LOCUS       NM_001371097            3428 bp    mRNA    linear   PRI 11-FEB-2024
DEFINITION  Homo sapiens SLCO1B3-SLCO1B7 readthrough (SLCO1B3-SLCO1B7), mRNA.
ACCESSION   NM_001371097
VERSION     NM_001371097.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3428)
  AUTHORS   Meyer Zu Schwabedissen,H.E., Seibert,I., Grube,M., Alter,C.L.,
            Siegmund,W. and Hussner,J.
  TITLE     Genetic variants of SLCO1B7 are of relevance for the transport
            function of OATP1B3-1B7
  JOURNAL   Pharmacol Res 161, 105155 (2020)
   PUBMED   32818652
  REMARK    GeneRIF: Genetic variants of SLCO1B7 are of relevance for the
            transport function of OATP1B3-1B7.
REFERENCE   2  (bases 1 to 3428)
  AUTHORS   Malagnino,V., Duthaler,U., Seibert,I., Krahenbuhl,S. and Meyer Zu
            Schwabedissen,H.E.
  TITLE     OATP1B3-1B7 (LST-3TM12) Is a Drug Transporter That Affects
            Endoplasmic Reticulum Access and the Metabolism of Ezetimibe
  JOURNAL   Mol Pharmacol 96 (2), 128-137 (2019)
   PUBMED   31127008
REFERENCE   3  (bases 1 to 3428)
  AUTHORS   Malagnino,V., Hussner,J., Seibert,I., Stolzenburg,A., Sager,C.P.
            and Meyer Zu Schwabedissen,H.E.
  TITLE     LST-3TM12 is a member of the OATP1B family and a functional
            transporter
  JOURNAL   Biochem Pharmacol 148, 75-87 (2018)
   PUBMED   29248594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY442326.1, AC011604.10 and AC087309.10.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring SLCO1B3 (solute carrier
            organic anion transporter family member 1B3) and SLCO1B7 (solute
            carrier organic anion transporter family member 1B7 (putative))
            genes on chromosome 12. The readthrough transcript encodes a
            protein that shares sequence identity with both the upstream and
            downstream genes. [provided by RefSeq, Jun 2019].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN04284274
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 28234, 338821
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1897              AY442326.1         2-1898
            1898-1898           AC011604.10        112155-112155
            1899-2342           AY442326.1         1900-2343
            2343-2343           AC087309.10        127252-127252
            2344-2431           AY442326.1         2345-2432
            2432-3428           AC087309.10        127341-128337
FEATURES             Location/Qualifiers
     source          1..3428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.2"
     gene            1..3428
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /note="SLCO1B3-SLCO1B7 readthrough"
                     /db_xref="GeneID:115072896"
                     /db_xref="HGNC:HGNC:54403"
     exon            1..149
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2312
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /note="liver specific transporter-3 transmembrane 12;
                     organic anion transporting polypeptide 1B3-1B7; solute
                     carrier organic anion transporter family member 1B3-1B7"
                     /codon_start=1
                     /product="SLCO1B3-SLCO1B7 readthrough transcript protein"
                     /protein_id="NP_001358026.1"
                     /db_xref="GeneID:115072896"
                     /db_xref="HGNC:HGNC:54403"
                     /translation="MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALG
                     GIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCL
                     LMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEK
                     DCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMI
                     GPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPF
                     FFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILT
                     NPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFL
                     GGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVAS
                     HVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVE
                     VTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPE
                     LKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGIV
                     QPELKALAIGFHSMIMRSLGGILVPIYFGALIDTTCMKWSTNSCGARGACRIYNSTYL
                     GRAFFGLKVALIFPVLVLLTVFIFVVRKKSHGKDTKVLENERQVMDEANLEFLNDSEH
                     FVPSAEEQ"
     exon            150..291
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            292..424
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            425..546
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            547..693
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            694..792
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1035
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1200
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1396
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1562
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1747
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1812
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1930
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1995
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2113
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..3428
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3403..3408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /note="hexamer: AATAAA"
     polyA_site      3428
                     /gene="SLCO1B3-SLCO1B7"
                     /gene_synonym="LST-3TM12; OATP1B3-1B7"
                     /note="major polyA site"
ORIGIN      
        1 gtgatcattt caaaccaagc atcagcaaca attaaaaata ttcacttggt atctgtagtt
       61 taataatgga ccaacatcaa catttgaata aaacagcaga gtcagcatct tcagagaaaa
      121 agaaaacaag acgctgcaat ggattcaaga tgttcttggc agccctgtca ttcagctata
      181 ttgctaaagc actaggtgga atcattatga aaatttccat cactcaaata gaaaggagat
      241 ttgacatatc ctcttctctt gctggtttaa ttgatggaag ctttgaaatt ggaaatttgc
      301 ttgtgattgt atttgtaagt tactttggat ctaaactaca cagaccgaag ttaattggaa
      361 ttggttgtct ccttatggga actggaagta ttttgacatc tttaccacat ttcttcatgg
      421 gatattatag gtattctaaa gaaacccata ttaatccatc agaaaattca acatcaagtt
      481 tatcaacctg tttaattaat caaaccttat cattcaatgg aacatcacct gagatagtag
      541 aaaaagattg tgtaaaggaa tctgggtcac acatgtggat ctatgtcttc atggggaata
      601 tgcttcgtgg cataggggaa acccccatag taccattggg gatttcatac attgatgatt
      661 ttgcaaaaga aggacattct tccttgtatt taggtagttt gaatgcaata ggaatgattg
      721 gtccagtcat tggctttgca ctgggatctc tgtttgctaa aatgtacgtg gatattggat
      781 atgtagatct gagcactatc agaataactc ctaaggactc tcgttgggtt ggagcttggt
      841 ggcttggttt ccttgtgtct ggactatttt ccattatttc ttccatacca ttttttttct
      901 tgccgaaaaa tccaaataaa ccacaaaaag aaagaaaaat ttcactatca ttgcatgtgc
      961 tgaaaacaaa tgatgataga aatcaaacag ctaatttgac caaccaagga aaaaatgtta
     1021 ccaaaaatgt gactggtttt ttccagtctt tgaaaagcat ccttaccaat cccctgtatg
     1081 ttatatttct gcttttgaca ttgttacaag taagcagctt tattggttct tttacttacg
     1141 tctttaaata tatggagcaa cagtacggtc agtctgcatc tcatgctaac tttttgttgg
     1201 gaatcataac cattcctacg gttgcaactg gaatgttttt aggaggattt atcattaaaa
     1261 aattcaaatt gtctttagtt ggaattgcca aattttcatt tcttacttcg atgatatcct
     1321 tcttgtttca acttctatat ttccctctaa tctgcgaaag caaatcagtt gccggcctaa
     1381 ccttgaccta tgatggaaat aattcagtgg catctcatgt agatgtacca ctttcttatt
     1441 gcaactcaga gtgcaattgt gatgaaagtc agtgggaacc agtctgtggg aacaatggaa
     1501 taacttacct gtcaccttgt ctagcaggat gcaaatcctc aagtggtatt aaaaagcata
     1561 cagtgtttta taactgtagt tgtgtggaag taactggtct ccagaacaga aattactcag
     1621 cacacttggg tgaatgccca agagataata cttgtacaag gaaatttttc atctatgttg
     1681 caattcaagt cataaactct ttgttctctg caacaggagg taccacattt atcttgttga
     1741 ctgtgaagat tgttcaacct gaattgaaag cacttgcaat gggtttccag tcaatggtta
     1801 taagaacact aggaggaatt ctagctccaa tatattttgg ggctctgatt gataaaacat
     1861 gtatgaagtg gtccaccaac agctgtggag cacaaggggc ttgtaggata tataattccg
     1921 tattttttgg gattgttcaa cctgaattga aagcacttgc aatcggcttc cattcaatga
     1981 ttatgcgatc gctaggaggt attctagttc caatatattt tggggctctg attgatacaa
     2041 cgtgtatgaa gtggtccacc aacagctgtg gagcacgagg ggcttgtagg atatataatt
     2101 ccacatattt gggaagagcc ttcttcggct tgaaggtagc cctaatattt ccagtacttg
     2161 ttttacttac tgtatttatt tttgttgtaa ggaaaaaatc ccatggaaag gataccaaag
     2221 tattagaaaa tgaaagacaa gtaatggatg aagcaaactt agaattctta aacgacagtg
     2281 aacattttgt accttctgct gaagaacagt aaagcatgta attaagagga ggaaaaaaat
     2341 aattttgctg ctgtttccaa ctaatgtatt gattccataa gacgttattt ttgtggtgtt
     2401 ctgagtcttt tcactgagaa ttcccacatt cttcacttat gatgcaacaa tgaataagcc
     2461 tatgaattta taatgaaaca aactataaaa aatggtaccc atggttagga catagctaca
     2521 caagcatttg tagtttagaa tatataattc ataaaaattt gaagtgagag gaatagttaa
     2581 tatgtaatag aagaaaaagt acttgctcag gtagttgtaa ctcttaataa aaccaatgac
     2641 tagaatacaa gtggaagtaa aaaggtggag atagattaat agcctaaata acgagagaac
     2701 cttatgcctt ttttaaaaca aaacaaaacc attgagacat tttacttagt cctaaaatct
     2761 agcctggatt tatgctataa tgatatctat ttttcatgtt aaattgtaca ttactcagaa
     2821 attataaata ttattacttt ataatttgaa attgtgtttg ctagccacct tgatgtattt
     2881 tcttccaaac tcccattaag atactattga aaaaatagaa atagtcaaat atttgcaagg
     2941 tataattgtt aggcaacata ttatagcatg tgttaagttt ctgctaggcc tatggaaatt
     3001 ttttttttta tttttgttcc atttttattc actttgagga agtgttgcct ttttttttga
     3061 tgtacttaaa tggctaaaat aaaaaagaca atcacaagaa aaaaaaagaa gaaaaaataa
     3121 aaatgaaaat aaaaataaaa tatccatcaa ttttaatttc actccagtta gagaaagtaa
     3181 aagctctggt cttagataca tctcttgtat ttcatctgta gtgagaagaa agaacactct
     3241 tcattggcaa ttatcaaatt atttgtttga agagcatttt tccacattca gctccccatc
     3301 ttcttgcata aggaaatggt ttaagaaaag ctgactttga cttgagaaac aaaatccatt
     3361 gataagatgt gtcttcattg catctgtctg ttctctggga gaaataaaat ctgtgtcact
     3421 ctcttgca
//
