LOCUS       NM_017435               3498 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            1C1 (SLCO1C1), transcript variant 2, mRNA.
ACCESSION   NM_017435
VERSION     NM_017435.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3498)
  AUTHORS   Wang,T., Wang,Y., Montero-Pedrazuela,A., Prensa,L.,
            Guadano-Ferraz,A. and Rausell,E.
  TITLE     Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in
            Projection Neurons and Interneurons of Basal Ganglia and Motor
            Thalamus in the Adult Human and Macaque Brains
  JOURNAL   Int J Mol Sci 24 (11), 9643 (2023)
   PUBMED   37298594
  REMARK    GeneRIF: Thyroid Hormone Transporters MCT8 and OATP1C1 Are
            Expressed in Projection Neurons and Interneurons of Basal Ganglia
            and Motor Thalamus in the Adult Human and Macaque Brains.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3498)
  AUTHORS   Laserna-Mendieta,E.J., Salvador-Martin,S., Arias,A.,
            Lopez-Cauce,B., Marin-Jimenez,I., Menchen,L.A., Marin-Rubio,L.,
            Ontanon Rodriguez,J., Lopez-Fernandez,L.A. and Lucendo,A.J.
  TITLE     Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes
            protect against infliximab failure in adults with Crohn's disease
  JOURNAL   Biomed Pharmacother 159, 114225 (2023)
   PUBMED   36621146
  REMARK    GeneRIF: Single nucleotide polymorphisms in ADAM17, IL23R and
            SLCO1C1 genes protect against infliximab failure in adults with
            Crohn's disease.
REFERENCE   3  (bases 1 to 3498)
  AUTHORS   Wang,Y., Wang,T., Montero-Pedrazuela,A., Guadano-Ferraz,A. and
            Rausell,E.
  TITLE     Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in
            Pyramidal Neurons and Interneurons in the Adult Motor Cortex of
            Human and Macaque Brain
  JOURNAL   Int J Mol Sci 24 (4), 3207 (2023)
   PUBMED   36834621
  REMARK    GeneRIF: Thyroid Hormone Transporters MCT8 and OATP1C1 Are
            Expressed in Pyramidal Neurons and Interneurons in the Adult Motor
            Cortex of Human and Macaque Brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3498)
  AUTHORS   Taroza,S., Rastenyte,D., Burkauskas,J., Podlipskyte,A.,
            Kazukauskiene,N., Patamsyte,V. and Mickuviene,N.
  TITLE     Deiodinases, organic anion transporter polypeptide polymorphisms
            and symptoms of anxiety and depression after ischemic stroke
  JOURNAL   J Stroke Cerebrovasc Dis 29 (9), 105040 (2020)
   PUBMED   32807452
  REMARK    GeneRIF: Deiodinases, organic anion transporter polypeptide
            polymorphisms and symptoms of anxiety and depression after ischemic
            stroke.
REFERENCE   5  (bases 1 to 3498)
  AUTHORS   Taroza,S., Rastenyte,D., Podlipskyte,A., Patamsyte,V. and
            Mickuviene,N.
  TITLE     Deiodinases, organic anion transporter polypeptide polymorphisms
            and ischemic stroke outcomes
  JOURNAL   J Neurol Sci 407, 116457 (2019)
   PUBMED   31677555
  REMARK    GeneRIF: Deiodinases, organic anion transporter polypeptide
            polymorphisms and ischemic stroke outcomes.
REFERENCE   6  (bases 1 to 3498)
  AUTHORS   Jansen,J., Friesema,E.C., Milici,C. and Visser,T.J.
  TITLE     Thyroid hormone transporters in health and disease
  JOURNAL   Thyroid 15 (8), 757-768 (2005)
   PUBMED   16131319
  REMARK    Review article
REFERENCE   7  (bases 1 to 3498)
  AUTHORS   Friesema,E.C., Jansen,J. and Visser,T.J.
  TITLE     Thyroid hormone transporters
  JOURNAL   Biochem Soc Trans 33 (Pt 1), 228-232 (2005)
   PUBMED   15667314
REFERENCE   8  (bases 1 to 3498)
  AUTHORS   Gao,B., Huber,R.D., Wenzel,A., Vavricka,S.R., Ismair,M.G., Reme,C.
            and Meier,P.J.
  TITLE     Localization of organic anion transporting polypeptides in the rat
            and human ciliary body epithelium
  JOURNAL   Exp Eye Res 80 (1), 61-72 (2005)
   PUBMED   15652527
REFERENCE   9  (bases 1 to 3498)
  AUTHORS   Hagenbuch,B. and Meier,P.J.
  TITLE     Organic anion transporting polypeptides of the OATP/ SLC21 family:
            phylogenetic classification as OATP/ SLCO superfamily, new
            nomenclature and molecular/functional properties
  JOURNAL   Pflugers Arch 447 (5), 653-665 (2004)
   PUBMED   14579113
  REMARK    Review article
REFERENCE   10 (bases 1 to 3498)
  AUTHORS   Pizzagalli,F., Hagenbuch,B., Stieger,B., Klenk,U., Folkers,G. and
            Meier,P.J.
  TITLE     Identification of a novel human organic anion transporting
            polypeptide as a high affinity thyroxine transporter
  JOURNAL   Mol Endocrinol 16 (10), 2283-2296 (2002)
   PUBMED   12351693
  REMARK    GeneRIF: We have isolated and functionally characterized OATP-F.
            OATP-F has a more selective substrate preference and may play an
            important role in the disposition of thyroid hormones in brain and
            testis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092491.6, AF205076.1 and
            AF260704.1.
            
            On Feb 27, 2020 this sequence version replaced NM_017435.4.
            
            Summary: This gene encodes a member of the organic anion
            transporter family. The encoded protein is a transmembrane receptor
            that mediates the sodium-independent uptake of thyroid hormones in
            brain tissues. This protein has particularly high affinity for the
            thyroid hormones thyroxine, tri-iodothyronine and reverse
            tri-iodothyronine. Polymorphisms in the gene encoding this protein
            may be associated with fatigue and depression in patients suffering
            from hyperthyroidism. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate splice site in the 3' coding region that results in a
            frameshift, compared to variant 1. The resulting protein (isoform
            2) has a distinct C-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF205076.1, AF260704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2146982
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266509.7/ ENSP00000266509.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC092491.6         7357-7489
            134-2427            AF205076.1         2-2295
            2428-3349           AF260704.1         1991-2912
            3350-3350           AC092491.6         65263-65263
            3351-3498           AF260704.1         2914-3061
FEATURES             Location/Qualifiers
     source          1..3498
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.2"
     gene            1..3498
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="solute carrier organic anion transporter family
                     member 1C1"
                     /db_xref="GeneID:53919"
                     /db_xref="HGNC:HGNC:13819"
                     /db_xref="MIM:613389"
     exon            1..476
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            477..630
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     CDS             502..2640
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     solute carrier family 21 (organic anion transporter),
                     member 14; solute carrier family 21 member 14; organic
                     anion transporter polypeptide-related protein 5; organic
                     anion transporter F; organic anion transporting
                     polypeptide 14; OATP-14; OAT-RP-5; thyroxine transporter;
                     organic anion transporter 1C1"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1C1 isoform 2"
                     /protein_id="NP_059131.1"
                     /db_xref="CCDS:CCDS8683.1"
                     /db_xref="GeneID:53919"
                     /db_xref="HGNC:HGNC:13819"
                     /db_xref="MIM:613389"
                     /translation="MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKV
                     FLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYF
                     GAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSS
                     QLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASE
                     DNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWL
                     GYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAK
                     IMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRAN
                     FVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENS
                     DVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQT
                     SNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLS
                     LGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRC
                     GSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERT
                     MVSTRFQKENYTTSDHLLQPNYWPGKETQL"
     exon            631..772
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            773..905
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1030
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1177
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1276
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1522
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1687
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1883
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2049
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2234
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2299
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2417
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..3498
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3305..3310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="hexamer: AATAAA"
     polyA_site      3330
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="major polyA site"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="hexamer: AATAAA"
     polyA_site      3498
                     /gene="SLCO1C1"
                     /gene_synonym="OATP-F; OATP-RP5; OATP1; OATP14; OATP1C1;
                     OATPF; OATPRP5; SLC21A14"
                     /note="major polyA site"
ORIGIN      
        1 ccttaccctc tgccccctgc ggagttgtgt tttctgggaa tcagcaagta agatcacaag
       61 tggtcttttc ttttattcac tctctcccat aaagaaagct ttatcacgtg tggccttaaa
      121 cttgcagcaa attgcaaaga aatggctcaa aagcttcagc tctttctgtg ccctgggagc
      181 tgagatgcac gtcagtggcc ttgccagcgt ggccaattct ctgctgactg ccagaaaaaa
      241 gaggccagga agaaagagga aagagaagag atcgctcagg ggtgagacca tgcccttcat
      301 cttttctttt ccctaatctc ctctgcttgt gtccacccac actctcccca cctggcaaaa
      361 ttgttcaaaa ttgctgtgga gtttacctca gtttcctctt tcagtctgtg gtgtgtggtc
      421 catcctcttg ctgagcacat tgaaaggaac tggctatctt tgatctcttc ctccagatca
      481 gagtcaagga atgtgtttat aatggacact tcatccaaag aaaatatcca gttgttctgc
      541 aaaacttcag tgcaacctgt tggaaggcct tcttttaaaa cagaatatcc ctcctcagaa
      601 gaaaagcaac catgctgtgg tgaactaaag gtgttcttgt gtgccttgtc ttttgtttac
      661 tttgccaaag cattggcaga aggctatctg aagagcacca tcactcagat agagagaagg
      721 tttgatatcc cttcttcact ggtgggagtt attgatggta gttttgaaat tgggaatctc
      781 ttagttataa catttgttag ctactttgga gccaaacttc acaggccaaa aataattgga
      841 gcagggtgtg taatcatggg agttggaaca ctgctcattg caatgcctca gttcttcatg
      901 gagcagtaca aatatgagag atattctcct tcctccaatt ccactctcag catctctccg
      961 tgtctcctag agtcaagcag tcaattacca gtttcagtta tggaaaaatc aaaatccaaa
     1021 ataagtaacg aatgtgaagt ggacactagc tcttccatgt ggatttatgt tttcctgggc
     1081 aatcttcttc gtggaatagg agaaactccc attcagcctt tgggcattgc ctacctggat
     1141 gattttgcca gtgaagacaa tgcagctttc tatattgggt gtgtgcagac ggttgcaatt
     1201 ataggaccaa tctttggttt cctgttaggc tcattatgtg ccaaactata tgttgacatt
     1261 ggctttgtaa acctagatca cataaccatt accccaaaag atccccagtg ggtaggagcc
     1321 tggtggcttg gctatctaat agcaggaatc ataagtcttc ttgcagctgt gcctttctgg
     1381 tatttaccaa agagtttacc aagatcccaa agtagagagg attctaattc ttcctctgag
     1441 aaatccaagt ttattataga tgatcacaca gactaccaaa caccccaggg agaaaatgca
     1501 aaaataatgg aaatggcaag agattttctt ccatcactga agaatctttt tggaaaccca
     1561 gtatacttcc tatatttatg tacaagcact gttcagttca attctctgtt cggcatggtg
     1621 acgtacaaac caaagtacat tgagcagcag tatggacagt catcctccag ggccaacttt
     1681 gtgatcgggc tcatcaacat tccagcagtg gcccttggaa tattctctgg ggggatagtt
     1741 atgaaaaaat tcagaatcag tgtgtgtgga gctgcaaaac tctacttggg atcatctgtc
     1801 tttggttacc tcctatttct ttccctgttt gcactgggct gtgaaaattc tgatgtggca
     1861 ggactaactg tctcctacca aggaaccaaa cctgtctctt atcatgaacg agctctcttt
     1921 tcagattgca actcaagatg caaatgttca gagacaaaat gggaacccat gtgcggtgaa
     1981 aatggaatca catatgtatc agcttgtctt gctggttgtc aaacctccaa caggagtgga
     2041 aaaaatatta tattttacaa ctgcacttgt gtgggaattg cagcttctaa atccggaaat
     2101 tcctcaggca tagtgggaag atgtcagaaa gacaatggat gtccccaaat gtttctgtat
     2161 ttccttgtaa tttcagtcat cacatcctat actttatccc taggtggcat acctggatac
     2221 atattacttc tgaggtgcat taagccacag cttaagtctt ttgccttggg tatctacaca
     2281 ttagcaataa gagttcttgc aggaatccca gctccagtgt attttggagt tttgattgat
     2341 acttcatgcc tcaaatgggg atttaaaaga tgtggaagta gaggatcatg cagattatat
     2401 gattcaaatg tcttcagaca tatatatctg ggactaactg tgatactggg cacagtgtca
     2461 attctcctaa gcattgcagt acttttcatt ttaaagaaaa attatgtttc aaaacacaga
     2521 agttttataa ccaagagaga aagaacaatg gtgtctacaa gattccaaaa ggaaaattac
     2581 actacaagtg atcatctgct acaacccaac tactggccag gcaaggaaac tcaactttag
     2641 aaacatgatg actggaagtc atgtcttcta attggttgac attttgcaaa caaataaatt
     2701 gtaatcaaaa gagctctaaa tttgtaattt ctttctcctt tcaaaaaatg tctactttgt
     2761 tttggtccta ggcattaggt aatataactg ataatatact gaaacatata atggaagatg
     2821 cagatgataa aactaatttt gaacttttta atttatataa attattttat atcacttact
     2881 tatttcactt tattttgctt tgtgctcatt gatatatatt agctgtactc ctagaagaac
     2941 aattgtctct attgtcacac atggttatat ttaaagtaat ttctgaactg tgtaatgtgt
     3001 ctagagtaag caaatactgc taacaattaa ctcatacctt gggttccttc aagtattact
     3061 cctatagtat tttctcccat agctgtcttc atctgtgtat tttaataatg atcttaggat
     3121 ggagcagaac atggagagga agatttcatt ttaagctcct ccttttcttt gaaatacaat
     3181 aatttatata gaaatgtgta gcagcaaatt atattgggga ttagaatttt gaattaatag
     3241 ctctcctact attaatttac atgtgctttt tgtgtggcgc tataagtgac tatggttgta
     3301 aagtaataaa attgatgtta acatgcccaa ttattgttct tttatgaatc caatgaattt
     3361 aaaactattg ttaaatataa tactgcccca ctttaatata tgtaagcaac ttcctactta
     3421 tacacgacgt gttcctaaaa catgtttgaa aggtgaattt ctgaaagtct acaataaatg
     3481 taggtgttac aacaggaa
//
