatc ctttgggatg attgggccag
     5461 aactcaaaga aatgggcctg aaatgtgcac cacagtgtta atattgtact tcctcaagta
     5521 tctgctcctt ataaatagca ggtatttcat taatgtgttg ttggtgaatg tagactaagt
     5581 agtaaaaatc atgagaaaat aaagctttgg aatatgtacc aattaagagt ggttcacaaa
     5641 atacttgggg ctatggtagc atcactggaa tattacatag ccaactgaag tgactgtttt
     5701 gtagatgata ccatttaatt gtatatatag ggtcttatat gtttcttaat aaattgatcc
     5761 cattacttta tagtcacagc tcctattaga agttttaatg aagactctcc atgagcttag
     5821 gcttcaaatt acttgttttg gaaaaggtca tcttgtcctt tataaactgt aaattcatat
     5881 attatttagc tttaatatgc aaatacaata tccttgagtt catcctatta atttagaaac
     5941 tcccaggagg taagatgggt ggttggagcg cattctttgg ttattttcat tagcattaag
     6001 tccttattct ttataggtgg atttaattct tgaaaatatt caaaagtaat tcagagtcaa
     6061 ggtgttgggg atggagagaa aggaggaaca gagaggaaaa aaattagcat ttgttgagtg
     6121 ttgacgattt gtagagcatt ttgacaagca cttaatatac atcatcattc attttgatcc
     6181 tcttaattac cttgcaaaga tttgattctt tttttttttt tgagacagag tcttgctctg
     6241 tcacccaggc tggagtgcag tggcttaatc tcagctcact gcaacctccg cttcctgggt
     6301 tcaagtgatt ctcctgtttc agtctcctga ggaactggga ttaaggtgtg tgccaccaca
     6361 cccagctatt ttttttctat ttttagtaga gagagggttt caccatgttg gccaggctgg
     6421 tcttgaactc ctgacctcaa gtgatccacc tgccttggcc tctcaaagtg ctgggattac
     6481 aggcatgagc caccatgccc ggctgatttt attatttttt taaaaaacat atgaaaccaa
     6541 gactcagaga agtaaaataa ctcatttagg atcatacaga atggtaaagt caggattcag
     6601 acatagattt ctctcactcc attattcatt ttttacacta cgcaatgtat acaatagctt
     6661 ttggttaaca aaggcaaggt gactataaaa tcgtgagatt aaagcatttc aattttttga
     6721 tatattaccg tttatgaaga gtagagaggt ttttttgtgt aaataaaaaa aactgtagga
     6781 aacatctgta ggaaatatca agatttaatg tttaactaga ttttcaaggt aaatttacat
     6841 ttatttagct aagtgttata ttaaagttat ttgtcataac atacctcaaa tatttattta
     6901 tagttcatat ttaatacaga acaaatctag tcttcgtgtt aacatcgggt ctcggcagag
     6961 tttctgaaat gaaacattat gaagaaaggt agttcagatt tgttgaatct gagctttagg
     7021 gatttcaagt gtattttttt ttattttcct ctttcagaat attaacatct ctattagttt
     7081 tttgatgaat atgagtttta agattcctaa taagggtttt aagtgaacac acataaaata
     7141 catatcaaac cactgatccc gattgttccc tttagtcgct gtgacattgt tacctttagt
     7201 ggcatgcact tggaaatgtc agccttcaga gaagggggag ttacatggag taaggcctca
     7261 tggatgtcat ggtggtcctc catgttcacc aaccaccaag aaaattcttc ttcagtccac
     7321 aattccagct tgcgctcttt ggtgcacttg gagccagaaa gtgtcttttt ggccctgttt
     7381 tgtagaaacc gtgcatgtac caaagagaaa ctttagagtt tggatggagc tgaagcattg
     7441 atgggaattc cctagtgcac ccaggagcag gaggcaagcc caagcctcgg gtggtagcca
     7501 attatatttt gtgatcgtgt atgtacttaa aacatcagag atgacacagc acatgaatat
     7561 aactattgat atgtaggtgc atactgagta ttctaagtag cagatagata ccaaaatact
     7621 gtataatccc agaattgcct aaactgcagg tttgctagtt ctctgttata cagaccagta
     7681 ggtagccttt ccacacattt gtgttttctc ttccataata agagagtgct gcggctggca
     7741 ggcaaaggta gttgcctcat gcactttatc tttttgtctt tttctcttct tcatcttttg
     7801 ggatgctgct ggctgtatct gtcccaaact tcttgttgca ttagaatcag atctgtgtat
     7861 gtttgaggag gttttatttt aaagacttca gttttactca gctctaggaa gggtcaaata
     7921 caacaacaac aacaaaaaac agaaaacaaa aaaccctccc taggtgtttg cttttgcaac
     7981 attaaaaaaa atgccttggt gctaaaaagt atttaatgac gcatgttcac cactaaaaag
     8041 cgccactgaa ttcacagtat ttcactgcta agtggctgca tgtactttgt gtttggaaat
     8101 ctgaagaatt ttccagaaaa caagcatcca ttactctcat ttcaacagtt actccatcta
     8161 tgctgcaaaa atgaagcgtg aaagggggga tacttttcta tggaatactc agtgcttttg
     8221 atatttattt tagcaagaat aatcagatgc caaaaataat ttcagagaaa ggtagaaaaa
     8281 atatttcagg taaccttttc ttatttcttc tccaaaaaga ttacacccat gtaaggtatt
     8341 tttaacactg gggttttgaa ggtgttatct tttctggtat cctatcacta catgttaaaa
     8401 ttgaaggaga aaatattatt gaaactaaag taattgcagg gacacattaa accaaagggg
     8461 tgaacaaaag aggtttaaag tttgtatcta gaaatgaaaa ataagaatca ttggtaagac
     8521 tagtaccgat tattggcaat tggtaattga taattggtaa gagtagtacc aaataatggg
     8581 catttttctt aaaatacata cctctacccc aaaccccaaa tgttaattta gaatcctgaa
     8641 acaggcaagt caggctctga ctcttttgtt taaggaaatg taatactgtg tcaactaaac
     8701 tggcattagg ttcttagtgg agtgtgtgtt tgtgtgtgtg tgtgtgtgtt ttgtgtagag
     8761 gtatgtttgt gatgaaaggt tttgcactgt tgcataaaga agtttgattt tgtgattttt
     8821 aaaatgatat tcatttggag actttttaag gtaatttaaa agatgtataa tttccgtgtg
     8881 tttaatgaaa tctgttgtcg atgtactaat cttggtttac agcatcttga atacttgatt
     8941 attgaaaatt aagaaaaaag ttaaaaatga ataaagtgtg ttggactgaa a
//
