LOCUS       NM_005630               4067 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            2A1 (SLCO2A1), mRNA.
ACCESSION   NM_005630
VERSION     NM_005630.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4067)
  AUTHORS   Shang,Q., Dai,Y., Huang,J., Liu,W., Zhou,W., Liu,Y., Yang,H.,
            Wang,Q. and Li,Y.
  TITLE     Clinical and genetic characteristics of Chinese patients diagnosed
            with chronic enteropathy associated with SLCO2A1 gene
  JOURNAL   Orphanet J Rare Dis 19 (1), 201 (2024)
   PUBMED   38755710
  REMARK    GeneRIF: Clinical and genetic characteristics of Chinese patients
            diagnosed with chronic enteropathy associated with SLCO2A1 gene.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4067)
  AUTHORS   Niizeki,H., Tanaka,R., Nomura,T., Seki,A., Miyasaka,M.,
            Matsumoto,Y., Ishibashi,M., Narumi,S., Nakabayashi,K. and
            Yoshida,K.
  TITLE     Lack of cutis verticis gyrata is associated with c.1279_1290del12
            of SLCO2A1 in 43 Japanese patients with pachydermoperiostosis
  JOURNAL   J Dermatol Sci 114 (2), 86-88 (2024)
   PUBMED   38644096
  REMARK    GeneRIF: Lack of cutis verticis gyrata is associated with
            c.1279_1290del12 of SLCO2A1 in 43 Japanese patients with
            pachydermoperiostosis.
REFERENCE   3  (bases 1 to 4067)
  AUTHORS   Kimball,T.N., Rivero-Garcia,P., Barrera-Godinez,A. and
            Dominguez-Cherit,J.
  TITLE     Genotype and phenotype characterization of primary hypertrophic
            osteoarthropathy type 2 and chronic enteropathy associated with
            SLCO2A1: Report of two cases and literature review
  JOURNAL   Am J Med Genet A 194 (3), e63446 (2024)
   PUBMED   37915296
  REMARK    GeneRIF: Genotype and phenotype characterization of primary
            hypertrophic osteoarthropathy type 2 and chronic enteropathy
            associated with SLCO2A1: Report of two cases and literature review.
            Review article
REFERENCE   4  (bases 1 to 4067)
  AUTHORS   Gowtham,L., Halder,N., Singh,S.B., Angmo,D., Jayasundar,R., Dada,T.
            and Velpandian,T.
  TITLE     Evaluation of ADRB2 and OATP2A1 genetic polymorphisms in Indian
            patients with primary open-angle glaucoma
  JOURNAL   Pharmacogenet Genomics 34 (1), 20-24 (2024)
   PUBMED   37906648
  REMARK    GeneRIF: Evaluation of ADRB2 and OATP2A1 genetic polymorphisms in
            Indian patients with primary open-angle glaucoma.
REFERENCE   5  (bases 1 to 4067)
  AUTHORS   Kang,J., Chapdelaine,P., Laberge,P.Y. and Fortier,M.A.
  TITLE     Functional characterization of prostaglandin transporter and
            terminal prostaglandin synthases during decidualization of human
            endometrial stromal cells
  JOURNAL   Hum Reprod 21 (3), 592-599 (2006)
   PUBMED   16339169
  REMARK    GeneRIF: Human endometrial stromal cells treated with a combination
            of cAMP and medroxyprogesterone acetate to induce decidualization
            showed an increase in protein and mRNA levels.
REFERENCE   6  (bases 1 to 4067)
  AUTHORS   Huang,C.S., Huang,M.J., Lin,M.S., Yang,S.S., Teng,H.C. and
            Tang,K.S.
  TITLE     Genetic factors related to unconjugated hyperbilirubinemia amongst
            adults
  JOURNAL   Pharmacogenet Genomics 15 (1), 43-50 (2005)
   PUBMED   15864125
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4067)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Organic anion transporting polypeptides of the OATP/ SLC21 family:
            phylogenetic classification as OATP/ SLCO superfamily, new
            nomenclature and molecular/functional properties
  JOURNAL   Pflugers Arch 447 (5), 653-665 (2004)
   PUBMED   14579113
  REMARK    Review article
REFERENCE   8  (bases 1 to 4067)
  AUTHORS   Topper,J.N., Cai,J., Stavrakis,G., Anderson,K.R., Woolf,E.A.,
            Sampson,B.A., Schoen,F.J., Falb,D. and Gimbrone,M.A. Jr.
  TITLE     Human prostaglandin transporter gene (hPGT) is regulated by fluid
            mechanical stimuli in cultured endothelial cells and expressed in
            vascular endothelium in vivo
  JOURNAL   Circulation 98 (22), 2396-2403 (1998)
   PUBMED   9832484
REFERENCE   9  (bases 1 to 4067)
  AUTHORS   Lu,R. and Schuster,V.L.
  TITLE     Molecular cloning of the gene for the human prostaglandin
            transporter hPGT: gene organization, promoter activity, and
            chromosomal localization
  JOURNAL   Biochem Biophys Res Commun 246 (3), 805-812 (1998)
   PUBMED   9618293
REFERENCE   10 (bases 1 to 4067)
  AUTHORS   Lu,R., Kanai,N., Bao,Y. and Schuster,V.L.
  TITLE     Cloning, in vitro expression, and tissue distribution of a human
            prostaglandin transporter cDNA(hPGT)
  JOURNAL   J Clin Invest 98 (5), 1142-1149 (1996)
   PUBMED   8787677
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC117475.2 and AC080128.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 29, 2019 this sequence version replaced NM_005630.2.
            
            Summary: This gene encodes a prostaglandin transporter that is a
            member of the 12-membrane-spanning superfamily of transporters. The
            encoded protein may be involved in mediating the uptake and
            clearance of prostaglandins in numerous tissues. [provided by
            RefSeq, Dec 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041140.1, SRR1803611.222946.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000310926.11/ ENSP00000311291.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC117475.2         24172-24390
            220-357             AC117475.2         74479-74616
            358-520             AC117475.2         80272-80434
            521-748             AC117475.2         98904-99131
            749-847             AC117475.2         100336-100434
            848-984             AC117475.2         102753-102889
            985-1063            AC117475.2         105126-105204
            1064-1228           AC117475.2         105397-105561
            1229-1418           AC117475.2         106652-106841
            1419-1584           AC117475.2         108837-109002
            1585-1748           AC117475.2         111329-111492
            1749-1813           AC080128.21        545-609
            1814-1937           AC080128.21        3141-3264
            1938-4067           AC080128.21        4208-6337
FEATURES             Location/Qualifiers
     source          1..4067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1-q22.2"
     gene            1..4067
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="solute carrier organic anion transporter family
                     member 2A1"
                     /db_xref="GeneID:6578"
                     /db_xref="HGNC:HGNC:10955"
                     /db_xref="MIM:601460"
     exon            1..219
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2055
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="solute carrier family 21 (prostaglandin
                     transporter), member 2; matrin F/G 1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 2A1"
                     /protein_id="NP_005621.2"
                     /db_xref="CCDS:CCDS3084.1"
                     /db_xref="GeneID:6578"
                     /db_xref="HGNC:HGNC:10955"
                     /db_xref="MIM:601460"
                     /translation="MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLC
                     QLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIG
                     IGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQ
                     NPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFG
                     PAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFF
                     FFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLA
                     QCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVF
                     SLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSC
                     PDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCP
                     VPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWL
                     PSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFI
                     SWRVKKNKEYNVQKAAGLI"
     exon            220..357
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..520
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            521..748
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..847
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            848..984
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1063
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1228
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1418
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1584
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1748
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1813
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1937
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..4067
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2162..2167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="hexamer: AAGAAA"
     polyA_site      2177
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="major polyA site"
     regulatory      4041..4046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="hexamer: ATTAAA"
     polyA_site      4067
                     /gene="SLCO2A1"
                     /gene_synonym="MATR1; OATP2A1; PGT; PHOAD; PHOAR2;
                     SLC21A2"
                     /note="major polyA site"
ORIGIN      
        1 agtctccgct ccgcgaatct cctccggcca ctgccgccgc ggtcgcctct cacccgcccg
       61 gccgctccag cccgaggcgc cccgaccccg cgccactccg cgcccggcca gccgcccgca
      121 gccatggggc tcctgcccaa gctcggcgcg tcccagggca gcgacacctc tactagccga
      181 gccggccgct gtgcccgctc ggtcttcggc aacattaagg tgtttgtgct ctgccaaggc
      241 ctcctgcagc tctgccaact cctgtacagc gcctacttca agagcagcct caccaccatt
      301 gagaagcgct ttgggctctc cagttcttca tcgggtctca tttccagctt gaatgagatc
      361 agcaatgcca tcctcatcat ctttgtcagc tactttggca gccgggtgca ccgtccacgt
      421 ctgattggca tcggaggtct cttcctggct gcaggtgcct tcatcctcac cctcccacac
      481 ttcctctccg agccctacca gtacaccttg gccagcactg ggaacaacag ccgcttgcag
      541 gccgagctct gccagaagca ttggcaggac ctgcctccca gtaagtgcca cagcaccacc
      601 cagaaccccc agaaggagac cagcagcatg tggggcctga tggtggttgc ccagctgctg
      661 gctggcatcg ggacagtgcc tattcagcca tttgggatct cctatgtgga tgacttctca
      721 gagcccagca actcgcccct gtacatctcc atcttatttg ccatctctgt atttggaccg
      781 gctttcgggt acctgctggg ctctgtcatg ctgcagatct ttgtggacta tggcagggtc
      841 aacacagctg cagttaactt ggtcccgggt gacccccgat ggattggagc ctggtggcta
      901 ggcctgctca tttcttcagc tttattggtt ctcacctctt tccccttttt tttcttccct
      961 cgagcaatgc ccataggagc aaagagggct cctgccacag cagatgaagc aaggaagttg
     1021 gaggaggcca agtcaagagg ctccctggtg gatttcatta aacggtttcc atgcatcttt
     1081 ctgaggctcc tgatgaactc actcttcgtc ctggtggtcc tggcccagtg caccttctcc
     1141 tccgtcattg ctggcctctc caccttcctc aacaagttcc tggagaagca gtatggcacc
     1201 tcagcagcct atgccaactt cctcattggt gctgtgaacc tccctgctgc agccttgggg
     1261 atgctgtttg gaggaatcct catgaagcgc tttgttttct ctctacaagc cattccccgc
     1321 atagctacca ccatcatcac catctccatg atcctttgtg ttcctttgtt cttcatggga
     1381 tgctccaccc caactgtggc cgaagtctac ccccctagca catcaagttc tatacatccg
     1441 cagtctcctg cctgccgcag ggactgctcg tgcccagatt ctatcttcca cccggtctgt
     1501 ggagacaatg gaatcgagta cctctcccct tgccatgccg gctgcagcaa catcaacatg
     1561 agctctgcaa cctccaagca actgatctat ttgaactgca gctgtgtgac cgggggatcc
     1621 gcttcagcaa agacaggatc gtgccctgtc ccctgtgccc acttcctgct cccggccatc
     1681 ttcctcatct ccttcgtgtc cctgatagcc tgcatctccc acaaccccct ctacatgatg
     1741 gttctgcgtg tggtgaacca ggaggaaaag tcatttgcca tcggggtgca gttcttgttg
     1801 atgcgcttgc tggcctggct gccatctcca gccctctatg gcctcaccat tgaccactcc
     1861 tgcatccggt ggaactcgct gtgcttgggg aggcgagggg cctgcgccta ctatgacaac
     1921 gatgctctcc gagacaggta cctgggcctg cagatgggct acaaggcgct gggcatgctg
     1981 ctgctttgct tcatcagctg gagggtgaag aagaacaagg agtacaacgt gcagaaggcg
     2041 gcaggcctca tctgacccca ccctgggcca ctgccctgct ccagagagtg gaccttgact
     2101 cttccacacc tgcctatact cactaatgtt aacacgtcat ttcctttttg tatttttaaa
     2161 caagaaagaa aaccccagtc ctcatttgcc ttccctacct cttcctccca gagtcctccc
     2221 cacagttcct aagggccact gtgtacccgg gctgtgtggg ccagaactgg ggggctgagt
     2281 cttccctggc cccttggaag aggcccccag atgcccaggc tcacttcagt gttgagtcct
     2341 ccattgagga tgcccactga ggcagccagg cccctcacca gccctggggg gaatcctaaa
     2401 cagagagaga aaaagggtat ctgcccttct tgccaggcag ctccactctc ccgctgactg
     2461 cccacaccct gcagagtggc aggggtgaaa ggaagaagga agtggctgag ttattaatag
     2521 ccagagccac tgggagactg gggagactgg ctgtaacccc cttcacacct gggtttggca
     2581 tcagcacaga ctacgggagg ggctggctcc ctccccctca gaccctcact tcctgtacct
     2641 agaggccatt ctggatgctg ccatgttggg aagtacagtc tctgcccatt acctgcatgc
     2701 aggcaccaga gcagggactg agaaacccca aggatgggtc atctaagtgc tgtccatatg
     2761 aaccctggac tttctgtcct tagatcctca catgttatcc ctgtctttct ggggtacgtt
     2821 tcaaactgag gaagctacaa cacagtgaag acccaaggaa ggcctatgaa aaggtcctga
     2881 tgcccaacct cccacccctt caatgtgggg acgagacccc ctcatctcag agtaatggga
     2941 agaacctccc acatctccct ggcagcagat gaggtggctt cacatgcact tccctgtctg
     3001 gacttcagcc cgtattccga ggagtagaga ggcagaagag atgtcagcaa agcaagtgat
     3061 gaagcagagt ggatgtccac tgtcaccaag ctggatggca agctgcggcc cacaaaacag
     3121 ccagtcaggt tggctttcct ggtttcagac atgctcatac cattcccatt ttctcagcct
     3181 cttctcactg cctccagaga ggtgggtgcc tgggttgaga gacacagctg ctacgtgata
     3241 gatgttgaga gacagaagcc aacgaaggag gtcattcatc aacaaatata tttattggag
     3301 accgactttg tgcaaagcaa tgctaatcag ggttctccat ggagcttccc tcagctctta
     3361 cctcacctcc ctccatttac attagggcct tctcccaggg tgtgctcggt gggcagtgtg
     3421 ggactggggg tgtgggagtt ggtgagagca ggaggagagg tggggacagc aagaagccac
     3481 agattggcat gaaggatcct gacctgacta tccatgccat ccatggcccc cagactgact
     3541 ctgcacctgg ccctttgcca gacagctctg tctccccatg tcctctggaa cagctgggca
     3601 tgggtcatgg ccattcatga cccttaagtg ccacccttct tggaagaccc cctccagaag
     3661 catactggaa gccacctctg gaaaagcctc atatggtgat atgccaaaat atttatgtca
     3721 atgtccaaac aaagtccaat gccatgagac tgaagtcttt gtggaaacca ctgttacaga
     3781 caagcttatt tccaaagcca cctcatttcc aaacatctca ctcaggaagg gaggctcaat
     3841 gtaacctcag gggccagttt tagcatttga aatggttctg cttggaaaat gatgccctgc
     3901 aactaaccct ggtctttccc atggcaattt aaccacattt ggaaggcact gccttcagct
     3961 gagtttatga acaatgaatg ccaaccttca ggttctagaa gattggttgc actcccaaac
     4021 ctttattcta ttatattact attaaaatat tctaattttg ctattga
//
