LOCUS       NM_007256               4374 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            2B1 (SLCO2B1), transcript variant 1, mRNA.
ACCESSION   NM_007256
VERSION     NM_007256.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4374)
  AUTHORS   Kataoka,H., Akiyoshi,T., Uchida,Y., Imaoka,A., Terasaki,T. and
            Ohtani,H.
  TITLE     The Effects of N-Glycosylation on the Expression and Transport
            Activity of OATP1A2 and OATP2B1
  JOURNAL   J Pharm Sci 113 (5), 1376-1384 (2024)
   PUBMED   38432624
  REMARK    GeneRIF: The Effects of N-Glycosylation on the Expression and
            Transport Activity of OATP1A2 and OATP2B1.
REFERENCE   2  (bases 1 to 4374)
  AUTHORS   Gulnaz,A., Lee,K.R., Kang,M.J., Chang,J.E. and Chae,Y.J.
  TITLE     Roles of breast cancer resistance protein and organic anion
            transporting polypeptide 2B1 in gastrointestinal toxicity induced
            by SN-38 under inflammatory conditions
  JOURNAL   Toxicol Lett 394, 57-65 (2024)
   PUBMED   38423481
  REMARK    GeneRIF: Roles of breast cancer resistance protein and organic
            anion transporting polypeptide 2B1 in gastrointestinal toxicity
            induced by SN-38 under inflammatory conditions.
REFERENCE   3  (bases 1 to 4374)
  AUTHORS   Rajanala,S.H., Plym,A., Vaselkiv,J.B., Ebot,E.M., Matsoukas,K.,
            Lin,Z., Chakraborty,G., Markt,S.C., Penney,K.L., Lee,G.M.,
            Mucci,L.A., Kantoff,P.W. and Stopsack,K.H.
  TITLE     SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and
            prostate cancer outcomes: a prospective cohort study and
            meta-analysis
  JOURNAL   Carcinogenesis 45 (1-2), 35-44 (2024)
   PUBMED   37856781
  REMARK    GeneRIF: SLCO1B3 and SLCO2B1 genotypes, androgen deprivation
            therapy, and prostate cancer outcomes: a prospective cohort study
            and meta-analysis.
REFERENCE   4  (bases 1 to 4374)
  AUTHORS   Hoste,E., Paquot,A., Panin,N., Horion,S., El Hamdaoui,H.,
            Muccioli,G.G., Haufroid,V. and Elens,L.
  TITLE     Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate
            Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell
            Lines
  JOURNAL   Ther Drug Monit 45 (3), 400-408 (2023)
   PUBMED   36253893
  REMARK    GeneRIF: Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly
            Modulate Atorvastatin Intracellular Accumulation in HEK293
            Recombinant Cell Lines.
REFERENCE   5  (bases 1 to 4374)
  AUTHORS   Kobayashi,D., Nozawa,T., Imai,K., Nezu,J., Tsuji,A. and Tamai,I.
  TITLE     Involvement of human organic anion transporting polypeptide OATP-B
            (SLC21A9) in pH-dependent transport across intestinal apical
            membrane
  JOURNAL   J Pharmacol Exp Ther 306 (2), 703-708 (2003)
   PUBMED   12724351
REFERENCE   6  (bases 1 to 4374)
  AUTHORS   Ugele,B., St-Pierre,M.V., Pihusch,M., Bahn,A. and Hantschmann,P.
  TITLE     Characterization and identification of steroid sulfate transporters
            of human placenta
  JOURNAL   Am J Physiol Endocrinol Metab 284 (2), E390-E398 (2003)
   PUBMED   12409283
  REMARK    GeneRIF: uptake of steroid sulfates by isolated trophoblasts is
            mediated by OATP-B and OAT-4 suggesting a physiological role of
            both carrier proteins in placental uptake of fetal-derived steroid
            sulfates.
REFERENCE   7  (bases 1 to 4374)
  AUTHORS   Nozawa,T., Nakajima,M., Tamai,I., Noda,K., Nezu,J., Sai,Y.,
            Tsuji,A. and Yokoi,T.
  TITLE     Genetic polymorphisms of human organic anion transporters OATP-C
            (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese
            population and functional analysis
  JOURNAL   J Pharmacol Exp Ther 302 (2), 804-813 (2002)
   PUBMED   12130747
  REMARK    GeneRIF: Genetic polymorphisms: allele frequencies in the Japanese
            population and functional analysis
            GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4374)
  AUTHORS   St-Pierre,M.V., Hagenbuch,B., Ugele,B., Meier,P.J. and Stallmach,T.
  TITLE     Characterization of an organic anion-transporting polypeptide
            (OATP-B) in human placenta
  JOURNAL   J Clin Endocrinol Metab 87 (4), 1856-1863 (2002)
   PUBMED   11932330
REFERENCE   9  (bases 1 to 4374)
  AUTHORS   Kullak-Ublick,G.A., Ismair,M.G., Stieger,B., Landmann,L., Huber,R.,
            Pizzagalli,F., Fattinger,K., Meier,P.J. and Hagenbuch,B.
  TITLE     Organic anion-transporting polypeptide B (OATP-B) and its
            functional comparison with three other OATPs of human liver
  JOURNAL   Gastroenterology 120 (2), 525-533 (2001)
   PUBMED   11159893
REFERENCE   10 (bases 1 to 4374)
  AUTHORS   Tamai,I., Nezu,J., Uchino,H., Sai,Y., Oku,A., Shimane,M. and
            Tsuji,A.
  TITLE     Molecular identification and characterization of novel members of
            the human organic anion transporter (OATP) family
  JOURNAL   Biochem Biophys Res Commun 273 (1), 251-260 (2000)
   PUBMED   10873595
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC343392.1, BC041095.1,
            CK299190.1 and AP001972.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007256.4.
            
            Summary: This locus encodes a member of the organic
            anion-transporting polypeptide family of membrane proteins. The
            protein encoded by this locus may function in regulation of
            placental uptake of sulfated steroids. Alternatively spliced
            transcript variants have been described. [provided by RefSeq, Nov
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.213777.1,
                                           SRR1803617.143303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289575.10/ ENSP00000289575.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                DC343392.1         123-209
            88-4079             BC041095.1         77-4068
            4080-4225           CK299190.1         18-163              c
            4226-4374           AP001972.4         109811-109959
FEATURES             Location/Qualifiers
     source          1..4374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..4374
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="solute carrier organic anion transporter family
                     member 2B1"
                     /db_xref="GeneID:11309"
                     /db_xref="HGNC:HGNC:10962"
                     /db_xref="MIM:604988"
     exon            1..291
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..2405
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 (organic anion transporter),
                     member 9; OATP-RP2; organic anion transporter B; organic
                     anion transporter polypeptide-related protein 2; organic
                     anion transporting polypeptide 2B1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2B1 isoform 1"
                     /protein_id="NP_009187.1"
                     /db_xref="CCDS:CCDS8235.1"
                     /db_xref="GeneID:11309"
                     /db_xref="HGNC:HGNC:10962"
                     /db_xref="MIM:604988"
                     /translation="MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSV
                     FHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALI
                     VFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASL
                     CLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFA
                     HNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAW
                     WLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSP
                     GESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMAT
                     FLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGM
                     LLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPST
                     RVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLL
                     LVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDT
                     TCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEART
                     KESRSSPAVEQQLLVSGPGKKPEDSRV"
     exon            292..422
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            423..560
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            561..723
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            724..957
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1056
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1247
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1350
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1708
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1874
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2038
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2103
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2224
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..4374
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="hexamer: AATAAA"
     polyA_site      3941
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="major polyA site"
     regulatory      4059..4064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="hexamer: ATTAAA"
     polyA_site      4079
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="major polyA site"
     regulatory      4204..4209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="hexamer: ATTACA"
     polyA_site      4225
                     /gene="SLCO2B1"
                     /gene_synonym="OATP-B; OATP2B1; OATPB; SLC21A9"
                     /note="major polyA site"
ORIGIN      
        1 agaaggagca agtgacccag ggagacaaac acttggagat acttggggct gagtttgagc
       61 aagactccct aacctgtgtc tggacaagtc tgatgtcctg tgtggcccaa gaagaactga
      121 ccccgtgtct ggagctccca ccgttattgc atccctgctg tggctcacct gctgctgtct
      181 ccaggagccc ctgagaagat ttgcttcctc tcccctgcta agctccaggt cctgagatta
      241 aattaggggc tggagctcac tgcactccag cagtcatggg acccaggata gggccagcgg
      301 gtgaggtacc ccaggtacca gacaaggaaa ccaaagccac aatgggcaca gaaaacacac
      361 ctggaggcaa agccagccca gaccctcagg acgtgcggcc aagtgtgttc cataacatca
      421 agctgttcgt tctgtgccac agcctgctgc agctggcgca gctcatgatc tccggctacc
      481 taaagagctc catctccaca gtggagaagc gcttcggcct ctccagccag acgtcggggc
      541 tgctggcctc cttcaacgag gtggggaaca cagccttgat tgtgtttgtg agctattttg
      601 gcagccgggt gcaccgaccc cgaatgattg gctatggggc tatccttgtg gccctggcgg
      661 gcctgctcat gactctcccg cacttcatct cggagccata ccgctacgac aacaccagcc
      721 ctgaggatat gccacaggac ttcaaggctt ccctgtgcct gcccacaacc tcggccccag
      781 cctcggcccc ctccaatggc aactgctcaa gctacacaga aacccagcat ctgagtgtgg
      841 tggggatcat gttcgtggca cagaccctgc tgggcgtggg cggggtgccc attcagccct
      901 ttggcatctc ctacatcgat gactttgccc acaacagcaa ctcgcccctc tacctcggga
      961 tcctgtttgc agtgaccatg atggggccag gcctggcctt tgggctgggc agcctcatgc
     1021 tgcgccttta tgtggacatt aaccagatgc cagaaggtgg tatcagcctg accataaagg
     1081 acccccgatg ggtgggtgcc tggtggctgg gtttcctcat cgctgccggt gcagtggccc
     1141 tggctgccat cccctacttc ttcttcccca aggaaatgcc caaggaaaaa cgtgagcttc
     1201 agtttcggcg aaaggtctta gcagtcacag actcacctgc caggaagggc aaggactctc
     1261 cctctaagca gagccctggg gagtccacga agaagcagga tggcctagtc cagattgcac
     1321 caaacctgac tgtgatccag ttcattaaag tcttccccag ggtgctgctg cagaccctac
     1381 gccaccccat cttcctgctg gtggtcctgt cccaggtatg cttgtcatcc atggctgcgg
     1441 gcatggccac cttcctgccc aagttcctgg agcgccagtt ttccatcaca gcctcctacg
     1501 ccaacctgct catcggctgc ctctccttcc cttcggtcat cgtgggcatc gtggtgggtg
     1561 gcgtcctggt caagcggctc cacctgggcc ctgtgggatg cggtgccctt tgcctgctgg
     1621 ggatgctgct gtgcctcttc ttcagcctgc cgctcttctt tatcggctgc tccagccacc
     1681 agattgcggg catcacacac cagaccagtg cccaccctgg gctggagctg tctccaagct
     1741 gcatggaggc ctgctcctgc ccattggacg gctttaaccc tgtctgcgac cccagcactc
     1801 gtgtggaata catcacaccc tgccacgcag gctgctcaag ctgggtggtc caggatgctc
     1861 tggacaacag ccaggttttc tacaccaact gcagctgcgt ggtggagggc aaccccgtgc
     1921 tggcaggatc ctgcgactca acgtgcagcc atctggtggt gcccttcctg ctcctggtca
     1981 gcctgggctc ggccctggcc tgtctcaccc acacaccctc cttcatgctc atcctaagag
     2041 gagtgaagaa agaagacaag actttggctg tgggcatcca gttcatgttc ctgaggattt
     2101 tggcctggat gcccagcccc gtgatccacg gcagcgccat cgacaccacc tgtgtgcact
     2161 gggccctgag ctgtgggcgt cgagctgtct gtcgctacta caataatgac ctgctccgaa
     2221 accggttcat cggcctccag ttcttcttca aaacaggttc tgtgatctgc ttcgccttag
     2281 ttttggctgt cctgaggcag caggacaaag aggcaaggac caaagagagc agatccagcc
     2341 ctgccgtaga gcagcaattg ctagtgtcgg ggccagggaa gaagccagag gattcccgag
     2401 tgtgagctgt cttggggccc cacctggcca agagtagcag ccacagcagt acctcctctg
     2461 agtcctttgc ccaagattgg gtgtcaagag ccctgtgttc cattctggct cctccactaa
     2521 attgctgtgt gacttcaggc aagacattga tcctctctca gcctttgctt gctagtctga
     2581 accaaagagt tgtttgggca tttgctgtgt tggccatttc tggagcaaga gggtcttctt
     2641 cctccttccc ccagccagcc agctgtcctg gggccaggct ttcctgggtg gaaagaagta
     2701 tacctttccc tggggcccta ggatagcaaa gtgagccata gtgggccagg ctgccctcca
     2761 tgctgggccc cagcccaggt ctgcactcgc ctggatcacc ttctttgagc cttagccatc
     2821 tcctgtcagg taggaatgaa cttgccagcc ttcaggctcg ttcagctatg accatctgtg
     2881 cggtcagggt acactcagct ctcctcccca actccagcag cctttaagaa gtgtcccttt
     2941 ggcgccccct ggaggcagag cactgagctg gaccctgggt agactcccac agggaggacg
     3001 gagctggcct caggagtggg acacccagac ttggcagggc cttcaagagg cctgtgtggg
     3061 ggccccagga atccttagct gaagcgggga gactcactct ccatctcagg aaattctagc
     3121 ccttgccctc agggagccac ggttgagggt gaggcccaac acctgcctta gggccctggg
     3181 tgggcaagtc tgggccctgg ggtagggagg gagactcagg cccacacttg ggtattttct
     3241 aatttcagac aaacacacac tcagcgcgca ctcactgatt cctacacatt gccaagattt
     3301 cacacatgtg accaggggcc accaaagtcc ctgtgacctt tgtgactagg atcctaattt
     3361 ctctattttc tcctgggtgc ctgggtctgt gtcacctggg gcagtgtgga taatgtttag
     3421 ttctgtgaca ctgttttttg ggggtggcac ctggttctcc gatgcctggg ctggtgtcag
     3481 gcccaggact gtagtgctgg gagcagtaaa gctcagctct gtgtaatgag tgatgctatg
     3541 gcttgctcgt gtcttatgat ccaatccttt tctacatcag cccttgtttt gttttatggc
     3601 tagtcttatc tggcctggtt atttccttgc ggggaggaga gggtttgcta atctgctccc
     3661 agcccaacct attaccaccc cacctcgctg ggacctactg ctcgggaggc agcagacagg
     3721 gagccaccag cagtggcttc ctggccctgt gctgggggtg gggggaagct gggggcacat
     3781 gtggcccttg ccttctgagc agctcccagt gccagggctt tgagactttc ccacatgata
     3841 aaagaaaagg gaggtacaga agttccaatt ccctttttat tttgctggtt ggtatctgta
     3901 aatgtttaat aaatatctga gcatgtatct atcaacgcca agaatttcaa agtctccttc
     3961 aacaatatga ggcttttagg atgtttatat tccttcatcc ctcttgtttc ccaggttttg
     4021 cagggaaaaa aagtctggaa ttatagatac agcttattat taaatttgtt cttgcataat
     4081 gtctcttcta ttacaaaaat tctttcttca taaactgcat tagaggtttg caacaaccac
     4141 atcatttcca ttaacttaga tttaggtttt actggattca ttgctcacca ttattgcttg
     4201 tatattacat cttttccaat ctttatattc tggtctaatt tttgtttgag tgtcttcgtc
     4261 tactaatggt ttcaaaaatg gaataaggtc atgaggattt ctgaatcctc acctgtccaa
     4321 attgtcattc acattttata gaagaggaaa ctggctcaga aagcacaagt gact
//
