LOCUS       NM_180991               5069 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            4C1 (SLCO4C1), mRNA.
ACCESSION   NM_180991 NM_018515
VERSION     NM_180991.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5069)
  AUTHORS   Sato,T., Maekawa,M., Mano,N., Abe,T. and Yamaguchi,H.
  TITLE     Role of OATP4C1 in Renal Handling of Remdesivir and its Nucleoside
            Analog GS-441524: The First Approved Drug for Patients with
            COVID-19
  JOURNAL   J Pharm Pharm Sci 24, 227-236 (2021)
   PUBMED   34048668
  REMARK    GeneRIF: Role of OATP4C1 in Renal Handling of Remdesivir and its
            Nucleoside Analog GS-441524: The First Approved Drug for Patients
            with COVID-19.
REFERENCE   2  (bases 1 to 5069)
  AUTHORS   Hu,X., Han,T., Bian,Y., Tong,H., Wen,X., Li,Y. and Wan,X.
  TITLE     Knockdown of SLCO4C1 inhibits cell proliferation and metastasis in
            endometrial cancer through inactivating the PI3K/Akt signaling
            pathway
  JOURNAL   Oncol Rep 43 (3), 919-929 (2020)
   PUBMED   32020231
  REMARK    GeneRIF: Knockdown of SLCO4C1 inhibits cell proliferation and
            metastasis in endometrial cancer through inactivating the PI3K/Akt
            signaling pathway.
REFERENCE   3  (bases 1 to 5069)
  AUTHORS   Li,X., Zhang,W., Song,J., Zhang,X., Ran,L. and He,Y.
  TITLE     SLCO4C1 promoter methylation is a potential biomarker for prognosis
            associated with biochemical recurrence-free survival after radical
            prostatectomy
  JOURNAL   Clin Epigenetics 11 (1), 99 (2019)
   PUBMED   31288850
  REMARK    GeneRIF: SLCO4C1 promoter methylation, including that at three CpG
            sites, namely, cg06480736, cg19774478 and cg22149516, is a
            potential biomarker for risk stratification and might offer
            significantly relevant prognostic information for prostate cancer
            patients after radical prostatectomy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5069)
  AUTHORS   Morrison,A.C., Srinivas,S.K., Elovitz,M.A. and Puschett,J.B.
  TITLE     Genetic variation in solute carrier genes is associated with
            preeclampsia
  JOURNAL   Am J Obstet Gynecol 203 (5), 491 (2010)
   PUBMED   20691413
  REMARK    GeneRIF: single-nucleotide polymorphisms and haplotypes in SLCO4C1
            in blacks are significantly associated with preeclampsia.
REFERENCE   5  (bases 1 to 5069)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 5069)
  AUTHORS   Tripodi,G., Citterio,L., Kouznetsova,T., Lanzani,C., Florio,M.,
            Modica,R., Messaggio,E., Hamlyn,J.M., Zagato,L., Bianchi,G.,
            Staessen,J.A. and Manunta,P.
  TITLE     Steroid biosynthesis and renal excretion in human essential
            hypertension: association with blood pressure and endogenous
            ouabain
  JOURNAL   Am J Hypertens 22 (4), 357-363 (2009)
   PUBMED   19197249
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5069)
  AUTHORS   Leuthold,S., Hagenbuch,B., Mohebbi,N., Wagner,C.A., Meier,P.J. and
            Stieger,B.
  TITLE     Mechanisms of pH-gradient driven transport mediated by organic
            anion polypeptide transporters
  JOURNAL   Am J Physiol Cell Physiol 296 (3), C570-C582 (2009)
   PUBMED   19129463
REFERENCE   8  (bases 1 to 5069)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 5069)
  AUTHORS   Mikkaichi,T., Suzuki,T., Onogawa,T., Tanemoto,M., Mizutamari,H.,
            Okada,M., Chaki,T., Masuda,S., Tokui,T., Eto,N., Abe,M., Satoh,F.,
            Unno,M., Hishinuma,T., Inui,K., Ito,S., Goto,J. and Abe,T.
  TITLE     Isolation and characterization of a digoxin transporter and its rat
            homologue expressed in the kidney
  JOURNAL   Proc Natl Acad Sci U S A 101 (10), 3569-3574 (2004)
   PUBMED   14993604
  REMARK    GeneRIF: isolation, cloning, and activity in the transport pathway
            of digoxin in the kidney
REFERENCE   10 (bases 1 to 5069)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Organic anion transporting polypeptides of the OATP/ SLC21 family:
            phylogenetic classification as OATP/ SLCO superfamily, new
            nomenclature and molecular/functional properties
  JOURNAL   Pflugers Arch 447 (5), 653-665 (2004)
   PUBMED   14579113
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY273896.2, AK128854.1, BX647577.1 and BX647349.1.
            
            On Nov 22, 2018 this sequence version replaced NM_180991.4.
            
            Summary: SLCO4C1 belongs to the organic anion transporter (OATP)
            family. OATPs are involved in the membrane transport of bile acids,
            conjugated steroids, thyroid hormone, eicosanoids, peptides, and
            numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed
            14993604]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647349.1, AK128854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159080 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310954.7/ ENSP00000309741.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1897              AY273896.2         266-2162
            1898-2473           AK128854.1         1891-2466
            2474-3033           AY273896.2         2739-3298
            3034-3448           BX647577.1         1120-1534
            3449-3558           AK128854.1         3444-3553
            3559-3742           BX647577.1         1645-1828
            3743-4069           AK128854.1         3738-4064
            4070-5000           BX647577.1         2156-3086
            5001-5069           BX647349.1         5155-5223
FEATURES             Location/Qualifiers
     source          1..5069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q21.1"
     gene            1..5069
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /note="solute carrier organic anion transporter family
                     member 4C1"
                     /db_xref="GeneID:353189"
                     /db_xref="HGNC:HGNC:23612"
                     /db_xref="MIM:609013"
     exon            1..377
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..2197
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /note="organic anion transporter M1; solute carrier family
                     21 member 20; organic anion transporting polypeptide 4C1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 4C1"
                     /protein_id="NP_851322.3"
                     /db_xref="CCDS:CCDS34205.1"
                     /db_xref="GeneID:353189"
                     /db_xref="HGNC:HGNC:23612"
                     /db_xref="MIM:609013"
                     /translation="MKSAKGIENLAFVPSSPDILRRLSASPSQIEVSALSSDPQRENS
                     QPQELQKPQEPQKSPEPSLPSAPPNVSEEKLRSLSLSEFEEGSYGWRNFHPQCLQRCN
                     TPGGFLLHYCLLAVTQGIVVNGLVNISISTVEKRYEMKSSLTGLISSSYDISFCLLSL
                     FVSFFGERGHKPRWLAFAAFMIGLGALVFSLPQFFSGEYKLGSLFEDTCVTTRNSTSC
                     TSSTSSLSNYLYVFILGQLLLGAGGTPLYTLGTAFLDDSVPTHKSSLYIGTGYAMSIL
                     GPAIGYVLGGQLLTIYIDVAMGESTDVTEDDPRWLGAWWIGFLLSWIFAWSLIIPFSC
                     FPKHLPGTAEIQAGKTSQAHQSNSNADVKFGKSIKDFPAALKNLMKNAVFMCLVLSTS
                     SEALITTGFATFLPKFIENQFGLTSSFAATLGGAVLIPGAALGQILGGFLVSKFRMTC
                     KNTMKFALFTSGVALTLSFVFMYAKCENEPFAGVSESYNGTGELGNLIAPCNANCNCS
                     RSYYYPVCGDGVQYFSPCFAGCSNPVAHRKPKVYYNCSCIERKTEITSTAETFGFEAK
                     AGKCETHCAKLPIFLCIFFIVIIFTFMAGTPITVSILRCVNHRQRSLALGIQFMVLRL
                     LGTIPGPIIFGFTIDSTCILWDINDCGIKGACWIYDNIKMAHMLVAISVTCKVITMFF
                     NGFAIFLYKPPPSATDVSFHKENAVVTNVLAEQDLNKIVKEG"
     exon            378..641
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            642..824
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            825..921
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1043
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1150
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1295
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1491
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1642
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1833
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1898
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2036
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     exon            2037..5069
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5045..5050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /note="hexamer: ATTAAA"
     polyA_site      5069
                     /gene="SLCO4C1"
                     /gene_synonym="OATP-H; OATP-M1; OATP4C1; OATPX; PRO2176;
                     SLC21A20"
                     /note="major polyA site"
ORIGIN      
        1 agtcgggaga acccatccag acatgaagag cgccaaaggt attgagaact tggcttttgt
       61 cccctccagc ccagacatcc tgcgccgctt gtctgcgtcg ccctcccaaa tcgaagtctc
      121 tgccttgtcc tctgaccccc aaagagagaa ttctcagcca caggagcttc agaagcccca
      181 ggagccccag aagtcaccag agccatctct gccttcagcc cctcccaatg tctccgaaga
      241 gaagctccgg tcactgtcgc tgtccgagtt tgaggagggg tcttacggct ggaggaactt
      301 ccatcctcaa tgtctccagc gctgcaacac acctggaggc tttctgcttc actactgcct
      361 cttggccgtc acgcaaggta ttgtagttaa tggcctagta aatattagca tttccactgt
      421 tgagaagcgt tatgaaatga agagttccct gactggcctg atttcatcaa gctacgatat
      481 ttcattctgt ttgttgtctt tatttgtatc attctttggt gaaagaggac ataagccgag
      541 atggcttgca tttgcagcct ttatgattgg actgggagca cttgtattct cattgccaca
      601 atttttcagt ggagaatata aattggggtc tctttttgaa gacacttgtg taacaacaag
      661 gaatagcacc agttgtacat cttcaacttc ttcactttct aactacttgt atgtcttcat
      721 cttgggacaa ctattgctgg gggcaggagg aactcctctt tatactctgg gaacagcctt
      781 tcttgatgat tctgtgccca cacacaagtc ttctctctat ataggaaccg gttatgctat
      841 gtcaatctta ggccctgcta ttggctatgt attgggagga caactgctaa ccatatacat
      901 tgatgttgct atgggagaaa gcactgatgt cactgaggat gatccgcgat ggttgggagc
      961 ttggtggatt gggtttcttc tatcatggat ctttgcttgg tctttaataa tacctttttc
     1021 ttgctttcca aaacatttac caggtacagc agaaattcaa gctggaaaaa cttcccaggc
     1081 tcatcagagt aatagtaatg cagatgtgaa atttggaaaa agtattaaag attttccagc
     1141 tgctctaaag aatttgatga agaatgctgt ctttatgtgt ttagttctat caacttcttc
     1201 agaagcctta attactactg gatttgctac atttttacct aaatttatag aaaatcaatt
     1261 cggattgaca tccagcttcg cagctactct tggaggggct gttttaattc ctggagctgc
     1321 tctcggtcaa attttaggtg gcttccttgt ttcaaaattc agaatgacat gtaaaaacac
     1381 aatgaagttt gcactgttca catctggagt tgcacttacg ctgagttttg tatttatgta
     1441 tgccaaatgt gaaaatgagc catttgctgg tgtatctgaa tcatataatg ggactggaga
     1501 attgggaaac ttgatagccc cttgtaatgc caattgtaac tgttcgcgat catattatta
     1561 tcctgtctgt ggagatggag tccaatattt ttctccctgc tttgcaggct gttcaaaccc
     1621 agttgcacac aggaagccaa aggtatatta caactgttcc tgtattgaaa ggaaaacaga
     1681 aataacatcc actgcagaaa cttttggttt tgaagctaaa gctggaaaat gtgaaactca
     1741 ttgtgcgaaa ctgcccatat tcctttgcat tttctttatt gtaattattt ttacctttat
     1801 ggccggtact cctataactg tgtctatcct aaggtgtgtt aatcacagac aacggtccct
     1861 agccttggga atacaattta tggtccttcg attattaggg acaattcctg gaccaattat
     1921 atttggtttc acaatagaca gcacatgtat tctttgggat ataaatgatt gtggaattaa
     1981 aggagcttgc tggatttatg ataacatcaa gatggcccat atgctagtag ccataagtgt
     2041 tacttgtaaa gttatcacca tgttcttcaa tggatttgca atctttttgt ataaaccacc
     2101 tccatcagcc acagatgtgt catttcataa agagaatgca gttgtgacta atgttttagc
     2161 agaacaggat ctcaacaaaa tagtaaaaga agggtgaaat gggaaaagag aagactgttt
     2221 tacacctgga aaatttacct cgatttttaa gaacacacat tgccatggca ggattatcta
     2281 tccaatatgg acaatcatat ttacaaaatt gatgttttta taatcaaatg tattttttta
     2341 cttatgtagt ttttgtttta tgcaagaaac agacctgtgc cttcaaagcc cacgtaaagc
     2401 ctcaaaacac agcacacaca cacacgagca cacacacaca cacacacacg aacacacaca
     2461 cacacacaca cacgcacaca tacacactta tttcctattc ccattgtcta ggtatgaaat
     2521 cctcaagcaa taacaagaaa aaaggcccac aattagaaaa atttacattt aaaaaaaatg
     2581 ttgtttctat ccccattaca acttgtttaa ttttaatttt cattgtcaat attttgagct
     2641 tagaacattt atggtataaa aatttaaact aatcaaagtt gtgtgatgat ttccgggaat
     2701 tattattgaa agcctatgaa tttaaaacca ggtttaccat gtaatttgtt tttaaattta
     2761 tgtatactag cctggccttt ctccaagcaa attattgaac tattagaata tgttagttat
     2821 catccttgtg tcttagtata tagtgaatac agaaacatca gcattgtata cacatatttt
     2881 cactttaact caagaattcc aggaggtaat ttgttgatat tacaattttt aacacattta
     2941 tgattctgtg ataatattat tcaattgcat atatttcaga ggaaagtacc agtcagtaaa
     3001 gaaaaatgcc aactaaacat gaaactattg atcaatactt atataccttt aatttttcct
     3061 atttgaaaag ccaaccactt aacacattac tcatagcacc taagacagtg ccttgcatag
     3121 tgtagtcatc tattattatt gtttaattag aatattaaac cctacccttt aactcagcag
     3181 tccccaacct tttttgcatc agggaccatt tttgtggaag acaatttttc catgggggaa
     3241 gaaggtatgg ttttgagatg aaactgctcc acctcagacc atcaggcatt agttagattc
     3301 tcataaggag agtgcaacct agatcccttg catgtgcagt tcccaatgga gtgtgcactc
     3361 ctatgagaat ctaatgccac tactgatcta acaagaggtg gagctcaggc agtaatgctc
     3421 actcacctgc ctctcagctc accaactgtg tggcccgatt cctaacaggc cacacacagc
     3481 ccagggctgg ggacccctgc tttaactgat gcattgattt gataaagtat tttacaagcc
     3541 tgataatgtt ataaccctgt ttattcaggt cagatttatg ccaactttgc tgagaatatg
     3601 gagggtatag atgagtgaac atcaacaaac ataacttcta ccatggttaa gaattttact
     3661 taggaaaagt attgaagttc aaatccagat agtattacat ttgaaattgt tataagggtt
     3721 attaatttaa taaaattcat catcaggttt cccctataag ctttctccta ggttaatttt
     3781 ccacaagcat tgttttatat acactgtaat caggataaca caagcttagt gttagatctt
     3841 gtaggaaacc aagattagaa acattagaaa tttgcagaat ttaagaaatt atgttttgtg
     3901 gtaatctatg gccaacgatg ttagaaccta gcgcaattgt aaagtgaaat tcaaggagaa
     3961 ggaatgagga gttagggaag cagcatactt gaatattaga gaaggagagg agctgtgggt
     4021 caggaatcag agagacctgc taaaaccaga cagatataaa caccaaagac ggaagccaaa
     4081 taggtagcca aaaatccaga tatttgagaa gcaggaaatt tatagcaacc aaagaaatag
     4141 ggcaagagag gcaggtgaac acacatgata cctcaattga caatcttcct cccaccaagc
     4201 cagacacgtt gtaaatgctg cttcctattg gagcccagaa aaaaggaaaa ggaaagttta
     4261 ggctttcttt gtcctttgtg tggaagcagg gaattggatt gaagactttc atagttgtaa
     4321 cataaaggca aatcctgagg aactcactga tggagatgtg aaatggcagt aaggaagaaa
     4381 acagaataac tgaacaaata tattagtcta gggccactta atttagagga agaaaaaaaa
     4441 tcaacccatc catagaaata gtttgataaa caggtcacta aatcattggc gtttataaag
     4501 attcttagct atcaagggct gcattgtatt ttatatactc agttttataa ggtgatactt
     4561 tttaaataag cgctttaatg aaaatggtta gactgaaaat aattttggtc cttaaaagga
     4621 gtcaggagct tttatatata aggtacatat tttaaaagaa tacctccttt ataacagggt
     4681 tttacagaca ctaccataat ttataatcat tattttttac ttttgggttc acctagatca
     4741 tatgagttga tgtgatactt ctagaacaaa attattcata gtgcgttttt tgtaatttat
     4801 gattgttaag taagcttgac ttataaattg acattgtaat tgtgtacata attggatata
     4861 tgtgttaaaa tttaacattt agatttactt aattgtagaa aatacaaatg taaaacttac
     4921 acatggaaag aactgtatgc agttgacttt actatgtaaa ttggagggaa acaaagtttt
     4981 agatccattt tctttcaaaa ttttctttat tgtaaagtat gcaaaatata tattcatacc
     5041 atttattaaa tcagaatgtt tatacaaaa
//
