LOCUS       NM_016354               2716 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            4A1 (SLCO4A1), mRNA.
ACCESSION   NM_016354
VERSION     NM_016354.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2716)
  AUTHORS   Li,S., Li,Z., Huang,L., Geng,Z., Li,F., Wu,B., Sheng,Y., Xu,Y.,
            Li,B., Xu,Y., Gu,Z. and Qi,Y.
  TITLE     SLCO4A1, as a novel prognostic biomarker of non-small cell lung
            cancer, promotes cell proliferation and migration
  JOURNAL   Int J Oncol 64 (3) (2024)
   PUBMED   38275113
  REMARK    GeneRIF: SLCO4A1, as a novel prognostic biomarker of non-small cell
            lung cancer, promotes cell proliferation and migration.
REFERENCE   2  (bases 1 to 2716)
  AUTHORS   Ontsouka,E., Epstein,A., Kallol,S., Zaugg,J., Baumann,M.,
            Schneider,H. and Albrecht,C.
  TITLE     Placental Expression of Bile Acid Transporters in Intrahepatic
            Cholestasis of Pregnancy
  JOURNAL   Int J Mol Sci 22 (19), 10434 (2021)
   PUBMED   34638773
  REMARK    GeneRIF: Placental Expression of Bile Acid Transporters in
            Intrahepatic Cholestasis of Pregnancy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2716)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2716)
  AUTHORS   Buxhofer-Ausch,V., Sheikh,M., Ausch,C., Zotter,S., Bauer,H.,
            Mollik,M., Reiner,A., Gleiss,A., Jager,W., Sebesta,C., Kriwanek,S.
            and Thalhammer,T.
  TITLE     Abundance of the Organic Anion-transporting Polypeptide OATP4A1 in
            Early-Stage Colorectal Cancer Patients: Association With Disease
            Relapse
  JOURNAL   Appl Immunohistochem Mol Morphol 27 (3), 185-194 (2019)
   PUBMED   29734253
  REMARK    GeneRIF: Abundance of the Organic Anion-transporting Polypeptide
            OATP4A1 in Early-Stage Colorectal Cancer Patients: Association With
            Disease Relapse.
REFERENCE   5  (bases 1 to 2716)
  AUTHORS   Ban,M.J., Ji,S.H., Lee,C.K., Bae,S.B., Kim,H.J., Ahn,T.S.,
            Lee,M.S., Baek,M.J. and Jeong,D.
  TITLE     Solute carrier organic anion transporter family member 4A1
            (SLCO4A1) as a prognosis marker of colorectal cancer
  JOURNAL   J Cancer Res Clin Oncol 143 (8), 1437-1447 (2017)
   PUBMED   28378090
  REMARK    GeneRIF: SLCO4A1 may be a valuable marker of poor prognostic for
            colorectal cancer (CRC). Furthermore, SLCO4A1 plays an important
            role in CRC cell proliferation, migration, invasion, and
            carcinogenesis
REFERENCE   6  (bases 1 to 2716)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Organic anion transporting polypeptides of the OATP/ SLC21 family:
            phylogenetic classification as OATP/ SLCO superfamily, new
            nomenclature and molecular/functional properties
  JOURNAL   Pflugers Arch 447 (5), 653-665 (2004)
   PUBMED   14579113
  REMARK    Review article
REFERENCE   7  (bases 1 to 2716)
  AUTHORS   Pizzagalli,F., Varga,Z., Huber,R.D., Folkers,G., Meier,P.J. and
            St-Pierre,M.V.
  TITLE     Identification of steroid sulfate transport processes in the human
            mammary gland
  JOURNAL   J Clin Endocrinol Metab 88 (8), 3902-3912 (2003)
   PUBMED   12915686
REFERENCE   8  (bases 1 to 2716)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 2716)
  AUTHORS   Fujiwara,K., Adachi,H., Nishio,T., Unno,M., Tokui,T., Okabe,M.,
            Onogawa,T., Suzuki,T., Asano,N., Tanemoto,M., Seki,M., Shiiba,K.,
            Suzuki,M., Kondo,Y., Nunoki,K., Shimosegawa,T., Iinuma,K., Ito,S.,
            Matsuno,S. and Abe,T.
  TITLE     Identification of thyroid hormone transporters in humans: different
            molecules are involved in a tissue-specific manner
  JOURNAL   Endocrinology 142 (5), 2005-2012 (2001)
   PUBMED   11316767
REFERENCE   10 (bases 1 to 2716)
  AUTHORS   Tamai,I., Nezu,J., Uchino,H., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Molecular identification and characterization of novel members of
            the human organic anion transporter (OATP) family
  JOURNAL   Biochem Biophys Res Commun 273 (1), 251-260 (2000)
   PUBMED   10873595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM846201.1, AB031051.1, BC015727.1, AI660559.1 and AF205072.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016354.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015727.1, SRR1803611.122216.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217159.6/ ENSP00000217159.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BM846201.1         59-114
            57-698              AB031051.1         1-642
            699-2636            BC015727.1         715-2652
            2637-2708           AI660559.1         7-78                c
            2709-2716           AF205072.1         2707-2714
FEATURES             Location/Qualifiers
     source          1..2716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2716
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /note="solute carrier organic anion transporter family
                     member 4A1"
                     /db_xref="GeneID:28231"
                     /db_xref="HGNC:HGNC:10953"
                     /db_xref="MIM:612436"
     exon            1..51
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            52..943
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2316
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /note="solute carrier family 21 (organic anion
                     transporter), member 12; organic anion transporting
                     polypeptide E; sodium-independent organic anion
                     transporter E; organic anion transporter
                     polypeptide-related protein 1; colon organic anion
                     transporter; solute carrier family 21 member 12; OATP-RP1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 4A1"
                     /protein_id="NP_057438.3"
                     /db_xref="CCDS:CCDS13501.1"
                     /db_xref="GeneID:28231"
                     /db_xref="HGNC:HGNC:10953"
                     /db_xref="MIM:612436"
                     /translation="MPLHQLGDKPLTFPSPNSAMENGLDHTPPSRRASPGTPLSPGSL
                     RSAAHSPLDTSKQPLCQLWAEKHGARGTHEVRYVSAGQSVACGWWAFAPPCLQVLNTP
                     KGILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFV
                     SYFGGSGHKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCAD
                     STSGLSRYQLVFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGP
                     AAGYLIGGALLNIYTEMGRRTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQ
                     LPGSQRYAVMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAG
                     ATEATLITGMSTFSPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLR
                     GSAVIKFCLFCTVVSLLGILVFSLHCPSVPMAGVTASYGGSLLPEGHLNLTAPCNAAC
                     SCQPEHYSPVCGSDGLMYFSLCHAGCPAATETNVDGQKVYRDCSCIPQNLSSGFGHAT
                     AGKCTSTCQRKPLLLVFIFVVIFFTFLSSIPALTATLRCVRDPQRSFALGIQWIVVRI
                     LGGIPGPIAFGWVIDKACLLWQDQCGQQGSCLVYQNSAMSRYILIMGLLYKVLGVLFF
                     AIACFLYKPLSESSDGLETCLPSQSSAPDSATDSQLQSSV"
     exon            944..1034
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1156
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1268
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1423
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1619
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1785
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1958
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2023
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2172
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2716
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /note="hexamer: AATATA"
     polyA_site      2533
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
     regulatory      2693..2698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /note="hexamer: AATATA"
     polyA_site      2716
                     /gene="SLCO4A1"
                     /gene_synonym="OATP-E; OATP1; OATP4A1; OATPE; OATPRP1;
                     POAT; SLC21A12"
                     /note="major polyA site"
ORIGIN      
        1 agagcgtgga gcgctgcgcg gcgcggcggc cgggccctcg agacggggac ggacacacca
       61 gcccctcgga taccacttgg ccactcccgc tgaggccact cccactgcgt ggctgaagcc
      121 tcgaggtcac caggcggagg cgcggagatg cccctgcatc agctggggga caagccgctc
      181 accttcccca gccccaactc agccatggaa aacgggcttg accacacccc acccagcagg
      241 agggcatccc cgggcacacc cctgagcccc ggctccctcc gctccgctgc ccatagcccc
      301 ctggacacca gcaagcagcc cctctgccag ctctgggccg agaagcatgg cgcccggggg
      361 acccatgagg tgcggtacgt ctcggccggg cagagcgtgg cgtgcggctg gtgggccttc
      421 gcaccgccgt gcctgcaggt cctcaacacg cccaagggca tcctgttctt cctgtgtgcg
      481 gccgcattcc tgcaggggat gactgtgaat ggcttcatca acacagtcat cacctccctg
      541 gagcgccgct atgacctgca cagctaccag agcgggctca tcgccagctc ctacgacatt
      601 gccgcctgcc tctgcctcac cttcgtcagc tacttcgggg gctcagggca caagccgcgc
      661 tggctgggct ggggcgtgct gcttatgggc acggggtcgc tggtgttcgc gctgccccac
      721 ttcacggctg gccgctatga ggtggagttg gacgcgggtg tcaggacgtg ccctgccaac
      781 cccggcgcgg tgtgtgcgga cagcacctcg ggcctgtccc gctaccagct ggtcttcatg
      841 ctgggccagt tcctgcatgg cgtgggtgcc acacccctct acacgctggg cgtcacctac
      901 ctggatgaga acgtcaagtc cagctgctcg cccgtctaca ttgccatctt ctacacagcg
      961 gccatcctgg gcccagctgc cggctacctg attggaggtg ccctgctgaa tatctacacg
     1021 gaaatgggcc gacggacgga gctgaccacc gagagcccac tgtgggtcgg cgcctggtgg
     1081 gtcggcttcc tgggctctgg ggccgctgct ttcttcaccg ccgttcccat ccttggttac
     1141 cctcggcagc tgccaggctc ccagcgctac gcggtcatga gagcggcgga aatgcaccag
     1201 ttgaaggaca gcagccgtgg ggaggcgagc aacccggact ttgggaaaac catcagagac
     1261 ctgcctctct ccatctggct cctgctgaag aaccccacgt tcatcctgct ctgcctggcc
     1321 ggggccaccg aggccactct catcaccggc atgtccacgt tcagccccaa gttcttggag
     1381 tcccagttca gcctgagtgc ctcagaagct gccaccttgt ttgggtacct ggtggtgcca
     1441 gcgggtggtg gcggcacctt cctgggcggc ttctttgtga acaagctcag gctccggggc
     1501 tccgcggtca tcaagttctg cctgttctgc accgttgtca gcctgctggg catcctcgtc
     1561 ttctcactgc actgccccag tgtgcccatg gcgggcgtca cagccagcta cggcgggagc
     1621 ctcctgcccg aaggccacct gaacctaacg gctccctgca acgctgcctg cagctgccag
     1681 ccagaacact acagccctgt gtgcggctcg gacggcctca tgtacttctc actgtgccac
     1741 gcagggtgcc ctgcagccac ggagacgaat gtggacggcc agaaggtgta ccgagactgt
     1801 agctgtatcc ctcagaatct ttcctctggt tttggccatg ccactgcagg gaaatgcact
     1861 tcaacttgtc agagaaagcc cctccttctg gttttcatat tcgttgtaat tttctttaca
     1921 ttcctcagca gcattcctgc actaacggca actctacgat gtgtccgtga ccctcagaga
     1981 tcctttgccc tgggaatcca gtggattgta gttagaatac tagggggcat cccggggccc
     2041 atcgccttcg gctgggtgat cgacaaggcc tgtctgctgt ggcaggacca gtgtggccag
     2101 cagggctcct gcttggtgta ccagaattcg gccatgagcc gctacatact catcatgggg
     2161 ctcctgtaca aggtgctggg cgtcctcttc tttgccatag cctgcttctt atacaagccc
     2221 ctgtcggagt cttcagatgg cctggaaact tgtctgccca gccagtcctc agcccctgac
     2281 agtgccacag atagccagct ccagagcagc gtctgaccac cgcccgcgcc cacccggcca
     2341 cggcgggcac tcagcatttc ctgatgacag aacagtgccg ttgggtgatg caatcacacg
     2401 ggaacttcta tttgacctgc aaccttctac ttaacctgtg gtttaaagtc ggctgtgacc
     2461 tcctgtcccc agagctgtac ggccctgcag tgggtgggag gaacttgcat aaatatatat
     2521 ttatggacac acagtttgca tcagaacgtg tttatagaat gtgttttata cccgatcgtg
     2581 tgtggtgtgc gtgaggacaa actccgcagg ggctgtgaat cccactggga gggcggtggg
     2641 cctgcagcct gaggaaggct tgtgtgtcct cagttaaaac tgtgcatatc gaaatatatt
     2701 ttgttattta agcctg
//
