LOCUS       NM_019844               3013 bp    mRNA    linear   PRI 14-JAN-2025
DEFINITION  Homo sapiens solute carrier organic anion transporter family member
            1B3 (SLCO1B3), transcript variant 1, mRNA.
ACCESSION   NM_019844
VERSION     NM_019844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Liang,T., Liu,H., Li,L., Huan,R. and Gui,C.
  TITLE     Human organic anion transporting polypeptide 1B3 (OATP1B3) is more
            heavily N-glycosylated than OATP1B1 in extracellular loops 2 and 5
  JOURNAL   Int J Biol Macromol 278 (Pt 2), 134748 (2024)
   PUBMED   39147348
  REMARK    GeneRIF: Human organic anion transporting polypeptide 1B3 (OATP1B3)
            is more heavily N-glycosylated than OATP1B1 in extracellular loops
            2 and 5.
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Li,J., Xu,X., Xu,K., Zhou,X., Wu,K., Yao,Y., Liu,Z., Chen,C.,
            Wang,L., Sun,Z., Jiao,D. and Han,X.
  TITLE     N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic
            cholangiocarcinoma progression via regulating HOXC8 and PD-L1
  JOURNAL   J Exp Clin Cancer Res 43 (1), 119 (2024)
   PUBMED   38641828
  REMARK    GeneRIF: N6-methyladenosine-modified circSLCO1B3 promotes
            intrahepatic cholangiocarcinoma progression via regulating HOXC8
            and PD-L1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Fan,J., He,H.Y., Li,H.H., Wu,P.L., Tang,L., Deng,B.Y., Dong,W.H.
            and Wang,J.H.
  TITLE     Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1
            polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population
  JOURNAL   BMC Pediatr 24 (1), 82 (2024)
   PUBMED   38279097
  REMARK    GeneRIF: Associations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and
            HMOX1 polymorphisms and susceptibility to neonatal severe
            hyperbilirubinemia in Chinese Han population.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Nagai,M., Furihata,T., Matsumoto,S., Ishii,S., Motohashi,S.,
            Yoshino,I., Ugajin,M., Miyajima,A., Matsumoto,S. and Chiba,K.
  TITLE     Identification of a new organic anion transporting polypeptide 1B3
            mRNA isoform primarily expressed in human cancerous tissues and
            cells
  JOURNAL   Biochem Biophys Res Commun 418 (4), 818-823 (2012)
   PUBMED   22326869
  REMARK    GeneRIF: Isoform specific mRNA quantification showed that the
            Ct-OATP1B3 mRNA level was strikingly higher than that of Lt-OATP1B3
            mRNA in human cancer tissues.
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   van de Steeg,E., Stranecky,V., Hartmannova,H., Noskova,L.,
            Hrebicek,M., Wagenaar,E., van Esch,A., de Waart,D.R., Oude
            Elferink,R.P., Kenworthy,K.E., Sticova,E., al-Edreesi,M.,
            Knisely,A.S., Kmoch,S., Jirsa,M. and Schinkel,A.H.
  TITLE     Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome
            by interrupting conjugated bilirubin reuptake into the liver
  JOURNAL   J Clin Invest 122 (2), 519-528 (2012)
   PUBMED   22232210
  REMARK    GeneRIF: Data show that Rotor syndrome was linked to mutations
            predicted to cause complete and simultaneous deficiencies of the
            organic anion transporting polypeptides OATP1B1 and OATP1B3.
REFERENCE   6  (bases 1 to 3013)
  AUTHORS   Ismair,M.G., Stieger,B., Cattori,V., Hagenbuch,B., Fried,M.,
            Meier,P.J. and Kullak-Ublick,G.A.
  TITLE     Hepatic uptake of cholecystokinin octapeptide by organic
            anion-transporting polypeptides OATP4 and OATP8 of rat and human
            liver
  JOURNAL   Gastroenterology 121 (5), 1185-1190 (2001)
   PUBMED   11677211
REFERENCE   7  (bases 1 to 3013)
  AUTHORS   Abe,T., Unno,M., Onogawa,T., Tokui,T., Kondo,T.N., Nakagomi,R.,
            Adachi,H., Fujiwara,K., Okabe,M., Suzuki,T., Nunoki,K., Sato,E.,
            Kakyo,M., Nishio,T., Sugita,J., Asano,N., Tanemoto,M., Seki,M.,
            Date,F., Ono,K., Kondo,Y., Shiiba,K., Suzuki,M., Ohtani,H.,
            Shimosegawa,T., Iinuma,K., Nagura,H., Ito,S. and Matsuno,S.
  TITLE     LST-2, a human liver-specific organic anion transporter, determines
            methotrexate sensitivity in gastrointestinal cancers
  JOURNAL   Gastroenterology 120 (7), 1689-1699 (2001)
   PUBMED   11375950
REFERENCE   8  (bases 1 to 3013)
  AUTHORS   Kullak-Ublick,G.A., Ismair,M.G., Stieger,B., Landmann,L., Huber,R.,
            Pizzagalli,F., Fattinger,K., Meier,P.J. and Hagenbuch,B.
  TITLE     Organic anion-transporting polypeptide B (OATP-B) and its
            functional comparison with three other OATPs of human liver
  JOURNAL   Gastroenterology 120 (2), 525-533 (2001)
   PUBMED   11159893
REFERENCE   9  (bases 1 to 3013)
  AUTHORS   Konig,J., Cui,Y., Nies,A.T. and Keppler,D.
  TITLE     Localization and genomic organization of a new hepatocellular
            organic anion transporting polypeptide
  JOURNAL   J Biol Chem 275 (30), 23161-23168 (2000)
   PUBMED   10779507
REFERENCE   10 (bases 1 to 3013)
  AUTHORS   Jirsa,M., Knisely,A.S., Schinkel,A. and Kmoch,S.
  TITLE     Rotor Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   23236639
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011604.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_019844.3.
            
            Summary: This gene encodes a liver-specific member of the organic
            anion transporter family. The encoded protein is a transmembrane
            receptor that mediates the sodium-independent uptake of endogenous
            and xenobiotic compounds and plays a critical role in bile acid and
            bilirubin transport. Mutations in this gene are a cause of Rotor
            type hyperbilirubinemia. Alternative splicing of this gene and the
            use of alternative promoters results in transcript variants
            encoding different isoforms that differ in their tissue
            specificity. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1), which is highly expressed in the liver.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055874.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMN03465408
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381545.8/ ENSP00000370956.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC011604.10        21425-21484
            61-175              AC011604.10        24244-24358
            176-324             AC011604.10        26394-26542
            325-466             AC011604.10        65748-65889
            467-599             AC011604.10        69159-69291
            600-721             AC011604.10        71737-71858
            722-868             AC011604.10        73132-73278
            869-967             AC011604.10        73476-73574
            968-1210            AC011604.10        85955-86197
            1211-1375           AC011604.10        88492-88656
            1376-1571           AC011604.10        90156-90351
            1572-1737           AC011604.10        91575-91740
            1738-1922           AC011604.10        94138-94322
            1923-1987           AC011604.10        109156-109220
            1988-2105           AC011604.10        112070-112187
            2106-3013           AC011604.10        126724-127631
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.2"
     gene            1..3013
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="solute carrier organic anion transporter family
                     member 1B3"
                     /db_xref="GeneID:28234"
                     /db_xref="HGNC:HGNC:10961"
                     /db_xref="MIM:605495"
     exon            1..60
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            61..175
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            176..324
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..2349
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 21 (organic anion transporter),
                     member 8; organic anion transporter LST-3c; liver-specific
                     organic anion transporter 3TM13; organic anion transporter
                     8; organic anion-transporting polypeptide 8;
                     liver-specific organic anion transporter 2"
                     /codon_start=1
                     /product="solute carrier organic anion transporter family
                     member 1B3 isoform 1"
                     /protein_id="NP_062818.1"
                     /db_xref="CCDS:CCDS8684.1"
                     /db_xref="GeneID:28234"
                     /db_xref="HGNC:HGNC:10961"
                     /db_xref="MIM:605495"
                     /translation="MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALG
                     GIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCL
                     LMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEK
                     DCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMI
                     GPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPF
                     FFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILT
                     NPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFL
                     GGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVAS
                     HVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVE
                     VTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPE
                     LKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRV
                     YLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVP
                     SAGTDSKTCNLDMQDNAAAN"
     exon            325..466
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            467..599
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            600..721
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            722..868
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            869..967
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1210
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1375
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1571
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1737
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1922
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..1987
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2105
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..3013
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2799..2804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="hexamer: TATAAA"
     polyA_site      2820
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="major polyA site"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="hexamer: AAGAAA"
     polyA_site      3013
                     /gene="SLCO1B3"
                     /gene_synonym="HBLRR; LST-2; LST-3TM13; LST3; OATP-8;
                     OATP1B3; OATP8; SLC21A8"
                     /note="major polyA site"
ORIGIN      
        1 agactttaac atcagaaaaa ggatggactt gttgcagttg ctgtagcatt caaagtcaag
       61 ttgtgctttg cgatgctgag tttactgttt taaatggact tcaagcatag ccctgaagtg
      121 ttgtcccgtt gttcccacct cctagagggc ctgacagaag aggtacatat gctatgtgat
      181 catttcaaac caagcatcag caacaattaa aaatattcac ttggtatctg tagtttaata
      241 atggaccaac atcaacattt gaataaaaca gcagagtcag catcttcaga gaaaaagaaa
      301 acaagacgct gcaatggatt caagatgttc ttggcagccc tgtcattcag ctatattgct
      361 aaagcactag gtggaatcat tatgaaaatt tccatcactc aaatagaaag gagatttgac
      421 atatcctctt ctcttgctgg tttaattgat ggaagctttg aaattggaaa tttgcttgtg
      481 attgtatttg taagttactt tggatctaaa ctacacagac cgaagttaat tggaattggt
      541 tgtctcctta tgggaactgg aagtattttg acatctttac cacatttctt catgggatat
      601 tataggtatt ctaaagaaac ccatattaat ccatcagaaa attcaacatc aagtttatca
      661 acctgtttaa ttaatcaaac cttatcattc aatggaacat cacctgagat agtagaaaaa
      721 gattgtgtaa aggaatctgg gtcacacatg tggatctatg tcttcatggg gaatatgctt
      781 cgtggcatag gggaaacccc catagtacca ttggggattt catacattga tgattttgca
      841 aaagaaggac attcttcctt gtatttaggt agtttgaatg caataggaat gattggtcca
      901 gtcattggct ttgcactggg atctctgttt gctaaaatgt acgtggatat tggatatgta
      961 gatctgagca ctatcagaat aactcctaag gactctcgtt gggttggagc ttggtggctt
     1021 ggtttccttg tgtctggact attttccatt atttcttcca taccattttt tttcttgccg
     1081 aaaaatccaa ataaaccaca aaaagaaaga aaaatttcac tatcattgca tgtgctgaaa
     1141 acaaatgatg atagaaatca aacagctaat ttgaccaacc aaggaaaaaa tgttaccaaa
     1201 aatgtgactg gttttttcca gtctttgaaa agcatcctta ccaatcccct gtatgttata
     1261 tttctgcttt tgacattgtt acaagtaagc agctttattg gttcttttac ttacgtcttt
     1321 aaatatatgg agcaacagta cggtcagtct gcatctcatg ctaacttttt gttgggaatc
     1381 ataaccattc ctacggttgc aactggaatg tttttaggag gatttatcat taaaaaattc
     1441 aaattgtctt tagttggaat tgccaaattt tcatttctta cttcgatgat atccttcttg
     1501 tttcaacttc tatatttccc tctaatctgc gaaagcaaat cagttgccgg cctaaccttg
     1561 acctatgatg gaaataattc agtggcatct catgtagatg taccactttc ttattgcaac
     1621 tcagagtgca attgtgatga aagtcagtgg gaaccagtct gtgggaacaa tggaataact
     1681 tacctgtcac cttgtctagc aggatgcaaa tcctcaagtg gtattaaaaa gcatacagtg
     1741 ttttataact gtagttgtgt ggaagtaact ggtctccaga acagaaatta ctcagcacac
     1801 ttgggtgaat gcccaagaga taatacttgt acaaggaaat ttttcatcta tgttgcaatt
     1861 caagtcataa actctttgtt ctctgcaaca ggaggtacca catttatctt gttgactgtg
     1921 aagattgttc aacctgaatt gaaagcactt gcaatgggtt tccagtcaat ggttataaga
     1981 acactaggag gaattctagc tccaatatat tttggggctc tgattgataa aacatgtatg
     2041 aagtggtcca ccaacagctg tggagcacaa ggggcttgta ggatatataa ttccgtattt
     2101 tttggaaggg tctacttggg cttatctata gctttaagat tcccagcact tgttttatat
     2161 attgttttca tttttgctat gaagaaaaaa tttcaaggaa aagataccaa ggcatcggac
     2221 aatgaaagaa aagtaatgga tgaagcaaac ttagaattct taaataatgg tgaacatttt
     2281 gtaccttctg ctggaacaga tagtaaaaca tgtaatttgg acatgcaaga caatgctgct
     2341 gccaactaac attgcattga ttcattaaga tgttattttt gaggtgttcc tggtctttca
     2401 ctgacaattc caacattctt tacttacagt ggaccaatgg ataagtctat gcatctataa
     2461 taaactataa aaaatgggag tacccatggt taggatatag ctatgccttt atggttaaga
     2521 ttagaatata tgatccataa aaatttaaag tgagaggcat ggttagtgtg tgatacaata
     2581 aaaagtaatt gtttggtagt tgtaactgct aataaaacca gtgactagaa tataagggag
     2641 gtaaaaagga caagatagat taatagccta aataaagaga aaagcctgat gcctttaaaa
     2701 aaaatgaaac actttggatg tattacttag gccaaaatct ggcctggatt tatgctataa
     2761 tatatatttt catgttaagt tgtatatttt tcagaaatta taaatattat taatttaaaa
     2821 tttgaatttg tgtttgacta acaacctcga tggatcttct tccaacctcc cattaagatc
     2881 ctgcagaaga aatagaaata ttcaaatatt gcaaggtgta attgtgagac aacttattat
     2941 aatacgtgtt aagtttctac tggacccatg gaagtggatt aagaaaaacc gactttagct
     3001 tgagaaagca aaa
//
