LOCUS       NM_013272               5102 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            3A1 (SLCO3A1), transcript variant 1, mRNA.
ACCESSION   NM_013272 XM_941061 XM_944958 XM_944959
VERSION     NM_013272.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5102)
  AUTHORS   Hau,R.K., Klein,R.R., Wright,S.H. and Cherrington,N.J.
  TITLE     Localization of Xenobiotic Transporters Expressed at the Human
            Blood-Testis Barrier
  JOURNAL   Drug Metab Dispos 50 (6), 770-780 (2022)
   PUBMED   35307651
REFERENCE   2  (bases 1 to 5102)
  AUTHORS   Li,M., Wang,W., Cheng,Y., Zhang,X., Zhao,N., Tan,Y., Xie,Q.,
            Chai,J. and Pan,Q.
  TITLE     Tumor necrosis factor alpha upregulates the bile acid efflux
            transporter OATP3A1 via multiple signaling pathways in cholestasis
  JOURNAL   J Biol Chem 298 (2), 101543 (2022)
   PUBMED   34971708
  REMARK    GeneRIF: Tumor necrosis factor alpha upregulates the bile acid
            efflux transporter OATP3A1 via multiple signaling pathways in
            cholestasis.
REFERENCE   3  (bases 1 to 5102)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5102)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   5  (bases 1 to 5102)
  AUTHORS   Pan,Q., Zhang,X., Zhang,L., Cheng,Y., Zhao,N., Li,F., Zhou,X.,
            Chen,S., Li,J., Xu,S., Huang,D., Chen,Y., Li,L., Wang,H., Chen,W.,
            Cai,S.Y., Boyer,J.L. and Chai,J.
  TITLE     Solute Carrier Organic Anion Transporter Family Member 3A1 Is a
            Bile Acid Efflux Transporter in Cholestasis
  JOURNAL   Gastroenterology 155 (5), 1578-1592 (2018)
   PUBMED   30063921
  REMARK    GeneRIF: OATP3A1 functions as a bile acid efflux transporter that
            is up-regulated as an adaptive response to cholestasis.
REFERENCE   6  (bases 1 to 5102)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Organic anion transporting polypeptides of the OATP/ SLC21 family:
            phylogenetic classification as OATP/ SLCO superfamily, new
            nomenclature and molecular/functional properties
  JOURNAL   Pflugers Arch 447 (5), 653-665 (2004)
   PUBMED   14579113
  REMARK    Review article
REFERENCE   7  (bases 1 to 5102)
  AUTHORS   Adachi,H., Suzuki,T., Abe,M., Asano,N., Mizutamari,H., Tanemoto,M.,
            Nishio,T., Onogawa,T., Toyohara,T., Kasai,S., Satoh,F., Suzuki,M.,
            Tokui,T., Unno,M., Shimosegawa,T., Matsuno,S., Ito,S. and Abe,T.
  TITLE     Molecular characterization of human and rat organic anion
            transporter OATP-D
  JOURNAL   Am J Physiol Renal Physiol 285 (6), F1188-F1197 (2003)
   PUBMED   14631946
  REMARK    GeneRIF: OATP-D plays an important role in translocating
            prostaglandins in specialized tissues and cells.
REFERENCE   8  (bases 1 to 5102)
  AUTHORS   Schiffer,R., Neis,M., Holler,D., Rodriguez,F., Geier,A.,
            Gartung,C., Lammert,F., Dreuw,A., Zwadlo-Klarwasser,G., Merk,H.,
            Jugert,F. and Baron,J.M.
  TITLE     Active influx transport is mediated by members of the organic anion
            transporting polypeptide family in human epidermal keratinocytes
  JOURNAL   J Invest Dermatol 120 (2), 285-291 (2003)
   PUBMED   12542534
REFERENCE   9  (bases 1 to 5102)
  AUTHORS   Patel,P., Weerasekera,N., Hitchins,M., Boyd,C.A., Johnston,D.G. and
            Williamson,C.
  TITLE     Semi quantitative expression analysis of MDR3, FIC1, BSEP, OATP-A,
            OATP-C,OATP-D, OATP-E and NTCP gene transcripts in 1st and 3rd
            trimester human placenta
  JOURNAL   Placenta 24 (1), 39-44 (2003)
   PUBMED   12495658
REFERENCE   10 (bases 1 to 5102)
  AUTHORS   Tamai,I., Nezu,J., Uchino,H., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Molecular identification and characterization of novel members of
            the human organic anion transporter (OATP) family
  JOURNAL   Biochem Biophys Res Commun 273 (1), 251-260 (2000)
   PUBMED   10873595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104020.10, AF205074.1, AC113190.8 and AC116903.3.
            
            On Nov 22, 2018 this sequence version replaced NM_013272.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205074.1, AB031050.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318445.11/ ENSP00000320634.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC104020.10        22249-22270         c
            23-1082             AF205074.1         11-1070
            1083-1102           AC113190.8         148330-148349
            1103-2562           AF205074.1         1091-2550
            2563-5102           AC116903.3         124950-127489       c
FEATURES             Location/Qualifiers
     source          1..5102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..5102
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /note="solute carrier organic anion transporter family
                     member 3A1"
                     /db_xref="GeneID:28232"
                     /db_xref="HGNC:HGNC:10952"
                     /db_xref="MIM:612435"
     exon            1..381
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2334
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 (organic anion transporter),
                     member 11; PGE1 transporter; solute carrier family 21
                     member 11; organic anion-transporting polypeptide D;
                     sodium-independent organic anion transporter D; organic
                     anion transporter polypeptide-related protein 3"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 3A1 isoform 1"
                     /protein_id="NP_037404.2"
                     /db_xref="CCDS:CCDS10371.1"
                     /db_xref="GeneID:28232"
                     /db_xref="HGNC:HGNC:10952"
                     /db_xref="MIM:612435"
                     /translation="MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLV
                     SECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGAR
                     GHRPRLIGCGGIVMALGALLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEG
                     PDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGIL
                     FTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLF
                     FSSLLMFGFPQSLPPHSEPAMESEQAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQ
                     LRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLG
                     MTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCDTGPVAG
                     VTVPYGNSTAPGSALDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG
                     CACLTTVPAENATVVPGKCPSPGCQEAFLTFLCVMCICSLIGAMAQTPSVIILIRTVS
                     PELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCLFWSTFCGEQGACVLYDNVVYRY
                     LYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTSEFFASTLTLDNLGRDP
                     VPANQTHRTKFIYNLEDHEWCENMESVL"
     exon            382..847
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..946
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1210
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1375
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1574
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1713
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1889
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..1954
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..5102
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5084..5089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /note="hexamer: AATAAA"
     polyA_site      5102
                     /gene="SLCO3A1"
                     /gene_synonym="OATP-D; OATP-RP3; OATP3A1; OATPD; OATPRP3;
                     SLC21A11"
                     /note="major polyA site"
ORIGIN      
        1 gcgatcgcgg cggcggcggc ggcggcgagg agctgtgcct tccacctctc cagccccggc
       61 aggacggggg cggccgccgc gaacccgggg cggggacagc acgcagcctc gaggcgcgca
      121 cccccgcccg gcagcggccc cgacacccgg ggcgagcggg aaagcggcag cggcggcggc
      181 ggcggcggcg gcgggggaag gatgcagggg aagaagccgg gcggttcgtc gggcggcggc
      241 cggagcggcg agctgcaggg ggacgaggcg cagaggaaca agaaaaagaa aaagaaggtg
      301 tcctgctttt ccaacatcaa gatcttcctg gtgtccgagt gcgccctgat gctggcgcag
      361 ggcacggtgg gcgcctacct ggtgagcgtc ctgaccaccc tggagcgtag gttcaacctg
      421 cagagcgctg acgtgggtgt gatcgctagc agcttcgaga tcgggaacct ggcgctcatc
      481 ctcttcgtga gctacttcgg ggcacgcggg caccggccgc gcctgatcgg ctgcggcggc
      541 atcgtcatgg cgctgggcgc gctgctgtcg gcgctgcccg agttcctgac ccaccagtac
      601 aagtacgagg cgggcgagat ccgctggggc gccgagggcc gcgacgtctg cgcagccaac
      661 ggctcgggcg gcgacgaggg gcccgacccc gacctcatct gccgcaaccg gacggctacc
      721 aacatgatgt acttgctgct cattggggcc caggtgctcc tgggcatcgg tgctacccct
      781 gtgcagcccc tgggcgtctc ctacatcgac gaccacgtgc ggaggaagga ctcctcgctc
      841 tatataggaa tcctgttcac gatgctggta tttggaccag cctgcgggtt tatcctgggc
      901 tctttctgta ccaaaatcta cgtggatgcg gtcttcattg acacaagtaa cctggacatc
      961 actccggacg acccccgctg gatcggagcc tggtggggtg gctttctgct ctgcggtgcc
     1021 ttactcttct tctcttccct cttgatgttt gggtttccac agtccctgcc cccgcactca
     1081 gagcccgcca tggaaagcga gcaggccatg ctctccgaaa gagaatacga gagacccaag
     1141 cccagcaacg gggtcctgag gcaccccctg gagccagaca gcagtgcctc ctgtttccag
     1201 cagctgagag tgatcccgaa ggtcaccaag cacctgctct caaaccctgt gttcacctgc
     1261 atcatcctgg ccgcctgcat ggagattgca gtggtggctg gcttcgctgc ctttttgggg
     1321 aagtacctgg agcagcagtt taacctcacc acctcttctg ccaaccagct gcttgggatg
     1381 actgcgatcc cgtgtgcttg tctgggtatc ttcctgggag gtcttttggt gaagaagctc
     1441 agcctgtctg ccctgggggc cattcggatg gccatgctcg tcaacctggt gtccactgct
     1501 tgctacgtct ccttcctctt cctgggctgc gacactggcc ctgtggctgg ggttactgtt
     1561 ccctatggaa acagcacagc acctggctca gccctggacc cctactcgcc ctgcaataat
     1621 aactgtgaat gccaaaccga ttccttcact ccagtgtgtg gggcagatgg catcacctac
     1681 ctgtctgcct gctttgctgg ctgcaacagc acgaatctca cgggctgtgc gtgcctcacc
     1741 accgtccctg ctgagaacgc aaccgtggtt cctggaaaat gccccagtcc tgggtgccaa
     1801 gaggccttcc tcactttcct ctgtgtgatg tgtatctgca gcctgatcgg tgccatggca
     1861 cagacaccct cagtcatcat cctcatcagg acagtcagcc ctgaactcaa gtcttacgct
     1921 ttgggagttc tttttctcct ccttcgtttg ttgggcttca tccctccacc cctcatcttc
     1981 ggggctggca tcgactccac ctgcctgttc tggagcacgt tctgtgggga gcaaggcgcc
     2041 tgcgtcctct acgacaatgt ggtctaccga tacctgtatg tcagcatcgc catcgcgctc
     2101 aaatccttcg ccttcatcct gtacaccacc acgtggcagt gcctgaggaa aaactataaa
     2161 cgctacatca aaaaccacga gggcgggctg agcaccagtg agttctttgc ctctactctg
     2221 accctagaca acctggggag ggaccctgtg cccgcaaacc agacacatag gacaaagttt
     2281 atctataacc tggaagacca tgagtggtgt gaaaacatgg agtccgtttt atagtgacta
     2341 aaggagggct gaactctgta ttagtaatcc aagggtcatt tttttcttaa aaaaagaaaa
     2401 aaaggttcca aaaaaaacca aaactcagta cacacacaca ggcacagatg cacacacacg
     2461 cagacagaca caccgacttt gtcctttttc tcagcatcag agccagacag gattcagaat
     2521 aaggagagaa tgacatcgtg cggcagggtc ctggaggcca cttgcgcggc tgggccacag
     2581 agtctacttt gaaggcacct catggttttc aggatgctga cagctgcaag caacaggcac
     2641 tgccaaattc agggaacagt ggtggccagc ttggaggatg gacatttctg gatacacata
     2701 cacatacaaa acagaaaaca ttttttaaaa gaagtttcct aaaataaaaa aaattaaaaa
     2761 aaaaaaaccc acaagttgaa aacattgcca gattaagcac tagtgacaca ccccgtgcca
     2821 ccctcttcct ccaggtgggg gtgggggcgg gcgcacaagt cggaggggtg gaagcaccac
     2881 tcctctctct gactttcgca atatgggtca ctgtgtagac gactcaccca gtctgcatgt
     2941 ggttcaaggc cccagagttc tctcagtgat gctaatgggt gatccgtgct ggagtttgta
     3001 attggcacct ctcaccagct ccatttccat gttcaagact gagggcctga gggggagcca
     3061 ggtggggggc cagcacctcc cagtggcggg catccacctt cccccagccc cacagagtga
     3121 cctcaggaag cagtaggcct cgcctggcta tgactgaccc ggctcagagc tggtgagacc
     3181 caacgcagtc caagtcattt gcttacattt gccaaaaaca ttttgccatt tttaaaagaa
     3241 aaaaatacaa tccatatgaa tttcaaactg ttgtatgtat aatcctctaa tactattttt
     3301 aactacttct aaaatctgtg ttaacccttc aagtcactaa cacagttctc taggccggat
     3361 ttattatgct ggttgctttt actttttttc tcctttttta atgcaccaaa aatatgtgat
     3421 acaagggatg caattaacct attgtaattt tcatcatttt atcctcattc gaatattcta
     3481 caaaaacaag aatatacaat gtgttacaag aagaaaaaaa aatgcttcaa aaagagagtg
     3541 tatatgcagc ctgcctttaa aagaatcaca tttgagacaa caggggataa tgtgatgaat
     3601 tgcaaatttg ccttttagct tccttcccca tgattcagtg atcactgtca cgggaaaccc
     3661 ttttatattc atgcttgaca ttccaagagg cgttcttttc agcctgtgga ggagacactc
     3721 ttagatgtgg gtttgtgtgt atgggtgcaa cacttccggg gataggaaag aagaacagtt
     3781 ccctaacaca agctgttaag aagtctgtag catctctgat aacgaataga cccacaagct
     3841 cctggaagct gtcgtgtgtc caatgcgtga aaatgtctgt gacattttca gtgttagtct
     3901 tgaactaagg cccttgtctg tgtgttttga aggtgggtga acctcagaga atgaacctgt
     3961 tatgatttgg ggtaagaatc acgttggaaa acctctcgca accagcacac taggccttct
     4021 acggccattt ctgtaagggg acagagctta ggtaaaggca cacactcata cacacacaac
     4081 aaagggccct gctaacttac tcctcatgct gcttcagtga cctttgttca tgtcacattc
     4141 ctggcgctgg aaaaaaaact caaaggttga ttggtttgct ttttcacctt ggacacattt
     4201 gcattttacc cacaaggcaa acaaaagaat caggaagtaa aaaatggttg ggagtgggac
     4261 aggtatggta ccgaattttt aatgaacatt gtaaatgaag aggcttgaat gacagcccaa
     4321 atctagagaa ggcactcagc aagaccaacc aaaagaaaag ctgtgtcgtg gtatggggcc
     4381 accgtgatca gctacctggg gcaggatgct tctgagacag gcctttcaac tgcttagtgt
     4441 tagtatgtcc ttgcttatga aaatggggac actcatcagt acgttaacta ctaaagggga
     4501 gatggttctc caaccacttc ataaaatatg tatgttctgt tgttcctaag gctttgataa
     4561 tatcctgtac agattttggt ttagttttgc aaatatattg ctaataggtc actcttatag
     4621 attattgctt ggcccttcaa actcagtaca cacacactga ggccctttga cctagtgttt
     4681 tatggaacta tttgctttga gagaaaaaaa aaagaaagtt ttttaaactc tttgcatttt
     4741 ggattttttt tcctaagatt ttaggatgaa tgtgaaaaag atgttagaat aacaggaaga
     4801 caactccagg gctgagtttt atcagcaatt gggtataaat ttaaagaccg ctgttgcagg
     4861 atggctctga attctgttgt gtcgtctttt aaaattttaa ttattctcat atagtaccga
     4921 acagaaaact cagtctagtt ttaatttgcc ttttgtgctc taaagaagca ttgtacatac
     4981 aacactagat ccagcccctc gattatctgt ttggtttcaa gtgaatgaaa agatttcctg
     5041 gtaagatcat tggatttaca gaatacaaaa atgtacggga tggaataaac ctagaaagtg
     5101 aa
//
